Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity

Molecular Pharmaceutics

Volumn 2, Issue 3, 2005, Pages 185-193

  Biot, Christophe ^a   Taramelli, Donatella ^b   Forfar Bares, Isabelle ^c   Maciejewski, Lucien A ^a   Boyce, Mlandzeni ^d   Nowogrocki, Guy ^e   Brocard, Jacques S ^a   Basilico, Nicoletta ^b   Olliaro, Piero ^f   Egan, Timothy J ^d  

^a Ecole Nationale Superieure de Chimie de Lille   (France)

^b UNIVERSITY OF MILAN   (Italy)

^c Laboratoire de Pharmacochimie   (France)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

^e UNITÉ DE CATALYSE ET DE CHIMIE DU SOLIDE   (France)

^f WORLD BANK   (United States)

Author keywords

Chloroquine; Drug resistance; Ferroquine; Hematin; Hemozoin; Malaria; Structure activity relationships

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; BETA HEMATIN; CHLOROQUINE; FERROQUINE; HEMATIN; HEMOZOIN; NITROGEN; UNCLASSIFIED DRUG;

ALKALINITY; ANTIMALARIAL ACTIVITY; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TARGETING; HYDROGEN BOND; IC 50; LIPOPHILICITY; MOLECULAR MODEL; PH MEASUREMENT; PKA; PLASMODIUM; PRIORITY JOURNAL; PROTEIN TARGETING; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANTIMALARIALS; CHLOROQUINE; FERROUS COMPOUNDS; HEMIN; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21544462570     PISSN: 15438384     EISSN: None     Source Type: Journal    
DOI: 10.1021/mp0500061     Document Type: Article

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