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Volumn 120, Issue 17, 1998, Pages 4057-4062

Oxygen-18 kinetic isotope effect studies of the tyrosine hydroxylase reaction: Evidence of rate limiting oxygen activation

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN 18; TYROSINE 3 MONOOXYGENASE;

EID: 0032490094     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja973543q     Document Type: Article
Times cited : (71)

References (34)
  • 1
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    • Kaufman, S.; Kaufman, E. E. In Folates and Pterins; Blakley, R. L., Benkovic, S. J., Eds.; John Wiley & Sons: New York, 1985; Vol 2, pp 251-352.
    • (1985) Folates and Pterins , vol.2 , pp. 251-352
    • Kaufman, S.1    Kaufman, E.E.2
  • 12
    • 2642700998 scopus 로고    scopus 로고
    • Ph.D. Thesis, Texas A&M University
    • Hillas, P. J. Ph.D. Thesis, Texas A&M University, 1997.
    • (1997)
    • Hillas, P.J.1
  • 19
    • 0004052075 scopus 로고
    • Oxford University Press: New York
    • Sawyer, D. T. Oxygen Chemistry; Oxford University Press: New York, 1991.
    • (1991) Oxygen Chemistry
    • Sawyer, D.T.1
  • 26
    • 0000204628 scopus 로고
    • Massey, V., Williams, C. H., Jr., Eds.; Elvesier: New York
    • Ballou, D. P. In Flavins and Flavoproteins; Massey, V., Williams, C. H., Jr., Eds.; Elvesier: New York, 1982; pp 301-310.
    • (1982) Flavins and Flavoproteins , pp. 301-310
    • Ballou, D.P.1
  • 28
    • 2642612219 scopus 로고    scopus 로고
    • note
    • The range of tetrahydropterins which could be used for the analyses was limited by the need to minimize the amount of nonenzymatic autoxidation. Consequently, low (25-50 μM) concentrations were used and the quininoid dihydropterin was recycled with use of dihydropteridine reductase and NADH. Tetrahydropterins which were poor substrates for the reductase or for which the autoxidation was too rapid were thus ruled out.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.