Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases

Chemistry - A European Journal

Volumn 17, Issue 13, 2011, Pages 3746-3758

  Olsson, Elaine ^a   Martinez, Aurora ^a   Teigen, Knut ^a   Jensen, Vidar R ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

cofactors; density functional calculations; hydroxylation; oxygen activation; transition states

Indexed keywords

AROMATIC AMINO ACID HYDROXYLASES; BOND CLEAVAGES; BOND RUPTURE; BRIDGE STRUCTURES; CATALYTIC CYCLES; CATALYTIC DOMAINS; COFACTORS; COMPLEX CLUSTERS; DENSITY-FUNCTIONAL CALCULATIONS; DIOXYGENS; ERYTHRO; LIGAND DISSOCIATION; MODEL COMPLEXES; NONHEME; ONE-ELECTRON TRANSFER; OXYGEN ACTIVATION; PHENYLALANINE HYDROXYLASE; QUINTET STATE; RADICAL REACTIONS; RATE-LIMITING STEPS; SUPEROXIDE ION; TETRAHYDROBIOPTERIN; TRANSITION STATES; TWO-ELECTRON OXIDATION; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; AROMATIC COMPOUNDS; CHEMICAL BONDS; DENSITY FUNCTIONAL THEORY; FREE RADICAL REACTIONS; HYDROXYLATION; OXYGEN; REACTION KINETICS;

CRYSTAL STRUCTURE;

5,6,7,8-TETRAHYDROBIOPTERIN; AROMATIC AMINO ACID; BIOPTERIN; DRUG DERIVATIVE; FERROUS ION; IRON; LIGAND; MIXED FUNCTION OXIDASE; PTERIN DERIVATIVE; TETRAHYDROBIOPTERIN;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COENZYME; HYDROXYLATION; METABOLISM; OXIDATION REDUCTION REACTION; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS, AROMATIC; BIOPTERIN; CATALYSIS; COENZYMES; CRYSTALLOGRAPHY, X-RAY; FERROUS COMPOUNDS; HYDROXYLATION; IRON; LIGANDS; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PTERINS;

EID: 79952610760     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201002910     Document Type: Article

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