CT and radionuclide study of BMP-2 gene therapy-induced bone formation

Academic Radiology

Volumn 9, Issue 6, 2002, Pages 632-637

  Varady, Peter ^a   Li, Jin Zhong ^a   Alden, Tord D ^a   Kallmes, David F ^a   Williams, Mark B ^a   Helm, Gregory A ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Bones CT; Bones, growth and development; Bones, radiography; Bones, radionuclide studies; Genes and genetics; Viruses

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; MEDRONATE TECHNETIUM TC 99M; RADIOISOTOPE; BMP2 PROTEIN, RAT; BONE MORPHOGENETIC PROTEIN; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE SCINTISCANNING; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION ANALYSIS; DIGITAL RADIOGRAPHY; GENE THERAPY; NONHUMAN; NUDE MOUSE; OSSIFICATION; PRIORITY JOURNAL; RAT; ANIMAL; BONE; GENE TRANSFER; GENE VECTOR; GENETICS; IMAGE PROCESSING; NUDE RAT; RADIOGRAPHY; SCINTISCANNING; THREE DIMENSIONAL IMAGING;

ADENOVIRIDAE; ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEINS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; OSTEOGENESIS; RADIOPHARMACEUTICALS; RATS; RATS, NUDE; TECHNETIUM TC 99M MEDRONATE; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036594740     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1076-6332(03)80307-0     Document Type: Article

References (26)

1. Circulating human factor IX produced in-keratin-promoter transgenic mice: A feasibility study for gene therapy of haemophilia B
2. Role of E4 in eliciting CD4 T-cell and B-cell responses to adenovirus vectors delivered to murine and nonhuman primate lungs
3. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors
4. Neural precursor cells: Applications for the study and repair of the central nervous system
5. Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models
6. In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector
7. Transient immunosuppression allows transgene expression following readministration of adeno-associated viral vectors
8. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
9. Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted
10. Bone morphogenetic proteins (BMPs) and BMP gene therapy in neurological surgery: A review
11. BMPs: Actions in flesh and bone
12. Bone morphogenetic protein-2: Biology and applications
13. Bone morphogenetic proteins: From basic studies to clinical approaches
14. Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion
15. Experimental spinal fusion with recombinant human bone morphogenetic protein-2
16. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy
17. Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent
18. Bone imaging
19. Radiopharmaceutical for bone imaging
20. 99mTc diphosphonate uptake mechanism on bone
21. Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer
22. Osteogenic protein-1: Biology and applications
23. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: A novel cell-mediated gene therapy
24. Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector
25. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography
26. Repetitive, non-invasive imaging of the dopamine D-2 receptor as a reporter gene in living animals