-
1
-
-
55049131325
-
Challenges facing drug development for malaria
-
Craft, J. C. Challenges facing drug development for malaria. Curr. Opin. Microbiol. 2008, 11(5), 428-33.
-
(2008)
Curr. Opin. Microbiol.
, vol.11
, Issue.5
, pp. 428-433
-
-
Craft, J.C.1
-
2
-
-
34548126497
-
Drug discovery for malaria: a very challenging and timely endeavor
-
DOI 10.1016/j.cbpa.2007.05.038, PII S136759310700083X
-
Gelb, M. H. Drug discovery for malaria: A very challenging and timely endeavor. Curr. Opin. Chem. Biol. 2007, 11(4), 440-5. (Pubitemid 47302852)
-
(2007)
Current Opinion in Chemical Biology
, vol.11
, Issue.4
, pp. 440-445
-
-
Gelb, M.H.1
-
3
-
-
34250742679
-
Recent advances in malaria drug discovery
-
Lanteri, C. A.; Johnson, J. D.; Waters, N. C. Recent advances in malaria drug discovery. Recent Pat. Antiinfect. Drug Discov. 2007, 2(2), 95-114. (Pubitemid 46957319)
-
(2007)
Recent Patents on Anti-Infective Drug Discovery
, vol.2
, Issue.2
, pp. 95-114
-
-
Lanteri, C.A.1
Johnson, J.D.2
Waters, N.C.3
-
4
-
-
70350778454
-
New medicines to improve control and contribute to the eradication of malaria
-
Wells, T. N.; Alonso, P. L.; Gutteridge, W. E. New medicines to improve control and contribute to the eradication of malaria. Nat. Rev. Drug Discov. 2009, 8(11), 879-91.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, Issue.11
, pp. 879-91
-
-
Wells, T.N.1
Alonso, P.L.2
Gutteridge, W.E.3
-
5
-
-
0036830528
-
Malarial dihydroorotate dehydrogenase
-
Baldwin, J.; Farajallah, A. M.; Malmquist, N. A.; Rathod, P. K.; Phillips, M. A. Malarial dihydroorotate dehydrogenase. J. Biol. Chem. 2002, 277(44), 41827-41834.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.44
, pp. 41827-41834
-
-
Baldwin, J.1
Farajallah, A.M.2
Malmquist, N.A.3
Rathod, P.K.4
Phillips, M.A.5
-
6
-
-
0037407201
-
Prized malaria drug target nailed
-
DOI 10.1038/nsb0503-316
-
Rathod, P. K.; Phillips, M. A. Prized malaria drug target nailed. Nat. Struct. Biol. 2003, 10(5), 316-318. (Pubitemid 36523262)
-
(2003)
Nature Structural Biology
, vol.10
, Issue.5
, pp. 316-318
-
-
Rathod, P.K.1
Phillips, M.A.2
-
7
-
-
65649152331
-
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
-
Davies, M.; Heikkila, T.; McConkey, G. A.; Fishwick, C. W. G.; Parsons, M. R.; Johnson, A. P. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J. Med. Chem. 2009, 52(9), 2683-2693.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.9
, pp. 2683-2693
-
-
Davies, M.1
Heikkila, T.2
McConkey, G.A.3
Fishwick, C.W.G.4
Parsons, M.R.5
Johnson, A.P.6
-
8
-
-
70350385202
-
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
-
Deng, X.; Gujjar, R.; El Mazouni, F.; Kaminsky, W.; Malmquist, N. A.; Goldsmith, E. J.; Rathod, P. K.; Phillips, M. A. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J. Biol. Chem. 2009, 284(39), 26999-7009.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.39
, pp. 26999-7009
-
-
Deng, X.1
Gujjar, R.2
El Mazouni, F.3
Kaminsky, W.4
Malmquist, N.A.5
Goldsmith, E.J.6
Rathod, P.K.7
Phillips, M.A.8
-
9
-
-
33646583490
-
Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor
-
DOI 10.1107/S0907444905042642
-
Hurt, D. E.; Widom, J.; Clardy, J. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystal. Sect. DBiol. Crystal. 2006, 62, 312-323. (Pubitemid 44185140)
-
(2006)
Acta Crystallographica Section D: Biological Crystallography
, vol.62
, Issue.3
, pp. 312-323
-
-
Hurt, D.E.1
Widom, J.2
Clardy, J.3
-
10
-
-
0034650342
-
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents
-
DOI 10.1016/S0969-2126(00)00077-0
-
Liu, S. P.; Neidhardt, E. A.; Grossman, T. H.; Ocain, T.; Clardy, J. Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Struct. Fold. Des. 2000, 8(1), 25-33. (Pubitemid 30051339)
-
(2000)
Structure
, vol.8
, Issue.1
, pp. 25-33
-
-
Liu, S.1
Neidhardt, E.A.2
Grossman, T.H.3
Ocain, T.4
Clardy, J.5
-
11
-
-
33847398001
-
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
-
DOI 10.1038/nature05572, PII NATURE05572
-
Painter, H. J.; Morrisey, J. M.; Mather, M. W.; Vaidya, A. B. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 2007, 446(7131), 88-91. (Pubitemid 46348043)
-
(2007)
Nature
, vol.446
, Issue.7131
, pp. 88-91
-
-
Painter, H.J.1
Morrisey, J.M.2
Mather, M.W.3
Vaidya, A.B.4
-
12
-
-
20444470318
-
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
-
DOI 10.1074/jbc.M501100200
-
Baldwin, J.; Michnoff, C. H.; Malmquist, N. A.; White, J.; Roth, M. G.; Rathod, P. K.; Phillips, M. A. High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J. Biol. Chem. 2005, 280(23), 21847-21853. (Pubitemid 40827835)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 21847-21853
-
-
Baldwin, J.1
Michnoff, C.H.2
Malmquist, N.A.3
White, J.4
Roth, M.G.5
Rathod, P.K.6
Phillips, M.A.7
-
13
-
-
45749119578
-
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum
-
DOI 10.1021/jm8001026
-
Phillips, M. A.; Gujjar, R.; Malmquist, N. A.; White, J.; El Mazouni, F.; Baldwin, J.; Rathod, P. K. Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. J. Med. Chem. 2008, 51(12), 3649-3653. (Pubitemid 351875021)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.12
, pp. 3649-3653
-
-
Phillips, M.A.1
Gujjar, R.2
Malmquist, N.A.3
White, J.4
El Mazouni, F.5
Baldwin, J.6
Rathod, P.K.7
-
14
-
-
64549087994
-
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
-
Gujjar, R.; Marwaha, A.; El Mazouni, F.; White, J.; White, K. L.; Creason, S.; Shackleford, D. M.; Baldwin, J.; Charman, W. N.; Buckner, F. S.; Charman, S.; Rathod, P. K.; Phillips, M. A. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J. Med. Chem. 2009, 52(7), 1864-1872.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.7
, pp. 1864-1872
-
-
Gujjar, R.1
Marwaha, A.2
El Mazouni, F.3
White, J.4
White, K.L.5
Creason, S.6
Shackleford, D.M.7
Baldwin, J.8
Charman, W.N.9
Buckner, F.S.10
Charman, S.11
Rathod, P.K.12
Phillips, M.A.13
-
15
-
-
58049219752
-
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
-
Patel, V.; Booker, M.; Kramer, M.; Ross, L.; Celatka, C. A.; Kennedy, L. M.; Dvorin, J. D.; Duraisingh, M. T.; Sliz, P.; Wirth, D. F.; Clardy, J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J. Biol. Chem. 2008, 283(50), 35078-85.
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.50
, pp. 35078-85
-
-
Patel, V.1
Booker, M.2
Kramer, M.3
Ross, L.4
Celatka, C.A.5
Kennedy, L.M.6
Dvorin, J.D.7
Duraisingh, M.T.8
Sliz, P.9
Wirth, D.F.10
Clardy, J.11
-
16
-
-
17144422120
-
Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
-
DOI 10.1111/j.1365-2958.2005.04556.x
-
Bray, P. G.; Martin, R. E.; Tilley, L.; Ward, S. A.; Kirk, K.; Fidock, D. A. Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Mol. Microbiol. 2005, 56(2), 323-33. (Pubitemid 40516774)
-
(2005)
Molecular Microbiology
, vol.56
, Issue.2
, pp. 323-333
-
-
Bray, P.G.1
Martin, R.E.2
Tilley, L.3
Ward, S.A.4
Kirk, K.5
Fidock, D.A.6
-
17
-
-
64349092617
-
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century
-
O'Neill, P. M.; Park, B. K.; Shone, A. E.; Maggs, J. L.; Roberts, P.; Stocks, P. A.; Biagini, G. A.; Bray, P. G.; Gibbons, P.; Berry, N.; Winstanley, P. A.; Mukhtar, A.; Bonar-Law, R.; Hindley, S.; Bambal, R. B.; Davis, C. B.; Bates, M.; Hart, T. K.; Gresham, S. L.; Lawrence, R. M.; Brigandi, R. A.; Gomez-Delas-Heras, F. M.; Gargallo, D. V.; Ward, S. A. Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. J. Med. Chem. 2009, 52(5), 1408-1415.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.5
, pp. 1408-1415
-
-
O'Neill, P.M.1
Park, B.K.2
Shone, A.E.3
Maggs, J.L.4
Roberts, P.5
Stocks, P.A.6
Biagini, G.A.7
Bray, P.G.8
Gibbons, P.9
Berry, N.10
Winstanley, P.A.11
Mukhtar, A.12
Bonar-Law, R.13
Hindley, S.14
Bambal, R.B.15
Davis, C.B.16
Bates, M.17
Hart, T.K.18
Gresham, S.L.19
Lawrence, R.M.20
Brigandi, R.A.21
Gomez-Delas-Heras, F.M.22
Gargallo, D.V.23
Ward, S.A.24
more..
-
18
-
-
64549138445
-
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine
-
O'Neill, P. M.; Shone, A. E.; Stanford, D.; Nixon, G.; Asadollahy, E.; Park, B. K.; Maggs, J. L.; Roberts, P.; Stocks, P. A.; Biagini, G.; Bray, P. G.; Davies, J.; Berry, N.; Hall, C.; Rimmer, K.; Winstanley, P. A.; Hindley, S.; Bambal, R. B.; Davis, C. B.; Bates, M.; Gresham, S. L.; Brigandi, R. A.; Gomez-de-Las-Heras, F. M.; Gargallo, D. V.; Parapini, S.; Vivas, L.; Lander, H.; Taramelli, D.; Ward, S. A. Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. J. Med. Chem. 2009, 52(7), 1828-44.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.7
, pp. 1828-1844
-
-
O'Neill, P.M.1
Shone, A.E.2
Stanford, D.3
Nixon, G.4
Asadollahy, E.5
Park, B.K.6
Maggs, J.L.7
Roberts, P.8
Stocks, P.A.9
Biagini, G.10
Bray, P.G.11
Davies, J.12
Berry, N.13
Hall, C.14
Rimmer, K.15
Winstanley, P.A.16
Hindley, S.17
Bambal, R.B.18
Davis, C.B.19
Bates, M.20
Gresham, S.L.21
Brigandi, R.A.22
Gomez-De-Las-Heras, F.M.23
Gargallo, D.V.24
Parapini, S.25
Vivas, L.26
Lander, H.27
Taramelli, D.28
Ward, S.A.29
more..
-
19
-
-
9844247985
-
Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue
-
DOI 10.1021/jm970401y
-
Biot, C.; Glorian, G.; Maciejewski, L. A.; Brocard, J. S.; Domarle, O.; Blampain, G.; Millet, P.; Georges, A. J.; Abessolo, H.; Dive, D.; Lebibi, J. Synthesis and antimalarial activity in vitro and in vivo of a new ferrocenechloroquine analogue. J. Med. Chem. 1997, 40(23), 3715-3718. (Pubitemid 27481715)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.23
, pp. 3715-3718
-
-
Biot, C.1
Glorian, G.2
Maciejewski, L.A.3
Brocard, J.S.4
Domarle, O.5
Blampain, G.6
Millet, P.7
Georges, A.J.8
Lebibi, J.9
-
20
-
-
60749093308
-
Structure-activity relationships of 4-N-substituted ferroquine analogues: Time to re-evaluate the mechanism of action of ferroquine
-
Biot, C.; Chavain, N.; Dubar, F.; Pradines, B.; Trivelli, X.; Brocard, J.; Forfar, I.; Dive, D. Structure-activity relationships of 4-N-substituted ferroquine analogues: Time to re-evaluate the mechanism of action of ferroquine. J. Organomet. Chem. 2009, 694(6), 845-854.
-
(2009)
J. Organomet. Chem.
, vol.694
, Issue.6
, pp. 845-854
-
-
Biot, C.1
Chavain, N.2
Dubar, F.3
Pradines, B.4
Trivelli, X.5
Brocard, J.6
Forfar, I.7
Dive, D.8
-
21
-
-
21544462570
-
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity
-
DOI 10.1021/mp0500061
-
Biot, C.; Taramelli, D.; Forfar-Bares, I.; Maciejewski, L. A.; Boyce, M.; Nowogrocki, G.; Brocard, J. S.; Basilico, N.; Olliaro, P.; Egan, T. J. Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity. Mol. Pharm. 2005, 2(3), 185-193. (Pubitemid 40921742)
-
(2005)
Molecular Pharmaceutics
, vol.2
, Issue.3
, pp. 185-193
-
-
Biot, C.1
Taramelli, D.2
Forfar-Bares, I.3
Maciejewski, L.A.4
Boyce, M.5
Nowogrocki, G.6
Brocard, J.S.7
Basilico, N.8
Olliaro, P.9
Egan, T.J.10
-
22
-
-
34249904428
-
Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers
-
Mzayek, F.; Deng, H. Y.; Mather, F. J.; Wasilevich, E. C.; Liu, H. Y.; Hadi, C. M.; Chansolme, D. H.; Murphy, H. A.; Melek, B. H.; Tenaglia, A. N.; Mushatt, D. M.; Dreisbach, A. W.; Lertora, J. J. L.; Krogstad, D. J. Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers. PLoS Clin. Trials. 2007, 2(1), E6.
-
(2007)
PLoS Clin. Trials.
, vol.2
, Issue.1
-
-
Mzayek, F.1
Deng, H.Y.2
Mather, F.J.3
Wasilevich, E.C.4
Liu, H.Y.5
Hadi, C.M.6
Chansolme, D.H.7
Murphy, H.A.8
Melek, B.H.9
Tenaglia, A.N.10
Mushatt, D.M.11
Dreisbach, A.W.12
Lertora, J.J.L.13
Krogstad, D.J.14
-
23
-
-
0032481004
-
Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines
-
DOI 10.1021/jm980146x
-
De, D. Y. D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Structureactivity relationships for antiplasmodial activity among 7-substituted 4- aminoquinolines. J. Med. Chem. 1998, 41(25), 4918-4926. (Pubitemid 28555449)
-
(1998)
Journal of Medicinal Chemistry
, vol.41
, Issue.25
, pp. 4918-4926
-
-
De, D.1
Krogstad, F.M.2
Byers, L.D.3
Krogstad, D.J.4
-
24
-
-
2342638285
-
Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice
-
DOI 10.1038/sj.bjp.0705721
-
Barraud de Lagerie, S.; Comets, E.; Gautrand, C.; Fernandez, C.; Auchere, D.; Singlas, E.; Mentre, F.; Gimenez, F. Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice. Br. J. Pharmacol. 2004, 141(7), 1214-22. (Pubitemid 38582259)
-
(2004)
British Journal of Pharmacology
, vol.141
, Issue.7
, pp. 1214-1222
-
-
De Lagerie, S.B.1
Comets, E.2
Gautrand, C.3
Fernandez, C.4
Auchere, D.5
Singlas, E.6
Mentre, F.7
Gimenez, F.8
-
25
-
-
70349802009
-
Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine
-
Wipf, P.; Mo, T.; Geib, S. J.; Caridha, D.; Dow, G. S.; Gerena, L.; Roncal, N.; Milner, E. E. Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. Org. Biomol. Chem. 2009, 7(20), 4163-5.
-
(2009)
Org. Biomol. Chem.
, vol.7
, Issue.20
, pp. 4163-4165
-
-
Wipf, P.1
Mo, T.2
Geib, S.J.3
Caridha, D.4
Dow, G.S.5
Gerena, L.6
Roncal, N.7
Milner, E.E.8
-
26
-
-
75449091246
-
Structureactivity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum
-
Milner, E.; McCalmont, W.; Bhonsle, J.; Caridha, D.; Carroll, D.; Gardner, S.; Gerena, L.; Gettayacamin, M.; Lanteri, C.; Luong, T.; Melendez, V.; Moon, J.; Roncal, N.; Sousa, J.; Tungtaeng, A.; Wipf, P.; Dow, G. Structureactivity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Bioorg. Med. Chem. Lett. 2010, 20(4), 1347-1351.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.4
, pp. 1347-1351
-
-
Milner, E.1
McCalmont, W.2
Bhonsle, J.3
Caridha, D.4
Carroll, D.5
Gardner, S.6
Gerena, L.7
Gettayacamin, M.8
Lanteri, C.9
Luong, T.10
Melendez, V.11
Moon, J.12
Roncal, N.13
Sousa, J.14
Tungtaeng, A.15
Wipf, P.16
Dow, G.17
-
27
-
-
77949285672
-
Anti-malarial activity of a non-piperidine library of nextgeneration quinoline methanols
-
Milner, E.; McCalmont, W.; Bhonsle, J.; Caridha, D.; Cobar, J.; Gardner, S.; Gerena, L.; Goodine, D.; Lanteri, C.; Melendez, V.; Roncal, N.; Sousa, J.; Wipf, P.; Dow, G. Anti-malarial activity of a non-piperidine library of nextgeneration quinoline methanols. Malar. J., 2010, 9(1), 51.
-
(2010)
Malar. J.
, vol.9
, Issue.1
, pp. 51
-
-
Milner, E.1
McCalmont, W.2
Bhonsle, J.3
Caridha, D.4
Cobar, J.5
Gardner, S.6
Gerena, L.7
Goodine, D.8
Lanteri, C.9
Melendez, V.10
Roncal, N.11
Sousa, J.12
Wipf, P.13
Dow, G.14
-
28
-
-
0031836936
-
First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial
-
Brueckner, R. P.; Lasseter, K. C.; Lin, E. T.; Schuster, B. G. First-time-inhumans safety and pharmacokinetics of WR 238605, a new antimalarial. Am. J. Trop. Med. Hyg. 1998, 58(5), 645-9. (Pubitemid 28237265)
-
(1998)
American Journal of Tropical Medicine and Hygiene
, vol.58
, Issue.5
, pp. 645-649
-
-
Brueckner, R.P.1
Lasseter, K.C.2
Lin, E.T.3
Schuster, B.G.4
-
29
-
-
0024311240
-
Antimalarials. 16. Synthesis of 2-substituted analogues of 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl) phenoxy]quinoline as candidate antimalarials
-
LaMontagne, M. P.; Blumbergs, P.; Smith, D. C. Antimalarials. 16. Synthesis of 2-substituted analogues of 8- [(4-amino-1-methylbutyl)amino]- 6-methoxy-4-methyl-5- [3- (trifluoromethyl)phenoxy]quinoline as candidate antimalarials. J. Med. Chem. 1989, 32(8), 1728-32. (Pubitemid 19204352)
-
(1989)
Journal of Medicinal Chemistry
, vol.32
, Issue.8
, pp. 1728-1732
-
-
LaMontagne, M.P.1
Blumbergs, P.2
Smith, D.C.3
-
30
-
-
0033383602
-
Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand
-
DOI 10.1086/315034
-
Walsh, D. S.; Looareesuwan, S.; Wilairatana, P.; Heppner, D. G. Jr.; Tang, D. B.; Brewer, T. G.; Chokejindachai, W.; Viriyavejakul, P.; Kyle, D. E.; Milhous, W. K.; Schuster, B. G.; Horton, J.; Braitman, D. J.; Brueckner, R. P. Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand. J. Infect. Dis. 1999, 180(4), 1282-7. (Pubitemid 30070215)
-
(1999)
Journal of Infectious Diseases
, vol.180
, Issue.4
, pp. 1282-1287
-
-
Walsh, D.S.1
Looareesuwan, S.2
Wilairatana, P.3
Gray Heppner Jr., D.4
Tang, D.B.5
Brewer, T.G.6
Chokejindachai, W.7
Viriyavejakul, P.8
Kyle, D.E.9
Milhous, W.K.10
Schuster, B.G.11
Horton, J.12
Braitman, D.J.13
Brueckner, R.P.14
-
31
-
-
0023555532
-
Antimalarial activity of new water-soluble dihydroartemisinin derivatives
-
Lin, A. J.; Klayman, D. L.; Milhous, W. K. Antimalarial activity of new water-soluble dihydroartemisinin derivatives. J. Med. Chem. 1987, 30(11), 2147-50. (Pubitemid 18046079)
-
(1987)
Journal of Medicinal Chemistry
, vol.30
, Issue.11
, pp. 2147-2150
-
-
Ling, A.J.1
Klayman, D.L.2
Milhous, W.K.3
-
32
-
-
33745975677
-
Artemisone - A highly active antimalarial drug of the artemisinin class
-
DOI 10.1002/anie.200503071
-
Haynes, R. K.; Fugmann, B.; Stetter, J.; Rieckmann, K.; Heilmann, H. D.; Chan, H. W.; Cheung, M. K.; Lam, W. L.; Wong, H. N.; Croft, S. L.; Vivas, L.; Rattray, L.; Stewart, L.; Peters, W.; Robinson, B. L.; Edstein, M. D.; Kotecka, B.; Kyle, D. E.; Beckermann, B.; Gerisch, M.; Radtke, M.; Schmuck, G.; Steinke, W.; Wollborn, U.; Schmeer, K.; Romer, A. Artemisone-a highly active antimalarial drug of the artemisinin class. Angew. Chem. Int. Ed. Engl. 2006, 45(13), 2082-8. (Pubitemid 44105182)
-
(2006)
Angewandte Chemie - International Edition
, vol.45
, Issue.13
, pp. 2082-2088
-
-
Haynes, R.K.1
Fugmann, B.2
Stetter, J.3
Rieckmann, K.4
Heilmann, H.-D.5
Chan, H.-W.6
Cheung, M.-K.7
Lam, W.-L.8
Wong, H.-N.9
Croft, S.L.10
Vivas, L.11
Rattray, L.12
Stewart, L.13
Peters, W.14
Robinson, B.L.15
Edstein, M.D.16
Kotecka, B.17
Kyle, D.E.18
Beckermann, B.19
Gerisch, M.20
Radtke, M.21
Schmuck, G.22
Steinke, W.23
Wollborn, U.24
Schmeer, K.25
Romer, A.26
more..
-
33
-
-
50949086688
-
First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone
-
Nagelschmitz, J.; Voith, B.; Wensing, G.; Roemer, A.; Fugmann, B.; Haynes, R. K.; Kotecka, B. M.; Rieckmann, K. H.; Edstein, M. D. First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone. Antimicrob. Agents Chemother. 2008, 52(9), 3085-91.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, Issue.9
, pp. 3085-3091
-
-
Nagelschmitz, J.1
Voith, B.2
Wensing, G.3
Roemer, A.4
Fugmann, B.5
Haynes, R.K.6
Kotecka, B.M.7
Rieckmann, K.H.8
Edstein, M.D.9
-
34
-
-
34249983249
-
Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo
-
DOI 10.1093/jac/dkl563
-
Vivas, L.; Rattray, L.; Stewart, L. B.; Robinson, B. L.; Fugmann, B.; Haynes, R. K.; Peters, W.; Croft, S. L. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J. Antimicrob. Chemother. 2007, 59(4), 658-65. (Pubitemid 47073399)
-
(2007)
Journal of Antimicrobial Chemotherapy
, vol.59
, Issue.4
, pp. 658-665
-
-
Vivas, L.1
Rattray, L.2
Stewart, L.B.3
Robinson, B.L.4
Fugmann, B.5
Haynes, R.K.6
Peters, W.7
Croft, S.L.8
-
35
-
-
57749099137
-
Evidence of artemisinin-resistant malaria in western Cambodia
-
Noedl, H.; Se, Y.; Schaecher, K.; Smith, B. L.; Socheat, D.; Fukuda, M. M. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 2008, 359(24), 2619-20.
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.24
, pp. 2619-2620
-
-
Noedl, H.1
Se, Y.2
Schaecher, K.3
Smith, B.L.4
Socheat, D.5
Fukuda, M.M.6
-
36
-
-
0035804312
-
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin
-
DOI 10.1021/jm000987f
-
O'Neill, P. M.; Miller, A.; Bishop, L. P.; Hindley, S.; Maggs, J. L.; Ward, S. A.; Roberts, S. M.; Scheinmann, F.; Stachulski, A. V.; Posner, G. H.; Park, B. K. Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin. J. Med. Chem. 2001, 44(1), 58-68. (Pubitemid 32049782)
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, Issue.1
, pp. 58-68
-
-
O'Neill, P.M.1
Miller, A.2
Bishop, L.P.D.3
Hindley, S.4
Maggs, J.L.5
Ward, S.A.6
Roberts, S.M.7
Scheinmann, F.8
Stachulski, A.V.9
Posner, G.H.10
Park, B.K.11
-
37
-
-
2342517468
-
Fluoroartemisinin: Trifluoromethyl Analogues of Artemether and Artesunate
-
DOI 10.1021/jm0310333
-
Magueur, G.; Crousse, B.; Charneau, S.; Grellier, P.; Begue, J. P.; Bonnet- Delpon, D. Fluoroartemisinin: Trifluoromethyl analogues of artemether and artesunate. J. Med. Chem. 2004, 47(10), 2694-2699. (Pubitemid 38580106)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.10
, pp. 2694-2699
-
-
Magueur, G.1
Crousse, B.2
Charneau, S.3
Grellier, P.4
Begue, J.-P.5
Bonnet-Delpon, D.6
-
38
-
-
0030796210
-
Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro
-
DOI 10.1016/S0968-0896(97)00079-5, PII S0968089697000795
-
Posner, G. H.; Ploypradith, P.; Hapangama, W.; Wang, D.; Cumming, J. N.; Dolan, P.; Kensler, T. W.; Klinedinst, D.; Shapiro, T. A.; Zheng, Q. Y.; Murray, C. K.; Pilkington, L. G.; Jayasinghe, L. R.; Bray, J. F.; Daughenbaugh, R. Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro. Bioorg. Med. Chem. 1997, 5(7), 1257-65. (Pubitemid 27321210)
-
(1997)
Bioorganic and Medicinal Chemistry
, vol.5
, Issue.7
, pp. 1257-1265
-
-
Posner, G.H.1
Ploypradith, P.2
Hapangama, W.3
Wang, D.4
Cumming, J.N.5
Dolan, P.6
Kensler, T.W.7
Klinedinst, D.8
Shapiro, T.A.9
Zheng, Q.Y.10
Murray, C.K.11
Pilkington, L.G.12
Jayasinghe, L.R.13
Bray, J.F.14
Daughenbaugh, R.15
-
39
-
-
0036132144
-
New chemical and biological aspects of artemisinin-Derived trioxane dimers
-
DOI 10.1016/S0968-0896(01)00270-X, PII S096808960100270X
-
Posner, G. H.; Northrop, J.; Paik, I. H.; Borstnik, K.; Dolan, P.; Kensler, T. W.; Xie, S.; Shapiro, T. A. New chemical and biological aspects of artemisinin-derived trioxane dimers. Bioorg. Med. Chem. 2002, 10(1), 227-232. (Pubitemid 33103749)
-
(2002)
Bioorganic and Medicinal Chemistry
, vol.10
, Issue.1
, pp. 227-232
-
-
Posner, G.H.1
Northrop, J.2
Paik, I.-H.3
Borstnik, K.4
Dolan, P.5
Kensler, T.W.6
Xie, S.7
Shapiro, T.A.8
-
40
-
-
0032725336
-
Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers
-
DOI 10.1021/jm990363d
-
Posner, G. H.; Ploypradith, P.; Parker, M. H.; O'Dowd, H.; Woo, S. H.; Northrop, J.; Krasavin, M.; Dolan, P.; Kensler, T. W.; Xie, S.; Shapiro, T. A. Antimalarial, antiproliferative, and antitumor activities of artemisininderived, chemically robust, trioxane dimers. J. Med. Chem. 1999, 42(21), 4275-80. (Pubitemid 29504131)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.21
, pp. 4275-4280
-
-
Posner, G.H.1
Ploypradith, P.2
Parker, M.H.3
O'Dowd, H.4
Woo, S.-H.5
Northrop, J.6
Krasavin, M.7
Dolan, P.8
Kensler, T.W.9
Xie, S.10
Shapiro, T.A.11
-
41
-
-
10744231930
-
Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin
-
DOI 10.1021/jm030974c
-
Jeyadevan, J. P.; Bray, P. G.; Chadwick, J.; Mercer, A. E.; Byrne, A.; Ward, S. A.; Park, B. K.; Williams, D. P.; Cosstick, R.; Davies, J.; Higson, A. P.; Irving, E.; Posner, G. H.; O'Neill, P. M. Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10 beta-(2- hydroxyethyl) deoxoartemisinin. J. Med. Chem. 2004, 47(5), 1290-1298. (Pubitemid 38229131)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.5
, pp. 1290-1298
-
-
Jeyadevan, J.P.1
Bray, P.G.2
Chadwick, J.3
Mercer, A.E.4
Byrne, A.5
Ward, S.A.6
Park, B.K.7
Williams, D.P.8
Cosstick, R.9
Davies, J.10
Higson, A.P.11
Irving, E.12
Posner, G.H.13
O'Neill, P.M.14
-
42
-
-
39749174331
-
Malaria-infected mice are cured by oral administration of new artemisinin derivatives
-
DOI 10.1021/jm701168h
-
Posner, G. H.; Chang, W.; Hess, L.; Woodard, L.; Sinishtaj, S.; Usera, A. R.; Maio, W.; Rosenthal, A. S.; Kalinda, A. S.; D'Angelo, J. G.; Petersen, K. S.; Stohler, R.; Chollet, J.; Santo-Tomas, J.; Snyder, C.; Rottmann, M.; Wittlin, S.; Brun, R.; Shapiro, T. A. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. J. Med. Chem. 2008, 51(4), 1035-1042. (Pubitemid 351304711)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.4
, pp. 1035-1042
-
-
Posner, G.H.1
Chang, W.2
Hess, L.3
Woodard, L.4
Sinishtaj, S.5
Usera, A.R.6
Maio, W.7
Rosenthal, A.S.8
Kalinda, A.S.9
D'Angelo, J.G.10
Petersen, K.S.11
Stohler, R.12
Chollet, J.13
Santo-Tomas, J.14
Snyder, C.15
Rottmann, M.16
Wittlin, S.17
Brun, R.18
Shapiro, T.A.19
-
43
-
-
1242296302
-
Anticancer and Antimalarial Efficacy and Safety of Artemisinin-Derived Trioxane Dimers in Rodents
-
DOI 10.1021/jm0303711
-
Posner, G. H.; McRiner, A. J.; Paik, I. H.; Sur, S.; Borstnik, K.; Xie, S. J.; Shapiro, T. A.; Alagbala, A.; Foster, B. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. J. Med. Chem. 2004, 47(5), 1299-1301. (Pubitemid 38229132)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.5
, pp. 1299-1301
-
-
Posner, G.H.1
McRiner, A.J.2
Paik, I.-H.3
Sur, S.4
Borstnik, K.5
Xie, S.6
Shapiro, T.A.7
Alagbala, A.8
Foster, B.9
-
44
-
-
34249097684
-
Malaria-infected mice are cured by a single dose of novel artemisinin derivatives
-
DOI 10.1021/jm070149m
-
Posner, G. H.; Paik, I. H.; Chang, W.; Borstnik, K.; Sinishtaj, S.; Rosenthal, A. S.; Shapiro, T. A. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives. J. Med. Chem. 2007, 50(10), 2516-2519. (Pubitemid 46799263)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.10
, pp. 2516-2519
-
-
Posner, G.H.1
Paik, I.-H.2
Chang, W.3
Borstnik, K.4
Sinishtaj, S.5
Rosenthal, A.S.6
Shapiro, T.A.7
-
45
-
-
0037435053
-
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy
-
DOI 10.1021/jm020461q
-
Posner, G. H.; Paik, I. H.; Sur, S.; McRiner, A. J.; Borstnik, K.; Xie, S. J.; Shapiro, T. A. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. J. Med. Chem. 2003, 46(6), 1060-1065. (Pubitemid 36423152)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.6
, pp. 1060-1065
-
-
Posner, G.H.1
Paik, I.-H.2
Sur, S.3
McRiner, A.J.4
Borstnik, K.5
Xie, S.6
Shapiro, T.A.7
-
46
-
-
64349121305
-
Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells
-
Rosenthal, A. S.; Chen, X. C.; Liu, J. O.; Weso, D. C.; Hergenrother, P. J.; Shapiro, T. A.; Posner, G. H. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. J. Med. Chem. 2009, 52(4), 1198-1203.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.4
, pp. 1198-1203
-
-
Rosenthal, A.S.1
Chen, X.C.2
Liu, J.O.3
Weso, D.C.4
Hergenrother, P.J.5
Shapiro, T.A.6
Posner, G.H.7
-
47
-
-
34249012765
-
New developments in synthetic peroxidic drugs as artemisinin mimics
-
DOI 10.1016/j.drudis.2007.04.009, PII S1359644607001870
-
Jefford, C. W. New developments in synthetic peroxidic drugs as artemisinin mimics. Drug Discov. Today 2007, 12(11-12), 487-495. (Pubitemid 46783690)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.11-12
, pp. 487-495
-
-
Jefford, C.W.1
-
48
-
-
26944458138
-
1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity
-
DOI 10.2174/138955705774575255
-
Masuyama, A.; Wu, J. M.; Nojima, M.; Kim, H. S.; Wataya, Y. 1,2,4,5- Tetraoxacycloalkanes: Synthesis and antimalarial activity. Mini-Rev. Med. Chem. 2005, 5(11), 1035-1043. (Pubitemid 41479693)
-
(2005)
Mini-Reviews in Medicinal Chemistry
, vol.5
, Issue.11
, pp. 1035-1043
-
-
Masuyama, A.1
Wu, J.-M.2
Nojima, M.3
Kim, H.-S.4
Wataya, Y.5
-
49
-
-
24344443742
-
The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents
-
DOI 10.1517/13543784.14.9.1117
-
O'Neill, P. M. The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents". Exp. Op. Investig. Drugs 2005, 14(9), 1117-1128. (Pubitemid 41246167)
-
(2005)
Expert Opinion on Investigational Drugs
, vol.14
, Issue.9
, pp. 1117-1128
-
-
O'Neill, P.M.1
-
50
-
-
79952795989
-
Synthesis of novel orally active antimalarials: 8-heterocyclemethyl substituted dispiro 1,2,4-trioxolanes
-
Tang, Y. Q.; Dong, Y. X.; Chollet, J.; Scorneaux, B.; Charman, W. N.; Wittlin, S.; Brun, R.; Vennerstrom, J. L. Synthesis of novel orally active antimalarials: 8-heterocyclemethyl substituted dispiro 1,2,4-trioxolanes. Abs. Pap. Am. Chem. Soc. 2004, 227, U15-U15.
-
(2004)
Abs. Pap. Am. Chem. Soc.
, vol.227
-
-
Tang, Y.Q.1
Dong, Y.X.2
Chollet, J.3
Scorneaux, B.4
Charman, W.N.5
Wittlin, S.6
Brun, R.7
Vennerstrom, J.L.8
-
51
-
-
4344630762
-
Identification of an antimalarial synthetic trioxolane drug development candidate
-
DOI 10.1038/nature02779
-
Vennerstrom, J. L.; Arbe-Barnes, S.; Brun, R.; Charman, S. A.; Chiu, F. C. K.; Chollet, J.; Dong, Y. X.; Dorn, A.; Hunziker, D.; Matile, H.; McIntosh, K.; Padmanilayam, M.; Tomas, J. S.; Scheurer, C.; Scorneaux, B.; Tang, Y. Q.; Urwyler, H.; Wittlin, S.; Charman, W. N. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 2004, 430(7002), 900-904. (Pubitemid 39119218)
-
(2004)
Nature
, vol.430
, Issue.7002
, pp. 900-904
-
-
Vennerstrom, J.L.1
Arbe-Barnes, S.2
Brun, R.3
Charman, S.A.4
Chiu, F.C.K.5
Chollet, J.6
Dong, Y.7
Dorn, A.8
Hunziker, D.9
Matile, H.10
McIntosh, K.11
Padmanilayam, M.12
Santo Tomas, J.13
Scheurer, C.14
Scorneaux, B.15
Tang, Y.16
Urwyler, H.17
Wittlin, S.18
Charman, W.H.19
-
53
-
-
33748832743
-
Ozonolyses of O-alkylated ketoximes in the presence of carbonyl groups: A facile access to ozonides
-
Griesbaum, K.; Liu, X. J.; Kassiaris, A.; Scherer, M. Ozonolyses of Oalkylated ketoximes in the presence of carbonyl groups: A facile access to ozonides. Liebigs Annalen-Recueil, 1997, (7), 1381-1390. (Pubitemid 127788727)
-
(1997)
Liebigs Annales
, Issue.7
, pp. 1381-1390
-
-
Griesbaum, K.1
Liu, X.2
Kassiaris, A.3
Scherer, M.4
-
54
-
-
22744432838
-
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes
-
DOI 10.1021/jm049040u
-
Dong, Y. X.; Chollet, J.; Matile, H.; Charman, S. A.; Chiu, F. C. K.; Charman, W. N.; Scorneaux, B.; Urwyler, H.; Tomas, J. S.; Scheurer, C.; Snyder, C.; Dorn, A.; Wang, X. F.; Karle, J. M.; Tang, Y. Q.; Wittlin, S.; Brun, R.; Vennerstrom, J. L. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes. J. Med. Chem. 2005, 48(15), 4953-4961. (Pubitemid 41033136)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.15
, pp. 4953-4961
-
-
Dong, Y.1
Chollet, J.2
Matile, H.3
Charman, S.A.4
Chiu, F.C.K.5
Charman, W.N.6
Scorneaux, B.7
Urwyler, H.8
Santo Tomas, J.9
Scheurer, C.10
Snyder, C.11
Dorn, A.12
Wang, X.13
Karle, J.M.14
Tang, Y.15
Wittlin, S.16
Brun, R.17
Vennerstrom, J.L.18
-
55
-
-
33747103049
-
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
-
DOI 10.1016/j.bmc.2006.05.041, PII S0968089606004160, Tetrahedron Prize for Creativity in Organic Chemistry 2005: B. Giese
-
Dong, Y. X.; Tang, Y. Q.; Chollet, J.; Matile, H.; Wittlin, S.; Charman, S. A.; Charman, W. N.; Tomas, J. S.; Scheurer, C.; Snyder, C.; Scorneaux, B.; Bajpai, S.; Alexander, S. A.; Wang, X. F.; Padmanilayam, M.; Cheruku, S. R.; Brun, R.; Vennerstrom, J. L. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes. Bioorg. Med. Chem. 2006, 14(18), 6368-6382. (Pubitemid 44224072)
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, Issue.18
, pp. 6368-6382
-
-
Dong, Y.1
Tang, Y.2
Chollet, J.3
Matile, H.4
Wittlin, S.5
Charman, S.A.6
Charman, W.N.7
Tomas, J.S.8
Scheurer, C.9
Snyder, C.10
Scorneaux, B.11
Bajpai, S.12
Alexander, S.A.13
Wang, X.14
Padmanilayam, M.15
Cheruku, S.R.16
Brun, R.17
Vennerstrom, J.L.18
-
56
-
-
74849086595
-
The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)
-
Dong, Y. X.; Wittlin, S.; Sriraghavan, K.; Chollet, J.; Charman, S. A.; Charman, W. N.; Scheurer, C.; Urwyler, H.; Tomas, J. S.; Snyder, C.; Creek, D. J.; Morizzi, J.; Koltun, M.; Matile, H.; Wang, X. F.; Padmanilayam, M.; Tang, Y.; Dorn, A.; Brun, R.; Vennerstrom, J. L. The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277). J. Med. Chem. 2010, 53(1), 481-491.
-
(2010)
J. Med. Chem.
, vol.53
, Issue.1
, pp. 481-491
-
-
Dong, Y.X.1
Wittlin, S.2
Sriraghavan, K.3
Chollet, J.4
Charman, S.A.5
Charman, W.N.6
Scheurer, C.7
Urwyler, H.8
Tomas, J.S.9
Snyder, C.10
Creek, D.J.11
Morizzi, J.12
Koltun, M.13
Matile, H.14
Wang, X.F.15
Padmanilayam, M.16
Tang, Y.17
Dorn, A.18
Brun, R.19
Vennerstrom, J.L.20
more..
-
57
-
-
33748881009
-
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine
-
DOI 10.1016/j.bmcl.2006.08.046, PII S0960894X06009292
-
Padmanilayam, M.; Scorneaux, B.; Dong, Y. X.; Chollet, J.; Matile, H.; Charman, S. A.; Creek, D. J.; Charman, W. N.; Tomas, J. S.; Scheurer, C.; Wittlin, S.; Brun, R.; Vennerstrom, J. L. Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4- trioxolane piperidine. Bioorg. Med. Chem. Lett. 2006, 16(21), 5542-5545. (Pubitemid 44419539)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.21
, pp. 5542-5545
-
-
Padmanilayam, M.1
Scorneaux, B.2
Dong, Y.3
Chollet, J.4
Matile, H.5
Charman, S.A.6
Creek, D.J.7
Charman, W.N.8
Tomas, J.S.9
Scheurer, C.10
Wittlin, S.11
Brun, R.12
Vennerstrom, J.L.13
-
58
-
-
33846935507
-
Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides
-
DOI 10.1016/j.bmcl.2006.12.007, PII S0960894X06013977
-
Tang, Y. Q.; Dong, Y. X.; Wittlin, S.; Charman, S. A.; Chollet, J.; Chiu, F. C. K.; Charman, W. N.; Matile, H.; Urwyler, H.; Dorn, A.; Bajpai, S.; Wang, X. F.; Padmanilayam, M.; Karle, J. M.; Brun, R.; Vennerstrom, J. L. Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides. Bioorg. Med. Chem. Lett. 2007, 17(5), 1260-1265. (Pubitemid 46240850)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.5
, pp. 1260-1265
-
-
Tang, Y.1
Dong, Y.2
Wittlin, S.3
Charman, S.A.4
Chollet, J.5
Chiu, F.C.K.6
Charman, W.N.7
Matile, H.8
Urwyler, H.9
Dorn, A.10
Bajpai, S.11
Wang, X.12
Padmanilayam, M.13
Karle, J.M.14
Brun, R.15
Vennerstrom, J.L.16
-
59
-
-
72249111952
-
The comparative antimalarial properties of weak base and neutral synthetic ozonides
-
Tang, Y. Q.; Wittlin, S.; Charman, S. A.; Chollet, J.; Chiu, F. C. K.; Morizzi, J.; Johnson, L. M.; Tomas, J. S.; Scheurer, C.; Snyder, C.; Zhou, L.; Dong, Y. X.; Charman, W. N.; Matile, H.; Urwyler, H.; Dorn, A.; Vennerstrom, J. L. The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorg. Med. Chem. Lett. 2010, 20(2), 563-566.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.2
, pp. 563-566
-
-
Tang, Y.Q.1
Wittlin, S.2
Charman, S.A.3
Chollet, J.4
Chiu, F.C.K.5
Morizzi, J.6
Johnson, L.M.7
Tomas, J.S.8
Scheurer, C.9
Snyder, C.10
Zhou, L.11
Dong, Y.X.12
Charman, W.N.13
Matile, H.14
Urwyler, H.15
Dorn, A.16
Vennerstrom, J.L.17
-
60
-
-
33750603248
-
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology
-
DOI 10.1016/j.bmcl.2006.08.098, PII S0960894X06009991
-
Amewu, R.; Stachulski, A. V.; Berry, N. G.; Ward, S. A.; Davies, J.; Labat, G.; Rossignol, J. F.; O'Neill, P. M. Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology. Bioorg. Med. Chem. Lett. 2006, 16(23), 6124-6130. (Pubitemid 44679840)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.23
, pp. 6124-6130
-
-
Amewu, R.1
Stachulski, A.V.2
Berry, N.G.3
Ward, S.A.4
Davies, J.5
Labat, G.6
Rossignol, J.-F.7
O'Neill, P.M.8
-
61
-
-
39849083194
-
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
-
DOI 10.1016/j.bmcl.2008.01.053, PII S0960894X08000681
-
Ellis, G. L.; Amewu, R.; Hall, C.; Rimmer, K.; Ward, S. A.; O'Neill, P. M. An efficient route into synthetically challenging bridged achiral 1,2,4,5- tetraoxanes with antimalarial activity. Bioorg. Med. Chem. Lett. 2008, 18(5), 1720-1724. (Pubitemid 351318243)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.5
, pp. 1720-1724
-
-
Ellis, G.L.1
Amewu, R.2
Hall, C.3
Rimmer, K.4
Ward, S.A.5
O'Neill, P.M.6
-
62
-
-
41849123835
-
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles
-
DOI 10.1021/jm701435h
-
Ellis, G. L.; Amewu, R.; Sabbani, S.; Stocks, P. A.; Shone, A.; Stanford, D.; Gibbons, P.; Davies, J.; Vivas, L.; Charnaud, S.; Bongard, E.; Hall, C.; Rimmer, K.; Lozanom, S.; Jesus, M.; Gargallo, D.; Ward, S. A.; O'Neill, P. M. Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. J. Med. Chem. 2008, 51(7), 2170-2177. (Pubitemid 351503272)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.7
, pp. 2170-2177
-
-
Ellis, G.L.1
Amewu, R.2
Sabbani, S.3
Stocks, P.A.4
Shone, A.5
Stanford, D.6
Gibbons, P.7
Davies, J.8
Vivas, L.9
Charnaud, S.10
Bongard, E.11
Hall, C.12
Rimmer, K.13
Lozanom, S.14
Jesus, M.15
Gargallo, D.16
Ward, S.A.17
O'Neill, P.M.18
-
64
-
-
0034605862
-
Ras - A molecular switch involved in tumor formation
-
Wittinghofer, A.; Waldmann, H. Ras - A molecular switch involved in tumor formation. Angew. Chem. Int. Ed. 2000, 39(23), 4193-4214.
-
(2000)
Angew. Chem. Int. Ed.
, vol.39
, Issue.23
, pp. 4193-4214
-
-
Wittinghofer, A.1
Waldmann, H.2
-
65
-
-
0036667388
-
Farnesyltransferase inhibitors: Promises and realities
-
DOI 10.1016/S1471-4892(02)00181-9
-
Cox, A. D.; Der, C. J. Farnesyltransferase inhibitors: Promises and realities. Curr. Opin. Pharmacol. 2002, 2(4), 388-93. (Pubitemid 34830969)
-
(2002)
Current Opinion in Pharmacology
, vol.2
, Issue.4
, pp. 388-393
-
-
Cox, A.D.1
Der, C.J.2
-
66
-
-
0036134355
-
Evolving therapies: Farnesyltransferase inhibitors
-
Purcell, W. T.; Donehower, R. C. Evolving therapies: Farnesyltransferase inhibitors. Curr. Oncol. Rep. 2002, 4(1), 29-36.
-
(2002)
Curr. Oncol. Rep.
, vol.4
, Issue.1
, pp. 29-36
-
-
Purcell, W.T.1
Donehower, R.C.2
-
67
-
-
23344435930
-
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis
-
Buckner, F. S.; Eastman, R. T.; Yokoyama, K.; Gelb, M. H.; Van Voorhis, W. C. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Curr. Opin. Investig. Drugs 2005, 6(8), 791-7. (Pubitemid 41103039)
-
(2005)
Current Opinion in Investigational Drugs
, vol.6
, Issue.8
, pp. 791-797
-
-
Buckner, F.S.1
Eastman, R.T.2
Yokoyama, K.3
Gelb, M.H.4
Van Voorhis, W.C.5
-
68
-
-
34648816239
-
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials
-
DOI 10.1021/jm0703340
-
Bendale, P.; Olepu, S.; Suryadevara, P. K.; Bulbule, V.; Rivas, K.; Nallan, L.; Smart, B.; Yokoyama, K.; Ankala, S.; Pendyala, P. R.; Floyd, D.; Lombardo, L. J.; Williams, D. K.; Buckner, F. S.; Chakrabarti, D.; Verlinde, C. L.; Van Voorhis, W. C.; Gelb, M. H. Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. J. Med. Chem. 2007, 50(19), 4585-605. (Pubitemid 47463234)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.19
, pp. 4585-4605
-
-
Bendale, P.1
Olepu, S.2
Suryadevara, P.K.3
Bulbule, V.4
Rivas, K.5
Nallan, L.6
Smart, B.7
Yokoyama, K.8
Ankala, S.9
Pendyala, P.R.10
Floyd, D.11
Lombardo, L.J.12
Williams, D.K.13
Buckner, F.S.14
Chakrabarti, D.15
Verlinde, C.L.M.J.16
Van Voorhis, W.C.17
Gelb, M.H.18
-
69
-
-
20144373679
-
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
-
DOI 10.1021/jm0491039
-
Nallan, L.; Bauer, K. D.; Bendale, P.; Rivas, K.; Yokoyama, K.; Horney, C. P.; Pendyala, P. R.; Floyd, D.; Lombardo, L. J.; Williams, D. K.; Hamilton, A.; Sebti, S.; Windsor, W. T.; Weber, P. C.; Buckner, F. S.; Chakrabarti, D.; Gelb, M. H.; Van Voorhis, W. C. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J. Med. Chem. 2005, 48(11), 3704-13. (Pubitemid 40776846)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.11
, pp. 3704-3713
-
-
Nallan, L.1
Bauer, K.D.2
Bendale, P.3
Rivas, K.4
Yokoyama, K.5
Horney, C.P.6
Pendyala, P.R.7
Floyd, D.8
Lombardo, L.J.9
Williams, D.K.10
Hamilton, A.11
Sebti, S.12
Windsor, W.T.13
Weber, P.C.14
Buckner, F.S.15
Chakrabarti, D.16
Gelb, M.H.17
Van Voorhis, W.C.18
-
70
-
-
34948910649
-
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase
-
DOI 10.1128/AAC.00246-07
-
Van Voorhis, W. C.; Rivas, K. L.; Bendale, P.; Nallan, L.; Horney, C.; Barrett, L. K.; Bauer, K. D.; Smart, B. P.; Ankala, S.; Hucke, O.; Verlinde, C. L.; Chakrabarti, D.; Strickland, C.; Yokoyama, K.; Buckner, F. S.; Hamilton, A. D.; Williams, D. K.; Lombardo, L. J.; Floyd, D.; Gelb, M. H. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob. Agents Chemother. 2007, 51(10), 3659-71. (Pubitemid 47519357)
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, Issue.10
, pp. 3659-3671
-
-
Van Voorhis, W.C.1
Rivas, K.L.2
Bendale, P.3
Nallan, L.4
Horney, C.5
Barrett, L.K.6
Bauer, K.D.7
Smart, B.P.8
Ankala, S.9
Hucke, O.10
Verlinde, C.L.M.J.11
Chakrabarti, D.12
Strickland, C.13
Yokoyama, K.14
Buckner, F.S.15
Hamilton, A.D.16
Williams, D.K.17
Lombardo, L.J.18
Floyd, D.19
Gelb, M.H.20
more..
-
71
-
-
39149093700
-
2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability
-
DOI 10.1021/jm7013138
-
Bulbule, V. J.; Rivas, K.; Verlinde, C. L.; Van Voorhis, W. C.; Gelb, M. H. 2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability. J. Med. Chem. 2008, 51(3), 384-7. (Pubitemid 351252264)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.3
, pp. 384-387
-
-
Bulbule, V.J.1
Rivas, K.2
Verlinde, C.L.M.J.3
Van Voorhis, W.C.4
Gelb, M.H.5
-
72
-
-
45449110504
-
Artemisinin resistance in Cambodia?
-
Noedl, H.; Chanthap, L.; Se, Y.; Socheat, D.; Peou, S.; Schaecher, K.; Srivichai, S.; Teja-Isavadharm, P.; Smith, B.; Jongsakul, K.; Surasri, S.; Fukuda, M. Artemisinin resistance in Cambodia? Trop. Med. Int. Health 2007, 12, 69-69.
-
(2007)
Trop. Med. Int. Health
, vol.12
, pp. 69-69
-
-
Noedl, H.1
Chanthap, L.2
Se, Y.3
Socheat, D.4
Peou, S.5
Schaecher, K.6
Srivichai, S.7
Teja-Isavadharm, P.8
Smith, B.9
Jongsakul, K.10
Surasri, S.11
Fukuda, M.12
-
73
-
-
67349124872
-
The global portfolio of new antimalarial medicines under development
-
Olliaro, P.; Wells, T. N. C. The global portfolio of new antimalarial medicines under development. Clin. Pharma. Therap. 2009, 85(6), 584-595.
-
(2009)
Clin. Pharma. Therap.
, vol.85
, Issue.6
, pp. 584-595
-
-
Olliaro, P.1
Wells, T.N.C.2
-
74
-
-
38949125112
-
Hybrid molecules with a dual mode of action: Dream or reality?
-
Meunier, B. Hybrid molecules with a dual mode of action: Dream or reality? Acc. Chem. Res. 2008, 41(1), 69-77.
-
(2008)
Acc. Chem. Res.
, vol.41
, Issue.1
, pp. 69-77
-
-
Meunier, B.1
-
75
-
-
70449399250
-
Hybrid drugs for malaria
-
Walsh, J. J.; Bell, A. Hybrid Drugs for Malaria. Curr. Pharma. Design 2009, 15(25), 2970-2985.
-
(2009)
Curr. Pharma. Design
, vol.15
, Issue.25
, pp. 2970-2985
-
-
Walsh, J.J.1
Bell, A.2
-
76
-
-
12144291704
-
Orally Active Antimalarials: Hydrolytically Stable Derivatives of 10-Trifluoromethyl Anhydrodihydroartemisinin
-
DOI 10.1021/jm030947m
-
Grellepois, F.; Chorki, F.; Ourevitch, M.; Charneau, S.; Grellier, P.; McIntosh, K. A.; Charman, W. N.; Pradines, B.; Crousse, B.; Bonnet- Delpon, D.; Begue, J. P. Orally active antimalarials: Hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin. J. Med. Chem. 2004, 47(6), 1423-1433. (Pubitemid 38327469)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.6
, pp. 1423-1433
-
-
Grellepois, F.1
Chorki, F.2
Ourevitch, M.3
Charneau, S.4
Grellie, P.5
McIntosh, K.A.6
Charman, W.N.7
Pradines, B.8
Crousse, B.9
Bonnet-Delpon, D.10
Begue, J.-P.11
-
77
-
-
21044435645
-
Design, synthesis and antimalarial activity of trifluoromethylartemisinin- mefloquine dual molecules
-
DOI 10.1002/cbic.200400347
-
Grellepois, F.; Grellier, P.; Bonnet-Delpon, D.; Begue, J. P. Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules. Chembiochem 2005, 6(4), 648-652. (Pubitemid 40873765)
-
(2005)
ChemBioChem
, vol.6
, Issue.4
, pp. 648-652
-
-
Grellepois, F.1
Grellier, P.2
Bonnet-Delpon, D.3
Begue, J.-P.4
-
78
-
-
53549086186
-
New chimeric antimalarials with 4- aminoquinoline moiety linked to a tetraoxane skeleton
-
Opsenica, I.; Opsenica, D.; Lanteri, C. A.; Anova, L.; Milhous, W. K.; Smith, K. S.; Solaja, B. A. New chimeric antimalarials with 4- aminoquinoline moiety linked to a tetraoxane skeleton. J. Med. Chem. 2008, 51(19), 6216-6219.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.19
, pp. 6216-6219
-
-
Opsenica, I.1
Opsenica, D.2
Lanteri, C.A.3
Anova, L.4
Milhous, W.K.5
Smith, K.S.6
Solaja, B.A.7
-
79
-
-
41849117634
-
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials
-
DOI 10.1021/jm701417a
-
Opsenica, I.; Opsenica, D.; Smith, K. S.; Milhous, W. K.; Solaja, B. A. Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane Antimalarials. J. Med. Chem. 2008, 51(7), 2261-2266. (Pubitemid 351503281)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.7
, pp. 2261-2266
-
-
Opsenica, I.1
Opsenica, D.2
Smith, K.S.3
Milhous, W.K.4
Solaja, B.A.5
-
80
-
-
56249098367
-
Selection of a trioxaquine as an antimalarial drug candidate
-
Cosledan, F.; Fraisse, L.; Pellet, A.; Guillou, F.; Mordmuller, B.; Kremsner, P. G.; Moreno, A.; Mazier, D.; Maffrand, J. P.; Meunier, B. Selection of a trioxaquine as an antimalarial drug candidate. Proc. Nat. Acad. Sci. USA 2008, 105(45), 17579-17584.
-
(2008)
Proc. Nat. Acad. Sci. USA
, vol.105
, Issue.45
, pp. 17579-17584
-
-
Cosledan, F.1
Fraisse, L.2
Pellet, A.3
Guillou, F.4
Mordmuller, B.5
Kremsner, P.G.6
Moreno, A.7
Mazier, D.8
Maffrand, J.P.9
Meunier, B.10
-
81
-
-
33748520577
-
A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum
-
DOI 10.1021/jm060399n
-
Burgess, S. J.; Selzer, A.; Kelly, J. X.; Smilkstein, M. J.; Riscoe, M. K.; Peyton, D. H. A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum. J. Med. Chem. 2006, 49(18), 5623-5625. (Pubitemid 44373193)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.18
, pp. 5623-5625
-
-
Burgess, S.J.1
Selzer, A.2
Kelly, J.X.3
Smilkstein, M.J.4
Riscoe, M.K.5
Peyton, D.H.6
-
82
-
-
0034876783
-
Structural analysis of chloroquine resistance reversal by imipramine analogs
-
DOI 10.1128/AAC.45.9.2655-2657.2001
-
Bhattacharjee, A. K.; Kyle, D. E.; Vennerstrom, J. L. Structural analysis of chloroquine resistance reversal by imipramine analogs. Antimicrob. Agents Chemother. 2001, 45(9), 2655-7. (Pubitemid 32801928)
-
(2001)
Antimicrobial Agents and Chemotherapy
, vol.45
, Issue.9
, pp. 2655-2657
-
-
Bhattacharjee, A.K.1
Kyle, D.E.2
Vennerstrom, J.L.3
-
83
-
-
0036708526
-
A 3D QSAR pharmacophore model and quantum chemical structure-activity analysis of chloroquine(CQ)-resistance reversal
-
DOI 10.1021/ci0200265
-
Bhattacharjee, A. K.; Kyle, D. E.; Vennerstrom, J. L.; Milhous, W. K. A 3D QSAR pharmacophore model and quantum chemical structure-activity analysis of chloroquine(CQ)-resistance reversal. J. Chem. Inf. Comput. Sci. 2002, 42(5), 1212-20. (Pubitemid 35360307)
-
(2002)
Journal of Chemical Information and Computer Sciences
, vol.42
, Issue.5
, pp. 1212-1220
-
-
Bhattacharjee, A.K.1
Kyle, D.E.2
Vennerstrom, J.L.3
Milhous, W.K.4
-
84
-
-
67349189204
-
Discovery of dual function acridones as a new antimalarial chemotype
-
Kelly, J. X.; Smilkstein, M. J.; Brun, R.; Wittlin, S.; Cooper, R. A.; Lane, K. D.; Janowsky, A.; Johnson, R. A.; Dodean, R. A.; Winter, R.; Hinrichs, D. J.; Riscoe, M. K. Discovery of dual function acridones as a new antimalarial chemotype. Nature 2009, 459(7244), 270-3.
-
(2009)
Nature
, vol.459
, Issue.7244
, pp. 270-273
-
-
Kelly, J.X.1
Smilkstein, M.J.2
Brun, R.3
Wittlin, S.4
Cooper, R.A.5
Lane, K.D.6
Janowsky, A.7
Johnson, R.A.8
Dodean, R.A.9
Winter, R.10
Hinrichs, D.J.11
Riscoe, M.K.12
-
85
-
-
20444436366
-
Drug discovery process for kinase inhibitors
-
DOI 10.1002/cbic.200500034
-
Weinmann, H.; Metternich, R. Drug discovery process for kinase inhibitors. Chembiochem 2005, 6(3), 455-459. (Pubitemid 40868133)
-
(2005)
ChemBioChem
, vol.6
, Issue.3
, pp. 455-459
-
-
Weinmann, H.1
Metternich, R.2
-
86
-
-
43049088111
-
Drugging the Plasmodium kinome: The benefits of academia-industry synergy
-
Leroy, D.; Doerig, C. Drugging the Plasmodium kinome: The benefits of academia-industry synergy. Trends Pharmacol. Sci. 2008, 29(5), 241-249.
-
(2008)
Trends Pharmacol. Sci.
, vol.29
, Issue.5
, pp. 241-249
-
-
Leroy, D.1
Doerig, C.2
-
87
-
-
75349099595
-
Malaria: Targeting parasite and host cell kinomes
-
Doerig, C.; Abdi, A.; Bland, N.; Eschenlauer, S.; Dorin-Semblat, D.; Fennell, C.; Halbert, J.; Holland, Z.; Nivez, M. P.; Semblat, J. P.; Sicard, A.; Reininger, L. Malaria: Targeting parasite and host cell kinomes. Biochim. Et Biophys. Acta-Prot. Proteom. 2010, 1804(3), 604-612.
-
(2010)
Biochim. Et Biophys. Acta-Prot. Proteom.
, vol.1804
, Issue.3
, pp. 604-612
-
-
Doerig, C.1
Abdi, A.2
Bland, N.3
Eschenlauer, S.4
Dorin-Semblat, D.5
Fennell, C.6
Halbert, J.7
Holland, Z.8
Nivez, M.P.9
Semblat, J.P.10
Sicard, A.11
Reininger, L.12
-
88
-
-
55749109023
-
Protein kinases of malaria parasites: An update
-
Doerig, C.; Billker, O.; Haystead, T.; Sharma, P.; Tobin, A. B.; Waters, N. C. Protein kinases of malaria parasites: An update. Trends Parasitol. 2008, 24(12), 570-577.
-
(2008)
Trends Parasitol.
, vol.24
, Issue.12
, pp. 570-577
-
-
Doerig, C.1
Billker, O.2
Haystead, T.3
Sharma, P.4
Tobin, A.B.5
Waters, N.C.6
-
89
-
-
34547569777
-
Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk
-
DOI 10.1016/j.bmcl.2007.06.032, PII S0960894X07007135
-
Woodard, C. L.; Keenan, S. M.; Gerena, L.; Welsh, W. J.; Geyer, J. A.; Waters, N. C. Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. Bioorg. Med. Chem. Lett. 2007, 17(17), 4961-4966. (Pubitemid 47193185)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.17
, pp. 4961-4966
-
-
Woodard, C.L.1
Keenan, S.M.2
Gerena, L.3
Welsh, W.J.4
Geyer, J.A.5
Waters, N.C.6
-
90
-
-
0042420753
-
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases
-
DOI 10.1021/jm0300983
-
Woodard, C. L.; Li, Z. Y.; Kathcart, A. K.; Terrell, J.; Gerena, L.; Lopez- Sanchez, M.; Kyle, D. E.; Bhattacharjee, A. K.; Nichols, D. A.; Ellis, W.; Prigge, S. T.; Geyer, J. A.; Waters, N. C. Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. J. Med. Chem. 2003, 46(18), 3877-3882. (Pubitemid 37034137)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.18
, pp. 3877-3882
-
-
Woodard, C.L.1
Li, Z.2
Kathcart, A.K.3
Terrell, J.4
Gerena, L.5
Lopez-Sanchez, M.6
Kyle, D.E.7
Bhattacharjee, A.K.8
Nichols, D.A.9
Ellis, W.10
Prigge, S.T.11
Geyer, J.A.12
Waters, N.C.13
-
91
-
-
61849181566
-
Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2- propenones
-
Geyer, J. A.; Keenan, S. M.; Woodard, C. L.; Thompson, P. A.; Gerena, L.; Nichols, D. A.; Gutteridge, C. E.; Waters, N. C. Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2- propenones. Bioorg. Med. Chem. Lett. 2009, 19(7), 1982-5.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.7
, pp. 1982-1985
-
-
Geyer, J.A.1
Keenan, S.M.2
Woodard, C.L.3
Thompson, P.A.4
Gerena, L.5
Nichols, D.A.6
Gutteridge, C.E.7
Waters, N.C.8
-
92
-
-
52049124549
-
Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7
-
Bouloc, N.; Large, J. M.; Smiljanic, E.; Whalley, D.; Ansell, K. H.; Edlin, C. D.; Bryans, J. S. Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Bioorg. Med. Chem. Lett. 2008, 18(19), 5294-5298.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.19
, pp. 5294-5298
-
-
Bouloc, N.1
Large, J.M.2
Smiljanic, E.3
Whalley, D.4
Ansell, K.H.5
Edlin, C.D.6
Bryans, J.S.7
-
93
-
-
29144433571
-
Targeting malaria with specific CDK inhibitors
-
DOI 10.1016/j.bbapap.2005.07.031, PII S1570963905002906
-
Geyer, J. A.; Prigge, S. T.; Waters, N. C. Targeting malaria with specific CDK inhibitors. Biochim. Et Biophys. Acta-Prot. Proteom. 2005, 1754(1-2), 160-170. (Pubitemid 41797696)
-
(2005)
Biochimica et Biophysica Acta - Proteins and Proteomics
, vol.1754
, Issue.1-2
, pp. 160-170
-
-
Geyer, J.A.1
Prigge, S.T.2
Waters, N.C.3
-
94
-
-
43749109597
-
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
-
DOI 10.1038/nchembio.87, PII NCHEMBIO87
-
Kato, N.; Sakata, T.; Breton, G.; Le Roch, K. G.; Nagle, A.; Andersen, C.; Bursulaya, B.; Henson, K.; Johnson, J.; Kumar, K. A.; Marr, F.; Mason, D.; McNamara, C.; Plouffe, D.; Ramachandran, V.; Spooner, M.; Tuntland, T.; Zhou, Y.; Peters, E. C.; Chatterjee, A.; Schultz, P. G.; Ward, G. E.; Gray, N.; Harper, J.; Winzeler, E. A. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat. Chem. Biol. 2008, 4(6), 347-356. (Pubitemid 351693992)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.6
, pp. 347-356
-
-
Kato, N.1
Sakata, T.2
Breton, G.3
Le Roch, K.G.4
Nagle, A.5
Andersen, C.6
Bursulaya, B.7
Henson, K.8
Johnson, J.9
Kumar, K.A.10
Marr, F.11
Mason, D.12
McNamara, C.13
Plouffe, D.14
Ramachandran, V.15
Spooner, M.16
Tuntland, T.17
Zhou, Y.18
Peters, E.C.19
Chatterjee, A.20
Schultz, P.G.21
Ward, G.E.22
Gray, N.23
Harper, J.24
Winzeler, E.A.25
more..
-
95
-
-
79952797697
-
MEDI 339-Cell-based optimization of novel benzamides as antimalarials
-
Wu, T.; Nagle, A.; Sakata, T.; Deng, X. M.; Chen, Z.; Henson, K.; Chang, J.; Plouffe, D.; Tuntland, T.; Kuhen, K.; Winzeler, E.; Gray, N.; Chatterjee, A. K. MEDI 339-Cell-based optimization of novel benzamides as antimalarials. Abs. Pap. Am. Chem. Soc. 2008, 236.
-
(2008)
Abs. Pap. Am. Chem. Soc.
, vol.236
-
-
Wu, T.1
Nagle, A.2
Sakata, T.3
Deng, X.M.4
Chen, Z.5
Henson, K.6
Chang, J.7
Plouffe, D.8
Tuntland, T.9
Kuhen, K.10
Winzeler, E.11
Gray, N.12
Chatterjee, A.K.13
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