Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: Similar fold, different stability and reaction rates

Journal of Molecular Biology

Volumn 320, Issue 3, 2002, Pages 645-661

  Erlandsen, Heidi ^a   Kim, Joo Y ^a   Patch, Marianne G ^a   Han, Andrew ^b   Volner, Alon ^b   Abu Omar, Mahdi M ^b   Stevens, Raymond C ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chromobacterium violaceum; Phenylalanine hydroxylase; PKU; Structure; Tetrahydrobiopterin

Indexed keywords

OXYGEN; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; SAPROPTERIN; TYROSINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMOBACTERIUM; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HYDROXYLATION; MELTING POINT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; REACTION TIME; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SPECIES COMPARISON; STRUCTURE ANALYSIS; X RAY ANALYSIS;

BACTERIA (MICROORGANISMS); CHROMOBACTERIUM; CHROMOBACTERIUM VIOLACEUM;

EID: 0036310665     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00496-5     Document Type: Article

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