BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution

Journal of Neurochemistry

Volumn 111, Issue 3, 2009, Pages 801-807

  Sroka, Kamila ^a,b,e   Voigt, Aaron ^b,c,f   Deeg, Sebastian ^a,b   Reed, John C ^d   Schulz, Jörg B ^b,c   Bähr, Mathias ^a,b   Kermer, Pawel ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Deutsche Forschungsgemeinschaft   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d BURNHAM INSTITUTE   (United States)

^e MERZ PHARMACEUTICALS GMBH   (Germany)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Aggregation; Bcl 2 associated athanogene 1; Huntington's disease; Polyglutamine; Proteasomal degradation; Seven in absentia homolog 1

Indexed keywords

ABSENTIA HOMOLOG 1; BAG 1 PROTEIN; HUNTINGTIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CELL LOSS; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOTOXICITY; DROSOPHILA MELANOGASTER; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; MUTANT; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HUMANS; HUNTINGTON DISEASE; LEUPEPTINS; MICE; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHOTORECEPTOR CELLS; PROTEINS; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER; MUS MUSCULUS;

EID: 70350004724     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06363.x     Document Type: Article

References (36)

1. Al-Ramahi I., Lam Y. C., Chen H. K. et al. (2006) CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J. Biol. Chem. 281, 26714 26724.
2. Bae B. I., Hara M. R., Cascio M. B. et al. (2006) Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proc. Natl Acad. Sci. USA 103, 3405 3409.
3. Bennett E. J., Shaler T. A., Woodman B., Ryu K. Y., Zaitseva T. S., Becker C. H., Bates G. P., Schulman H. Kopito R. R. (2007) Global changes to the ubiquitin system in Huntington's disease. Nature 448, 704 708.
4. Demand J., Alberti S., Patterson C. Hohfeld J. (2001) Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr. Biol. 11, 1569 1577.
5. Dunah A. W., Jeong H., Griffin A. et al. (2002) Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science 296, 2238 2243.
6. Gotz R., Wiese S., Takayama S. et al. (2005) Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat. Neurosci. 8, 1169 1178.
7. Graham R. K., Deng Y., Slow E. J. et al. (2006) Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125, 1179 1191.
8. Gunawardena S., Her L. S., Brusch R. G., Laymon R. A., Niesman I. R., Gordesky-Gold B., Sintasath L., Bonini N. M. Goldstein L. S. (2003) Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40, 25 40.
9. Hara M. R., Agrawal N., Kim S. F. et al. (2005) S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat. Cell Biol. 7, 665 674.
10. Hohfeld J. Jentsch S. (1997) GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16, 6209 6216.
11. Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971 983.
12. Jana N. R. Nukina N. (2005) BAG-1 associates with the polyglutamine-expanded huntingtin aggregates. Neurosci. Lett. 378, 171 175.
13. Jana N. R., Tanaka M., Wang G. Nukina N. (2000) Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum. Mol. Genet. 9, 2009 2018.
14. Jana N. R., Zemskov E. A., Wang G. Nukina N. (2001) Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum. Mol. Genet. 10, 1049 1059.
15. Jana N. R., Dikshit P., Goswami A., Kotliarova S., Murata S., Tanaka K. Nukina N. (2005) Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. J. Biol. Chem. 280, 11635 11640.
16. Kermer P., Krajewska M., Zapata J. M., Takayama S., Mai J., Krajewski S. Reed J. C. (2002) Bag1 is a regulator and marker of neuronal differentiation. Cell Death Differ. 9, 405 413.
17. Kermer P., Digicaylioglu M. H., Kaul M. et al. (2003) BAG1 over-expression in brain protects against stroke. Brain Pathol. 13, 495 506.
18. Liman J., Ganesan S., Dohm C. P., Krajewski S., Reed J. C., Bahr M., Wouters F. S. Kermer P. (2005) Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol. Cell. Biol. 25, 3715 3725.
19. Luders J., Demand J. Hohfeld J. (2000) The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. J. Biol. Chem. 275, 4613 4617.
20. Matsuzawa S., Takayama S., Froesch B. A., Zapata J. M. Reed J. C. (1998) p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J. 17, 2736 2747.
21. Orr A. L., Huang S., Roberts M. A., Reed J. C., S Li. XJ Li. (2008) Sex-dependent effect of bag1 in ameliorating motor deficits of Huntington's disease transgenic mice. J. Biol. Chem. 283, 16027 16036.
22. Peters M. F., Nucifora F. C. Jr., Kushi J., Seaman H. C., Cooper J. K., Herring W. J., Dawson V. L., Dawson T. M. Ross C. A. (1999) Nuclear targeting of mutant Huntingtin increases toxicity. Mol. Cell. Neurosci. 14, 121 128.
23. Pichaud F. Desplan C. (2001) A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development 128, 815 826.
24. Planchamp V., Bermel C., Tonges L., Ostendorf T., Kugler S., Reed J. C., Kermer P., Bahr M. Lingor P. (2008) BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity. Brain. 131, 2606 2619.
25. Saudou F., Finkbeiner S., Devys D. Greenberg M. E. (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95, 55 66.
26. Sourisseau T., Desbois C., Debure L., Bowtell D. D., Cato A. C., Schneikert J., Moyse E. Michel D. (2001) Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis. J. Cell Sci. 114, 1409 1416.
27. Steffan J. S., Bodai L., Pallos J. et al. (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413, 739 743.
28. Szebenyi G., Morfini G. A., Babcock A. et al. (2003) Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. Neuron 40, 41 52.
29. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J. A. Reed J. C. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80, 279 284.
30. Takayama S., Bimston D. N., Matsuzawa S., Freeman B. C., Aime-Sempe C., Xie Z., Morimoto R. I. Reed J. C. (1997) BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 16, 4887 4896.
31. Trettel F., Rigamonti D., Hilditch-Maguire P., Wheeler V. C., Sharp A. H., Persichetti F., Cattaneo E. MacDonald M. E. (2000) Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum. Mol. Genet. 9, 2799 2809.
32. Verhoef L. G., Lindsten K., Masucci M. G. Dantuma N. P. (2002) Aggregate formation inhibits proteasomal degradation of polyglutamine proteins. Hum. Mol. Genet. 11, 2689 2700.
33. Wellington C. L., Ellerby L. M., Hackam A. S. et al. (1998) Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem. 273, 9158 9167.
34. Wyttenbach A., Swartz J., Kita H. et al. (2001) Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. Hum. Mol. Genet. 10, 1829 1845.
35. Zhai W., Jeong H., Cui L., Krainc D. Tjian R. (2005) In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell 123, 1241 1253.
36. Zuccato C., Tartari M., Crotti A. et al. (2003) Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 35, 76 83.