-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
0034660892
-
The Pezcoller lecture: Cancer cell cycles revisited
-
Sherr CJ. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 2000;60:3689-3695.
-
(2000)
Cancer Res
, vol.60
, pp. 3689-3695
-
-
Sherr, C.J.1
-
3
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
-
Chang HW, Aoki M, Fruman D et al. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 1997;276: 1848-1850.
-
(1997)
Science
, vol.276
, pp. 1848-1850
-
-
Chang, H.W.1
Aoki, M.2
Fruman, D.3
-
4
-
-
68049085887
-
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
-
Hoeflich KP, O'Brien C, Boyd Z et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009;15:4649-4664.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4649-4664
-
-
Hoeflich, K.P.1
O'Brien, C.2
Boyd, Z.3
-
5
-
-
33646706052
-
Oncogenic PI3K and its role in cancer
-
Samuels Y, Ericson K. Oncogenic PI3K and its role in cancer. Curr Opin Oncol 2006;18:77-82.
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 77-82
-
-
Samuels, Y.1
Ericson, K.2
-
6
-
-
77952936573
-
PI3K pathway-directed therapeutic strategies in cancer
-
Agarwal R, Carey M, Hennessy B et al. PI3K pathway-directed therapeutic strategies in cancer. Curr Opin Investig Drugs 2010;11:615-628.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 615-628
-
-
Agarwal, R.1
Carey, M.2
Hennessy, B.3
-
8
-
-
46149106818
-
The p110beta isoform of phosphoinositide 3-kinase signals downstream ofGprotein-coupled receptors and is functionally redundant with p110gamma
-
Guillermet-Guibert J, Bjorklof K, Salpekar A et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream ofGprotein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A 2008;105:8292-8297.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
Bjorklof, K.2
Salpekar, A.3
-
9
-
-
26444620098
-
The negative regulation of phosphoinositide 3-kinase signaling by p85 and its implication in cancer
-
Luo J, Cantley LC. The negative regulation of phosphoinositide 3-kinase signaling by p85 and its implication in cancer. Cell Cycle 2005;4:1309-1312.
-
(2005)
Cell Cycle
, vol.4
, pp. 1309-1312
-
-
Luo, J.1
Cantley, L.C.2
-
10
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP et al. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991; 254:274-277.
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
-
11
-
-
0034194786
-
Biotinylated phosphatidylinositol 3,4,5-trisphosphate as affinity ligand
-
Wang DS, Ching TT, St Pyrek J et al. Biotinylated phosphatidylinositol 3,4,5-trisphosphate as affinity ligand. Anal Biochem 2000;280:301-307.
-
(2000)
Anal Biochem
, vol.280
, pp. 301-307
-
-
Wang, D.S.1
Ching, T.T.2
Pyrek, J.3
-
12
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 2005;4:988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
-
14
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001;17:615-675.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
-
15
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002;4:648-657.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
-
16
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning BD, Tee AR, Logsdon MN et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002;10:151-162.
-
(2002)
Mol Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
-
17
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002;4:658-665.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
18
-
-
0347318056
-
TSC2: Filling the GAP in the mTOR signaling pathway
-
Li Y, Corradetti MN, Inoki K et al. TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci 2004;29:32-38.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 32-38
-
-
Li, Y.1
Corradetti, M.N.2
Inoki, K.3
-
19
-
-
34547133519
-
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
-
Oshiro N, Takahashi R, Yoshino K et al. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 2007;282:20329-20339.
-
(2007)
J Biol Chem
, vol.282
, pp. 20329-20339
-
-
Oshiro, N.1
Takahashi, R.2
Yoshino, K.3
-
20
-
-
34547099855
-
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
-
Wang L, Harris TE, Roth RA et al. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 2007;282:20036-20044.
-
(2007)
J Biol Chem
, vol.282
, pp. 20036-20044
-
-
Wang, L.1
Harris, T.E.2
Roth, R.A.3
-
21
-
-
72049117072
-
Mammalian target of rapamycin: Discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth
-
Gibbons JJ, Abraham RT, Yu K. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol 2009;36 Suppl 3:S3-S17.
-
Semin Oncol
, vol.2009
, Issue.36 SUPPL 3
-
-
Gibbons, J.J.1
Abraham, R.T.2
Yu, K.3
-
22
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
23
-
-
0041821468
-
Raptor and mTOR: Subunits of a nutrient-sensitive complex
-
Kim DH, Sabatini DM. Raptor and mTOR: subunits of a nutrient-sensitive complex. Curr Top Microbiol Immunol 2004;279:259-270.
-
(2004)
Curr Top Microbiol Immunol
, vol.279
, pp. 259-270
-
-
Kim, D.H.1
Sabatini, D.M.2
-
24
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
Barbet NC, Schneider U, Helliwell SB et al. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 1996;7:25-42.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 25-42
-
-
Barbet, N.C.1
Schneider, U.2
Helliwell, S.B.3
-
25
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A et al. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 1997;277:99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
-
26
-
-
0032834055
-
EIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
Gingras AC, Raught B, Sonenberg N. EIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999;68:913-963.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
27
-
-
33750325725
-
S6K1-and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
-
Dorrello NV, Peschiaroli A, Guardavaccaro D et al. S6K1-and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 2006;314:467-471.
-
(2006)
Science
, vol.314
, pp. 467-471
-
-
Dorrello, N.V.1
Peschiaroli, A.2
Guardavaccaro, D.3
-
28
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
29
-
-
1642355123
-
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin
-
Browne GJ, Proud CG. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol 2004;24:2986-2997.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2986-2997
-
-
Browne, G.J.1
Proud, C.G.2
-
30
-
-
59749098906
-
MTORC1 signalling and mRNA translation
-
Proud CG. MTORC1 signalling and mRNA translation. Biochem Soc Trans 2009;37:227-231.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 227-231
-
-
Proud, C.G.1
-
31
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14:1296-1302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
-
32
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
Huang J, Dibble CC, Matsuzaki M et al. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008;28: 4104-4115.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
-
33
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
34
-
-
73149122504
-
Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer
-
Gulhati P, Cai Q, Li J et al. Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. Clin Cancer Res 2009;15:7207-7216.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7207-7216
-
-
Gulhati, P.1
Cai, Q.2
Li, J.3
-
35
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006;22:159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
36
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/ mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
Ozes ON, Akca H, Mayo LD et al. A phosphatidylinositol 3-kinase/Akt/ mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A 2001;98:4640-4645.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4640-4645
-
-
Ozes, O.N.1
Akca, H.2
Mayo, L.D.3
-
37
-
-
35348832340
-
Identification of IRS-1 Ser-1101 asa target of S6K1 in utrient-and obesity-induced insulin resistance
-
Tremblay F, Brule S, Hee Um S et al. Identification of IRS-1 Ser-1101 asa target of S6K1 in utrient-and obesity-induced insulin resistance. Proc Natl Acad Sci U S A 2007;104:14056-14061.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14056-14061
-
-
Tremblay, F.1
Brule, S.2
Heeum, S.3
-
38
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB et al. MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66: 1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
39
-
-
34547574720
-
Mills GB.Anew mutational AKTivation in the PI3K pathway
-
Brugge J, Hung MC, Mills GB.Anew mutational AKTivation in the PI3K pathway. Cancer Cell 2007;12:104-107.
-
(2007)
Cancer Cell
, vol.12
, pp. 104-107
-
-
Brugge, J.1
Hung, M.C.2
-
40
-
-
0033628571
-
Phosphatidylinositol-3 kinase dependent pathways: The role in control of cell growth, survival, and malignant transformation
-
Krasilnikov MA. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry (Mosc) 2000;65:59-67.
-
(2000)
Biochemistry (Mosc)
, vol.65
, pp. 59-67
-
-
Krasilnikov, M.A.1
-
41
-
-
27144480288
-
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(_/_) mice
-
Bayascas JR, Leslie NR, Parsons R et al. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(_/_) mice. Curr Biol 2005;15:1839-1846.
-
(2005)
Curr Biol
, vol.15
, pp. 1839-1846
-
-
Bayascas, J.R.1
Leslie, N.R.2
Parsons, R.3
-
42
-
-
33745172528
-
The deficiency of Akt1 is sufficient to suppress tumor development in Pten_/_ mice
-
Chen ML, Xu PZ, Peng XD et al. The deficiency of Akt1 is sufficient to suppress tumor development in Pten_/_ mice. Genes Dev 2006;20: 1569-1574.
-
(2006)
Genes Dev
, vol.20
, pp. 1569-1574
-
-
Chen, M.L.1
Xu, P.Z.2
Peng, X.D.3
-
43
-
-
10744230387
-
Linking molecular diagnostics to molecular therapeutics: Targeting the PI3K pathway in breast cancer
-
Mills GB, Kohn E, Lu Y et al. Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer. Semin Oncol 2003;30:93-104.
-
(2003)
Semin Oncol
, vol.30
, pp. 93-104
-
-
Mills, G.B.1
Kohn, E.2
Lu, Y.3
-
44
-
-
74049107249
-
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality
-
Lopez-Knowles E, O'Toole SA, McNeil CM et al. PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality. Int J Cancer 2010;126:1121-1131.
-
(2010)
Int J Cancer
, vol.126
, pp. 1121-1131
-
-
Lopez-Knowles, E.1
O'Toole, S.A.2
McNeil, C.M.3
-
45
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
Vasudevan KM, Barbie DA, Davies MA et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009;16:21-32.
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
-
46
-
-
34250687198
-
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
-
Saal LH, Johansson P, Holm K et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad SciUSA 2007;104:7564-7569.
-
(2007)
Proc Natl Acad SciUSA
, vol.104
, pp. 7564-7569
-
-
Saal, L.H.1
Johansson, P.2
Holm, K.3
-
47
-
-
0034462121
-
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
-
Nakamura N, Ramaswamy S, Vazquez F et al. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 2000;20:8969-8982.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8969-8982
-
-
Nakamura, N.1
Ramaswamy, S.2
Vazquez, F.3
-
48
-
-
14144252004
-
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
-
Kang S, Bader AG, Vogt PK. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad SciUSA 2005; 102:802-807.
-
(2005)
Proc Natl Acad SciUSA
, vol.102
, pp. 802-807
-
-
Kang, S.1
Bader, A.G.2
Vogt, P.K.3
-
49
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
50
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
-
Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997;57:2124-2129.
-
(1997)
Cancer Res
, vol.57
, pp. 2124-2129
-
-
Li, D.M.1
Sun, H.2
-
51
-
-
0033957661
-
The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
-
Vazquez F, Sellers WR. The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 2000; 1470:M21-M35.
-
(2000)
Biochim Biophys Acta
, vol.1470
-
-
Vazquez, F.1
Sellers, W.R.2
-
52
-
-
43749120732
-
The PTEN/PI3K/AKT signaling pathway in cancer, therapeutic implications
-
Carnero A, Blanco-Aparicio C, RennerO et al. The PTEN/PI3K/AKT signaling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008;8:187-198.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
-
53
-
-
0032857217
-
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
-
Perren A, Weng LP, Boag AH et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 1999;155:1253-1260.
-
(1999)
Am J Pathol
, vol.155
, pp. 1253-1260
-
-
Perren, A.1
Weng, L.P.2
Boag, A.H.3
-
54
-
-
0032500108
-
Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas
-
Bose S, Wang SI, Terry MB et al. Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas. Oncogene 1998; 17:123-127.
-
(1998)
Oncogene
, vol.17
, pp. 123-127
-
-
Bose, S.1
Wang, S.I.2
Terry, M.B.3
-
55
-
-
17944377486
-
Enhanced sensitivity of PTENdeficient tumors to inhibition of FRAP/mTOR
-
Neshat MS, Mellinghoff IK, Tran C et al. Enhanced sensitivity of PTENdeficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001;98:10314-10319.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
-
56
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y, Gera J, Hu L et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 2002;62:5027-5034.
-
(2002)
Cancer Res
, vol.62
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
-
57
-
-
42449107999
-
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors
-
Steelman LS, Navolanic PM, Sokolosky ML et al. Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. Oncogene 2008;27:4086-4095.
-
(2008)
Oncogene
, vol.27
, pp. 4086-4095
-
-
Steelman, L.S.1
Navolanic, P.M.2
Sokolosky, M.L.3
-
58
-
-
30944442856
-
The Akt pathway in human breast cancer: A tissue-array-based analysis
-
Bose S, Chandran S, Mirocha JM et al. The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol 2006;19:238-245.
-
(2006)
Mod Pathol
, vol.19
, pp. 238-245
-
-
Bose, S.1
Chandran, S.2
Mirocha, J.M.3
-
59
-
-
16544380194
-
Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast
-
Lee JS, Kim HS, Kim YB et al. Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast. Appl Immunohistochem Mol Morphol 2004;12:205-210.
-
(2004)
Appl Immunohistochem Mol Morphol
, vol.12
, pp. 205-210
-
-
Lee, J.S.1
Kim, H.S.2
Kim, Y.B.3
-
60
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman KE, Argani P, Samuels Y et al. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004;3: 772-775.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
-
61
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
Saal LH, Holm K, Maurer M et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005;65:2554-2559.
-
(2005)
Cancer Res
, vol.65
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
-
62
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
63
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008;68:6084-6091.
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
-
64
-
-
33645224005
-
PIK3CA mutations in breast cancer are associated with poor outcome
-
Li SY, Rong M, Grieu F et al. PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 2006;96:91-95.
-
(2006)
Breast Cancer Res Treat
, vol.96
, pp. 91-95
-
-
Li, S.Y.1
Rong, M.2
Grieu, F.3
-
65
-
-
33846854921
-
Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
-
Maruyama N, Miyoshi Y, Taguchi T et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007;13:408-414.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 408-414
-
-
Maruyama, N.1
Miyoshi, Y.2
Taguchi, T.3
-
66
-
-
33748041667
-
CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
-
Slagsvold T, Marchese A, Brech A et al. CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. EMBO J 2006;25:3738-3749.
-
(2006)
EMBO J
, vol.25
, pp. 3738-3749
-
-
Slagsvold, T.1
Marchese, A.2
Brech, A.3
-
67
-
-
27844461512
-
Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3_ kinase/AKT pathways
-
Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3_ kinase/AKT pathways. Oncogene 2005;24:7443-7454.
-
(2005)
Oncogene
, vol.24
, pp. 7443-7454
-
-
Larue, L.1
Bellacosa, A.2
-
68
-
-
0034954054
-
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells
-
Thant AA, Nawa A, Kikkawa F et al. Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells. Clin Exp Metastasis 2000;18:423-428.
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 423-428
-
-
Thant, A.A.1
Nawa, A.2
Kikkawa, F.3
-
69
-
-
0037229714
-
Overexpression of AKT2/ protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
Arboleda MJ, Lyons JF, Kabbinavar FF et al. Overexpression of AKT2/ protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 2003;63:196-206.
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
-
70
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
-
Maroulakou IG, Oemler W, Naber SP et al. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007;67:167-177.
-
(2007)
Cancer Res
, vol.67
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
-
71
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
Irie HY, Pearline RV, Grueneberg D et al. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005;171:1023-1034.
-
(2005)
J Cell Biol
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
-
72
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I et al. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005;20:539-550.
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
-
73
-
-
33847314539
-
The phosphatidyl inositol 3-kinase signaling network: Implications for human breast cancer
-
Dillon RL, White DE, Muller WJ. The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene 2007; 26:1338-1345.
-
(2007)
Oncogene
, vol.26
, pp. 1338-1345
-
-
Dillon, R.L.1
White, D.E.2
Muller, W.J.3
-
74
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A, de Feo D, Godwin AK et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995;64: 280-285.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
de Feo, D.2
Godwin, A.K.3
-
75
-
-
0033618371
-
Up-regulation of Akt3 in es-trogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani K, Thompson DA, Barthel A et al. Up-regulation of Akt3 in es-trogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999;274:21528-21532.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
-
76
-
-
77953158079
-
Distinct biological roles for the akt family in mammary tumor progression
-
Dillon RL, Muller WJ. Distinct biological roles for the akt family in mammary tumor progression. Cancer Res 2010;70:4260-4264.
-
(2010)
Cancer Res
, vol.70
, pp. 4260-4264
-
-
Dillon, R.L.1
Muller, W.J.2
-
77
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-10874.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
-
78
-
-
77953422867
-
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
-
Loi S, Haibe-Kains B, Majjaj S et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A 2010;107: 10208-10213.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10208-10213
-
-
Loi, S.1
Haibe-Kains, B.2
Majjaj, S.3
-
79
-
-
78651233471
-
Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: Major implication of the Wnt signaling pathway
-
Cizkova M, Cizeron-Clairac G, Vacher S et al. Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway. PLoS One 2010;5: e15647.
-
(2010)
PLoS One
, vol.5
-
-
Cizkova, M.1
Cizeron-Clairac, G.2
Vacher, S.3
-
80
-
-
32944482243
-
Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy
-
Cui X, Schiff R, Arpino G et al. Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 2005;23:7721-7735.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7721-7735
-
-
Cui, X.1
Schiff, R.2
Arpino, G.3
-
81
-
-
0038688478
-
Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases
-
Bardou VJ, Arpino G, Elledge RM et al. Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. J Clin Oncol 2003;21:1973-1979.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1973-1979
-
-
Bardou, V.J.1
Arpino, G.2
Elledge, R.M.3
-
82
-
-
42049121934
-
Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: Molecular mechanism and clinical implications for endocrine therapy resistance
-
Arpino G, Wiechmann L, Osborne CK et al. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev 2008;29:217-233.
-
(2008)
Endocr Rev
, vol.29
, pp. 217-233
-
-
Arpino, G.1
Wiechmann, L.2
Osborne, C.K.3
-
83
-
-
33748064399
-
Oestrogen receptor is a critical component required for insulin-like growth factor (IGF)-mediated signalling and growth in MCF-7 cells
-
Lee AV, Guler BL, Sun X et al. Oestrogen receptor is a critical component required for insulin-like growth factor (IGF)-mediated signalling and growth in MCF-7 cells. Eur J Cancer 2000;36 Suppl 4:109-110.
-
Eur J Cancer
, vol.2000
, Issue.36 SUPPL 4
, pp. 109-110
-
-
Lee, A.V.1
Guler, B.L.2
Sun, X.3
-
84
-
-
0034526749
-
A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I
-
Martin MB, Franke TF, Stoica GE et al. A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I. Endocrinology 2000;141:4503-4511.
-
(2000)
Endocrinology
, vol.141
, pp. 4503-4511
-
-
Martin, M.B.1
Franke, T.F.2
Stoica, G.E.3
-
85
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato S, Endoh H, Masuhiro Y et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270:1491-1494.
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
-
86
-
-
0037462733
-
Proximal events in signaling by plasma membrane estrogen receptors
-
Razandi M, Pedram A, Park ST et al. Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem 2003;278:2701-2712.
-
(2003)
J Biol Chem
, vol.278
, pp. 2701-2712
-
-
Razandi, M.1
Pedram, A.2
Park, S.T.3
-
87
-
-
27644597480
-
A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer
-
De Laurentiis M, Arpino G, Massarelli E et al. A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer. Clin Cancer Res 2005;11:4741-4748.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4741-4748
-
-
de Laurentiis, M.1
Arpino, G.2
Massarelli, E.3
-
88
-
-
4444278403
-
HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: A southwest oncology group study
-
Arpino G, Green SJ, Allred DC et al. HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study. Clin Cancer Res 2004; 10:5670-5676.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5670-5676
-
-
Arpino, G.1
Green, S.J.2
Allred, D.C.3
-
89
-
-
34748922324
-
The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo
-
Martin LA, Head JE, Pancholi S et al. The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo. Mol Cancer Ther 2007;6:2458-2467.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2458-2467
-
-
Martin, L.A.1
Head, J.E.2
Pancholi, S.3
-
90
-
-
6944235337
-
Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
-
deGraffenried LA, Friedrichs WE, Russell DH et al. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res 2004;10:8059-8067.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8059-8067
-
-
Degraffenried, L.A.1
Friedrichs, W.E.2
Russell, D.H.3
-
91
-
-
78149473552
-
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogenreceptor (ER) levels and activity in ER_breast cancer
-
Creighton CJ, Fu X, Hennessy BT et al. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogenreceptor (ER) levels and activity in ER_breast cancer. Breast Cancer Res 2010;12:R40.
-
(2010)
Breast Cancer Res
, vol.12
-
-
Creighton, C.J.1
Fu, X.2
Hennessy, B.T.3
-
92
-
-
68049102319
-
Inhibition of PI3K and MEK: It is all about combinations and biomarkers
-
Rexer BN, Ghosh R, Arteaga CL. Inhibition of PI3K and MEK: it is all about combinations and biomarkers. Clin Cancer Res 2009;15:4518-4520.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4518-4520
-
-
Rexer, B.N.1
Ghosh, R.2
Arteaga, C.L.3
-
93
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y, Lan KH, Zhou X et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004;6:117-127.
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
-
94
-
-
77953411708
-
Activated phosphoinositide 3-kinase/ AKT signaling confers resistance to trastuzumab but not lapatinib
-
O'Brien NA, Browne BC, Chow L et al. Activated phosphoinositide 3-kinase/ AKT signaling confers resistance to trastuzumab but not lapatinib. Mol Cancer Ther 2010;9:1489-1502.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1489-1502
-
-
O'Brien, N.A.1
Browne, B.C.2
Chow, L.3
-
95
-
-
65349101151
-
Ligand-independent HER2/ HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
Junttila TT, Akita RW, Parsons K et al. Ligand-independent HER2/ HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 2009;15:429-440.
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parsons, K.3
-
96
-
-
77957352037
-
PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
-
Esteva FJ, Guo H, Zhang S et al. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol 2010;177:1647-1656.
-
(2010)
Am J Pathol
, vol.177
, pp. 1647-1656
-
-
Esteva, F.J.1
Guo, H.2
Zhang, S.3
-
97
-
-
38149120449
-
Targeting phosphoinositide 3-kinase: Moving towards therapy
-
Marone R, Cmiljanovic V, Giese B et al. Targeting phosphoinositide 3-kinase: moving towards therapy. Biochim Biophys Acta 2008;1784:159-185.
-
(2008)
Biochim Biophys Acta
, vol.1784
, pp. 159-185
-
-
Marone, R.1
Cmiljanovic, V.2
Giese, B.3
-
98
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
-
Knight ZA, Gonzalez B, Feldman ME et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006; 125:733-747.
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
-
99
-
-
51449095342
-
Targeting the PI3K-AKT-mTOR pathway: Progress, pitfalls, and promises
-
Yap TA, Garrett MD, Walton MI et al. Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol 2008;8: 393-412.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 393-412
-
-
Yap, T.A.1
Garrett, M.D.2
Walton, M.I.3
-
100
-
-
20344384859
-
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
-
Luo Y, Shoemaker AR, Liu X et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther 2005;4: 977-986.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 977-986
-
-
Luo, Y.1
Shoemaker, A.R.2
Liu, X.3
-
101
-
-
20144388779
-
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
-
Zhao Z, Leister WH, Robinson RG et al. Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors. Bioorg Med Chem Lett 2005;15:905-909.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 905-909
-
-
Zhao, Z.1
Leister, W.H.2
Robinson, R.G.3
-
102
-
-
77949430065
-
The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
-
Lindsley CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem 2010;10:458-477.
-
(2010)
Curr Top Med Chem
, vol.10
, pp. 458-477
-
-
Lindsley, C.W.1
-
103
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975;28:721-726.
-
(1975)
J Antibiot (Tokyo)
, vol.28
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
104
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi J, Chen J, Schreiber SL et al. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 1996;273:239-242.
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
-
105
-
-
0026721092
-
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
-
Kuo CJ, Chung J, Fiorentino DF et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992;358:70-73.
-
(1992)
Nature
, vol.358
, pp. 70-73
-
-
Kuo, C.J.1
Chung, J.2
Fiorentino, D.F.3
-
106
-
-
65549167833
-
Targeting the mTOR signaling network for cancer therapy
-
Meric-Bernstam F, Gonzalez-Angulo AM. Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 2009;27:2278-2287.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2278-2287
-
-
Meric-Bernstam, F.1
Gonzalez-Angulo, A.M.2
-
107
-
-
33748578327
-
Combination therapy with aromatase inhibitors: The next era of breast cancer treatment?
-
Leary A, Dowsett M. Combination therapy with aromatase inhibitors: the next era of breast cancer treatment? Br J Cancer 2006;95:661-666.
-
(2006)
Br J Cancer
, vol.95
, pp. 661-666
-
-
Leary, A.1
Dowsett, M.2
-
108
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005;65:7052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
|