Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4953-4961

  Dong, Yuxiang ^a   Chollet, Jacques ^b   Matile, Hugues ^c   Charman, Susan A ^d   Chiu, Francis C K ^d   Charman, William N ^d   Scorneaux, Bernard ^b   Urwyler, Heinrich ^e   Santo Tomas, Josefina ^b   Scheurer, Christian ^b   Snyder, Christopher ^b   Dorn, Arnulf ^c   Wang, Xiaofang ^a   Karle, Jean M ^f   Tang, Yuanqing ^a   Wittlin, Sergio ^b   Brun, Reto ^b   Vennerstrom, Jonathan L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d MONASH UNIVERSITY   (Australia)

^e BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^f WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIOXANE DERIVATIVE; 1,2,4 TRIOXOLANE DERIVATIVE; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISIN; ARTESUNATE; PEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG FORMULATION; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; METABOLIC REGULATION; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SOLUBILITY; STRUCTURE ACTIVITY RELATION; TOXICOLOGICAL PARAMETERS;

ADAMANTANE; ANIMALS; ANTIMALARIALS; CELL LINE, TUMOR; DRUG RESISTANCE; HALF-LIFE; MALARIA; MALARIA, FALCIPARUM; MICE; MICRONUCLEUS TESTS; OZONE; PEROXIDES; PLASMODIUM BERGHEI; RATS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22744432838     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049040u     Document Type: Article

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