Metabonomics study of urine from Sprague-Dawley rats exposed to Huang-yao-zi using 1H NMR spectroscopy

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 1, 2010, Pages 136-141

  Liu, Yanru ^a,b   Huang, Rongqing ^a   Liu, Lijun ^c   Peng, Jiangnan ^a   Xiao, Bingkun ^a   Yang, Jianyun ^a   Miao, Zhenchun ^c   Huang, Honglin ^b  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b Jiangxi College of Chinese Medicine   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

1H NMR; Biomarker; Huang yao zi; Liver toxicity; Metabonomics

Indexed keywords

2 OXOGLUTARIC ACID; ACETIC ACID; BETAINE; CITRIC ACID; CREATINE; DIMETHYLGLYCINE; GLYCINE; HIPPURIC ACID; HUANG YAO ZI; PLANT MEDICINAL PRODUCT; SUCCINIC ACID; TAURINE; UNCLASSIFIED DRUG; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOINFORMATICS; BODY WEIGHT; CONTROLLED STUDY; DIOSCOREA BULBIFERA; DISCRIMINANT ANALYSIS; HISTOPATHOLOGY; LIVER MITOCHONDRION; LIVER TOXICITY; LIVER WEIGHT; MALE; MAXIMUM TOLERATED DOSE; METABONOMICS; NONHUMAN; OXIDATIVE STRESS; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPRAGUE DAWLEY RAT; URINALYSIS; YAM;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; DISCRIMINANT ANALYSIS; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; LEAST-SQUARES ANALYSIS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MAXIMUM TOLERATED DOSE; METABOLOMICS; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; URINALYSIS;

EID: 74449092161     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.12.026     Document Type: Article

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