Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes

Biomaterials

Volumn 32, Issue 20, 2011, Pages 4639-4646

  Thibault, Marc ^a   Astolfi, Mélina ^a   Tran Khanh, Nicolas ^a   Lavertu, Marc ^a   Darras, Vincent ^a   Merzouki, Abderrazzak ^a   Buschmann, Michael D ^a  

^a ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

Author keywords

Chitosan; Confocal microscopy; DNA; Gene transfer; Nanoparticle

Indexed keywords

CELLULAR UPTAKE; COLOCALISATION; CYTOSOLS; GENE DELIVERY; INTRACELLULAR TRAFFICKING; N:P RATIO; OPTIMISATIONS; PHOSPHATE GROUP; POLYCATIONS; POLYPLEXES; RESIDENCE TIME; TRANSFECTION EFFICIENCY;

CHITIN; CHITOSAN; CONFOCAL MICROSCOPY; DNA; GENE THERAPY; GENE TRANSFER; NANOPARTICLES; NUCLEIC ACIDS; OPTIMIZATION;

MULTILAYERS;

CHITOSAN; DNA; POLYCATION;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL;

ANTIMALARIALS; CHITOSAN; CHLOROQUINE; DNA; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEK293 CELLS; HUMANS; LYSOSOMES; MATERIALS TESTING; POLYAMINES; TRANSFECTION;

EID: 79955524676     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.010     Document Type: Article

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