-
1
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235:177-182
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
2
-
-
0032475456
-
Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk
-
Rohan TE, Hartwick W, Miller AB, Kandel RA: Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk. J Natl Cancer Inst 1998, 90:1262-1269
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1262-1269
-
-
Rohan, T.E.1
Hartwick, W.2
Miller, A.B.3
Kandel, R.A.4
-
3
-
-
63749086305
-
ErbB receptors and signaling pathways in cancer
-
Hynes NE, MacDonald G: ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 2009, 21:177-184
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 177-184
-
-
Hynes, N.E.1
MacDonald, G.2
-
4
-
-
0037240275
-
ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms
-
Kurokawa H, Arteaga CL: ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms. Clin Cancer Res 2003, 9:511S-515S
-
(2003)
Clin Cancer Res
, vol.9
-
-
Kurokawa, H.1
Arteaga, C.L.2
-
5
-
-
20444502625
-
Trastuzumab: Targeted therapy for the management of HER-2/neu- Overexpressing metastatic breast cancer
-
Emens LA: Trastuzumab: targeted therapy for the management of HER-2/neu-overexpressing metastatic breast cancer. Am J Ther 2005, 12:243-253 (Pubitemid 40825130)
-
(2005)
American Journal of Therapeutics
, vol.12
, Issue.3
, pp. 243-253
-
-
Emens, L.A.1
-
6
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein PM, Ingle JN, Wolmark N: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005, 353:1673-1684
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer Jr., C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
Swain, S.M.11
Pisansky, T.M.12
Fehrenbacher, L.13
Kutteh, L.A.14
Vogel, V.G.15
Visscher, D.W.16
Yothers, G.17
Jenkins, R.B.18
Brown, A.M.19
Dakhil, S.R.20
Mamounas, E.P.21
Lingle, W.L.22
Klein, P.M.23
Ingle, J.N.24
Wolmark, N.25
more..
-
7
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
DOI 10.1056/NEJMoa052306
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, Gianni L, Baselga J, Bell R, Jackisch C, Cameron D, Dowsett M, Barrios CH, Steger G, Huang CS, Andersson M, Inbar M, Lichinitser M, Lang I, Nitz U, Iwata H, Thomssen C, Lohrisch C, Suter TM, Ruschoff J, Suto T, Greatorex V, Ward C, Straehle C, McFadden E, Dolci MS, Gelber RD: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005, 353:1659-1672 (Pubitemid 41464705)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
Goldhirsch, A.4
Untch, M.5
Smith, I.6
Gianni, L.7
Baselga, J.8
Bell, R.9
Jackisch, C.10
Cameron, D.11
Dowsett, M.12
Barrios, C.H.13
Steger, G.14
Huang, C.-S.15
Andersson, M.16
Inbar, M.17
Lichinitser, M.18
Lang, I.19
Nitz, U.20
Iwata, H.21
Thomssen, C.22
Lohrisch, C.23
Suter, T.M.24
Ruschoff, J.25
Suto, T.26
Greatorex, V.27
Ward, C.28
Straehle, C.29
McFadden, E.30
Dolci, M.S.31
Gelber, R.D.32
more..
-
8
-
-
0036534121
-
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
-
DOI 10.1200/JCO.2002.07.058
-
Esteva FJ, Valero V, Booser D, Guerra LT, Murray JL, Pusztai L, Cristofanilli M, Arun B, Esmaeli B, Fritsche HA, Sneige N, Smith TL, Hortobagyi GN: Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2002, 20:1800-1808 (Pubitemid 34273269)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.7
, pp. 1800-1808
-
-
Esteva, F.J.1
Valero, V.2
Booser, D.3
Guerra, L.T.4
Murray, J.L.5
Pusztai, L.6
Cristofanilli, M.7
Arun, B.8
Esmaeli, B.9
Fritsche, H.A.10
Sneige, N.11
Smith, T.L.12
Hortobagyi, G.N.13
-
9
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
-
Clynes RA, Towers TL, Presta LG, Ravetch JV: Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000, 6:443-446
-
(2000)
Nat Med
, vol.6
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
10
-
-
0035874981
-
Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J: Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 2001, 61:4744-4749 (Pubitemid 32691885)
-
(2001)
Cancer Research
, vol.61
, Issue.12
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
11
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
DOI 10.1016/j.ccr.2004.06.022, PII S1535610804002107
-
Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, Yu D: PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004, 6:117-127 (Pubitemid 39485684)
-
(2004)
Cancer Cell
, vol.6
, Issue.2
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.-H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.-C.12
Yu, D.13
-
12
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL: Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002, 62:4132-4141 (Pubitemid 34791085)
-
(2002)
Cancer Research
, vol.62
, Issue.14
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
King, W.4
Seelig, S.5
Arteaga, C.L.6
-
13
-
-
55249119148
-
HER-2-positive metastatic breast cancer: Trastuzumab and beyond
-
Metro G, Mottolese M, Fabi A: HER-2-positive metastatic breast cancer: trastuzumab and beyond. Expert Opin Pharmacother 2008, 9:2583-2601
-
(2008)
Expert Opin Pharmacother
, vol.9
, pp. 2583-2601
-
-
Metro, G.1
Mottolese, M.2
Fabi, A.3
-
14
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
DOI 10.1038/ncponc0509, PII N0509
-
Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ: Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006, 3:269-280 (Pubitemid 43731112)
-
(2006)
Nature Clinical Practice Oncology
, vol.3
, Issue.5
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.-C.3
Hortobagyi, G.N.4
Esteva, F.J.5
-
15
-
-
76449104021
-
Molecular predictors of response to trastuzumab and lapatinib in breast cancer
-
Esteva FJ, Yu D, Hung MC, Hortobagyi GN: Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol 2010, 7:98-107
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 98-107
-
-
Esteva, F.J.1
Yu, D.2
Hung, M.C.3
Hortobagyi, G.N.4
-
16
-
-
10744230387
-
Linking Molecular Diagnostics to Molecular Therapeutics: Targeting the PI3K Pathway in Breast Cancer
-
Mills GB, Kohn E, Lu Y, Eder A, Fang X, Wang H, Bast RC, Gray J, Jaffe R, Hortobagyi G: Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer. Semin Oncol 2003, 30:93-104 (Pubitemid 37433400)
-
(2003)
Seminars in Oncology
, vol.30
, Issue.5 SUPPL. 16
, pp. 93-104
-
-
Mills, G.B.1
Kohn, E.2
Lu, Y.3
Eder, A.4
Fang, X.5
Wang, H.6
Bast, R.C.7
Gray, J.8
Jaffe, R.9
Hortobagyi, G.10
-
17
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2:489-501 (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
18
-
-
65349164153
-
PI3K inhibition overcomes trastuzumab resistance: Blockade of ErbB2/ErbB3 is not always enough
-
Hynes NE, Dey JH: PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enough. Cancer Cell 2009, 15:353-355
-
(2009)
Cancer Cell
, vol.15
, pp. 353-355
-
-
Hynes, N.E.1
Dey, J.H.2
-
19
-
-
18844365440
-
Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide- 3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors
-
Chan CT, Metz MZ, Kane SE: Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide- 3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors. Breast Cancer Res Treat 2005, 91:187-201
-
(2005)
Breast Cancer Res Treat
, vol.91
, pp. 187-201
-
-
Chan, C.T.1
Metz, M.Z.2
Kane, S.E.3
-
20
-
-
0033957661
-
The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
-
Vazquez F, Sellers WR: The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 2000, 1470:M21-M35
-
(2000)
Biochim Biophys Acta
, vol.1470
-
-
Vazquez, F.1
Sellers, W.R.2
-
21
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH: The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004, 3:772-775 (Pubitemid 41351083)
-
(2004)
Cancer Biology and Therapy
, vol.3
, Issue.8
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Konishi, H.7
Karakas, B.8
Blair, B.G.9
Lin, C.10
Peters, B.A.11
Velculescu, V.E.12
Park, B.H.13
-
22
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, Yu JS, Malmstrom PO, Mansukhani M, Enoksson J, Hibshoosh H, Borg A, Parsons R: PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005, 65:2554-2559
-
(2005)
Cancer Res
, vol.65
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
Memeo, L.4
Su, T.5
Wang, X.6
Yu, J.S.7
Malmstrom, P.O.8
Mansukhani, M.9
Enoksson, J.10
Hibshoosh, H.11
Borg, A.12
Parsons, R.13
-
23
-
-
34250749822
-
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
-
DOI 10.1158/1078-0432.CCR-06-1609
-
Perez-Tenorio G, Alkhori L, Olsson B, Waltersson MA, Nordenskjold B, Rutqvist LE, Skoog L, Stal O: PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res 2007, 13:3577-3584 (Pubitemid 46955118)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3577-3584
-
-
Perez-Tenorio, G.1
Alkhori, L.2
Olsson, B.3
Waltersson, M.A.4
Nordenskjold, B.5
Rutqvist, L.E.6
Skoog, L.7
Stal, O.8
-
24
-
-
28244479028
-
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
-
Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS: Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 2005, 65:10992-11000
-
(2005)
Cancer Res
, vol.65
, pp. 10992-11000
-
-
Isakoff, S.J.1
Engelman, J.A.2
Irie, H.Y.3
Luo, J.4
Brachmann, S.M.5
Pearline, R.V.6
Cantley, L.C.7
Brugge, J.S.8
-
25
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R: A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12:395-402
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
Van De Vijver, M.J.13
Bernards, R.14
-
26
-
-
65349101151
-
Ligand-independent HER2/ HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
Junttila TT, Akita RW, Parsons K, Fields C, Lewis Phillips GD, Friedman LS, Sampath D, Sliwkowski MX: Ligand-independent HER2/ HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 2009, 15:429-440
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parsons, K.3
Fields, C.4
Lewis Phillips, G.D.5
Friedman, L.S.6
Sampath, D.7
Sliwkowski, M.X.8
-
27
-
-
77953873255
-
Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy
-
Yonemori K, Tsuta K, Shimizu C, Hatanaka Y, Hashizume K, Ono M, Kouno T, Ando M, Tamura K, Katsumata N, Hasegawa T, Kinoshita T, Fujiwara Y: Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy. Med Oncol 2008, 26:344-349
-
(2008)
Med Oncol
, vol.26
, pp. 344-349
-
-
Yonemori, K.1
Tsuta, K.2
Shimizu, C.3
Hatanaka, Y.4
Hashizume, K.5
Ono, M.6
Kouno, T.7
Ando, M.8
Tamura, K.9
Katsumata, N.10
Hasegawa, T.11
Kinoshita, T.12
Fujiwara, Y.13
-
28
-
-
63549133332
-
EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: Correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab
-
Gori S, Sidoni A, Colozza M, Ferri I, Mameli MG, Fenocchio D, Stocchi L, Foglietta J, Ludovini V, Minenza E, De Angelis V, Crino L: EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. Ann Oncol 2009, 20:648-654
-
(2009)
Ann Oncol
, vol.20
, pp. 648-654
-
-
Gori, S.1
Sidoni, A.2
Colozza, M.3
Ferri, I.4
Mameli, M.G.5
Fenocchio, D.6
Stocchi, L.7
Foglietta, J.8
Ludovini, V.9
Minenza, E.10
De Angelis, V.11
Crino, L.12
-
29
-
-
33644529055
-
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/ p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
-
Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN, Yu D: ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/ p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Res 2006, 66:2028-2037
-
(2006)
Cancer Res
, vol.66
, pp. 2028-2037
-
-
Klos, K.S.1
Wyszomierski, S.L.2
Sun, M.3
Tan, M.4
Zhou, X.5
Li, P.6
Yang, W.7
Yin, G.8
Hittelman, W.N.9
Yu, D.10
-
30
-
-
34447340582
-
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer
-
Zhou Y, Pan Y, Zhang S, Shi X, Ning T, Ke Y: Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer. Br J Cancer 2007, 97:218-222
-
(2007)
Br J Cancer
, vol.97
, pp. 218-222
-
-
Zhou, Y.1
Pan, Y.2
Zhang, S.3
Shi, X.4
Ning, T.5
Ke, Y.6
-
31
-
-
50049129087
-
Oestrogen receptor status of breast carcinoma: Allred/H score conversion table
-
Shousha S: Oestrogen receptor status of breast carcinoma: allred/H score conversion table. Histopathology 2008, 53:346-347
-
(2008)
Histopathology
, vol.53
, pp. 346-347
-
-
Shousha, S.1
-
32
-
-
0037087536
-
Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: Analysis of 10,000 individuals
-
Frank TS, Deffenbaugh AM, Reid JE, Hulick M, Ward BE, Lingenfelter B, Gumpper KL, Scholl T, Tavtigian SV, Pruss DR, Critchfield GC: Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 2002, 20:1480-1490
-
(2002)
J Clin Oncol
, vol.20
, pp. 1480-1490
-
-
Frank, T.S.1
Deffenbaugh, A.M.2
Reid, J.E.3
Hulick, M.4
Ward, B.E.5
Lingenfelter, B.6
Gumpper, K.L.7
Scholl, T.8
Tavtigian, S.V.9
Pruss, D.R.10
Critchfield, G.C.11
-
33
-
-
33745953240
-
Measures of response: RECIST. WHO, and new alternatives
-
Jaffe CC: Measures of response: rECIST. WHO, and new alternatives J Clin Oncol 2006, 24:3245-3251
-
(2006)
J Clin Oncol
, vol.24
, pp. 3245-3251
-
-
Jaffe, C.C.1
-
34
-
-
56349170884
-
Predicting the efficacy of trastuzumab- based therapy in breast cancer: Current standards and future strategies
-
Singer CF, Kostler WJ, Hudelist G: Predicting the efficacy of trastuzumab- based therapy in breast cancer: current standards and future strategies. Biochim Biophys Acta 2008, 1786:105-113
-
(2008)
Biochim Biophys Acta
, vol.1786
, pp. 105-113
-
-
Singer, C.F.1
Kostler, W.J.2
Hudelist, G.3
-
35
-
-
59549083317
-
Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancer
-
Mariani G, Fasolo A, De Benedictis E, Gianni L: Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancer. Nat Clin Pract Oncol 2009, 6:93-104
-
(2009)
Nat Clin Pract Oncol
, vol.6
, pp. 93-104
-
-
Mariani, G.1
Fasolo, A.2
De Benedictis, E.3
Gianni, L.4
-
36
-
-
31444444131
-
PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2- overexpressing breast cancer
-
Fujita T, Doihara H, Kawasaki K, Takabatake D, Takahashi H, Washio K, Tsukuda K, Ogasawara Y, Shimizu N: PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2- overexpressing breast cancer. Br J Cancer 2006, 94:247-252
-
(2006)
Br J Cancer
, vol.94
, pp. 247-252
-
-
Fujita, T.1
Doihara, H.2
Kawasaki, K.3
Takabatake, D.4
Takahashi, H.5
Washio, K.6
Tsukuda, K.7
Ogasawara, Y.8
Shimizu, N.9
-
37
-
-
0034920457
-
Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
-
Depowski PL, Rosenthal SI, Ross JS: Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer. Mod Pathol 2001, 14:672-676
-
(2001)
Mod Pathol
, vol.14
, pp. 672-676
-
-
Depowski, P.L.1
Rosenthal, S.I.2
Ross, J.S.3
-
38
-
-
33847013396
-
Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers
-
Xia W, Husain I, Liu L, Bacus S, Saini S, Spohn J, Pry K, Westlund R, Stein SH, Spector NL: Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer Res 2007, 67:1170-1175
-
(2007)
Cancer Res
, vol.67
, pp. 1170-1175
-
-
Xia, W.1
Husain, I.2
Liu, L.3
Bacus, S.4
Saini, S.5
Spohn, J.6
Pry, K.7
Westlund, R.8
Stein, S.H.9
Spector, N.L.10
-
39
-
-
35348917266
-
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency
-
Lu CH, Wyszomierski SL, Tseng LM, Sun MH, Lan KH, Neal CL, Mills GB, Hortobagyi GN, Esteva FJ, Yu D: Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Clin Cancer Res 2007, 13:5883-5888
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5883-5888
-
-
Lu, C.H.1
Wyszomierski, S.L.2
Tseng, L.M.3
Sun, M.H.4
Lan, K.H.5
Neal, C.L.6
Mills, G.B.7
Hortobagyi, G.N.8
Esteva, F.J.9
Yu, D.10
-
40
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA: AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009, 16:21-32
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
Root, D.E.29
Lander, E.S.30
Mills, G.B.31
Hahn, W.C.32
Sellers, W.R.33
Garraway, L.A.34
more..
-
41
-
-
0032857217
-
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
-
Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, Komminoth P, Lees JA, Mulligan LM, Mutter GL, Eng C: Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 1999, 155:1253-1260
-
(1999)
Am J Pathol
, vol.155
, pp. 1253-1260
-
-
Perren, A.1
Weng, L.P.2
Boag, A.H.3
Ziebold, U.4
Thakore, K.5
Dahia, P.L.6
Komminoth, P.7
Lees, J.A.8
Mulligan, L.M.9
Mutter, G.L.10
Eng, C.11
-
42
-
-
33846557325
-
Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma
-
Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, Koga T, Morita M, Kakeji Y, Maehara Y: Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma. Breast Cancer Res Treat 2007, 101:249-257
-
(2007)
Breast Cancer Res Treat
, vol.101
, pp. 249-257
-
-
Tokunaga, E.1
Oki, E.2
Kimura, Y.3
Yamanaka, T.4
Egashira, A.5
Nishida, K.6
Koga, T.7
Morita, M.8
Kakeji, Y.9
Maehara, Y.10
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