New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton

Journal of Medicinal Chemistry

Volumn 51, Issue 19, 2008, Pages 6216-6219

  Opsenica, Igor ^a   Opsenica, Dejan ^a   Lanteri, Charlotte Anne ^b   Anova, Lalaine ^b   Milhous, Wilbur K ^b   Smith, Kirsten S ^b   Šolaja, Bogdan A ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; MEFLOQUINE; N 1 (7 CHLOROQUINOLIN 4 YL) N 2 (7,8,15,16 TETRAOXADISPIRO[5.2.5.2]HEXADEC 3 YLMETHYL) 1,2 ETHANEDIAMINE; N 1 (7 CHLOROQUINOLIN 4 YL) N 2 (7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDO 3 SPIRO 6' (1',2',4',5' TETRAOXACYCLOHEXANE 3' SPIROCYCLOHEXANE; N 2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL 7,8,15,16 TETRAOXADISPIRO[5.2.5.2]HEXADECANE 3 CARBOXAMIDE; N 2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL 7ALPHA,12ALPHA DIACETOXY 5BETA CHOLAN 24 AMIDO 3 SPIRO 6' (1',2',4',5' TETRAOXACYCLOHEXANE) 3' SPIROCYCLOHEXANE; TETRAOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHIMERA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; BINDING SITES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALARIA; MAXIMUM TOLERATED DOSE; MICE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAOXANES;

EID: 53549086186     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8006905     Document Type: Article

References (37)

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