Inhibition of Hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation

Journal of Biological Chemistry

Volumn 285, Issue 21, 2010, Pages 15714-15723

  Wang, Adrienne M ^a   Morishima, Yoshihiro ^a   Clapp, Kelly M ^a   Peng, Hwei Ming ^a   Pratt, William B ^a   Gestwicki, Jason E ^a   Osawa, Yoichi ^a   Lieberman, Andrew P ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTORS; ATP-ASE ACTIVITY; AUTOPHAGY; DEPENDENT FUNCTIONS; E3 UBIQUITIN LIGASES; GLUCOCORTICOID RECEPTOR; LIGAND BINDING; LIGAND BINDING DOMAIN; METHYLENE BLUE; NITRIC-OXIDE SYNTHASE; POLYGLUTAMINE; POLYGLUTAMINE PROTEINS; PROTEASOMAL DEGRADATION; PROTEIN DEGRADATION; SIGNALING PROTEINS; SMALL MOLECULE INHIBITOR; UBIQUITIN LIGASES; UBIQUITINATION;

COMPLEXATION; DEGRADATION; LIGANDS; MACHINERY; SIGNALING;

PROTEINS;

ANDROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; METHYLENE BLUE; NEURONAL NITRIC OXIDE SYNTHASE; POLYGLUTAMINE; UBIQUITIN PROTEIN LIGASE E3;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; RETICULOCYTE LYSATE; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; ENZYME INHIBITORS; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; METHYLENE BLUE; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77952332824     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.098806     Document Type: Article

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