Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-l-alanine, and its implications for the mechanism of catalysis and substrate activation

Journal of Molecular Biology

Volumn 320, Issue 5, 2002, Pages 1095-1108

  Andreas Andersen, Ole ^a   Flatmark, Torgeir ^b   Hough, Edward ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Conformational change; Phenylalanine hydroxylase; Protein crystallography; Tetrahydrobiopterin; Thienylalanine

Indexed keywords

BETA (2 THIENYL)ALANINE; GLUTAMINE; HISTIDINE; HYDROGEN; HYDROXYL GROUP; IMIDAZOLE; IRON; OXYGEN; PHENYLALANINE 4 MONOOXYGENASE; SAPROPTERIN; TETRAHYDROBIOPTERIN; THIOPHENE; TYROSINE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

EID: 0036071847     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00560-0     Document Type: Article

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