Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry

Analytical Biochemistry

Volumn 395, Issue 2, 2009, Pages 125-133

  Sun, Bo ^a,b   Li, Ling ^a   Wu, Shengming ^a   Zhang, Qi ^a   Li, Haijing ^a   Chen, Hebing ^a   Li, Famei ^b   Dong, Fangting ^a   Yan, Xianzhong ^a  

^a NATIONAL CENTER OF BIOMEDICAL ANALYSIS   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Aconitum alkaloids; Gas chromatography time of flight mass spectrometry; Metabonomics; Nuclear magnetic resonance; Toxicity

Indexed keywords

ALKALOIDS; AMINO ACIDS; BODY FLUIDS; DRUG PRODUCTS; GAS CHROMATOGRAPHY; GLUCOSE; MAGNETISM; MASS SPECTROMETRY; MEDICINE; METABOLISM; METABOLITES; PLANTS (BOTANY); RATS; TOXICITY; WAVE PLASMA INTERACTIONS;

ACONITUM ALKALOIDS; BETA-HYDROXYBUTYRATE; INTEGRATED ANALYSIS; METABOLOMIC ANALYSIS; METABONOMICS; NUCLEAR MAGNETIC RESONANCE(NMR); TRADITIONAL CHINESE HERBAL MEDICINE; TRIMETHYLAMINE N OXIDES;

NUCLEAR MAGNETIC RESONANCE;

2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACONITINE; ACONITUM EXTRACT; ALANINE; ALKALOID DERIVATIVE; CITRIC ACID; CREATINE; CREATININE; DIMETHYLGLYCINE; GLUCOSE; HYPACONITINE; LIPID; MESACONITINE; SUCCINIC ACID; TRIMETHYLAMINE OXIDE;

ACONITUM; ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; BODY FLUID; CONTROLLED STUDY; CREATININE URINE LEVEL; GAS CHROMATOGRAPHY; GLUCOSE BLOOD LEVEL; GLUCOSE URINE LEVEL; KIDNEY TUBULE DISORDER; KIDNEY TUBULE FUNCTION; LACTATE BLOOD LEVEL; LIPID BLOOD LEVEL; MALE; METABOLITE; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TIME OF FLIGHT MASS SPECTROMETRY; TOXICITY TESTING; WISTAR RAT;

ACONITUM; RATTUS; RATTUS NORVEGICUS;

EID: 70349785147     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2009.08.014     Document Type: Article

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