Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin

Biochemistry

Volumn 41, Issue 42, 2002, Pages 12569-12574

  Wang, Lin ^a   Erlandsen, Heidi ^a   Haavik, Jan ^b   Knappskog, Per M ^b   Stevens, Raymond C ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES;

AMINO ACIDS; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; ENZYMES;

BIOCHEMISTRY;

MELATONIN; PHENYLALANINE 4 MONOOXYGENASE; SEROTONIN; TRYPTOPHAN HYDROXYLASE; TYROSINE 3 MONOOXYGENASE;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ENZYME STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; SEROTONIN METABOLISM; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; BIOPTERIN; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; MELATONIN; MOLECULAR SEQUENCE DATA; NEUROTRANSMITTER AGENTS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 0037159254     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026561f     Document Type: Article

References (33)

1. Martinez, A., Knappskog, P. M., and Haavik, J. (2001) Curr. Med. Chem. 8, 1077-1091.
2. Abbar, M., Courtet, P., Bellivier, F., Leboyer, M., Boulenger, J. P., Castelhau, D., Ferreira, M., Lambercy, C., Mouthon, D., Paoloni-Giacobino, A., Vessaz, M., Malafosse, A., and Buresi, C. (2001) Mol. Psychiatry 6, 268-273.
3. Bell, C., Abrams, J., and Nutt, D. (2001) Br. J. Psychiatry 178, 399-405.
4. Kim, S. W., Park, S. Y., and Hwang, O. (2002) Mol. Pharmacol. 61, 778-785.
5. Stokes, A. H., Xu, Y., Daunais, J. A., Tamir, H., Gershon, M. D., Butkerait, P., Kayser, B., Altman, J., Beck, W., and Vrana, K. E. (2000) J. Neurochem. 74, 2067-2073.
6. Zimmer, L., Luxen, A., Giacomelli, F., and Pujol, J. F. (2002) Neurochem. Res. 27, 269-275.
7. Kapatos, G., and Kaufman, S. (1981) Science 212, 955-956.
8. Vanhoutte, P. M., Ed. (1985) Serotonin and the vascular system, Raven Press, New York.
9. Ekwall, O., Hedstrand, H., Grimelius, L., Haavik, J., Perheentupa, J., Gustafsson, J., Husebye, E., Kampe, O., and Rorsman, F. (1998) Lancet 352, 279-283.
10. Talley, N. J. (2001) Lancet 358, 2061-2068.
11. Goodwill, K. E., Sabatier, C., Marks, C., Raag, R., Fitzpatrick, P. F., and Stevens, R. C. (1997) Nat. Struct. Biol. 4, 578-585.
12. Goodwill, K. E., Sabatier, C., and Stevens, R. C. (1998) Biochemistry 37, 13437-13445.
13. Fusetti, F., Erlandsen, H., Flatmark, T., and Stevens, R. C. (1998) J. Biol. Chem. 273, 16962-16967.
14. Erlandsen, H., Fusetti, F., Martinez, A., Hough, E., Flatmark, T., and Stevens, R. C. (1997) Nat. Struct. Biol. 4, 995-1000.
15. Erlandsen, H., Flatmark, T., Stevens, R. C., and Hough, E. (1998) Biochemistry 37, 15638-15646.
16. Erlandsen, H., Bjørgo, E., Flatmark, T., and Stevens, R. C. (2000) Biochemistry 39, 2208-2217.
17. Kobe, B., Jennings, I. G., House, C. M., Michell, B. J., Goodwill, K. E., Santarsiero, B. D., Stevens, R. C., Cotton, R. G. H., and Kemp, B. E. (1999) Nat. Struct. Biol. 6, 442-448.
18. Erlandsen, H., Kim, J. Y., Patch, M. G., Han, A., Volner, A., Abu-Omar, M. M., and Stevens, R. C. (2002) J. Mol. Biol. 320, 645-661.
19. McKinney, J., Teigen, K., Frøystein, N. A., Salaun, C., Knappskog, P. M., Haavik, J., and Martinez, A. (2001) Biochemistry 40, 15591-15601.
20. Moran, G. R., Daubner, S. C., and Fitzpatrick, P. F. (1998) J. Biol. Chem. 273, 12259-12266.
21. Otwinowski, Z., and Minor, W. (1997) Processing of X-ray Diffraction Data Collected in Oscillation Mode, in Methods in Enzymology (Carter, C. W., Jr., and Sweet, R. M., Eds.) Vol. 276, pp 307-326, Academic Press, New York.
22. Kissinger, C. R., Gehlhaar, D. K., and Fogel, D. B. (1999) Acta Crystallogr. D55, 484-491.
23. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
24. Jones, T. A., Zou, J.-Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
25. Lu, G. (2000) J. Appl. Crystallogr. 33, 176-183.
26. Daubner, S. C., Moran, G. R., and Fitzpatrick, P. F. (2002) Biochem. Biophys. Res. Commun. 292, 639-641.
27. Daubner, S. C., Melendez, J., and Fitzpatrick, P. F. (2000) Biochemistry 39, 9652-9661.
28. Lovenberg, W., Jequier, E., and Sjoerdsma, A. (1967) Science 155, 217-219.
29. Kappock, T. J., and Caradonna, J. P. (1996) Chem. Rev. 96, 2659-2756.
30. Almås, B., Toska, K., Teigen, K., Groehn, V., Pfleiderer, W., Martinez, A., Flatmark, T., and Haavik, J. (2000) Biochemistry 39, 13676-13686.
31. Andersen, O. A., Flatmark, T., and Hough, E. (2001) J. Mol. Biol. 314, 279-291.
32. Jiang, G. C. T., Yohrling, G. J., Schmitt, I. V. J. D., and Vrana, K. E. (2000) J. Mol. Biol. 302, 1005-1017.
33. Kabsch, W., and Sander, C. (1983) Biopolymers 22, 2577-2637.