메뉴 건너뛰기




Volumn 177, Issue 4, 2010, Pages 1647-1656

PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; PROTEIN KINASE B; S6 KINASE; TRASTUZUMAB;

EID: 77957352037     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090885     Document Type: Article
Times cited : (269)

References (42)
  • 1
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235:177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 2
    • 0032475456 scopus 로고    scopus 로고
    • Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk
    • Rohan TE, Hartwick W, Miller AB, Kandel RA: Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk. J Natl Cancer Inst 1998, 90:1262-1269
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1262-1269
    • Rohan, T.E.1    Hartwick, W.2    Miller, A.B.3    Kandel, R.A.4
  • 3
    • 63749086305 scopus 로고    scopus 로고
    • ErbB receptors and signaling pathways in cancer
    • Hynes NE, MacDonald G: ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 2009, 21:177-184
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 177-184
    • Hynes, N.E.1    MacDonald, G.2
  • 4
    • 0037240275 scopus 로고    scopus 로고
    • ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms
    • Kurokawa H, Arteaga CL: ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms. Clin Cancer Res 2003, 9:511S-515S
    • (2003) Clin Cancer Res , vol.9
    • Kurokawa, H.1    Arteaga, C.L.2
  • 5
    • 20444502625 scopus 로고    scopus 로고
    • Trastuzumab: Targeted therapy for the management of HER-2/neu- Overexpressing metastatic breast cancer
    • Emens LA: Trastuzumab: targeted therapy for the management of HER-2/neu-overexpressing metastatic breast cancer. Am J Ther 2005, 12:243-253 (Pubitemid 40825130)
    • (2005) American Journal of Therapeutics , vol.12 , Issue.3 , pp. 243-253
    • Emens, L.A.1
  • 9
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV: Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000, 6:443-446
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 10
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
    • Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J: Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 2001, 61:4744-4749 (Pubitemid 32691885)
    • (2001) Cancer Research , vol.61 , Issue.12 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3    Rojo, F.4    Arribas, J.5    Baselga, J.6
  • 12
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL: Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002, 62:4132-4141 (Pubitemid 34791085)
    • (2002) Cancer Research , vol.62 , Issue.14 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3    King, W.4    Seelig, S.5    Arteaga, C.L.6
  • 13
    • 55249119148 scopus 로고    scopus 로고
    • HER-2-positive metastatic breast cancer: Trastuzumab and beyond
    • Metro G, Mottolese M, Fabi A: HER-2-positive metastatic breast cancer: trastuzumab and beyond. Expert Opin Pharmacother 2008, 9:2583-2601
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 2583-2601
    • Metro, G.1    Mottolese, M.2    Fabi, A.3
  • 14
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • DOI 10.1038/ncponc0509, PII N0509
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ: Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006, 3:269-280 (Pubitemid 43731112)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.-C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 15
    • 76449104021 scopus 로고    scopus 로고
    • Molecular predictors of response to trastuzumab and lapatinib in breast cancer
    • Esteva FJ, Yu D, Hung MC, Hortobagyi GN: Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol 2010, 7:98-107
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 98-107
    • Esteva, F.J.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4
  • 17
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2:489-501 (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 18
    • 65349164153 scopus 로고    scopus 로고
    • PI3K inhibition overcomes trastuzumab resistance: Blockade of ErbB2/ErbB3 is not always enough
    • Hynes NE, Dey JH: PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enough. Cancer Cell 2009, 15:353-355
    • (2009) Cancer Cell , vol.15 , pp. 353-355
    • Hynes, N.E.1    Dey, J.H.2
  • 19
    • 18844365440 scopus 로고    scopus 로고
    • Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide- 3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors
    • Chan CT, Metz MZ, Kane SE: Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide- 3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors. Breast Cancer Res Treat 2005, 91:187-201
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 187-201
    • Chan, C.T.1    Metz, M.Z.2    Kane, S.E.3
  • 20
    • 0033957661 scopus 로고    scopus 로고
    • The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
    • Vazquez F, Sellers WR: The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 2000, 1470:M21-M35
    • (2000) Biochim Biophys Acta , vol.1470
    • Vazquez, F.1    Sellers, W.R.2
  • 29
    • 33644529055 scopus 로고    scopus 로고
    • ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/ p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
    • Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN, Yu D: ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/ p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Res 2006, 66:2028-2037
    • (2006) Cancer Res , vol.66 , pp. 2028-2037
    • Klos, K.S.1    Wyszomierski, S.L.2    Sun, M.3    Tan, M.4    Zhou, X.5    Li, P.6    Yang, W.7    Yin, G.8    Hittelman, W.N.9    Yu, D.10
  • 30
    • 34447340582 scopus 로고    scopus 로고
    • Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer
    • Zhou Y, Pan Y, Zhang S, Shi X, Ning T, Ke Y: Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer. Br J Cancer 2007, 97:218-222
    • (2007) Br J Cancer , vol.97 , pp. 218-222
    • Zhou, Y.1    Pan, Y.2    Zhang, S.3    Shi, X.4    Ning, T.5    Ke, Y.6
  • 31
    • 50049129087 scopus 로고    scopus 로고
    • Oestrogen receptor status of breast carcinoma: Allred/H score conversion table
    • Shousha S: Oestrogen receptor status of breast carcinoma: allred/H score conversion table. Histopathology 2008, 53:346-347
    • (2008) Histopathology , vol.53 , pp. 346-347
    • Shousha, S.1
  • 33
    • 33745953240 scopus 로고    scopus 로고
    • Measures of response: RECIST. WHO, and new alternatives
    • Jaffe CC: Measures of response: rECIST. WHO, and new alternatives J Clin Oncol 2006, 24:3245-3251
    • (2006) J Clin Oncol , vol.24 , pp. 3245-3251
    • Jaffe, C.C.1
  • 34
    • 56349170884 scopus 로고    scopus 로고
    • Predicting the efficacy of trastuzumab- based therapy in breast cancer: Current standards and future strategies
    • Singer CF, Kostler WJ, Hudelist G: Predicting the efficacy of trastuzumab- based therapy in breast cancer: current standards and future strategies. Biochim Biophys Acta 2008, 1786:105-113
    • (2008) Biochim Biophys Acta , vol.1786 , pp. 105-113
    • Singer, C.F.1    Kostler, W.J.2    Hudelist, G.3
  • 35
    • 59549083317 scopus 로고    scopus 로고
    • Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancer
    • Mariani G, Fasolo A, De Benedictis E, Gianni L: Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancer. Nat Clin Pract Oncol 2009, 6:93-104
    • (2009) Nat Clin Pract Oncol , vol.6 , pp. 93-104
    • Mariani, G.1    Fasolo, A.2    De Benedictis, E.3    Gianni, L.4
  • 37
    • 0034920457 scopus 로고    scopus 로고
    • Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
    • Depowski PL, Rosenthal SI, Ross JS: Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer. Mod Pathol 2001, 14:672-676
    • (2001) Mod Pathol , vol.14 , pp. 672-676
    • Depowski, P.L.1    Rosenthal, S.I.2    Ross, J.S.3
  • 38
    • 33847013396 scopus 로고    scopus 로고
    • Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers
    • Xia W, Husain I, Liu L, Bacus S, Saini S, Spohn J, Pry K, Westlund R, Stein SH, Spector NL: Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer Res 2007, 67:1170-1175
    • (2007) Cancer Res , vol.67 , pp. 1170-1175
    • Xia, W.1    Husain, I.2    Liu, L.3    Bacus, S.4    Saini, S.5    Spohn, J.6    Pry, K.7    Westlund, R.8    Stein, S.H.9    Spector, N.L.10
  • 42
    • 33846557325 scopus 로고    scopus 로고
    • Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma
    • Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, Koga T, Morita M, Kakeji Y, Maehara Y: Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma. Breast Cancer Res Treat 2007, 101:249-257
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 249-257
    • Tokunaga, E.1    Oki, E.2    Kimura, Y.3    Yamanaka, T.4    Egashira, A.5    Nishida, K.6    Koga, T.7    Morita, M.8    Kakeji, Y.9    Maehara, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.