Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo

Gene Therapy

Volumn 7, Issue 7, 2000, Pages 556-567

  Steinwaerder, D S ^a   Lieber, A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Boundary elements; E1A enhancer; LCR; MRE

Indexed keywords

IMMUNOGLOBULIN; TRANSCRIPTION FACTOR;

ADENOVIRUS; ARTICLE; CHICKEN; ENHANCER REGION; EXPRESSION VECTOR; GENE EXPRESSION; GENE LOCUS; GENE TRANSFER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE;

ADENOVIRIDAE; GALLUS GALLUS;

EID: 0034068781     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301139     Document Type: Article

References (55)

1. Schiedner G et al. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat Genet 1998; 18: 180-183.
2. Burcin MM et al. Adenovirus-mediated regulable target gene expression in vivo. Proc Natl Acad Sci USA 1999; 96: 355-360.
3. Hatfield L, Hearing P. Redundant elements in the adenovirus type 5 inverted terminal repeat promote bidirectional transcription in vitro and are important for virus growth in vivo. Virology 1991; 184: 265-276.
4. Miralles VJ, Cortes P, Stone N, Reinberg D. The adenovirus inverted terminal repeat functions as an enhancer in a cell-free system. J Biol Chem 1989; 264: 10763-10772.
5. Leza M, Hearing P. Cellular transcription factors bind to adenovirus early region promoters and to cAMP response elements. J Virol 1988; 62: 3003-3013.
6. Sassone-Corsi P et al. Far upstream sequences are required for efficient transcription form the adenovirus-2 E1A transcription unit. Nucleic Acids Res 1983; 11: 8735-8745.
7. Hearing P, Shenk T. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element. Cell 1983; 33: 695-703.
8. Hearing P, Shenk T. Adenovirus 5 E1A enhancer contains two distinct domains: one is specific for E1A and the other modulates expression of all early units in cis. Cell 1986; 45: 229-236.
9. Ohyama T. Bent DNA in the human adenovirus type 2 E1A enhancer is an architectural element for transcription stimulation. J Biol Chem 1996; 271: 27823-27828.
10. Grable M, Hearing P. Cis and trans requirements for the selective packaging of adenovirus type 5 DNA. J Virol 1992; 66: 723-731.
11. Loeken MR, Brady J. The adenovirus E2a enhancer: analysis of regulatory sequences and changes in binding activity of ATF and E2F following adenovirus infection. J Biol Chem 1989; 264: 6572-6579.
12. Zajchowski DA, Jalinot P, Kedinger C. E1a-mediated stimulation of the adenovirus E3 promoter involves an enhancer element within the nearby E2a promoter. J Virol 1988; 62: 1762-1767.
13. Imperiale MJ, Hart RP, Nevins JR. An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription. Proc Natl Acad Sci USA 1985; 82: 381-385.
14. Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
15. Lieber A et al. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 1996; 70: 8944-8960.
16. Spergel JM, Chen-Kiang S. Interleukin 6 enhances a cellular activity that functionally substitutes for E1a protein in transactivation. Proc Natl Acad Sci USA 1991; 88: 6472-6476.
17. La Thangue NB, Rigby PW. An adenovirus E1a-like transcription factor is regulated during the differentiation of murine embryonal carcinoma cells. Cell 1987; 49: 507-513.
18. Ptashne M. How eukaryotic transcriptional activators work. Nature 1988; 335: 683-689.
19. Felsenfeld G et al. Chromatin structure and gene expression. Proc Natl Acad Sci USA 1996; 93: 93840-93886.
20. Udvardy A. Dividing the empire: boundary chroma tin elements delimit the territory of enhancers. EMBO J 1999; 18: 1-8.
21. Bell AC, Felsenfeld G. Stopped at the border: boundaries and insulators. Curr Opin Genet Dev 1999; 9: 191-198.
22. Walters MC et al. The chicken beta-globin 5′ HS4 boundary element blocks enhancer-mediated suppression of silencing. Mol Cell Biol 1999; 19: 3714-3726.
23. Chung JH, Bell AC, Felsenfeld G. Characterization of the chicken beta-globin insulator. Proc Natl Acad Sci USA 1997; 94: 575-580.
24. Bell AC, West AG, Felsenfeld G. The protein CTCF is required for enhancer blocking activity of vertebrate insulators. Cell 1999; 98: 387-396.
25. Chung JH, Whiteley M, Felsenfeld G. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effects in Drosophila. Cell 1993; 74: 505-514.
26. Emery DW, Yannaki E, Spyridis J, Stamatoyannopoulos G. A chroma tin insulator inhibits negative position effects on retrovirus vector expression in vivo. American Society of Gene Therapy, 2nd Annual Meeting of the American Society of Gene Therapy, 1999, Vol. abstr. No. 951, p 240a.
27. Rivella S et al. The insulator cHS4 increases the probability that randomly integrated recombinant retroviruses escape transcriptional silencing: implication for gene therapy. American Society of Gene Therapy, Washington, DC, 2nd Annual Meeting of the American Society of Gene Therapy, 1999, Vol. abstr. No. 66, p17a.
28. Palmiter RD. Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with constitutively active transcription factor, MTF-1. Proc Natl Acad Sci USA 1994; 91: 1219-1223.
29. Searle PF, Stuart GW, Palmiter RD. Metal regulatory elements of the mouse metallothionein-1 gene. FXS 1987; 52: 407-414.
30. Nelson J, Kay MA. Persistence of recombinant adenovirus in vivo is not dependent on vector replication. J Virol 1997; 71: 8902-8907.
31. Barr D et al. Strain related variations in adenoviral mediated transgene expression from mouse hepatocytes in vivo: comparison between immunocompetent and immunodeficient inbred strains. Gene Therapy 1995; 2: 151-156.
32. Vrancken Peeters M-J, Lieber A, Perkins J, Kay MA. Method for multiple portal vein infusions in mice: quantification of adenovirus-mediated hepatic gene transfer. BioTechniques 1996; 20: 278-285.
33. Shi Q, Wang Y, Worton R. Modulation of the specificity and activity of a cellular promoter in an adenoviral vector. Hum Gene Ther 1997; 8: 403-410.
34. Friedman JM, Babiss LE, Clayton DF, Darnell JE Jr. Cellular promoter incorporated into adenovirus genome: cell specificity of albumin and immunoglobulin expression. Mol Cell Biol 1986; 6: 3791-3797.
35. Babiss LE, Friedman JM, Darnell JE Jr. Cellular promoter incorporated into adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters. Mol Cell Biol 1986; 6: 3798-3806.
36. Quantin B, Perricaudet LD, Tajbakhsh S, Mandel J-L. Adenovirus as an expression vector in muscle cells in vivo. Proc Natl Acad Sci USA 1992; 89: 2581-2584.
37. Imler J-L et al. Targeting cell type-specific gene expression with an adenovirus vector containing the lacZ gene under the control of the CFTR promoter. Gene Therapy 1996; 3: 49-58.
38. Ring CJA, Harris JD, Hurst HC, Lemoine NR. Suicide gene expression in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter. Gene Therapy 1996; 3: 1094-1103.
39. Smale SR, Baltimore D. The 'initiator' as a transcriptional control element. Cell 1989; 57: 103-113.
40. Hitt MM, Addison CL, Graham FL. Human adenoviral vectors for gene transfer into mammalian cells. Adv Pharmacol 1997; 40: 137-205.
41. Griscelli F et al. Heart-specific targeting of beta-galactosiclase by the ventricle-specific cardiac myosin light chain 2 promoter using adenovirus vectors. Hum Gene Therapy 1998; 9: 1919-1928.
42. Kay MA, Graham F, Leland F, Woo SL. Therapeutic serum concentrations of human alphal-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 1995; 21: 815-819.
43. Kellum R, Schedl P. A group of scs elements function as domain boundaries in an enhancer blocking assay. Mol Cell Biol 1992; 12: 2424-2431.
44. Workman JL, Taylor ICA, Kingston RE. Activation domains of stably bound Ga14 derivatives alleviate repression of promoters by nucleosomes. Cell 1991; 64: 533-544.
45. Dunaway M, Hwang JY, Xiong M, Yuen H-L. The activity of the ses and scs' insulator elements is not dependent on chromosomal context. Mol Cell Biol 1997; 17: 182-189.
46. Krebs JE, Dunaway M. The ses and scs' insulator elements impart a cis requirement on enhancer-promoter interactions. Mol Cell 1998; 1: 301-308.
47. D'ery CV et al. The structure of adenovirus chromatin in infected cells. J Gen Virol 1985; 66: 2671-2684.
48. Daniell E, Groff DE, Fedor MJ. Adenovirus chromatin structure at different stages of infection. Mol Cell Biol 1981; 1: 1094-1105.
49. Wong ML, Tsu MT. Fsoralen-crosslinking study of the organization of intracellular adenovirus nucleoprotein complexes. J Virol 1988; 62: 1227-1234.
50. Vassaux G, Hurst HC, Lemoine NR. Insulation of a conditionally expressed transgene in an adenoviral vector. Gene Therapy 1999; 6: 1192-1197.
51. Kistner A et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci USA 1996; 93: 10933-10938.
52. Wang Y, O'Malley BW Jr, Tsai SY, O'Malley BW. A regulatory system for use in gene transfer. Proc Natl Acad Sci USA 1994; 91: 8180-8184.
53. Lieber A et al. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J Virol 1997; 71: 8798-8807.
54. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetraeycline-responsive elements. Proc Natl Acad Sci USA 1992; 89: 5547-5551.
55. Bett AJ, Krougliak V, Graham FL. DNA sequence of deletions/insertions in early region 3 of Ad5 dl309. Virus Res 1995; 39: 75-82.