Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats

British Journal of Nutrition

Volumn 99, Issue 5, 2008, Pages 993-999

  Pexa, Annette ^a,b   Boeger, Rainer H ^c   Henle, Thomas ^b   Schwedhelm, Edzard ^c   Deussen, Andreas ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Amino acids; Asymmetrical dimethylarginine; Homocysteine; Vessel function

Indexed keywords

ACETYLCHOLINE; ADENOSINE; HOMOCYSTEINE; METHIONINE; N(G),N(G) DIMETHYLARGININE; NITROPRUSSIDE SODIUM; S ADENOSYLHOMOCYSTEINE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; DOSE RESPONSE; FOOD COMPOSITION; FOOD INTAKE; HYPERHOMOCYSTEINEMIA; LIVER; MALE; MESENTERIC ARTERY; METABOLISM; METABOLITE; NONHUMAN; OVERNUTRITION; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RAT; SPLEEN; TISSUE LEVEL; VASODILATATION;

ANIMALS; ARGININE; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MALE; MESENTERIC ARTERIES; METHIONINE; RATS; RATS, WISTAR; VASODILATION;

MAMMALIA; RATTUS;

EID: 53049100454     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508853408     Document Type: Article

References (45)

1. Young VR, Wagner DA, Burini R & Storch KJ (1991) Methionine kinetics and balance at the 1985 FAO/WHO/UNU intake requirement in adult men studied with L-[2H3-methyl-1-13C]methionine as a tracer. Am J Clin Nutr 54, 377-385.
2. Fonseca V, Guba SC & Fink LM (1999) Hyperhomocysteinemia and the endocrine system: Implications for atherosclerosis and thrombosis. Endocr Rev 20, 738-759.
3. Finkelstein JD (1998) The metabolism of homocysteine: Pathways and regulation. Eur J Pediatr 157, Suppl. 2, S40-S44.
4. Kloor D, Stumvoll W, Schmid H, Kompf J, Mack A & Osswald H (2000) Localization of S-adenosylhomocysteine hydrolase in the rat kidney. J Histochem Cytochent 48, 211-218.
5. Refsum H, Guttormsen AB, Fiskerstrand T & Ueland PM (1998) Hyperhomocysteinemia in terms of steady-state kinetics. Eur J Pediatr 157, Suppl. 2, S45-S49.
6. De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA & Blom HJ (2002) Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 54 599-618.
7. van Guldener C, Stam F & Stehouwer CD (2005) Hyperhomocysteinaemia in chronic kidney disease: Focus on transmethylation. Clin Chem Lab Med 43, 1026-1031.
8. Allen RH, Stabler SP & Lindenbaum J (1998) Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders. Eur J Pediatr 157, Suppl. 2, S122-S126.
9. El Khairy L, Vollset SE, Refsum H & Ueland PM (2003) Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: The Hordaland Homocysteine Study. Am J Clin Nutr 77, 467-472.
10. Ingec M, Borekci B & Kadanali S (2005) Elevated plasma homocysteine concentrations in severe preeclampsia and eclampsia. Tohoku J Exp Med 206, 225-231.
11. Reish O, Townsend D, Berry SA, Tsai MY & King RA (1995) Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: The mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 57, 127-132.
12. Blom HJ (1998) Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia. Eur J Pediatr 157, Suppl. 2, S131-S134.
13. Herrmann W & Obeid R (2005) Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients. Clin Chem Lab Med 43, 1039-1047.
14. Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG & Lewis MJ (1998) Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 98, 1848-1852.
15. Klee CB (1974) Stereospecific irreversible inhibition of histidine ammonia-lyase by L-cysteine. Biochemistry 13, 4501-4507.
16. Stühlinger MC, Oka RK, Graf EE, et al. (2003) Endothelial dysfunction induced by hyperhomocyst(e)inemia: Role of asymmetric dimethylarginine. Circulation 108, 933-938.
17. Böger RH, Lentz SR, Bode-Böger SM, Knapp HR & Haynes WG (2001) Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(c)-inaemia in humans. Clin Sci (Lond) 100, 161-167.
18. Deussen A (2003) Adenosine - the missing link to understanding homocysteine pathogenicity or more smoke on the horizon? Cardiovasc Res 59, 259-261.
19. Chen YF, Li PL & Zou AP (2002) Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function. Circulation 106 1275-1281.
20. Riksen NP, Rongen, GA, Blom HJ, Russel FG, Boers GH & Smits P (2003) Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia. Cardiovasc Res 59, 271-276.
21. Borst MM, Deussen A & Schrader J (1992) S-adenosylhomocysteine hydrolase activity in human myocardium. Cardiovasc Res 26, 143-147.
22. Kerins DM, Koury MJ, Capdevila A, Rana S & Wagner C (2001) Plasma S-adenosylbomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. Am J Clin Nutr 74, 723-729.
23. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ & James SJ (2000) Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275, 29318-29323.
24. Perna AF, Capasso R, Lombardi C, Acanfora F, Satta E & Ingrosso D (2005) Hyperhomocysteinemia and macromolecule modifications in uremic patients. Clin Chem Lab Med 43, 1032-1038.
25. Ingrosso D, Cimmino A, Perna AF, et al. (2003) Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet 361, 1693-1099.
26. Ward M, McNulty H, Pentieva K, McPartlin J, Strain JJ, Weir DG & Scott JM (2000) Fluctuations in dietary methionine intake do not alter plasma homocysteine concentration in healthy men. J Nutr 130, 2653-2657.
27. Dimitrova KR, DeGroot KW, Pacquing AM, Suyderhoud JP, Pirovic EA, Munro TJ, Wieneke JA, Myers AK & Kim YD (2002) Estradiol prevents homocysteine-induced endothelial injury in male rats. Cardiovasc Res 53, 589-596.
28. Pexa A, Fischer K, Deussen A & Henle T (2007) Homocysteine in food. Eur Food Res Tech Published online (14 February 2007, DOI 10.1007/ s00211-007-0583-2).
29. Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara, Y, Yazaki Y & Nagai R (2001) Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury. Circulation 103, 133-139.
30. Buns NH, VanBavel E & Mulvany MJ (1994) Differences in sensitivity of rat mesenteric small arteries to agonists when studied as ring preparations or as cannulated preparations. Br J Pharmacol 112 579-587.
31. Dieckmann-Schuppert A & Schnittler HJ (1997) A simple assay for quantification of protein in tissue sections, cell cultures, and cell homogenates, and of protein immobilized on solid surfaces. Cell Tissue Res 288, 119-126.
32. Schwedhelm E, Tan-Andresen J, Maas R, Riederer U, Schulze F & Boger RH (2005) Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma. Clin Chem 51, 1268-1271.
33. Haink G & Deussen A (2003) Liquid chromatography method for the analysis of adenosine compounds. J Chromatogr B Analyt Technol Biomed Life Sci 784, 189-193.
34. Loehrer FM, Tschopl M, Angst CP, Litynski P, Jager K, Fowler B & Haefeli WE (2001) Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease. Atherosclerosis 154, 147-154.
35. Lentz SR (1997) Homocysteine and vascular dysfunction. Life Sci 61, 1205-1215.
36. Ungvari Z, Pacher P, Rischak K, Szollar L & Koller A (1999) Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 19, 1899-1904.
37. Woo CW, Cheung F, Chan VW & Siow YLOK (2003) Honiocysteine stimulates inducible nitric oxide synthase expression in macrophages: Antagonizing effect of ginkgolides and bilobalide. Mol Cell Biochem 243, 37-47.
38. Schroecksnadel K, Frick B, Wirleitner B, Schennach H & Fuchs D (2003) Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells. Clin Exp Immunol 134, 53-56.
39. Young SN & Shalchi M (2005) The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain. J Psychiatry Neurosci 30, 44-48.
40. Deussen A, Borst M & Schrader J (1988) Formation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine. Circ Res 63, 240-249.
41. Böger RH, Bode-Böger SM, Sydow K, Heistad DD & Lentz SR (2000) Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia. Arterioscler Thromb Vasc Biol 20, 1557-1564.
42. Sugiyama K, Kushima Y & Muramatsu K (1987) Effect of dietary glycine on methionine metabolism in rats fed a high-methionine diet. J Nutr Sci Vitaminol (Tokyo) 33, 195-205.
43. Rowling MJ, McMullen MH, Chipman DC & Schalinske KL (2002) Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr 132, 2545-2550.
44. Kloor ' D, Stumvoll W, Schmid H, Kompf J, Mack A & Osswald H (2000) Localization of S-adenosylhomocysteine hydrolase in the rat kidney. J Histochem Cytochem 48, 211-218.
45. Fell D & Steele RD (1983) Effect of methionine on in vivo histidine metabolism in rats. J Nutr 113, 860-866.