Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5542-5545

  Padmanilayam, Maniyan ^a   Scorneaux, Bernard ^b   Dong, Yuxiang ^a   Chollet, Jacques ^b   Matile, Hugues ^c   Charman, Susan A ^d   Creek, Darren J ^d   Charman, William N ^d   Tomas, Josefina Santo ^b   Scheurer, Christian ^b   Wittlin, Sergio ^b   Brun, Reto ^b   Vennerstrom, Jonathan L ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d MONASH UNIVERSITY   (Australia)

Author keywords

1,2,4 Trioxolane; Antimalarial; Artemisinin; Secondary ozonide

Indexed keywords

ALIPHATIC AMINE; AMIDE; ANTIMALARIAL AGENT; ARTEMETHER; ARTESUNATE; PIPERIDINE DERIVATIVE; SULFONAMIDE; UREA DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SENSITIVITY; DRUG SYNTHESIS; IC 50; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY;

AMINES; ANIMALS; ANTIMALARIALS; HUMANS; MALARIA; MICE; MICROSOMES, LIVER; PIPERIDINES; PLASMODIUM BERGHEI; SULFONAMIDES; UREA;

ARTESUNATE;

EID: 33748881009     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.046     Document Type: Article

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