Quantitative metabolomics by 1H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Lanza, Ian R ^a   Zhang, Shucha ^b   Ward, Lawrence E ^a   Karakelides, Helen ^a   Raftery, Daniel ^b   Sreekumaran Nair, K ^a  

^a Mayo Clinic   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ACETONE; ALANINE; ALLANTOIN; CITRIC ACID; CREATININE; FORMIC ACID; GLUCOSE; HISTIDINE; INSULIN; KETONE; LACTIC ACID; TYROSINE; AMINO ACID; PLASMA PROTEIN;

ADULT; AMINO ACID BLOOD LEVEL; ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; GLUCONEOGENESIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; KETOGENESIS; LIQUID CHROMATOGRAPHY; METABOLITE; METABOLOMICS; MITOCHONDRIAL RESPIRATION; OXIDATION; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STUDY; TANDEM MASS SPECTROMETRY; BLOOD; CLINICAL TRIAL; DIABETES MELLITUS; MASS SPECTROMETRY; METABOLISM; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRINCIPAL COMPONENT ANALYSIS;

ADULT; AMINO ACIDS; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; DIABETES MELLITUS; GLUCOSE; HUMANS; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS;

EID: 77956276702     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010538     Document Type: Article

References (37)

1. Berger M, Zimmermann-Telschow H, Berchtold P, Drost H, Muller WA, et al. (1978) Blood amine acid levels in patients with insulin excess (functioning insulinoma) and insulin deficiency (diabetic ketosis). Metabolism 27: 793-799.
2. Felig P, Marliss E, Ohman JL, Cahill CF, Jr. (1970) Plasma amino acid levels in diabetic ketoacidosis. Diabetes 19: 727-728.
3. Gerich JE, Tsalikian E, Lorenzi M, Karam JH, Bier DM (1975) Plasma glucagon and alanine responses to acute insulin deficiency in man. J Clin Endocrinol Metab 40: 526-529.
4. Wahren J, Felig P, Hagenfeldt L (1976) Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest 57: 987-999.
5. Boden G, Cheung P, Homko C (2003) Effects of acute insulin excess and deficiency on gluconeogenesis and glycogenolysis in type 1 diabetes. Diabetes 52: 133-137.
6. Zhang S, Nagana Gowda GA, Asiago V, Shanaiah N, Barbas C, et al. (2008) Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats. Anal Biochem 383: 76-84.
7. Zuppi C, Messana I, Tapanainen P, Knip M, Vincenzoni F, et al. (2002) Proton nuclear magnetic resonance spectral profiles of urine from children and adolescents with type 1 diabetes. Clin Chem 48: 660-662.
8. Bennet WM, Connacher AA, Jung RT, Stehle P, Rennie MJ (1991) Effects of insulin and amino acids on leg protein turnover in IDDM patients. Diabetes 40: 499-508.
9. Nair KS, Ford GC, Ekberg K, Fernqvist-Forbes E, Wahren J (1995) Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J Clin Invest 95: 2926-2937.
10. Nair KS, Halliday D, Garrow JS (1984) Increased energy expenditure in poorly controlled Type 1 (insulin-dependent) diabetic patients. Diabetologia 27: 13-16.
11. Tessari P, Biolo G, Inchiostro S, Sacca L, Nosadini R, et al. (1990) Effects of insulin on whole body and forearm leucine and KIC metabolism in type 1 diabetes. Am J Physiol 259: E96-103.
12. Tessari P, Nissen SL, Miles JM, Haymond MW (1986) Inverse relationship of leucine flux and oxidation to free fatty acid availability in vivo. J Clin Invest 77: 575-581.
13. Karakelides H, Asmann YW, Bigelow ML, Short KR, Dhatariya K, et al. (2007) Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects. Diabetes 56: 2683-2689.
14. Jaleel A, Klaus KA, Morse DM, Karakelides H, Ward LE, et al. (2009) Differential Effects of Insulin Deprivation and Systemic Insulin Treatment on Plasma Protein Synthesis in Type 1 Diabetic People. Am J Physiol Endocrinol Metab.
15. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29: 1181-1189.
16. Dunn WB, Bailey NJ, Johnson HE (2005) Measuring the metabolome: current analytical technologies. Analyst 130: 606-625.
17. Gowda GA, Zhang S, Gu H, Asiago V, Shanaiah N, et al. (2008) Metabolomicsbased methods for early disease diagnostics. Expert Rev Mol Diagn 8: 617-633.
18. Pan Z, Raftery D (2007) Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics. Anal Bioanal Chem 387: 525-527.
19. Robertson DG (2005) Metabonomics in toxicology: a review. Toxicol Sci 85: 809-822.
20. Makinen VP, Soininen P, Forsblom C, Parkkonen M, Ingman P, et al. (2008) 1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death. Mol Syst Biol 4: 167.
21. Bougneres P, Valleron AJ (2008) Causes of early-onset type 1 diabetes: toward data-driven environmental approaches. J Exp Med 205: 2953-2957.
22. Oresic M, Simell S, Sysi-Aho M, Nanto-Salonen K, Seppanen-Laakso T, et al. (2008) Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 205: 2975-2984.
23. Bennet WM, Connacher AA, Smith K, Jung RT, Rennie MJ (1990) Inability to stimulate skeletal muscle or whole body protein synthesis in type 1 (insulindependent) diabetic patients by insulin-plus-glucose during amino acid infusion: studies of incorporation and turnover of tracer L-[1-13C]leucine. Diabetologia 33: 43-51.
24. Pacy PJ, Nair KS, Ford C, Halliday D (1989) Failure of insulin infusion to stimulate fractional muscle protein synthesis in type I diabetic patients. Anabolic effect of insulin and decreased proteolysis. Diabetes 38: 618-624.
25. Elia M, Carter A, Bacon S, Winearls CG, Smith R (1981) Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown. Br Med J (Clin Res Ed) 282: 351-354.
26. Felig P, Wahren J (1971) Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest 50: 1702-1711.
27. Vannini P, Marchesini G, Forlani G, Angiolini A, Ciavarella A, et al. (1982) Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. Diabetologia 22: 217-219.
28. Miles JM, Nissen SL, Rizza RA, Gerich JE, Haymond MW (1983) Failure of infused beta-hydroxybutyrate to decrease proteolysis in man. Diabetes 32: 197-205.
29. Nair KS, Welle SL, Halliday D, Campbell RG (1988) Effect of betahydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans. J Clin Invest 82: 198-205.
30. Fatland BL, Ke J, Anderson MD, Mentzen WI, Cui LW, et al. (2002) Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis. Plant Physiol 130: 740-756.
31. Brooks GA (2002) Lactate shuttles in nature. Biochem Soc Trans 30: 258-264.
32. Wolfe AJ (2005) The acetate switch. Microbiol Mol Biol Rev 69: 12-50.
33. Bala L, Ghoshal UC, Ghoshal U, Tripathi P, Misra A, et al. (2006) Malabsorption syndrome with and without small intestinal bacterial overgrowth: a study on upper-gut aspirate using 1H NMR spectroscopy. Magn Reson Med 56: 738-744.
34. Feillet-Coudray C, Rock E, Coudray C, Grzelkowska K, Azais-Braesco V, et al. (1999) Lipid peroxidation and antioxidant status in experimental diabetes. Clin Chim Acta 284: 31-43.
35. Gruber J, Tang SY, Jenner AM, Mudway I, Blomberg A, et al. (2009) Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations. Antioxid Redox Signal 11: 1767-1776.
36. Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, et al. (2002) Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105: 1656-1662.
37. Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, et al. (2000) Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci USA 97: 12222-12226.