Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: Mechanistic insight into O2 activation

Journal of the American Chemical Society

Volumn 131, Issue 22, 2009, Pages 7685-7698

  Chow, Marina S ^a   Eser, Bekir E ^c,d   Wilson, Samuel A ^a   Hodgson, Keith O ^a,b   Hedman, Britt ^b   Fitzpatrick, Paul F ^c,d   Solomon, Edward I ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CO-SUBSTRATE; COFACTOR; KINETIC EXPERIMENT; MAGNETIC CIRCULAR DICHROISMS; NON-HEME IRON ENZYMES; ORDERS OF MAGNITUDE; PHENYLALANINE HYDROXYLASE; RATE-LIMITING STEPS; REDOX-ACTIVE; SPECTROSCOPIC DATA; STEADY-STATE KINETICS; TWO-ELECTRON REDUCTION; TYROSINE HYDROXYLASE; VARIABLE TEMPERATURE; WILD TYPES;

AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CHEMICAL ACTIVATION; CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; ELECTRONIC STRUCTURE; ENZYMES; X RAY SPECTROSCOPY;

SUBSTRATES;

FERROUS ION; NONHEME IRON PROTEIN; OXYGEN; PEROXIDE; PTERIN; TYROSINE 3 MONOOXYGENASE; IRON DERIVATIVE; PTERIN DERIVATIVE; TYROSINE;

ABSORPTION SPECTROSCOPY; ARTICLE; CHEMICAL REACTION KINETICS; CIRCULAR DICHROISM; CONTROLLED STUDY; ELECTRON; ELECTRONICS; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; GEOMETRY; MOLECULAR INTERACTION; MUTANT; OXIDATION REDUCTION REACTION; PROTON TRANSPORT; ROENTGEN SPECTROSCOPY; SPECTROSCOPY; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY; WILD TYPE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MUTATION; NEAR INFRARED SPECTROSCOPY; RAT; SPECTROMETRY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ANIMALS; CIRCULAR DICHROISM; IRON COMPOUNDS; KINETICS; MODELS, MOLECULAR; MUTATION; OXYGEN; PTERINS; RATS; SPECTROMETRY, X-RAY EMISSION; SPECTROSCOPY, NEAR-INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TYROSINE; TYROSINE 3-MONOOXYGENASE;

EID: 67650510925     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja810080c     Document Type: Article

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