The structure - Activity relationship of the antimalarial ozonide arterolane (OZ277)

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 481-491

  Dong, Yuxiang ^a   Wittlin, Sergio ^b   Sriraghavan, Kamaraj ^a   Chollet, Jacques ^b   Charman, Susan A ^c   Charman, William N ^c   Scheurer, Christian ^b   Urwyler, Heinrich ^d   Tomas, Josefina Santo ^c   Snyder, Christopher ^b   Creek, Darren J ^c   Morizzi, Julia ^c   Koltun, Maria ^c   Matile, Hugues ^e   Wang, Xiaofang ^a   Padmanilayam, Maniyan ^a   Tang, Yuanqing ^a   Dorn, Arnulf ^e   Brun, Reto ^b   Vennerstrom, Jonathan L ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c MONASH UNIVERSITY   (Australia)

^d BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTANE 2 SPIRO 3' 8' [(1' PIPERAZINYLCARBONYL)METHYL] 1',2',4' TRIOXASPIRO[4.5]DECANE 4 TOSYLATE; ADAMANTANE 2 SPIRO 3' 8' [2' [[(2' AMINO 2' METHYLPROPYL)AMINO]CARBONYL]ETHYL] 1',2',4' TRIOXASPIRO[4.5]DECANE 4 TOSYLATE; ADAMANTANE 2 SPIRO 3' 8' [[(4' AMINO 1' PIPERIDINYL)CARBONYL]METHYL] 1',2',4' TRIOXASPIRO[4.5]DECANE 4 TOSYLATE; ADAMANTANE 2 SPIRO 3' 8' [[[(2' AMINO 2' METHYLPROPYL)AMINO]CARBONYL]METHYL] 1',2',4' TRIOXASPIRO[4.5]DECANE 4 TOSYLATE; ADAMANTANE 2 SPIRO 3' 8' [[[(4' AMINOCYCLOHEXYL)AMINO]CARBONYL]METHYL] 1',2',4' TRIOXASPIRO[4.5]DECANCE 4 TOSYLATE; ADAMANTANE 2 SPIRO 3' 8' [[[[(2' AMINO 2' METHYLPROPYL)AMINO]CARBONYL]OXY]METHYL] 1',2',4' TRIOXASPIRO[4.5]DECANE 4 TOSYLATE; ANTIMALARIAL AGENT; ARTESUNATE; CHLOROQUINE; CYCLOHEXANE; DISPIRO[ADAMANTANE 2,3' [1,2,4]TRIOXOLANE 5',4'' CYCLOHEXANEACETIC ACID 2 AMINO 2 METHYLPROPYLAMIDE]; FUNCTIONAL GROUP; MEFLOQUINE; OZONIDE ARTEROLANE; OZONIDE ARTEROLANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SURVIVAL TIME;

ANIMALS; ANTIMALARIALS; HETEROCYCLIC COMPOUNDS, 1-RING; MALARIA, FALCIPARUM; MICE; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; PEROXIDES; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74849086595     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901473s     Document Type: Article

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