Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(γ-glutamic acid) complexes as a gene delivery vector

Biomaterials

Volumn 32, Issue 1, 2011, Pages 239-248

  Peng, Shu Fen ^a,d   Tseng, Michael T ^b   Ho, Yi Cheng ^c   Wei, Ming Cheng ^a   Liao, Zi Xian ^a   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b University of Louisville School of Medicine   (United States)

^c VANUNG UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Caveolae mediated pathway; Cellular uptake; Lysosome; Macropinocytosis; Transfection efficiency

Indexed keywords

CAVEOLAE; CELLULAR UPTAKE; LYSOSOME; MACROPINOCYTOSIS; TRANSFECTION EFFICIENCY;

AMINO ACIDS; CELL MEMBRANES; COMPUTER SIMULATION; CYTOLOGY; DRUG THERAPY; ENZYME ACTIVITY; GENE THERAPY; GENE TRANSFER; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS;

GENE EXPRESSION;

CHITOSAN; ENHANCED GREEN FLUORESCENT PROTEIN; GAMMA GLUTAMYLTRANSFERASE; LUCIFERASE; PLASMID DNA; POLY(GAMMA GLUTAMIC ACID); POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; COMPLEX FORMATION; ENDOCYTOSIS; FIBROSARCOMA; FLOW CYTOMETRY; FLUORESCENCE; INTERNALIZATION; LYSOSOME; NONVIRAL GENE DELIVERY SYSTEM; PINOCYTOSIS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

CELL LINE, TUMOR; CELL SURVIVAL; CHITOSAN; DNA; ENDOCYTOSIS; GENE TRANSFER TECHNIQUES; HUMANS; INTRACELLULAR SPACE; KINETICS; LUCIFERASES; MODELS, BIOLOGICAL; MOLECULAR DYNAMICS SIMULATION; POLYGLUTAMIC ACID; PROTEIN TRANSPORT; TRANSFECTION;

EID: 78349309344     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.08.081     Document Type: Article

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