-
1
-
-
52949108806
-
Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki
-
19209263
-
Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki. GS Dow AJ Magill C Ohrt, Ther Clin Risk Manag 2008 4 19209263
-
(2008)
Ther Clin Risk Manag
, vol.4
-
-
Dow, G.S.1
Magill, A.J.2
Ohrt, C.3
-
2
-
-
33745651114
-
The IPTi Consortium: Research for policy and action
-
10.1016/j.pt.2006.05.006. 16713739
-
The IPTi Consortium: research for policy and action. D Schellenberg B Cisse C Mendendez, Trends Parasitol 2006 22 296 300 10.1016/j.pt.2006.05.006 16713739
-
(2006)
Trends Parasitol
, vol.22
, pp. 296-300
-
-
Schellenberg, D.1
Cisse, B.2
Mendendez, C.3
-
4
-
-
0036153103
-
Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults
-
10.1016/S0001-706X(01)00210-8. 11801224
-
Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults. P Rendi-Wagner H Noedl WH Wernsdorfer G Weidermann A Mikolasek H Kollaristch, Acta Trop 2002 81 167 173 10.1016/S0001-706X(01)00210-8 11801224
-
(2002)
Acta Trop
, vol.81
, pp. 167-173
-
-
Rendi-Wagner, P.1
Noedl, H.2
Wernsdorfer, W.H.3
Weidermann, G.4
Mikolasek, A.5
Kollaristch, H.6
-
5
-
-
38649134796
-
Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin
-
10.1128/AAC.00874-07
-
Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin. A Caridha D Yourick M Cabezas L Wolf TH Hudson GS Dow, Antimicrob Agent Chemother 2008 52 684 693 10.1128/AAC.00874-07
-
(2008)
Antimicrob Agent Chemother
, vol.52
, pp. 684-693
-
-
Caridha, A.1
Yourick, D.2
Cabezas, M.3
Wolf, L.4
Hudson, T.H.5
Dow, G.S.6
-
6
-
-
33644655507
-
Mefloquine induces dose-related neurological effects in a rat model
-
10.1128/AAC.50.3.1045-1053.2006
-
Mefloquine induces dose-related neurological effects in a rat model. G Dow R Bauman D Caridha M Cabezas F Du R Gomez-Lobo M Park K Smith K Cannard, Antimicrob Agent Chemother 2006 50 1045 1053 10.1128/AAC.50.3.1045-1053.2006
-
(2006)
Antimicrob Agent Chemother
, vol.50
, pp. 1045-1053
-
-
Dow, G.1
Bauman, R.2
Caridha, D.3
Cabezas, M.4
Du, F.5
Gomez-Lobo, R.6
Park, M.7
Smith, K.8
Cannard, K.9
-
7
-
-
0141958109
-
In silico prediction of blood-brain barrier permeation
-
10.1016/S1359-6446(03)02827-7. 14554156
-
In silico prediction of blood-brain barrier permeation. DE CLARK, Drug Discov Today 2003 8 927 933 10.1016/S1359-6446(03)02827-7 14554156
-
(2003)
Drug Discov Today
, vol.8
, pp. 927-933
-
-
Clark, D.E.1
-
8
-
-
0036896304
-
Passive permeability and p-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
-
10.1124/jpet.102.039255
-
Passive permeability and p-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. KM Doan JE Humphreys LO Webster SA Wring LL Shampine CJ Serabit-Singh KK Adkinson JW Polli, J Pharmacol Exp Therap 2002 303 1029 1037 10.1124/jpet.102.039255
-
(2002)
J Pharmacol Exp Therap
, vol.303
, pp. 1029-1037
-
-
Doan, K.M.1
Humphreys, J.E.2
Webster, L.O.3
Wring, S.A.4
Shampine, L.L.5
Serabit-Singh, C.J.6
Adkinson, K.K.7
Polli, J.W.8
-
9
-
-
0029035114
-
Transport of small molecules through blood-brain barrier: Biology and methodology
-
10.1016/0169-409X(95)00003-P
-
Transport of small molecules through blood-brain barrier: biology and methodology. WM Pardridge, Adv Drug Deliv Rev 1995 15 5 36 10.1016/0169-409X(95) 00003-P
-
(1995)
Adv Drug Deliv Rev
, vol.15
, pp. 5-36
-
-
Pardridge, W.M.1
-
10
-
-
0031959341
-
CNS drug design based on principles of blood-brain barrier transport
-
9572261
-
CNS drug design based on principles of blood-brain barrier transport. WM Pardridge, J Neurochem 1998 70 1781 1792 9572261
-
(1998)
J Neurochem
, vol.70
, pp. 1781-1792
-
-
Pardridge, W.M.1
-
11
-
-
2142769136
-
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
-
10.1016/S0140-6736(04)16767-6. 15288742
-
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. RN Price AC Uhleman A Brockman R McGready E Ashley L Phaipun R Patel K Laing S Looareesuwan NJ White F Nosten S Krishna, Lancet 2004 364 438 447 10.1016/S0140-6736(04)16767-6 15288742
-
(2004)
Lancet
, vol.364
, pp. 438-447
-
-
Price, R.N.1
Uhleman, A.C.2
Brockman, A.3
McGready, R.4
Ashley, E.5
Phaipun, L.6
Patel, R.7
Laing, K.8
Looareesuwan, S.9
White, N.J.10
Nosten, F.11
Krishna, S.12
-
12
-
-
33845247980
-
Utility of alkylaminoquinolinyl methanols as new antimalarial drugs
-
10.1128/AAC.00631-06. 16966402
-
Utility of alkylaminoquinolinyl methanols as new antimalarial drugs. GS Dow TN Heady AK Bhattarchargee D Caridha L Gerena M Gettayacamin CA Lanteri III Obaldia N N Roncal T Shearer PL Smith A Tungtaeng L Wolf M Cabezas D Yourick KS Smith, Antimicrob Agents Chemother 2006 50 4132 4143 10.1128/AAC.00631-06 16966402
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 4132-4143
-
-
Dow, G.S.1
Heady, T.N.2
Bhattarchargee, A.K.3
Caridha, D.4
Gerena, L.5
Gettayacamin, M.6
Lanteri, C.A.7
Obaldia, N.I.I.I.8
Roncal, N.9
Shearer, T.10
Smith, P.L.11
Tungtaeng, A.12
Wolf, L.13
Cabezas, M.14
Yourick, D.15
Smith, K.S.16
-
13
-
-
75449091246
-
Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum
-
20097070
-
Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. E Milner W McCalmont J Bhonsle C Caridha D Carroll S Gardner L Gerena M Gettayacamin C Lanteri T Luong V Melendez J Moon N Roncal J Sousa A Tangtaeng P Wipf GS Dow, Bioorg Med Chem Lett 2010 20097070
-
(2010)
Bioorg Med Chem Lett
-
-
Milner, E.1
McCalmont, W.2
Bhonsle, J.3
Caridha, C.4
Carroll, D.5
Gardner, S.6
Gerena, L.7
Gettayacamin, M.8
Lanteri, C.9
Luong, T.10
Melendez, V.11
Moon, J.12
Roncal, N.13
Sousa, J.14
Tangtaeng, A.15
Wipf, P.16
Dow, G.S.17
-
14
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
10.1016/S1056-8719(00)00107-6. 11274893
-
Drug-like properties and the causes of poor solubility and poor permeability. CA Lipinski, J Pharmacol Toxicol Methods 2000 44 235 249 10.1016/S1056-8719(00)00107-6 11274893
-
(2000)
J Pharmacol Toxicol Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
15
-
-
84882088781
-
-
Burlington, MA, Elsevier Inc. Dow GS, Chen Y, Andrews KT, Caridha D, Gerena L, Gettayacamin M, Johnson J, Li Q, Melendez V, Obaldia N III, Tran TN and Kozikowski A:Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrob Agents Chemother 2008 52:3467-3477.
-
EH Kerns L Di, Drug-like properties: concepts, structure design and methods Burlington, MA, Elsevier Inc 2008 Dow GS, Chen Y, Andrews KT, Caridha D, Gerena L, Gettayacamin M, Johnson J, Li Q, Melendez V, Obaldia N III, Tran TN and Kozikowski A: Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrob Agents Chemother 2008 52: 3467-3477.
-
(2008)
Drug-like Properties: Concepts, Structure Design and Methods
-
-
Kerns, E.H.1
Di, L.2
-
16
-
-
0018606732
-
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
-
394674
-
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. RE Desjardins CJ Canfield JD Haynes JD Chulay, Antimicrob Agents Chemother 1979 16 710 8 394674
-
(1979)
Antimicrob Agents Chemother
, vol.16
, pp. 710-8
-
-
Desjardins, R.E.1
Canfield, C.J.2
Haynes, J.D.3
Chulay, J.D.4
-
18
-
-
42949171996
-
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives
-
10.1016/j.bmcl.2008.03.075. 18406614
-
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. JJ Gillespie DR Adams D Bebbington K Benwell IA Cliffe CF Dawson CT Dourish A Fletcher S Gaur PR Giles AM Jordan AR Knight LJ Knutsen A Lawrence J Lerpiniere A Misra RH Porter RM Pratt R Shepherd R Upton S Ward SM Weiss DS Williamson, Bioorg Med Chem Lett 2008 18 2916 2919 10.1016/j.bmcl.2008.03.075 18406614
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 2916-2919
-
-
Gillespie, J.J.1
Adams, D.R.2
Bebbington, D.3
Benwell, K.4
Cliffe, I.A.5
Dawson, C.F.6
Dourish, C.T.7
Fletcher, A.8
Gaur, S.9
Giles, P.R.10
Jordan, A.M.11
Knight, A.R.12
Knutsen, L.J.13
Lawrence, A.14
Lerpiniere, J.15
Misra, A.16
Porter, R.H.17
Pratt, R.M.18
Shepherd, R.19
Upton, R.20
Ward, S.21
Weiss, S.M.22
Williamson, D.S.23
more..
-
19
-
-
10744233114
-
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease
-
14663021
-
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease. SM Weiss K Benwell IA Cliffe RJ Gillespie AR Knight J Lerpiniere A Misar RM Pratt D Revell R Upton CT Dourish, Neurology 2003 61 101 106 14663021
-
(2003)
Neurology
, vol.61
, pp. 19101-106
-
-
Weiss, S.M.1
Benwell, K.2
Cliffe, I.A.3
Gillespie, R.J.4
Knight, A.R.5
Lerpiniere, J.6
Misar, A.7
Pratt, R.M.8
Revell, D.9
Upton, R.10
Dourish, C.T.11
-
20
-
-
11144249849
-
Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier
-
10.1016/j.ijpharm.2004.10.007. 15620875
-
Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier. Q Wang JD Rager K Weinstein PS Kardos GL Dobson J Li IJ Hidalgo, Int J Pharm 2005 288 349 359 10.1016/j.ijpharm.2004.10.007 15620875
-
(2005)
Int J Pharm
, vol.288
, pp. 349-359
-
-
Wang, Q.1
Rager, J.D.2
Weinstein, K.3
Kardos, P.S.4
Dobson, G.L.5
Li, J.6
Hidalgo, I.J.7
-
21
-
-
0031459897
-
Thermodynamics of partitioning of the antimalarial drug mefloquine in phospholipid bilayers and bulk solvents
-
9433777
-
Thermodynamics of partitioning of the antimalarial drug mefloquine in phospholipid bilayers and bulk solvents. ML Go TL Ngiam, Chem Pharm Bull 1997 45 2055 2060 9433777
-
(1997)
Chem Pharm Bull
, vol.45
, pp. 2055-2060
-
-
Go, M.L.1
Ngiam, T.L.2
-
22
-
-
0024391155
-
A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with dipalmitoylphosphatidylcholine bilayers
-
10.1016/0166-6851(89)90206-5. 2787476
-
A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with dipalmitoylphosphatidylcholine bilayers. R Zidovetzki IW Sherman A Attiya H De Boeck, Mol Biochem Parasitol 1989 35 199 207 10.1016/0166-6851(89)90206-5 2787476
-
(1989)
Mol Biochem Parasitol
, vol.35
, pp. 199-207
-
-
Zidovetzki, R.1
Sherman, I.W.2
Attiya, A.3
De Boeck, H.4
|