Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand

Journal of Infectious Diseases

Volumn 180, Issue 4, 1999, Pages 1282-1287

  Walsh, Douglas S ^e   Looareesuwan, Sornchai ^a   Wilairatana, Polrat ^a   Gray Heppner Jr , D ^e   Tang, Douglas B ^b   Brewer, Thomas G ^e   Chokejindachai, Watcharee ^a   Viriyavejakul, Parnpen ^a   Kyle, Dennis E ^b   Milhous, Wilbur K ^b   Schuster, Brian G ^b   Horton, John ^d   Braitman, David J ^c   Brueckner, Ralf P ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c US Army Medical Materiel Development Activity   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; TAFENOQUINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; MALARIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; RANDOMIZED CONTROLLED TRIAL; RELAPSE; THAILAND; TREATMENT OUTCOME; TROPICAL DISEASE;

ADOLESCENT; ADULT; AMINOQUINOLINES; ANTIMALARIALS; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALARIA, VIVAX; MALE; PROSPECTIVE STUDIES; RECURRENCE; THAILAND;

EID: 0033383602     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315034     Document Type: Article

References (17)

1. Collins WE, Jeffery GM. Primaquine resistance in Plasmodium vivax. Am J Trop Mod Hyg 1996; 55:243-9.
2. Clyde DF. Clinical problems associated with the use of primaquine as a tissue schizonticidal and gametocytocidal drug. Bull WHO 1981; 59:391-5.
3. Cooper RD, Milhous WK, Rieckmann KH. The efficacy of WR238605 against the blood stages of a chloroquine resistant strain or Plasmodium vivax. Trans R Soc Trop Med Hyg 1994; 88:691-2
4. Fisk TL, Millet P, Collins WE, Nguyen-Dinh P. In vitro activity of antimatarial compounds on the exoerythrocytic stages of Plasmodium cynomolgi and P. knowlesi. Am J Trop Med Hyg 1989; 40:235-9.
5. Obaldia N, Rossan RN, Cooper RD, et al. WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys. Am J Trop Med Hyg 1997; 56:508-10.
6. Brueckner RP, Lasseter K., Lin E, Schuster BG. First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial. Am J Trop Med Hyg 1998; 58:645-9.
7. Brueckner RP, Coster T, Wesche DL, Shmuklarsky M, Schuster BG. Prophylaxis of Plasmodium falciparum in a human challenge model by WR 238605, a new antimalarial. Antimicrob Agents Chemother 1998; 42:1293-4.
8. Tirasophon W, Rajkulchai P, Ponglikitmongkol M, Wilairat P, Boonsaeng V, Panyim S. A highly sensitive, rapid, and simple polymerase chain reaction based method in detect human malaria (Plasmodium falciparum and Plasmodium vivax) in blood samples. Am J Trop Med Hyg 1994; 51:308-13.
9. Lee ET, Statistical methods for survival analysis data. 2nd ed. New York: Wiley, 1992:109-12.
10. Ederer F, Mantel N. Confidence limits on the ratio of two Poisson variables. Am J Epidemiol 1974; 100:165-7.
11. Altman DG. Practical satistics for medical research, New York: Chapman and Hall, 1991.
12. Brueckner RP, Fleckenstein L. Simultaneous modeling of the pharmacokinetics and methemoglobin pharmacodynamics of an 8-aminoquinoline candidate antimalarial (WR 238605). Pharm Res 1991; 8:1505-10.
13. Lukens JN. Methemoglobinemia and other disorders accompanied by cyanosis. In: Lec GR, ed. Wintrobe's clinical hematology. 9th ed. Philadelphia: Lea & Febiger, 1993; 1262-71.
14. Murphy GS, Basri H, Purnomo, et al. Vivax malaria resistant to treatment and prophylaxis with chloroquine. Lancet 1993; 341:96-100.
15. Looarcesuwan S, Buchachart K, Wilairatana P, et al. Primaquine-tolerant vivax malaria in Thailand. Ann Trop Med Parasitol 1997; 91:939-43.
16. Looarcesuwan S, Wilairatana P, Treeprasertsuk S, et al. Chloroquine sensitivity of plasmodium vivax in Thailand. Ann Trop Med Parasitol 1999; 93:225-30.
17. Bunnag D, Karbwang J, Thanavibul A, et al. High dose of primaquine in primaquine resistant vivax malaria. Trans R Soc Trop Med Hyg 1994; 88:218-9.