Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin

Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2001, Pages 58-68

  O'Neill, P M ^a   Miller, A ^a   Bishop, L P D ^d   Hindley, S ^a   Maggs, J L ^d   Ward, S A ^a   Roberts, S M ^a   Scheinmann, F ^b   Stachulski, A V ^b   Posner, G H ^c   Park, B K ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Ultrafine UFC Ltd   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

10ALPHA (4 TRIFLUOROMETHYLPHENOXY)DIHYDROARTEMISININ; 10ALPHA PHENOXYDIHYDROARTEMISININ; 10BETA (4 TRIFLUOROMETHYLPHENOXY)DIHYDROARTEMISININ; 10BETA PHENOXYDIHYDROARTEMISININ; 4 METHOXYPHENYL; 4 METHOXYPHENYLDIHYDROARTEMISININ; 4 METHYLPHENYL; 4 TRIFLUOROMETHYLPHENYLDIHYDROARTEMISININ; ARTEETHER; ARTEMETHER; BENFLUMETOL; BETA PHENOXYTRIOXANE; DIHYDROARTEMISININ; IRON; MEFLOQUINE; NAPHTHYL GROUP; PHENOL DERIVATIVE; PHENYLDIHYDROARTEMISININ; SILVER CHLORIDE; SULFOXIDE; TRIOXANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; RAT; STEREOCHEMISTRY;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BILE; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERROUS COMPOUNDS; FREE RADICALS; MALARIA; MALE; MICE; PHENYL ETHERS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; RATS; RATS, WISTAR; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035804312     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000987f     Document Type: Article

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