Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model

Calcified Tissue International

Volumn 63, Issue 4, 1998, Pages 357-360

  Riew, K D ^a   Wright, N M ^a   Cheng, S L ^a   Avioli, L V ^a   Lou, J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone induction; Bone morphogenetic protein; Gene therapy; Spinal fusion; Stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE THERAPY; MESENCHYME; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RABBIT; REVIEW; SPINE FUSION; STEM CELL; TISSUE CULTURE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; BONE REMODELING; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; GENE THERAPY; GENETIC VECTORS; HUMANS; MALE; RABBITS; RECOMBINANT PROTEINS; SPINAL FUSION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031685274     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900540     Document Type: Review

References (28)

1. Bernhardt M, Swartz DE, Clothiaux PL, Crowell RR, White AA III (1992) Posterolateral lumbar and lumbosacral fusion with and without pedicle screw internal fixation. Clin Orthop 284: 109-15
2. Steinmann JC, Herkowitz HN (1992) Pseudarthrosis of the spine. Clin Orthop 284:80-90
3. Zdeblick TA (1993) A prospective, randomized study of lumbar fusion. Preliminary results [see comments]. Spine 18:983-991
4. Sandhu HS, Kanim LE, Kabo JM, Toth JM, Zeegen EN, Liu D, Delamarter RB, Dawson EG (1996) Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion. Spine 21:2115-2122
5. Holliger EH, Trawick RH, Boden SD, Hutton WC (1996) Morphology of the lumbar intertransverse process fusion mass in the rabbit model: a comparison between two bone graft materials - rhBMP-2 and autograft. J Spinal Disorders 9:125-128
6. Helm GA, Sheehan JM, Sheehan JP, Jane JA Jr, diPierro CG, Simmons NE, Gillies GT, Kallmes DF, Sweeney TM (1997) Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion J Neurosurg 86:93-100
7. Boden SD, Moskovitz PA, Morone MA, Toribitake Y (1996) Video-assisted lateral intertransverse process arthrodesis. Validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and nonhuman primate (rhesus) models. Spine 21:2689-2697
8. Bruder SP, Fink DJ, Caplan AI (1994) Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283-294
9. Goshima J, Goldberg VM, Caplan AI (1991) The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop 269:274-283
10. Goshima J, Goldberg VM, Caplan AI (1991) The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop 262:298-311
11. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI (1992) Characterization of cells with osteogenic potential from human marrow. Bone 13:81-88
12. Nakahara H, Bruder SP, Goldberg VM, Caplan AI (1990) In vivo osteochondrogenic potential of cultured cells derived from the periosteum. Clin Orthop 259:223-232
13. Nakahara H, Goldberg VM, Caplan AI (1992) Culture-expanded periosteal-derived cells exhibit osteochondrogenic potential in porous calcium phosphate ceramics in vivo. Clin Orthop 276:291-298
14. Ohgushi H, Goldberg VM, Caplan AI (1989) Heterotopic osteogenesis in porous ceramics induced by marrow cells. J Orthop Res 7:568-578
15. Ohgushi H, Goldberg VM, Caplan AI (1989) Repair of bone defects with marrow cells and porous ceramic. Experiments in rats. Acta Orthop Scand 60:334-339
16. Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, Goldberg VM (1994) Mesenchymal cell-based repair of large, full-thickness defects of articular cartilate. J Bone Joint Surg [Am] 76:579-592
17. Cassiede P, Dennis JE, Ma F, Caplan AI (1996) Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-beta 1 or PDGF-BB as assayed in vivo and in vitro. J Bone Miner Res 11:1264-1273
18. Erlebacher A, Derynck R (1996) Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol 132:195-210
19. Cook SD, Rueger DC (1996) Osteogenic protein-1: biology and applications. Clin Orthop 324:29-38
20. Gerhart TN, Kirker-Head CA, Kriz MJ, Holtrop ME, Hennig GE, Hipp J, Schelling SH, Wang E (1993) Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop 293:317-326
21. Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA (1992) The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats [published erratum appears in J Bone Joint Surg Am 1992 Aug;74(7):1111]. J Bone Joint Surg [Am] 74:659-670
22. Ashton BA, Eaglesom CC, Bab I, Owen ME (1984) Distribution of fibroblastic colony-forming cells in rabbit bone marrow and assay of their osteogenic potential by an in vivo diffusion chamber method. Calcif Tissue Int 36:83-86
23. Cheng SL, Yang JW, Rifas L, Zhang SF, Avioli LV (1994) Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone. Endocrinology 134:277-286
24. Lou J, Manske PR, Aoki M, Joyce ME (1996) Adenovirus-mediated gene transfer into tendon and tendon sheath. J Orthop Res 14:513-517
25. Wozniak M, Limbird LE (1996) The three alpha 2-adrenergic receptor subtypes achieve basolateral localization in Madin-Darby canine kidney II cells via different targeting mechanisms. J Biol Chem 271:5017-5024
26. Yoshikawa H, Rettig WJ, Takaoka K, Alderman E, Rup B, Rosen V, Wozney JM, Lane JM, Huvos AG, Garin-Chesa P (1994) Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. Cancer 73:85-91
27. Muschler GF, Hyodo A, Manning T, Kambic H, Easley K (1994) Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin Orthop 308:229-240
28. Bourdeau JE, Hesselton RA (1988) Serum calcium concentrations in wild rabbits. Miner Electrolyte Metab 14:253-256