Identification of a functional water channel in cytochrome P450 enzymes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 6, 1997, Pages 2133-2138

  Oprea, Tudor I ^a,c   Hummer, Gerhard ^a,b   García, Angel E ^a  

^a MS K710   (United States)

^b CENTER FOR NONLINEAR STUDIES   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

aromatase; potentials of mean force; protein cavities; protein dynamics; protein hydration

Indexed keywords

ARGININE; CYSTEINE; CYTOCHROME P450; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; HEME; HEMOPROTEIN; HYDROGEN PEROXIDE; IRON;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; DNA DETERMINATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HYDRATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMINO ACID SEQUENCE; ARGININE; BINDING SITES; CAMPHOR 5-MONOOXYGENASE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME STABILITY; HEME; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; PROTEIN CONFORMATION; WATER;

EID: 0030987236     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.6.2133     Document Type: Article

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