Insulation from viral transcriptional regulatory elements enables improvement to hepatoma-specific gene expression from adenovirus vectors

Biochemical and Biophysical Research Communications

Volumn 307, Issue 4, 2003, Pages 759-764

  Ye, Xun ^a   Liang, Min ^a,b   Meng, Xia ^a   Ren, XiaoWei ^a   Chen, HongZhuan ^d   Li, Zong Yi ^c   Ni, ShaoHeng ^c   Lieber, Andre ^c   Hu, Fang ^a  

^a Shanghai Sunway Biotech Co Ltd   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d NONE

Author keywords

Adenovirus; HS 4; Tumor specific; Fetoprotein

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; ONCOLYTIC VIRUS;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SUICIDE GENE; TUMOR CELL; TUMOR CELL LINE;

ADENOVIRIDAE; GALLUS GALLUS;

EID: 0037768685     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01251-8     Document Type: Article

References (20)

1. Kanai F. Transcriptional targeted gene therapy for hepatocellular carcinoma by adenovirus vector. Mol. Biotechnol. 18:2001;243-250.
2. Deutsch H.F. Chemistry and biology of alpha-fetoprotein. Adv. Cancer Res. 56:1991;253-312.
3. Cao G., Kuriyama S., Gao J., Nakatani T., Chen Q., Yoshiji H., Zhao L., Kojima H., Dong Y., Fukui H., Hou J. Gene therapy for hepatocellular carcinoma based on tumour-selective suicide gene expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter. Eur. J. Cancer. 37:2001;140-147.
4. Ido A., Uto H., Moriuchi A., Nagata K., Onaga Y., Onaga M., Hori T., Hirono S., Hayashi K., Tamaoki T., Tsubouchi H. Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter. Cancer Res. 61:2001;3016-3021.
5. Hatfield L., Hearing P. Redundant elements in the adenovirus type 5 inverted terminal repeat promote bidirectional transcription in vitro and are important for virus growth in vivo. Virology. 184:1991;265-276.
6. Leza M.A., Hearing P. Cellular transcription factor binds to adenovirus early region promoters and to a cyclic AMP response element. J. Virol. 62:1988;3003-3013.
7. Steinwaerder D.S., Lieber A. Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo. Gene Ther. 7:2000;556-567.
8. Scholz C., Starck L., Willimsky G., Blankenstein T., Dorken B., Daniel P.T. Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes. Gene Ther. 9:2002;1346-1438.
9. Abramovich C., Chebath J., Revel M. The human interferon alpha-receptor protein confers differential responses to human interferon-beta versus interferon-alpha subtypes in mouse and hamster cell transfectants. Cytokine. 16:1994;414-424.
10. Kaneko S., Hallenbeck P., Kotani T., Nakabayashi H., McGarrity G., Tamaoki T., Anderson W.F., Chiang Y.L. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res. 55:1995;5283-5287.
11. Carlson C.A., Steinwaerder D.S., Stecher H., Shayakhmetov D.M., Lieber A. Rearrangements in adenoviral genomes mediated by inverted repeats. Methods Enzymol. 346:2002;277-292.
12. Bernt K., Liang M., Ye X., Ni S., Li Z.Y., Ye S.L., Hu F., Lieber A. A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication. J. Virol. 76:2002;10994-21002.
13. Nakabayashi H., Taketa K., Yamane T., Miyazaki M., Miyano K., Sato J. Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium. Gann. 75:1984;151-158.
14. Steinwaerder D.S., Carlson C.A., Otto D.L., Li Z.Y., Ni S., Lieber A. Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector. Nat. Med. 7:2001;240-243.
15. Shering A.F., Bain D., Stewart K., Epstein A.L., Castro M.G., Wilkinson G.W., Lowenstein P.R. Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors. J. Gen. Virol. 78:1997;445-459.
16. Nakabayashi H., Hashimoto T., Miyao Y., Tjong K.K., Chan J., Tamaoki T. A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma. Mol. Cell. Biol. 11:1991;5885-5893.
17. Steinwaerder D.S., Carlson C.A., Lieber A. DNA replication of first-generation adenovirus vectors in tumor cells. Hum. Gene Ther. 11:2000;1933-1948.
18. Lee S.J., Kim H.S., Yu R., Lee K., Gardner T.A., Jung C., Jeng M.H., Yeung F., Cheng L., Kao C. Novel prostate-specific promoter derived from PSA and PSMA enhancers. Mol. Ther. 6:2002;415-421.
19. McCart J.A., Wang Z.H., Xu H., Hu Y., Park B., Alexander H.R., Bartlett D.L. Development of a melanoma-specific adenovirus. Mol. Ther. 6:2002;471-480.
20. Hernandez-Alcoceba R., Pihalja M., Qian D., Clarke M.F. New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum. Gene Ther. 13:2002;1737-1750.