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Volumn 55, Issue 5, 2011, Pages 859-868

Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: As pillars of the bridge between Chinese and Western medicine

Author keywords

Biomarkers; Metabolomics; Principal component analysis; Systems biology; Traditional Chinese medicine; Western medicine

Indexed keywords

CHINESE DRUG; GINSENG EXTRACT; PANAX NOTOGINSENG EXTRACT; QIYINLIANGXUZHENG; UNCLASSIFIED DRUG; XINXUEYUZUZHENG; YIN CHEN HAO TANG;

EID: 79956151568     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.01.042     Document Type: Review
Times cited : (273)

References (97)
  • 1
    • 78649908579 scopus 로고    scopus 로고
    • Metabolomics: towards understanding traditional Chinese medicine
    • Zhang A., Sun H., Wang Z., Sun W., Wang P., Wang X. Metabolomics: towards understanding traditional Chinese medicine. Planta Med. 2010, 76:2026-2035.
    • (2010) Planta Med. , vol.76 , pp. 2026-2035
    • Zhang, A.1    Sun, H.2    Wang, Z.3    Sun, W.4    Wang, P.5    Wang, X.6
  • 2
    • 33750719994 scopus 로고    scopus 로고
    • Global systems biology, personalized medicine and molecular epidemiology
    • Nicholson J.K. Global systems biology, personalized medicine and molecular epidemiology. Mol. Syst. Biol. 2008, 2:52-57.
    • (2008) Mol. Syst. Biol. , vol.2 , pp. 52-57
    • Nicholson, J.K.1
  • 3
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: metabonomics
    • Nicholson J.K., Lindon J.C. Systems biology: metabonomics. Nature 2008, 455:1054-1056.
    • (2008) Nature , vol.455 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 4
    • 57049151909 scopus 로고    scopus 로고
    • Marker metabolites can be therapeutic targets as well
    • Arakaki A.K., Skolnick J., McDonald J.F. Marker metabolites can be therapeutic targets as well. Nature 2008, 456:443.
    • (2008) Nature , vol.456 , pp. 443
    • Arakaki, A.K.1    Skolnick, J.2    McDonald, J.F.3
  • 7
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systems biology: metabonomics and the continuum of metabolism
    • Nicholson J.K., Wilson I.D. Understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. 2003, 2:668-676.
    • (2003) Nat. Rev. , vol.2 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 8
    • 73849141263 scopus 로고    scopus 로고
    • The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability
    • Vineis P., Khan A.E., Vlaanderen J., Vermeulen R. The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability. Environ. Health 2003, 8:54.
    • (2003) Environ. Health , vol.8 , pp. 54
    • Vineis, P.1    Khan, A.E.2    Vlaanderen, J.3    Vermeulen, R.4
  • 10
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 12
    • 74449084552 scopus 로고    scopus 로고
    • Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics
    • Wang J., Reijmers T., Chen L., Van Der Heijden R., Wang M., Peng S., Hankemeier T., Xu G., Van Der Greef J. Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics. Metabolomics 2009, 5:407-418.
    • (2009) Metabolomics , vol.5 , pp. 407-418
    • Wang, J.1    Reijmers, T.2    Chen, L.3    Van Der Heijden, R.4    Wang, M.5    Peng, S.6    Hankemeier, T.7    Xu, G.8    Van Der Greef, J.9
  • 13
    • 53049100454 scopus 로고    scopus 로고
    • Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats
    • Pexa A., Boeger R.H., Henle T., Schwedhelm E., Deussen A. Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats. Br. J. Nutr. 2009, 99:993-999.
    • (2009) Br. J. Nutr. , vol.99 , pp. 993-999
    • Pexa, A.1    Boeger, R.H.2    Henle, T.3    Schwedhelm, E.4    Deussen, A.5
  • 15
    • 77950417420 scopus 로고    scopus 로고
    • Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: thiol-specific regulation of cellular metabolism with N-acetyl-L-cysteine pretreatment
    • Lee R., West D., Phillips S.M., Britz-McKibbin P. Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: thiol-specific regulation of cellular metabolism with N-acetyl-L-cysteine pretreatment. Anal. Chem. 2010, 82:2959-2968.
    • (2010) Anal. Chem. , vol.82 , pp. 2959-2968
    • Lee, R.1    West, D.2    Phillips, S.M.3    Britz-McKibbin, P.4
  • 16
    • 77953888141 scopus 로고    scopus 로고
    • Quantitative metabolome profiling of Illicium anisatum by capillary electrophoresis time-of-flight mass spectrometry
    • Urakami K., Zangiacomi V., Yamaguchi K., Kusuhara M. Quantitative metabolome profiling of Illicium anisatum by capillary electrophoresis time-of-flight mass spectrometry. Biomed. Res. 2010, 31:161-163.
    • (2010) Biomed. Res. , vol.31 , pp. 161-163
    • Urakami, K.1    Zangiacomi, V.2    Yamaguchi, K.3    Kusuhara, M.4
  • 17
    • 77954396635 scopus 로고    scopus 로고
    • Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function
    • Tohge T., Fernie A.R. Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function. Nat. Protoc. 2010, 5:1210-1227.
    • (2010) Nat. Protoc. , vol.5 , pp. 1210-1227
    • Tohge, T.1    Fernie, A.R.2
  • 18
    • 72949116339 scopus 로고    scopus 로고
    • Metabolic profiling of the fission yeast S. pombe: quantification of compounds under different temperatures and genetic perturbation
    • Pluskal T., Nakamura T., Villar-Briones A., Yanagida M. Metabolic profiling of the fission yeast S. pombe: quantification of compounds under different temperatures and genetic perturbation. Mol. Biosyst. 2010, 6:182-198.
    • (2010) Mol. Biosyst. , vol.6 , pp. 182-198
    • Pluskal, T.1    Nakamura, T.2    Villar-Briones, A.3    Yanagida, M.4
  • 20
    • 77955983759 scopus 로고    scopus 로고
    • Activity-based protein profiling for biochemical pathway discovery in cancer
    • Nomura D.K., Dix M.M., Cravatt B.F. Activity-based protein profiling for biochemical pathway discovery in cancer. Nat. Rev. Cancer 2010, 10:630-638.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 630-638
    • Nomura, D.K.1    Dix, M.M.2    Cravatt, B.F.3
  • 25
    • 73949088016 scopus 로고    scopus 로고
    • Secondary metabolic profiling and artemisinin biosynthesis of two genotypes of Artemisia annua
    • Wang H., Ma C., Ma L., Du Z., Wang H., Ye H., Li G., Liu B., Xu G. Secondary metabolic profiling and artemisinin biosynthesis of two genotypes of Artemisia annua. Planta Med. 2009, 75:1625-1633.
    • (2009) Planta Med. , vol.75 , pp. 1625-1633
    • Wang, H.1    Ma, C.2    Ma, L.3    Du, Z.4    Wang, H.5    Ye, H.6    Li, G.7    Liu, B.8    Xu, G.9
  • 28
    • 77956276702 scopus 로고    scopus 로고
    • Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    • Lanza I.R., Zhang S., Ward L.E., Karakelides H., Raftery D., Nair K.S. Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS ONE 2010, 5:10538.
    • (2010) PLoS ONE , vol.5 , pp. 10538
    • Lanza, I.R.1    Zhang, S.2    Ward, L.E.3    Karakelides, H.4    Raftery, D.5    Nair, K.S.6
  • 29
    • 77952339975 scopus 로고    scopus 로고
    • Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes
    • Connor S.C., Hansen M.K., Corner A., Smith R.F., Ryan T.E. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Mol. Biosyst. 2010, 6:909-921.
    • (2010) Mol. Biosyst. , vol.6 , pp. 909-921
    • Connor, S.C.1    Hansen, M.K.2    Corner, A.3    Smith, R.F.4    Ryan, T.E.5
  • 30
    • 79956064790 scopus 로고    scopus 로고
    • Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern
    • Jian W.X., Yuan Z.K., Huang X.P. Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern. Zhongguo. Zhong. Xi. Yi. Jie. He. Za. Zhi. 2010, 30:579-584.
    • (2010) Zhongguo. Zhong. Xi. Yi. Jie. He. Za. Zhi. , vol.30 , pp. 579-584
    • Jian, W.X.1    Yuan, Z.K.2    Huang, X.P.3
  • 31
    • 64549088438 scopus 로고    scopus 로고
    • Application of rotated PCA models to facilitate interpretation of metabolite profiles: commercial preparations of St. John's Wort
    • Lawaetz A.J., Schmidt B., Staerk D., Jaroszewski J.W., Bro R. Application of rotated PCA models to facilitate interpretation of metabolite profiles: commercial preparations of St. John's Wort. Planta Med. 2009, 75:271-279.
    • (2009) Planta Med. , vol.75 , pp. 271-279
    • Lawaetz, A.J.1    Schmidt, B.2    Staerk, D.3    Jaroszewski, J.W.4    Bro, R.5
  • 32
    • 77955080186 scopus 로고    scopus 로고
    • Metabolomics: a tool for anticancer lead-finding from natural products
    • Kim H.K., Wilson E.G., Choi Y.H., Verpoorte R. Metabolomics: a tool for anticancer lead-finding from natural products. Planta Med. 2010, 76:1094-1102.
    • (2010) Planta Med. , vol.76 , pp. 1094-1102
    • Kim, H.K.1    Wilson, E.G.2    Choi, Y.H.3    Verpoorte, R.4
  • 35
    • 70449408035 scopus 로고    scopus 로고
    • Characterization of H NMR spectroscopic data and the generation of synthetic validation sets
    • Anderson P.E., Raymer M.L., Kelly B.J., Reo N.V., DelRaso N.J., Doom T.E. Characterization of H NMR spectroscopic data and the generation of synthetic validation sets. Bioinformatics 2009, 25:2992-3000.
    • (2009) Bioinformatics , vol.25 , pp. 2992-3000
    • Anderson, P.E.1    Raymer, M.L.2    Kelly, B.J.3    Reo, N.V.4    DelRaso, N.J.5    Doom, T.E.6
  • 36
    • 77954196304 scopus 로고    scopus 로고
    • Dynamic transcriptional and metabolic responses in yeast adapting to temperature stress
    • Strassburg K., Walther D., Takahashi H., Kanaya S., Kopka J. Dynamic transcriptional and metabolic responses in yeast adapting to temperature stress. OMICS 2010, 14:249-259.
    • (2010) OMICS , vol.14 , pp. 249-259
    • Strassburg, K.1    Walther, D.2    Takahashi, H.3    Kanaya, S.4    Kopka, J.5
  • 37
    • 71649089762 scopus 로고    scopus 로고
    • Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation
    • Xu F., Zou L., Ong C.N. Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation. J. Proteome Res. 2009, 8:5657-5665.
    • (2009) J. Proteome Res. , vol.8 , pp. 5657-5665
    • Xu, F.1    Zou, L.2    Ong, C.N.3
  • 38
    • 67649854431 scopus 로고    scopus 로고
    • Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics
    • Shroff R., Rulísek L., Doubsky J., Svatos A. Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10092-10096.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 10092-10096
    • Shroff, R.1    Rulísek, L.2    Doubsky, J.3    Svatos, A.4
  • 39
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: a platform for studying drug toxicity and gene function
    • Nicholoson J.K., Connelly J., Lindon J.C., Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat. Rev. 2002, 1:153-161.
    • (2002) Nat. Rev. , vol.1 , pp. 153-161
    • Nicholoson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 41
    • 78649907347 scopus 로고    scopus 로고
    • Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine
    • van der Greef J., van Wietmarschen H., Schroën J., Wang M., Hankemeier T., Xu G. Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine. Planta Med. 2010, 76:2036-2047.
    • (2010) Planta Med. , vol.76 , pp. 2036-2047
    • van der Greef, J.1    van Wietmarschen, H.2    Schroën, J.3    Wang, M.4    Hankemeier, T.5    Xu, G.6
  • 42
    • 33646784011 scopus 로고    scopus 로고
    • Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in cultured hippocampal neuron of rat
    • Sheng Y., Wenxia Z., Yongxiang Z., Cunyu Y., Yimin Z. Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in cultured hippocampal neuron of rat. J. Ethnopharmacol. 2006, 106:166-172.
    • (2006) J. Ethnopharmacol. , vol.106 , pp. 166-172
    • Sheng, Y.1    Wenxia, Z.2    Yongxiang, Z.3    Cunyu, Y.4    Yimin, Z.5
  • 43
    • 77954865767 scopus 로고    scopus 로고
    • Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS
    • Wang P., Sun H., Lv H., Sun W., Yuan Y., Han Y., Wang D., Zhang A., Wang X. Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS. J. Pharm. Biomed. Anal. 2010, 53:631-645.
    • (2010) J. Pharm. Biomed. Anal. , vol.53 , pp. 631-645
    • Wang, P.1    Sun, H.2    Lv, H.3    Sun, W.4    Yuan, Y.5    Han, Y.6    Wang, D.7    Zhang, A.8    Wang, X.9
  • 44
    • 78650178723 scopus 로고    scopus 로고
    • Metabonomic study on 'Kidney-Yang Deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry
    • Lu X., Xiong Z., Li J., Zheng S., Huo T., Li F. Metabonomic study on 'Kidney-Yang Deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry. Talanta 2011, 83:700-708.
    • (2011) Talanta , vol.83 , pp. 700-708
    • Lu, X.1    Xiong, Z.2    Li, J.3    Zheng, S.4    Huo, T.5    Li, F.6
  • 45
    • 77949682260 scopus 로고    scopus 로고
    • Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network
    • Ma T., Tan C., Zhang H., Wang M., Ding W., Li S. Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network. Mol. Biosyst. 2010, 6:613-619.
    • (2010) Mol. Biosyst. , vol.6 , pp. 613-619
    • Ma, T.1    Tan, C.2    Zhang, H.3    Wang, M.4    Ding, W.5    Li, S.6
  • 46
    • 77953567230 scopus 로고    scopus 로고
    • NMR-spectroscopy-based metabonomic approach to analysis of Siwutang, a novel prescription, treated blood deficiency in mice
    • Wang M., Rang W., Zhang Q., Huo C., Ma Z., Wang Y., Yan X., Gao Y. NMR-spectroscopy-based metabonomic approach to analysis of Siwutang, a novel prescription, treated blood deficiency in mice. Zhongguo. Zhong. Yao. Za. Zhi. 2010, 35:630-634.
    • (2010) Zhongguo. Zhong. Yao. Za. Zhi. , vol.35 , pp. 630-634
    • Wang, M.1    Rang, W.2    Zhang, Q.3    Huo, C.4    Ma, Z.5    Wang, Y.6    Yan, X.7    Gao, Y.8
  • 47
    • 68149171590 scopus 로고    scopus 로고
    • New exploration and understanding of traditional Chinese medicine
    • Xutian S., Zhang J., Louise W. New exploration and understanding of traditional Chinese medicine. Am. J. Chin. Med. 2009, 37:411-426.
    • (2009) Am. J. Chin. Med. , vol.37 , pp. 411-426
    • Xutian, S.1    Zhang, J.2    Louise, W.3
  • 48
    • 42349115178 scopus 로고    scopus 로고
    • Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced ; kidney-deficiency syndrome;
    • Qiu Y., Chen M., Su M., Xie G., Li X., Zhou M., Zhao A., Jiang J., Jia W. Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced ; kidney-deficiency syndrome; Chin. Med. 2008, 3:3.
    • (2008) Chin. Med. , vol.3 , pp. 3
    • Qiu, Y.1    Chen, M.2    Su, M.3    Xie, G.4    Li, X.5    Zhou, M.6    Zhao, A.7    Jiang, J.8    Jia, W.9
  • 49
    • 73249141246 scopus 로고    scopus 로고
    • Metabonomic phenotype and identification of ; heart blood stasis obstruction pattern
    • qi and yin deficiency pattern; of myocardial ischemia rat models, Sci. China C: Life Sci.
    • B. Yan, J. A, H. Hao, G. Wang, X. Zhu, W. Zha, L. Liu, E. Guan, Y. Zhang, S. Gu, Q, Huang, Y. Zheng, Metabonomic phenotype and identification of ; heart blood stasis obstruction pattern; and ; qi and yin deficiency pattern; of myocardial ischemia rat models, Sci. China C: Life Sci. 52 (2009) 1081-1090.
    • (2009) , vol.52 , pp. 1081-1090
    • Yan, B.1    Hao, J.A.H.2    Wang, G.3    Zhu, X.4    Zha, W.5    Liu, L.6    Guan, E.7    Zhang, Y.8    Gu, S.9    Huang, Q.10    Zheng, Y.11
  • 51
    • 29144486833 scopus 로고    scopus 로고
    • Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model
    • Chen M., Zhao L., Jia W. Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model. J. Proteome Res. 2005, 4:2196-2391.
    • (2005) J. Proteome Res. , vol.4 , pp. 2196-2391
    • Chen, M.1    Zhao, L.2    Jia, W.3
  • 52
    • 34249689721 scopus 로고    scopus 로고
    • Metabonomic study of syndrome of liver qi stagnation and spleen deficiency in rats
    • Luo H.G., Ding J., Yue G.X., Chen J.X. Metabonomic study of syndrome of liver qi stagnation and spleen deficiency in rats. Zhong. Xi. Yi. Jie. He. Xue. Bao. 2007, 5:307-313.
    • (2007) Zhong. Xi. Yi. Jie. He. Xue. Bao. , vol.5 , pp. 307-313
    • Luo, H.G.1    Ding, J.2    Yue, G.X.3    Chen, J.X.4
  • 53
    • 33750475205 scopus 로고    scopus 로고
    • Metabolomics-based systems biology and personalized medicine: moving towards n=1 clinical trials?
    • van der Greef J., Hankemeier T., McBurney R.N. Metabolomics-based systems biology and personalized medicine: moving towards n=1 clinical trials?. Pharmacogenomics 2006, 7:1087-1094.
    • (2006) Pharmacogenomics , vol.7 , pp. 1087-1094
    • van der Greef, J.1    Hankemeier, T.2    McBurney, R.N.3
  • 54
    • 77951641206 scopus 로고    scopus 로고
    • Development of traditional Chinese medicine clinical data warehouse for medical knowledge discovery and decision support
    • Zhou X., Chen S., Liu B., Zhang R., Wang Y., Li P., Guo Y., Zhang H., Gao Z., Yan X. Development of traditional Chinese medicine clinical data warehouse for medical knowledge discovery and decision support. Artif. Intell. Med. 2010, 48:139-152.
    • (2010) Artif. Intell. Med. , vol.48 , pp. 139-152
    • Zhou, X.1    Chen, S.2    Liu, B.3    Zhang, R.4    Wang, Y.5    Li, P.6    Guo, Y.7    Zhang, H.8    Gao, Z.9    Yan, X.10
  • 55
    • 77952334124 scopus 로고    scopus 로고
    • Preventive treatment of traditional Chinese medicine as antistress and antiaging strategy
    • Liang Z.H., Yin D.Z. Preventive treatment of traditional Chinese medicine as antistress and antiaging strategy. Rejuvenation Res. 2010, 13:248-252.
    • (2010) Rejuvenation Res. , vol.13 , pp. 248-252
    • Liang, Z.H.1    Yin, D.Z.2
  • 58
    • 38349179764 scopus 로고    scopus 로고
    • Early detection of ovarian cancer: new technologies in pursuit of a disease that is neither common nor rare
    • Bast R.C. Early detection of ovarian cancer: new technologies in pursuit of a disease that is neither common nor rare. Trans. Am. Clin. Climatol. Assoc. 2004, 115:233-247.
    • (2004) Trans. Am. Clin. Climatol. Assoc. , vol.115 , pp. 233-247
    • Bast, R.C.1
  • 59
    • 77955463490 scopus 로고    scopus 로고
    • Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse
    • Manna S.K., Patterson A.D., Yang Q., Krausz K.W., Li H., Idle J.R., Fornace A.J., Gonzalez F.J. Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J. Proteome Res. 2010, 9:4176-4188.
    • (2010) J. Proteome Res. , vol.9 , pp. 4176-4188
    • Manna, S.K.1    Patterson, A.D.2    Yang, Q.3    Krausz, K.W.4    Li, H.5    Idle, J.R.6    Fornace, A.J.7    Gonzalez, F.J.8
  • 60
    • 78449279678 scopus 로고    scopus 로고
    • Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry
    • Li Z.Y., Zheng X.Y., Gao X.X., Zhou Y.Z., Sun H.F., Zhang L.Z., Guo X.Q., Du G.H., Qin X.M. Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry. Rapid. Commun. Mass Spectrom. 2010, 24:3539-3546.
    • (2010) Rapid. Commun. Mass Spectrom. , vol.24 , pp. 3539-3546
    • Li, Z.Y.1    Zheng, X.Y.2    Gao, X.X.3    Zhou, Y.Z.4    Sun, H.F.5    Zhang, L.Z.6    Guo, X.Q.7    Du, G.H.8    Qin, X.M.9
  • 61
    • 39549102648 scopus 로고    scopus 로고
    • Metabolomics in biomarker discovery: future uses for cancer prevention
    • Kim Y.S., Maruvada P., Milner J.A. Metabolomics in biomarker discovery: future uses for cancer prevention. Future Oncol. 2008, 4:93-102.
    • (2008) Future Oncol. , vol.4 , pp. 93-102
    • Kim, Y.S.1    Maruvada, P.2    Milner, J.A.3
  • 63
    • 70350067670 scopus 로고    scopus 로고
    • Study of metabonomics on pharmacological action appraisal Rhizoma coptidis in rats
    • Xu G., Ma X., Zhang Q., Li B., Huang L., Yu R., Liu H. Study of metabonomics on pharmacological action appraisal Rhizoma coptidis in rats. Zhongguo. Zhong. Yao. Za. Zhi. 2009, 34:1845-1847.
    • (2009) Zhongguo. Zhong. Yao. Za. Zhi. , vol.34 , pp. 1845-1847
    • Xu, G.1    Ma, X.2    Zhang, Q.3    Li, B.4    Huang, L.5    Yu, R.6    Liu, H.7
  • 64
    • 78649909049 scopus 로고    scopus 로고
    • H NMR-based metabolomics combined with HPLC-PDA-MS-SPE-NMR for investigation of standardized Ginkgo biloba preparations
    • Agnolet S., Jaroszewski J.W., Verpoorte R., Staerk D. H NMR-based metabolomics combined with HPLC-PDA-MS-SPE-NMR for investigation of standardized Ginkgo biloba preparations. Metabolomics 2010, 6:292-302.
    • (2010) Metabolomics , vol.6 , pp. 292-302
    • Agnolet, S.1    Jaroszewski, J.W.2    Verpoorte, R.3    Staerk, D.4
  • 65
    • 74949095844 scopus 로고    scopus 로고
    • Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats
    • Zhang Q., Wang G.J., J.Y A., Wu D., Zhu L.L., Ma B., Du Y. Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats. Acta Pharmacol. Sin. 2009, 30:1674-1687.
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 1674-1687
    • Zhang, Q.1    Wang, G.J.2    J.Y, A.3    Wu, D.4    Zhu, L.L.5    Ma, B.6    Du, Y.7
  • 66
    • 70349339355 scopus 로고    scopus 로고
    • Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of epimedium
    • Yan S., Wu B., Lin Z., Jin H., Huang J., Yang Y., Zhang X., Shen Z., Zhang W. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of epimedium. Mol. Biosyst. 2009, 5:1204-1213.
    • (2009) Mol. Biosyst. , vol.5 , pp. 1204-1213
    • Yan, S.1    Wu, B.2    Lin, Z.3    Jin, H.4    Huang, J.5    Yang, Y.6    Zhang, X.7    Shen, Z.8    Zhang, W.9
  • 67
    • 47549117219 scopus 로고    scopus 로고
    • Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of epimedium
    • Wu B., Yan S., Lin Z., Wang Q., Yang Y., Yang G., Shen Z., Zhang W. Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of epimedium. Mol. Biosyst. 2008, 4:855-861.
    • (2008) Mol. Biosyst. , vol.4 , pp. 855-861
    • Wu, B.1    Yan, S.2    Lin, Z.3    Wang, Q.4    Yang, Y.5    Yang, G.6    Shen, Z.7    Zhang, W.8
  • 68
    • 58149352676 scopus 로고    scopus 로고
    • Revealing the metabonomic variation of rosemary extracts using 1H NMR spectroscopy and multivariate data analysis
    • Xiao C., Dai H., Liu H., Wang Y., Tang H. Revealing the metabonomic variation of rosemary extracts using 1H NMR spectroscopy and multivariate data analysis. J. Agric. Food Chem. 2008, 56:10142-10153.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 10142-10153
    • Xiao, C.1    Dai, H.2    Liu, H.3    Wang, Y.4    Tang, H.5
  • 69
    • 43249119417 scopus 로고    scopus 로고
    • Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research
    • Xie G., Plumb R., Su M., Xu Z., Zhao A., Qiu M., Long X., Liu Z., Jia W. Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. J. Sep. Sci. 2008, 31:1015-1026.
    • (2008) J. Sep. Sci. , vol.31 , pp. 1015-1026
    • Xie, G.1    Plumb, R.2    Su, M.3    Xu, Z.4    Zhao, A.5    Qiu, M.6    Long, X.7    Liu, Z.8    Jia, W.9
  • 70
    • 45249120387 scopus 로고    scopus 로고
    • Metabonomics study on the effects of the ginsenoside Rg3 in a beta-cyclodextrin-based formulation on tumor-bearing rats by a fully automatic hydrophilic interaction/reversed-phase column-switching HPLC-ESI-MS approach
    • Wang Y., Wang J., Yao M., Zhao X., Fritsche J., Schmitt-Kopplin P., Cai Z., Wan D., Lu X., Yang S., Gu J., Häring H.U., Schleicher E.D., Lehmann R., Xu G. Metabonomics study on the effects of the ginsenoside Rg3 in a beta-cyclodextrin-based formulation on tumor-bearing rats by a fully automatic hydrophilic interaction/reversed-phase column-switching HPLC-ESI-MS approach. Anal. Chem. 2008, 80:4680-4688.
    • (2008) Anal. Chem. , vol.80 , pp. 4680-4688
    • Wang, Y.1    Wang, J.2    Yao, M.3    Zhao, X.4    Fritsche, J.5    Schmitt-Kopplin, P.6    Cai, Z.7    Wan, D.8    Lu, X.9    Yang, S.10    Gu, J.11    Häring, H.U.12    Schleicher, E.D.13    Lehmann, R.14    Xu, G.15
  • 71
    • 78650255057 scopus 로고    scopus 로고
    • Effects of storage period and heat treatment on phenolic compound composition in dried Citrus peels (Chenpi) and discrimination of Chenpi with different storage periods through targeted metabolomic study using HPLC-DAD analysis
    • Choi M.Y., Chai C., Park J.H., Lim J., Lee J., Kwon S.W. Effects of storage period and heat treatment on phenolic compound composition in dried Citrus peels (Chenpi) and discrimination of Chenpi with different storage periods through targeted metabolomic study using HPLC-DAD analysis. J. Pharm. Biomed. Anal. 2011, 54:638-645.
    • (2011) J. Pharm. Biomed. Anal. , vol.54 , pp. 638-645
    • Choi, M.Y.1    Chai, C.2    Park, J.H.3    Lim, J.4    Lee, J.5    Kwon, S.W.6
  • 72
    • 79951630349 scopus 로고    scopus 로고
    • Chromatographic fingerprinting and metabolomics for quality control of TCM
    • Liang Y.Z., Xie P.S., Chan K. Chromatographic fingerprinting and metabolomics for quality control of TCM. Comb. Chem. High Throughput Screen 2010, 13:943-953.
    • (2010) Comb. Chem. High Throughput Screen , vol.13 , pp. 943-953
    • Liang, Y.Z.1    Xie, P.S.2    Chan, K.3
  • 74
    • 72249121001 scopus 로고    scopus 로고
    • Pyrolysis GC-MS-based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots
    • Tianniam S., Bamba T., Fukusaki E. Pyrolysis GC-MS-based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots. J. Biosci. Bioeng. 2010, 109:89-93.
    • (2010) J. Biosci. Bioeng. , vol.109 , pp. 89-93
    • Tianniam, S.1    Bamba, T.2    Fukusaki, E.3
  • 75
    • 70349785147 scopus 로고    scopus 로고
    • Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry
    • Sun B., Li L., Wu S., Zhang Q., Li H., Chen H., Li F., Dong F., Yan X. Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry. Anal. Biochem. 2009, 395:125-133.
    • (2009) Anal. Biochem. , vol.395 , pp. 125-133
    • Sun, B.1    Li, L.2    Wu, S.3    Zhang, Q.4    Li, H.5    Chen, H.6    Li, F.7    Dong, F.8    Yan, X.9
  • 76
    • 65749118391 scopus 로고    scopus 로고
    • A metabolomic analysis of the toxicity of Aconitum sp. alkaloids in rats using gas chromatography/mass spectrometry
    • Sun B., Li L., Wu S., Zhang Q., Li H., Chen H., Li F., Dong F., Yan X. A metabolomic analysis of the toxicity of Aconitum sp. alkaloids in rats using gas chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:1221-1228.
    • (2009) Rapid Commun. Mass Spectrom. , vol.23 , pp. 1221-1228
    • Sun, B.1    Li, L.2    Wu, S.3    Zhang, Q.4    Li, H.5    Chen, H.6    Li, F.7    Dong, F.8    Yan, X.9
  • 77
    • 40249093007 scopus 로고    scopus 로고
    • Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx (Ranunculaceae)
    • Li L., Sun B., Zhang Q., Fang J., Ma K., Li Y., Chen H., Dong F., Gao Y., Li F., Yan X. Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx (Ranunculaceae). J. Ethnopharmacol. 2008, 116:561-568.
    • (2008) J. Ethnopharmacol. , vol.116 , pp. 561-568
    • Li, L.1    Sun, B.2    Zhang, Q.3    Fang, J.4    Ma, K.5    Li, Y.6    Chen, H.7    Dong, F.8    Gao, Y.9    Li, F.10    Yan, X.11
  • 78
    • 50249178449 scopus 로고    scopus 로고
    • Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and (1)H NMR spectroscopy
    • Law W.S., Huang P.Y., Ong E.S., Ong C.N., Li S.F., Pasikanti K.K., Chan E.C. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and (1)H NMR spectroscopy. Rapid Commun. Mass Spectrom. 2008, 22:2436-2446.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 2436-2446
    • Law, W.S.1    Huang, P.Y.2    Ong, E.S.3    Ong, C.N.4    Li, S.F.5    Pasikanti, K.K.6    Chan, E.C.7
  • 79
    • 33748911193 scopus 로고    scopus 로고
    • Metabonomics approach to determine metabolic differences between green tea and black tea consumption
    • Van Dorsten F.A., Daykin C.A., Mulder T.P., Van Duynhoven J.P. Metabonomics approach to determine metabolic differences between green tea and black tea consumption. J. Agric. Food Chem. 2006, 54:6929-6938.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 6929-6938
    • Van Dorsten, F.A.1    Daykin, C.A.2    Mulder, T.P.3    Van Duynhoven, J.P.4
  • 80
    • 74449092161 scopus 로고    scopus 로고
    • Metabonomics study of urine from Sprague-Dawley rats exposed to Huang-yao-zi using (1)H NMR spectroscopy
    • Liu Y., Huang R., Liu L., Peng J., Xiao B., Yang J., Miao Z., Huang H. Metabonomics study of urine from Sprague-Dawley rats exposed to Huang-yao-zi using (1)H NMR spectroscopy. J. Pharm. Biomed. Anal. 2010, 52:136-141.
    • (2010) J. Pharm. Biomed. Anal. , vol.52 , pp. 136-141
    • Liu, Y.1    Huang, R.2    Liu, L.3    Peng, J.4    Xiao, B.5    Yang, J.6    Miao, Z.7    Huang, H.8
  • 81
    • 77954861437 scopus 로고    scopus 로고
    • Metabonomic study of biochemical changes in the urine of Morning Glory Seed treated rat
    • Ma C., Bi K., Zhang M., Su D., Fan X., Ji W., Wang C., Chen X. Metabonomic study of biochemical changes in the urine of Morning Glory Seed treated rat. J. Pharm. Biomed. Anal. 2010, 53:559-566.
    • (2010) J. Pharm. Biomed. Anal. , vol.53 , pp. 559-566
    • Ma, C.1    Bi, K.2    Zhang, M.3    Su, D.4    Fan, X.5    Ji, W.6    Wang, C.7    Chen, X.8
  • 82
    • 77956344105 scopus 로고    scopus 로고
    • Serum and kidney metabolic changes of rat nephrotoxicity induced by Morning Glory Seed
    • Ma C., Bi K., Su D., Ji W., Zhang M., Fan X., Wang C., Chen X. Serum and kidney metabolic changes of rat nephrotoxicity induced by Morning Glory Seed. Food Chem. Toxicol. 2010, 48:2988-2993.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 2988-2993
    • Ma, C.1    Bi, K.2    Su, D.3    Ji, W.4    Zhang, M.5    Fan, X.6    Wang, C.7    Chen, X.8
  • 83
    • 39849110282 scopus 로고    scopus 로고
    • Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum
    • Wei L., Liao P., Wu H., Li X., Pei F., Li W., Wu Y. Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. Toxicol. Appl. Pharmacol. 2008, 227:417-429.
    • (2008) Toxicol. Appl. Pharmacol. , vol.227 , pp. 417-429
    • Wei, L.1    Liao, P.2    Wu, H.3    Li, X.4    Pei, F.5    Li, W.6    Wu, Y.7
  • 86
    • 1842847386 scopus 로고    scopus 로고
    • What's in a name? A systematic review of the nomenclature of Chinese medical formulae
    • Park A.J. What's in a name? A systematic review of the nomenclature of Chinese medical formulae. J. Chin. Med. 2002, 30:419-427.
    • (2002) J. Chin. Med. , vol.30 , pp. 419-427
    • Park, A.J.1
  • 87
    • 57849120057 scopus 로고    scopus 로고
    • Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry
    • Wang X., Lv H., Sun H., Liu L., Yang B., Sun W., Wang P., Zhou D., Zhao L., Dou S., Zhang G., Cao H. Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 2008, 48:1161-1168.
    • (2008) J. Pharm. Biomed. Anal. , vol.48 , pp. 1161-1168
    • Wang, X.1    Lv, H.2    Sun, H.3    Liu, L.4    Yang, B.5    Sun, W.6    Wang, P.7    Zhou, D.8    Zhao, L.9    Dou, S.10    Zhang, G.11    Cao, H.12
  • 88
    • 59049088576 scopus 로고    scopus 로고
    • Development of rat urinary HPLC-UV profiling for metabonomic study on Liuwei Dihuang Pills
    • Xie B., Gong T., Gao R., Liu J., Zuo J., Wang X., Zhang Z. Development of rat urinary HPLC-UV profiling for metabonomic study on Liuwei Dihuang Pills. J. Pharm. Biomed. Anal. 2009, 49:492-497.
    • (2009) J. Pharm. Biomed. Anal. , vol.49 , pp. 492-497
    • Xie, B.1    Gong, T.2    Gao, R.3    Liu, J.4    Zuo, J.5    Wang, X.6    Zhang, Z.7
  • 89
    • 52149124125 scopus 로고    scopus 로고
    • Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: a urinary metabonomics study based on liquid chromatography-mass spectrometry
    • Zhao X., Zhang Y., Meng X., Yin P., Deng C., Chen J., Wang Z., Xu G. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: a urinary metabonomics study based on liquid chromatography-mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life. Sci. 2008, 873:151-158.
    • (2008) J. Chromatogr. B: Anal. Technol. Biomed. Life. Sci. , vol.873 , pp. 151-158
    • Zhao, X.1    Zhang, Y.2    Meng, X.3    Yin, P.4    Deng, C.5    Chen, J.6    Wang, Z.7    Xu, G.8
  • 90
    • 74249085418 scopus 로고    scopus 로고
    • Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Lv Y., Liu X., Yan S., Liang X., Yang Y., Dai W., Zhang W. Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 2010, 52:129-135.
    • (2010) J. Pharm. Biomed. Anal. , vol.52 , pp. 129-135
    • Lv, Y.1    Liu, X.2    Yan, S.3    Liang, X.4    Yang, Y.5    Dai, W.6    Zhang, W.7
  • 91
    • 77952530987 scopus 로고    scopus 로고
    • Comparison between modern and ancient thoughts about acupuncture treatment of migraine
    • Hu J., Wu Z.C., Wang J.J., Jiao Y. Comparison between modern and ancient thoughts about acupuncture treatment of migraine. Zhen. Ci. Yan. Jiu. 2009, 34:276-278.
    • (2009) Zhen. Ci. Yan. Jiu. , vol.34 , pp. 276-278
    • Hu, J.1    Wu, Z.C.2    Wang, J.J.3    Jiao, Y.4
  • 92
    • 69849094792 scopus 로고    scopus 로고
    • Overview of relation between retaining time of acupuncture and effect for apoplexy
    • Zhang T.S., Guan F., Jin C.N., Hao C.Y., Liu X.G., Ji L.X. Overview of relation between retaining time of acupuncture and effect for apoplexy. Zhen. Ci. Yan. Jiu. 2009, 34:140-142.
    • (2009) Zhen. Ci. Yan. Jiu. , vol.34 , pp. 140-142
    • Zhang, T.S.1    Guan, F.2    Jin, C.N.3    Hao, C.Y.4    Liu, X.G.5    Ji, L.X.6
  • 93
    • 78649899919 scopus 로고    scopus 로고
    • A randomised, placebo-controlled trial of manual and electrical acupuncture for the treatment of tinnitus
    • Wang K., Bugge J., Bugge S. A randomised, placebo-controlled trial of manual and electrical acupuncture for the treatment of tinnitus. Complement Ther. Med. 2010, 18:249-255.
    • (2010) Complement Ther. Med. , vol.18 , pp. 249-255
    • Wang, K.1    Bugge, J.2    Bugge, S.3
  • 94
    • 67651176422 scopus 로고    scopus 로고
    • Survey of acupuncture and moxibustion for clinical treatment of renal diseases
    • Wan R.J., Li Y.H. Survey of acupuncture and moxibustion for clinical treatment of renal diseases. Zhongguo. Zhen. Jiu. 2009, 29:342-344.
    • (2009) Zhongguo. Zhen. Jiu. , vol.29 , pp. 342-344
    • Wan, R.J.1    Li, Y.H.2
  • 95
    • 60749089955 scopus 로고    scopus 로고
    • Approach to clinical trial design for acupuncture and moxibustion treatment of stroke
    • Hao L., Zhao X.F., Li J. Approach to clinical trial design for acupuncture and moxibustion treatment of stroke. Zhongguo. Zhen. Jiu. 2009, 29:56-58.
    • (2009) Zhongguo. Zhen. Jiu. , vol.29 , pp. 56-58
    • Hao, L.1    Zhao, X.F.2    Li, J.3
  • 96
    • 77954192921 scopus 로고    scopus 로고
    • Acupuncture: is it effective for treatment of insulin resistance?
    • Liang F., Koya D. Acupuncture: is it effective for treatment of insulin resistance?. Diabetes Obes. Metab. 2010, 12:555-569.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 555-569
    • Liang, F.1    Koya, D.2
  • 97
    • 70350586733 scopus 로고    scopus 로고
    • (1)H NMR-based metabonomic study on the metabolic changes in the plasma of patients with functional dyspepsia and the effect of acupuncture
    • Wu Q., Zhang Q., Sun B., Yan X., Tang Y., Qiao X., Chen Q., Yu S., Liang F. (1)H NMR-based metabonomic study on the metabolic changes in the plasma of patients with functional dyspepsia and the effect of acupuncture. J. Pharm. Biomed. Anal. 2010, 51:698-704.
    • (2010) J. Pharm. Biomed. Anal. , vol.51 , pp. 698-704
    • Wu, Q.1    Zhang, Q.2    Sun, B.3    Yan, X.4    Tang, Y.5    Qiao, X.6    Chen, Q.7    Yu, S.8    Liang, F.9


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