ANIMAL MODEL;
ARTICLE;
BIOAVAILABILITY;
CONTROLLED STUDY;
DRUG BLOOD LEVEL;
DRUG STABILITY;
DRUG SYNTHESIS;
IN VIVO STUDY;
MALARIA;
MOUSE;
NONHUMAN;
PLASMODIUM BERGHEI;
REACTION ANALYSIS;
SUBSTITUTION REACTION;
ADMINISTRATION, ORAL;
ANIMALS;
ANTIMALARIALS;
ARTEMISININS;
BIOLOGICAL AVAILABILITY;
DRUG RESISTANCE;
DRUG STABILITY;
HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS;
HYDROLYSIS;
MALARIA;
MICE;
PLASMODIUM BERGHEI;
PLASMODIUM FALCIPARUM;
RATS;
RATS, SPRAGUE-DAWLEY;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
The Chemistry, Pharmacology, and Clinical Applications of Qinghaosu (Artemisinin) and Its Derivatives
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Arteether, a New Antimalarial Drug: Synthesis and Antimalarial Properties
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The Chemistry and Synthesis of Qinghaosu Derivatives
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Antimalarial Activity of New Water-Soluble Dihydroartemisinin Derivatives
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Artemisinin and the Antimalarial Endoperoxides: From Herbal Remedy to Targeted Chemotherapy
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Penetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intravenous Artesunate in Severe Falciparum Malaria
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Synthesis, Stability, and Antimalarial Activity of New Hydrolytically Stable and Water-Soluble (+)-Deoxoartelinic Acid
Jung, M.; Lee, K.; Kendrick, H.; Robinson, B. L.; Croft, S. L. Synthesis, Stability, and Antimalarial Activity of New Hydrolytically Stable and Water-Soluble (+)-Deoxoartelinic Acid. J. Med. Chem. 2002, 45, 4940-4944.
Synthesis and Antimalarial Activities of 10-Substituted Deoxoartemisinins
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Correlation of Antimalarial Activity of Artemisinin Derivatives with Ferroprotoporphyrin IX.J
Pitayatat, S.; Tarnchompoo, B.; Thebtaranonth, Y.; Yuthavong, Y. Correlation of Antimalarial Activity of Artemisinin Derivatives with Ferroprotoporphyrin IX. J. Med. Chem. 1997, 40, 633-638.
C-16-Artemisinin Derivatives and Their Antimalarial and Cytotoxic Activities: Syntheses of Artemisinin Monomers, Dimers, Trimers, and Tetramers by Nucleophilic Additions to Artemisitene
Ekthawatchai, S.; Kamchonwongpaisan, S.; Kongsaeree, P.; Tarnchompoo, B. ; Thebtaranonth, Y.; Yuthavong, Y. C-16-Artemisinin Derivatives and Their Antimalarial and Cytotoxic Activities: Syntheses of Artemisinin Monomers, Dimers, Trimers, and Tetramers by Nucleophilic Additions to Artemisitene. J. Med. Chem. 2001, 44, 4688-4695.
Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 7. Direct Modification of (+)-Artemisinin and in Vivo Antimalarial Sreening of New, Potential Preclinical Antimalarial Candidates
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Inhibition of Rat Liver Microsomal Lipid Peroxidation Elicited by 2,2-Dimethylchromenes and Chromans Containing Fluorinated Moieties Resistant to Cytochrome P-450 metabolism
Irurre, J., Jr.; Casas, J.; Ramos, I.; Messeguer, A. Inhibition of Rat Liver Microsomal Lipid Peroxidation Elicited by 2,2-Dimethylchromenes and Chromans Containing Fluorinated Moieties Resistant to Cytochrome P-450 metabolism. Bioorg. Med. Chem. 1993, 1, 219-225.
Resistance of the 2,2,2-trifluoroethoxy aryl moiety to the cytochrome P-450 metabolism in rat liver microsomes
Irurre, J., Jr.; Casas, J.; Messeguer, A. Resistance of the 2,2,2-trifluoroethoxy aryl moiety to the cytochrome P-450 metabolism in rat liver microsomes. Bioorg. Med. Chem. Lett. 1993, 3, 179-182.
Banks, R. E., Smart, B. E., Tatlow, J. C., Eds.; Plenum Press: New York
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Synthesis and in Vivo Antimalarial Activity of 12α -Trifluoromethyl-hydroartemisinin
Abouabdellah, A.; Bégué, J. P.; Bonnet-Delpon, D.; Gantier, J. C.; Thanh Nga, T. T.; Truong Dinh, T. Synthesis and in Vivo Antimalarial Activity of 12α-Trifluoromethyl-hydroartemisinin. Bioorg. Biomed. Chem. Lett. 1996, 2717-2720.
Synthesis and Antimalarial Activities of Fluoroalkyl Derivatives of Dihydroartemisinin
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The Effect of 10α-Trifluoromethyl Hydroartemisinin on Plasmodium berghei Infection and Its Toxicity in Experimental Animals
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Allylic Bromination of Anhydrodihydroartemisinin and of Its 10-Trifluoromethyl Analogue: A New Access to 16-Substituted Artemisinin Derivatives
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Antimalarial Activity of New Water-Soluble Dihydroartemisinin Derivatives. 2. Stereospecificity of the Ether Side Chain
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Antimalarial Activity of New Water-Soluble Dihydroartemisinin Derivatives. 3. Aromatic Amine Analogues
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Comparison of the Formation Energy of Fluorinated Alkoxycarbenium Ion
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Fluorinated Synthons: Reactivity of 1-Rf-Epoxy Ethers with Lewis Acid
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