Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics

Metabolomics

Volumn 5, Issue 4, 2009, Pages 407-418

  Wang, Jiangshan ^a,b   Reijmers, Theo ^b   Chen, Lijuan ^d   van der Heijden, Rob ^b   Wang, Mei ^c   Peng, Shuangqing ^d   Hankemeier, Thomas ^b   Xu, Guowang ^a   van der Greef, Jan ^b,c  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b LEIDEN UNIVERSITY   (Netherlands)

^c TNO   (Netherlands)

^d BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Doxorubicin; FTMS; Metabolomics; Systems toxicology; UPLC MS

Indexed keywords

RATTUS;

EID: 74449084552     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-009-0165-3     Document Type: Article

References (44)

1. Adrien Bodet, C., III, Jorgensen, J. H., & Drutz, D. J. (1985). Antibacterial activities of antineoplastic agents. Antimicrobial Agents and Chemotherapy, 28, 437-439.
2. Bagchi, D., Bagchi, M., Hassoun, E. A., Kelly, J., & Stohs, S. J. (1995). Adriamycin-induced hepatic and myocardial lipid peroxidation and DNA damage, and enhanced excretion of urinary lipid metabolites in rats. Toxicology, 95, 1-9.
3. Beckwith-Hall, B. M., Nicholson, J. K., Nicholls, A. W., et al. (1998). Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chemical Research in Toxicology, 11, 260-272.
4. Berthiaume, J. M., & Wallace, K. B. (2007). Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biology and Toxicology, 23, 15-25.
5. Björkhem, I., & Eggertsen, G. (2001). Genes involved in initial steps of bile acid synthesis. Current Opinion in Lipidology, 12, 97-103.
6. Bugrim, A., Nikolskaya, T., & Nikolsky, Y. (2004). Early prediction of drug metabolism and toxicity: Systems biology approach and modeling. Drug Discovery Today, 9, 127-135.
7. De Beer, E. L., Bottone, A. E., & Voest, E. E. (2001). Doxorubicin and mechanical performance of cardiac trabeculae after acute and chronic treatment: A review. European Journal of Pharmacology, 415, 1-11.
8. Dewald, O., Sharma, S., Adrogue, J., et al. (2005). Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation, 112, 407-415.
9. Gatley, S. J., & Sherratt, H. S. A. (1977). The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics. The Biochemical Journal, 166, 39-47.
10. Goormaghtigh, E., Huart, P., Praet, M., Brasseur, R., & Ruysschaert, J. M. (1990). Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity. Biophysical Chemistry, 35, 247-257.
11. 1H NMR spectroscopy. Toxicology Letters, 81, 15-21.
12. Holmes, E., Bonner, F. W., Sweatman, B. C., et al. (1992). Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine. Molecular Pharmacology, 42, 922-930.
13. Inagami, K., Kaihara, M., & Price, J. M. (1965). The identification of 2, 8-quinolinediol in the urine of rats fed a diet containing corn. The Journal of Biological Chemistry, 240, 3682-3684.
14. Jansen, J. J., Hoefsloot, H. C. J., van der Greef, J., Timmerman, M. E., Westerhuis, J. A., & Smilde, A. K. (2005). ASCA: analysis of multivariate data obtained from an experimental design. Journal of Chemometrics, 19, 469-481.
15. Kalender, Y., Yel, M., & Kalender, S. (2005). Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology, 209, 39-45.
16. Kamphorst, J. J., van der Heijden, R., DeGroot, J., et al. (2007). Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: Method validation and peptide identification. Journal of Proteome Research, 6, 4388-4396.
17. Keun, H. C. (2006). Metabonomic modeling of drug toxicity. Pharmacology & Therapeutics, 109, 92-106.
18. Keun, H. C., Ebbels, T. M. D., Bollard, M. E., et al. (2004). Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles. Chemical Research in Toxicology, 17, 579-587.
19. Lafaye, A., Junot, C., Ramounet-Le Gall, B., Fritsch, P., Tabet, J. C., & Ezan, E. (2003). Metabolite profiling in rat urine by liquid chromatography/electrospray ion trap mass spectrometry. Application to the study of heavy metal toxicity. Rapid Communications in Mass Spectrometry, 17, 2541-2549.
20. 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics. Journal of Pharmaceutical and Biomedical Analysis, 35, 599-608.
21. Lindon, J. C., Nicholson, J. K., Holmes, E., et al. (2003). Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicology and Applied Pharmacology, 187, 137-146.
22. Meliksetian, M. B., Daviyan, T. K., Chirkowa, I. V., Alexanyan, Y. U. T., & Ignatova, T. N. (1997). Alterations in immunoglobulin synthesis during adriamycin-induced apoptosis in mouse hybridoma cells. Cell Biology International, 21, 69-74.
23. Nicholls, A. W., Mortishire-Smith, R. J., & Nicholson, J. K. (2003). NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chemical Research in Toxicology, 16, 1395-1404.
24. Nicholson, J. K., Holmes, E., Lindon, J. C., & Wilson, I. D. (2004). The challenges of modeling mammalian biocomplexity. Nature Biotechnology, 22, 1268-1274.
25. Nicholson, J. K., Lindon, J. C., & Holmes, E. (1999). 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica, 29, 1181-1189.
26. Oliveira, P. J., Bjork, J. A., Santos, M. S., et al. (2004). Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity. Toxicology and Applied Pharmacology, 200, 159-168.
27. Öz, E., & İlhan, M. N. (2006). Effects of melatonin in reducing the toxic effects of doxorubicin. Molecular and Cellular Biochemistry, 286, 11-15.
28. Rezzi, S., Vera, F. A., Martin, F. P., Wang, S., Lawler, D., & Kochhar, S. (2008). Automated SPE-RP-HPLC fractionation of biofluids combined to off-line NMR spectroscopy for biomarker identification in metabonomics. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 871, 271-278.
29. Saad, S. Y., Najjar, T. A., & Al Rikabi, A. C. (2001). The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. Pharmacological Research, 43, 211-218.
30. Shukla, O. P. (1986). Microbial transformation of quinoline by a Pseudomonas sp. Applied and Environmental Microbiology, 51, 1332-1342.
31. Singal, P. K., & Iliskovic, N. (1998). Doxorubicin-induced cardiomyopathy. The New England Journal of Medicine, 339, 900-905.
32. Smilde, A. K., Jansen, J. J., Hoefsloot, H. C. J., Lamers, R. A. N., van der Greef, J., & Timmerman, M. E. (2005). ANOVA-simultaneous component analysis (ASCA): A new tool for analyzing designed metabolomics data. Bioinformatics, 21, 3043-3048.
33. Swift, L. P., Rephaeli, A., Nudelman, A., Phillips, D. R., & Cutts, S. M. (2006). Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death. Cancer Research, 9, 4863-4871.
34. Theodoridis, G., Gika, H. G., & Wilson, I. D. (2008). LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics. Trends in Analytical Chemistry, 27, 251-260.
35. van der Greef, J., Martin, S., Juhasz, P., et al. (2007). The art and practice of systems biology in medicine: mapping patterns of relationships. Journal of Proteome Research, 6, 1540-1559.
36. van der Greef, J., Stroobant, P., & van der Heijden, R. (2004). The role of analytical sciences in medical systems biology. Current Opinion in Chemical Biology, 8, 559-565.
37. Wang, Y., Tang, H., Nicholson, J. K., Hylands, P. J., Sampson, J., & Holmes, E. (2005). A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion. Journal of Agricultural and Food Chemistry, 53(19), 1-196.
38. Wapstra, F. H., van Goor, H., de Jong, P. E., Navis, G., & de Zeeuw, D. (1999). Dose of doxorubicin determines severity of renal damage and responsiveness to ACE-inhibition in experimental nephrosis. Journal of Pharmacological and Toxicological Methods, 41, 69-73.
39. Waring, W. S., Convery, A., Mishra, V., Shenkin, A., Webb, D. J., & Maxwell, S. R. J. (2003). Uric acid reduces exercise-induced oxidative stress in healthy adults. Clinical Science, 105, 425-430.
40. Waring, W. S., Webb, D. J., & Maxwell, S. R. (2001). Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. Journal of Cardiovascular Pharmacology, 38, 365-371.
41. Waters, N. J., Waterfield, C. J., Farrant, R. D., Holmes, E., & Nicholson, J. K. (2005). Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity. Chemical Research in Toxicology, 18, 639-654.
42. Williams, R. E., Major, H., Lock, E. A., Lenz, E. M., & Wilson, I. D. (2005). D-Serine-induced nephrotoxicity: A HPLC-TOF/MS-based metabonomics approach. Toxicology, 207, 179-190.
43. Yang, J., Zhao, X., Liu, X., et al. (2006). High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B. Journal of Proteome Research, 5, 554-561.
44. Zhen, Y., Krausz, K. W., Chen, C., Idle, J. R., & Gonzalez, F. J. (2007). Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Molecular Endocrinology, 21, 2136-2151.