Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers

Journal of Medicinal Chemistry

Volumn 42, Issue 21, 1999, Pages 4275-4280

  Posner, Gary H ^a   Ploypradith, Poonsakdi ^a   Parker, Michael H ^a   O'Dowd, Hardwin ^a   Woo, Soon Hyung ^a   Northrop, John ^a   Krasavin, Mikhail ^a   Dolan, Patrick ^b   Kensler, Thomas W ^b   Xie, Suji ^c   Shapiro, Theresa A ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10,4 ACETYLPHENYLARTEMISININ DIMER; 10,4 DIETHYNYLPHENYLARTEMISININ DIMER; 12ALPHA (2',4' DIMETHOXYPHENYL) 10 DEOXOARTEMISININ; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ARTEMISININ DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL;

ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; ARTEMISININS; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; MICE; NEOPLASM TRANSPLANTATION; PLASMODIUM FALCIPARUM; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032725336     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990363d     Document Type: Article

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