Binding of a small molecule at a protein-protein interface regulates the chaperone activity of Hsp70-Hsp40

ACS Chemical Biology

Volumn 5, Issue 6, 2010, Pages 611-622

  Wisén, Susanne ^a   Bertelsen, Eric B ^b   Thompson, Andrea D ^a   Patury, Srikanth ^a   Ung, Peter ^c   Chang, Lyra ^a   Evans, Christopher G ^a   Walter, Gladis M ^a   Wipf, Peter ^b   Carlson, Heather A ^c   Brodsky, Jeffrey L ^d   Zuiderweg, Erik R P ^b   Gestwicki, Jason E ^a,b,c  

^a Life Sciences Institute   (United States)

^b Department of Biological Chemistry ^*  (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHAPERONE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; PROTEIN DNAK; DNAK PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; MOLECULAR LIBRARY; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; BINDING COMPETITION; BINDING SITE; COMPLEX FORMATION; HOMEOSTASIS; MUTAGENESIS; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STEREOCHEMISTRY; YEAST; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

PROKARYOTA;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 77953850922     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb1000422     Document Type: Article

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