2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability

Journal of Medicinal Chemistry

Volumn 51, Issue 3, 2008, Pages 384-387

  Bulbule, Vivek J ^a   Rivas, Kasey ^a   Verlinde, Christophe L M J ^a   Van Voorhis, Wesley C ^a   Gelb, Michael H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOTETRAHYDROQUINOLINE; ANTIMALARIAL AGENT; FARNESYL TRANS TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLASMODIUM;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; HUMANS; MICE; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39149093700     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7013138     Document Type: Article

References (12)

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