메뉴 건너뛰기




Volumn 227, Issue 3, 2008, Pages 417-429

Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum

Author keywords

Cinnabar; Metabolomics; NMR; Pattern recognition; Serum; Urine

Indexed keywords

ACETIC ACID; ACETOACETIC ACID; AMINO ACID; CHOLINE; CITRIC ACID; CREATINE; CREATININE; DIMETHYLGLYCINE; HIPPURIC ACID; HYDROXYBUTYRIC ACID; ISOLEUCINE; KETONE; LEUCINE; LIPOPROTEIN; MERCURY SULFIDE; OXIDE; TAURINE; VALINE;

EID: 39849110282     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.11.015     Document Type: Article
Times cited : (116)

References (66)
  • 2
    • 22044447452 scopus 로고    scopus 로고
    • Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication
    • Bando I., Reus M.I.S., Andres D., and Cascales M. Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication. J. Biochem. Mol. Toxicol. 19 3 (2005) 154-161
    • (2005) J. Biochem. Mol. Toxicol. , vol.19 , Issue.3 , pp. 154-161
    • Bando, I.1    Reus, M.I.S.2    Andres, D.3    Cascales, M.4
  • 6
    • 33847076215 scopus 로고    scopus 로고
    • Differential neurotoxic effects of methylmercury and mercuric sulfide in rats
    • Chuu J.J., Liu S.H., and Lin-Shiau S.Y. Differential neurotoxic effects of methylmercury and mercuric sulfide in rats. Toxicol. Lett. 169 (2007) 109-120
    • (2007) Toxicol. Lett. , vol.169 , pp. 109-120
    • Chuu, J.J.1    Liu, S.H.2    Lin-Shiau, S.Y.3
  • 8
    • 1542313741 scopus 로고    scopus 로고
    • Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status
    • Clayton T.A., Lindon J.C., Everett J.R., Charuel C., Hanton G., Le N.J., Provost J.P., and Nicholson J.K. Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status. Arch. Toxicol. 78 (2004) 86-96
    • (2004) Arch. Toxicol. , vol.78 , pp. 86-96
    • Clayton, T.A.1    Lindon, J.C.2    Everett, J.R.3    Charuel, C.4    Hanton, G.5    Le, N.J.6    Provost, J.P.7    Nicholson, J.K.8
  • 10
    • 18944388783 scopus 로고    scopus 로고
    • Growing pains for metabolomics
    • Daviss B. Growing pains for metabolomics. Scientist 19 (2005) 25-28
    • (2005) Scientist , vol.19 , pp. 25-28
    • Daviss, B.1
  • 11
    • 11844289653 scopus 로고    scopus 로고
    • Phenylacetylglycine, a putative biomarker of phospholipidosis: its origins and relevance to phospholipids accumulation using amiodarone treated rats as a model
    • Delaney J., Neville W.A., Swain A., Miles A., Leonard M.S., and Waterfield C.J. Phenylacetylglycine, a putative biomarker of phospholipidosis: its origins and relevance to phospholipids accumulation using amiodarone treated rats as a model. Biomarkers 9 3 (2004) 271-290
    • (2004) Biomarkers , vol.9 , Issue.3 , pp. 271-290
    • Delaney, J.1    Neville, W.A.2    Swain, A.3    Miles, A.4    Leonard, M.S.5    Waterfield, C.J.6
  • 13
    • 58649087657 scopus 로고    scopus 로고
    • Gao T.A. (Ed), China Press of Traditional Chinese Medicine, Beijing
    • In: Gao T.A. (Ed). Chinese Mineral Drugs and Their Application (1997), China Press of Traditional Chinese Medicine, Beijing 56-62
    • (1997) Chinese Mineral Drugs and Their Application , pp. 56-62
  • 14
    • 0037163864 scopus 로고    scopus 로고
    • Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA
    • Gavaghan C.L., Wilson I.D., and Nicholson J.K. Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA. FEBS Lett. 530 1-3 (2002) 191-196
    • (2002) FEBS Lett. , vol.530 , Issue.1-3 , pp. 191-196
    • Gavaghan, C.L.1    Wilson, I.D.2    Nicholson, J.K.3
  • 15
    • 0035824834 scopus 로고    scopus 로고
    • Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes
    • Griffin J.L., Mann C.J., Scott J., Shoulders C.C., and Nicholson J.K. Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes. FEBS Lett. 509 (2001) 263-266
    • (2001) FEBS Lett. , vol.509 , pp. 263-266
    • Griffin, J.L.1    Mann, C.J.2    Scott, J.3    Shoulders, C.C.4    Nicholson, J.K.5
  • 16
    • 1842430173 scopus 로고    scopus 로고
    • Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3
    • Griffin J.L., Cemal C.K., and Pook M.A. Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3. Physiol. Genomics 16 3 (2004) 334-340
    • (2004) Physiol. Genomics , vol.16 , Issue.3 , pp. 334-340
    • Griffin, J.L.1    Cemal, C.K.2    Pook, M.A.3
  • 17
    • 0027169242 scopus 로고
    • Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes
    • Gut I., and Conney A.H. Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes. Biochem. Pharmacol. 46 2 (1993) 239-244
    • (1993) Biochem. Pharmacol. , vol.46 , Issue.2 , pp. 239-244
    • Gut, I.1    Conney, A.H.2
  • 18
    • 0029567965 scopus 로고
    • A report on the composition of mercurials used in traditional medicines in Oman
    • Hardy A.D., Sutherland H.H., Vaishnav R., and Worthing M.A. A report on the composition of mercurials used in traditional medicines in Oman. J. Ethnopharmacol. 49 (1995) 17-22
    • (1995) J. Ethnopharmacol. , vol.49 , pp. 17-22
    • Hardy, A.D.1    Sutherland, H.H.2    Vaishnav, R.3    Worthing, M.A.4
  • 20
    • 0027052705 scopus 로고
    • Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rats induced by mecury (II) chloride and 2-bromoethanamine
    • Holmes E., Bonner F.W., Sweatman B.C., Lindon J.C., Beddell C.R., Rahr E., and Nicholson J.K. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rats induced by mecury (II) chloride and 2-bromoethanamine. Mol. Pharmacol. 42 (1992) 922-930
    • (1992) Mol. Pharmacol. , vol.42 , pp. 922-930
    • Holmes, E.1    Bonner, F.W.2    Sweatman, B.C.3    Lindon, J.C.4    Beddell, C.R.5    Rahr, E.6    Nicholson, J.K.7
  • 21
    • 17444384847 scopus 로고    scopus 로고
    • Investigation of metal-binding metallothioneins in the tissues of rats after oral intake of cinnabar
    • Huang Z.Y., Shen J.C., Zhuang Z.X., Wang X.R., and Frank S.C.L. Investigation of metal-binding metallothioneins in the tissues of rats after oral intake of cinnabar. Anal. Bioanal. Chem. 379 (2004) 427-432
    • (2004) Anal. Bioanal. Chem. , vol.379 , pp. 427-432
    • Huang, Z.Y.1    Shen, J.C.2    Zhuang, Z.X.3    Wang, X.R.4    Frank, S.C.L.5
  • 22
    • 2942737135 scopus 로고    scopus 로고
    • Metallothionein as a biomarker for mercury in tissues of rat fed orally with cinnabar
    • Huang Z.Y., Shen J.C., Zhuang Z.X., Wang X.R., and Frank S.C.L. Metallothionein as a biomarker for mercury in tissues of rat fed orally with cinnabar. Appl. Organomet. Chem. 18 (2004) 255-261
    • (2004) Appl. Organomet. Chem. , vol.18 , pp. 255-261
    • Huang, Z.Y.1    Shen, J.C.2    Zhuang, Z.X.3    Wang, X.R.4    Frank, S.C.L.5
  • 23
    • 17844405873 scopus 로고    scopus 로고
    • An analytical study of bioaccumulation and the binding forms of mercury in rat body using thermolysis coupled with atomic absorption spectrometry
    • Huang R.J., Zhuang Z.X., Wang Y.R., Huang Z.Y., Wang X.R., and Frank S.C.L. An analytical study of bioaccumulation and the binding forms of mercury in rat body using thermolysis coupled with atomic absorption spectrometry. Anal. Chim. Acta 538 (2005) 313-321
    • (2005) Anal. Chim. Acta , vol.538 , pp. 313-321
    • Huang, R.J.1    Zhuang, Z.X.2    Wang, Y.R.3    Huang, Z.Y.4    Wang, X.R.5    Frank, S.C.L.6
  • 24
    • 0033961939 scopus 로고    scopus 로고
    • Difference of the liver and kidney in glycine conjugation of ortho-substituted benzoic acids
    • Kasuya F., Yamaoka Y., Osawa E., Igarashi K., and Fukui M. Difference of the liver and kidney in glycine conjugation of ortho-substituted benzoic acids. Chem.-Biol. Interact. 125 1 (2000) 39-50
    • (2000) Chem.-Biol. Interact. , vol.125 , Issue.1 , pp. 39-50
    • Kasuya, F.1    Yamaoka, Y.2    Osawa, E.3    Igarashi, K.4    Fukui, M.5
  • 26
    • 33847377573 scopus 로고    scopus 로고
    • Innovation-a robustness-based approach to systems-oriented drug design
    • Kitano H. Innovation-a robustness-based approach to systems-oriented drug design. Nat. Rev., Drug Discov. 6 3 (2007) 202-210
    • (2007) Nat. Rev., Drug Discov. , vol.6 , Issue.3 , pp. 202-210
    • Kitano, H.1
  • 27
    • 39849084273 scopus 로고
    • Li H.C. (Ed), Geological Publishing House, Beijing
    • In: Li H.C. (Ed). Chinese Mineral Drugs (1988), Geological Publishing House, Beijing 100-105
    • (1988) Chinese Mineral Drugs , pp. 100-105
  • 29
    • 0034368580 scopus 로고    scopus 로고
    • Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids
    • Lindon J.C., Nicholson J.K., Holmes E., and Everett J.R. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn. Reson. 12 (2000) 289-320
    • (2000) Concepts Magn. Reson. , vol.12 , pp. 289-320
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3    Everett, J.R.4
  • 30
    • 39849088174 scopus 로고
    • Researches in cinnarbar induced assimilation and accumulation of mercury
    • Liu Z.S., Zhang J.Y., and Dai T.Z. Researches in cinnarbar induced assimilation and accumulation of mercury. J. Trad. Chin. Med. 2 (1986) 38-41
    • (1986) J. Trad. Chin. Med. , vol.2 , pp. 38-41
    • Liu, Z.S.1    Zhang, J.Y.2    Dai, T.Z.3
  • 31
    • 0034798545 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury
    • Mahboob M., Shireen K.F., Atkinson A., and Khan A.T. Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J. Environ. Sci. Health, Part B 36 (2001) 687-697
    • (2001) J. Environ. Sci. Health, Part B , vol.36 , pp. 687-697
    • Mahboob, M.1    Shireen, K.F.2    Atkinson, A.3    Khan, A.T.4
  • 33
    • 0027136709 scopus 로고
    • Urinary porphyrins as biological indicators of oxidative stress in the kidney: interaction of mercury and cephaloridine
    • Miller D.M., and Woods J.S. Urinary porphyrins as biological indicators of oxidative stress in the kidney: interaction of mercury and cephaloridine. Biochem. Pharmacol. 46 (1993) 2235-2241
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 2235-2241
    • Miller, D.M.1    Woods, J.S.2
  • 34
    • 0000034243 scopus 로고
    • Mercury toxicity: biochemical aspects
    • Goyer R.A., and Cherian G. (Eds), Springer Verlag, Berlín
    • Miura K., Naganuma A., Himeno S., and Imura N. Mercury toxicity: biochemical aspects. In: Goyer R.A., and Cherian G. (Eds). Toxicology of Metals (1995), Springer Verlag, Berlín 163-187
    • (1995) Toxicology of Metals , pp. 163-187
    • Miura, K.1    Naganuma, A.2    Himeno, S.3    Imura, N.4
  • 35
    • 0345714918 scopus 로고    scopus 로고
    • NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats
    • Nicholls A.W., Mortishire-Smith R.J., and Nicholson J.K. NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chem. Res. Toxicol. 16 (2003) 1395-1404
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 1395-1404
    • Nicholls, A.W.1    Mortishire-Smith, R.J.2    Nicholson, J.K.3
  • 36
    • 0024946615 scopus 로고
    • High-resolution proton magnetic resonance spectroscopy of biological fluids
    • Nicholson J.K., and Wilson I.D. High-resolution proton magnetic resonance spectroscopy of biological fluids. Prog. NMR Spectrosc. 21 (1989) 449-501
    • (1989) Prog. NMR Spectrosc. , vol.21 , pp. 449-501
    • Nicholson, J.K.1    Wilson, I.D.2
  • 37
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systems biology: metabonomics and the continuum of metabolism
    • Nicholson J.K., and Wilson I.D. Understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev., Drug Discov. 2 (2003) 668-676
    • (2003) Nat. Rev., Drug Discov. , vol.2 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 38
    • 0022254437 scopus 로고
    • Proton NMR spectra of urine as indicators of renal damage mercury-induced nephrotoxicity in rats
    • Nicholson J.K., Timbrell J.A., and Sadler P.J. Proton NMR spectra of urine as indicators of renal damage mercury-induced nephrotoxicity in rats. Mol. Pharmacol. 27 (1985) 644-651
    • (1985) Mol. Pharmacol. , vol.27 , pp. 644-651
    • Nicholson, J.K.1    Timbrell, J.A.2    Sadler, P.J.3
  • 39
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: a platform for studying drug toxicity and gene function
    • Nicholson J.K., Connelly J., Lindon J.C., and Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat. Rev., Drug Discov. 1 2 (2002) 153-161
    • (2002) Nat. Rev., Drug Discov. , vol.1 , Issue.2 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 40
    • 0031839564 scopus 로고    scopus 로고
    • Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity
    • Phipps A.N., Stewart J., Wright B., and Wilson I.D. Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity. Xenobiotica 28 5 (1998) 527-537
    • (1998) Xenobiotica , vol.28 , Issue.5 , pp. 527-537
    • Phipps, A.N.1    Stewart, J.2    Wright, B.3    Wilson, I.D.4
  • 42
    • 17144467091 scopus 로고    scopus 로고
    • Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats
    • Reus I.S., Bando I., Anres D., and Cascales M. Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats. J. Biochem. Mol. Toxicol. 17 3 (2003) 161-168
    • (2003) J. Biochem. Mol. Toxicol. , vol.17 , Issue.3 , pp. 161-168
    • Reus, I.S.1    Bando, I.2    Anres, D.3    Cascales, M.4
  • 43
    • 34247327455 scopus 로고    scopus 로고
    • The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury
    • Rooney J.P.K. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234 3 (2007) 145-156
    • (2007) Toxicology , vol.234 , Issue.3 , pp. 145-156
    • Rooney, J.P.K.1
  • 46
    • 18744364709 scopus 로고    scopus 로고
    • Oxidative stress mediated idiosyncratic drug toxicity
    • Tafazoli S., Spehar D.D., and O'Brien P.J. Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab. Rev. 37 (2005) 311-325
    • (2005) Drug Metab. Rev. , vol.37 , pp. 311-325
    • Tafazoli, S.1    Spehar, D.D.2    O'Brien, P.J.3
  • 47
    • 0025737250 scopus 로고
    • The identification of trimethylamine excess in man: quantitative analysis and biochemical origins
    • Tjoa S., and Fennessey P. The identification of trimethylamine excess in man: quantitative analysis and biochemical origins. Anal. Biochem. 197 (1991) 77-82
    • (1991) Anal. Biochem. , vol.197 , pp. 77-82
    • Tjoa, S.1    Fennessey, P.2
  • 49
    • 12344311533 scopus 로고    scopus 로고
    • A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion
    • Wang Y.L., Tang H.R., Nicholson J.K., Hylands P., Sampson J., and Holmes E. A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion. J. Agric. Food Chem. 53 2 (2005) 191-196
    • (2005) J. Agric. Food Chem. , vol.53 , Issue.2 , pp. 191-196
    • Wang, Y.L.1    Tang, H.R.2    Nicholson, J.K.3    Hylands, P.4    Sampson, J.5    Holmes, E.6
  • 50
    • 0027508182 scopus 로고
    • Effect of various non-hepatotoxic compounds on urinary and liver taurine levels in rats
    • Waterfield C.J., Turton J.A., Scales M.D., and Timbrell J.A. Effect of various non-hepatotoxic compounds on urinary and liver taurine levels in rats. Arch. Toxicol. 67 (1993) 538-546
    • (1993) Arch. Toxicol. , vol.67 , pp. 538-546
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.3    Timbrell, J.A.4
  • 51
    • 0027161423 scopus 로고
    • Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats
    • Waterfield C.J., Turton J.A., Scales M.D., and Timbrell J.A. Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch. Toxicol. 67 (1993) 244-254
    • (1993) Arch. Toxicol. , vol.67 , pp. 244-254
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.3    Timbrell, J.A.4
  • 52
    • 0034775361 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on the time-related metabolic effects of α-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach
    • Waters N.J., Holmes E., Williams A., Waterfield C.J., Farrant R.D., and Nicholson J.K. NMR and pattern recognition studies on the time-related metabolic effects of α-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chem. Res. Toxicol. 14 (2001) 1401-1412
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1401-1412
    • Waters, N.J.1    Holmes, E.2    Williams, A.3    Waterfield, C.J.4    Farrant, R.D.5    Nicholson, J.K.6
  • 53
    • 17644369998 scopus 로고    scopus 로고
    • Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity
    • Waters N.J., Waterfield C.J., Farrant R.D., Holmes E., and Nicholson J.K. Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity. Chem. Res. Toxicol. 18 4 (2005) 639-654
    • (2005) Chem. Res. Toxicol. , vol.18 , Issue.4 , pp. 639-654
    • Waters, N.J.1    Waterfield, C.J.2    Farrant, R.D.3    Holmes, E.4    Nicholson, J.K.5
  • 54
    • 33745005962 scopus 로고    scopus 로고
    • Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 6-oxoprolinosis
    • Waters N.J., Waterfield C.J., Farrant R.D., Holmes E., and Nicholson J.K. Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 6-oxoprolinosis. J. Proteome Res. 5 (2006) 1448-1459
    • (2006) J. Proteome Res. , vol.5 , pp. 1448-1459
    • Waters, N.J.1    Waterfield, C.J.2    Farrant, R.D.3    Holmes, E.4    Nicholson, J.K.5
  • 55
    • 20544452036 scopus 로고    scopus 로고
    • Study on the pharmacology and toxicology of cinnabar
    • Wei J.F., Shang W.F., and Yang S.L. Study on the pharmacology and toxicology of cinnabar. Chin. Trad. Herb. Drugs 30 12 (1999) 953-956
    • (1999) Chin. Trad. Herb. Drugs , vol.30 , Issue.12 , pp. 953-956
    • Wei, J.F.1    Shang, W.F.2    Yang, S.L.3
  • 56
    • 33947250076 scopus 로고    scopus 로고
    • Carbamazepine treatment recovered low N-acetylaspartate + N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph)
    • Westman E., Spenger C., Wahlund L.O., and Lavebratt C. Carbamazepine treatment recovered low N-acetylaspartate + N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph). Neurobiol. Dis. 26 (2007) 221-228
    • (2007) Neurobiol. Dis. , vol.26 , pp. 221-228
    • Westman, E.1    Spenger, C.2    Wahlund, L.O.3    Lavebratt, C.4
  • 60
    • 0033935979 scopus 로고    scopus 로고
    • Creatine and Creatinine Metabolism
    • Wyss M., and Kaddurah-Daouk R. Creatine and Creatinine Metabolism. Physiol. Rev. 80 3 (2000) 1107-1213
    • (2000) Physiol. Rev. , vol.80 , Issue.3 , pp. 1107-1213
    • Wyss, M.1    Kaddurah-Daouk, R.2
  • 61
    • 0004734553 scopus 로고    scopus 로고
    • Xu L. (Ed), Science Press, Beijing
    • In: Xu L. (Ed). Methods of Chemometrics (2004), Science Press, Beijing 221-227
    • (2004) Methods of Chemometrics , pp. 221-227
  • 62
    • 0022901554 scopus 로고
    • Absorption of mercuric sulphide following oral administration in mice
    • Yeoh T.S., Lee A.S., and Lee H.S. Absorption of mercuric sulphide following oral administration in mice. Toxicology 4 1 (1986) 107-111
    • (1986) Toxicology , vol.4 , Issue.1 , pp. 107-111
    • Yeoh, T.S.1    Lee, A.S.2    Lee, H.S.3
  • 63
    • 0036305964 scopus 로고    scopus 로고
    • Neurotoxic mechanism of cinnabar and mercuric sulfide on the vestibulo-ocular reflex system of guinea pigs
    • Young Y.H., Chuu J.J., Liu S.H., and Lin-Shiau S.Y. Neurotoxic mechanism of cinnabar and mercuric sulfide on the vestibulo-ocular reflex system of guinea pigs. Toxicol. Sci. 67 2 (2002) 256-263
    • (2002) Toxicol. Sci. , vol.67 , Issue.2 , pp. 256-263
    • Young, Y.H.1    Chuu, J.J.2    Liu, S.H.3    Lin-Shiau, S.Y.4
  • 64
    • 0010471495 scopus 로고
    • Cellular defense against damage from reactive oxygen species
    • Yu B.P. Cellular defense against damage from reactive oxygen species. Physiol. Rev. 74 (1994) 139-162
    • (1994) Physiol. Rev. , vol.74 , pp. 139-162
    • Yu, B.P.1
  • 65
    • 0034006391 scopus 로고    scopus 로고
    • Molecular interactions with mercury in the kidney
    • Zalups R.K. Molecular interactions with mercury in the kidney. Pharmacol. Rev. 52 1 (2000) 113-144
    • (2000) Pharmacol. Rev. , vol.52 , Issue.1 , pp. 113-144
    • Zalups, R.K.1
  • 66


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.