Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 284, Issue 1 28-1, 2003, Pages

  Carpenter, Todd C ^a   Schomberg, Stacey ^a   Nichols, Christopher ^a   Stenmark, Kurt R ^a   Weil, John V ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Pulmonary edema; sodium channels

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARRIER PROTEIN; LUNG ENZYME; MESSENGER RNA; SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; GENE EXPRESSION; HYPOXIA; LUNG ALVEOLUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REOXYGENATION; RESPIRATORY EPITHELIUM; SODIUM TRANSPORT;

EID: 0037213984     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00181.2002     Document Type: Article

References (19)

1. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, and Crandall ED. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 282: L599-L608, 2002.
2. +-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J Physiol 511: 235-243, 1998.
3. + currents in Xenopus oocytes expressing α-, β-, γ-rENaC. Am J Physiol Cell Physiol 274: C1417-C1423, 1998.
4. 1 subunit gene. J Clin Invest 102: 1421-1430, 1998.
5. Harder KW, Owen P, Wong LK, Aebersold R, Clark-Lewis I, and Jirik FR. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (HPTP β) using synthetic phosphopeptides. Biochem J 298: 395-401, 1994.
6. Hardiman KM and Matalon S. Modification of sodium transport and alveolar fluid clearance by hypoxia: Mechanisms and physiological implications. Am J Respir Cell Mol Biol 25: 538-541, 2001.
7. Johnson MD, Widdicombe JH, Allen L, Barbry P, and Dobbs LG. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci USA 99: 1966-1971, 2002.
8. +-ATPase: Enzyme sources, preparative problems, and preparation from mammalian kidney. Methods Enzymol 156: 29-43, 1988.
9. Mairbaurl H, Wodopia R, Eckes S, Schulz S, and Bartsch P. Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am J Physiol Lung Cell Mol Physiol 273: L797-L806, 1997.
10. Planes C, Escoubet B, Blot-Chabaud M, Friedlander G, Farman N, and Clerici C. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Mol Biol 17: 508-518, 1997.
11. Planes C, Friedlander G, Loiseau A, Amiel C, and Clerici C. Inhibition of Na-K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line. Am J Physiol Lung Cell Mol Physiol 271: L70-L78, 1996.
12. +-ATPase modification during hypoxia in the cerebral cortex of the guinea pig fetus. Neurochem Res 26: 1163-1169, 2001.
13. Rotin D, Kanelis V, and Schild L. Trafficking and cell surface stability of ENaC. Am J Physiol Renal Physiol 281: F391-F399, 2001.
14. Sartori C, Allemann Y, Duplain H, Lepori M, Egli M, Lipp E, Hutter D, Turini P, Hugli O, Cook S, Nicod P, and Scherrer U. Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 346: 1631-1636, 2002.
15. Scherrer U, Sartori C, Lepori M, Allemann Y, Duplain H, Trueb L, and Nicod P. High-altitude pulmonary edema: From exaggerated pulmonary hypertension to a defect in transepithelial sodium transport. Adv Exp Med Biol 474: 93-107, 1999.
16. +-ATPase function by hypoxia in rats. J Appl Physiol 87: 962-968, 1999.
17. Tomlinson LA, Carpenter TC, Baker EH, Bridges JB, and Weil JV. Hypoxia reduces airway epithelial sodium transport in rats. Am J Physiol Lung Cell Mol Physiol 277: L881-L886, 1999.
18. Vivona ML, Matthay M, Chabaud MB, Friedlander G, and Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: Reversal by β-adrenergic agonist treatment. Am J Respir Cell Mol Biol 25: 554-561, 2001.
19. Wodopia R, Ko HS, Billian J, Wiesner R, Bartsch P, and Mairbaurl H. Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung. Am J Physiol Lung Cell Mol Physiol 279: L1110-L1119, 2000.