메뉴 건너뛰기




Volumn 31, Issue 1, 2011, Pages 11-32

Epithelial-mesenchymal interactions in biliary diseases

Author keywords

cholangiocytes; Cholangiopathies; ductular reaction; endothelial cells; myofibroblasts

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; FRACTALKINE; GELATINASE B; GROWTH FACTOR; INTERLEUKIN 6; MACROPHAGE ELASTASE; MORPHOGEN; NITRIC OXIDE; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; SONIC HEDGEHOG PROTEIN; STROMAL CELL DERIVED FACTOR 1; TOLL LIKE RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; VASCULOTROPIN;

EID: 79951900204     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0031-1272832     Document Type: Article
Times cited : (75)

References (201)
  • 1
    • 7644234675 scopus 로고    scopus 로고
    • The cholangiopathies: Disorders of biliary epithelia
    • DOI 10.1053/j.gastro.2004.08.006, PII S0016508504013952
    • Lazaridis K N., Strazzabosco M, Larusso N F. The cholangiopathies: disorders of bili (Pubitemid 39457780)
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1565-1577
    • Lazaridis, K.N.1    Strazzabosco, M.2    Larusso, N.F.3
  • 4
    • 0031788501 scopus 로고    scopus 로고
    • Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type I ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium
    • DOI 10.1002/hep.510280514
    • Liu Z, Sakamoto T, Ezure T et al. Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type I ductular reaction in mice: interactions between the periductal inflammatory and stromal cells and the biliary epithelium. Hepatology 1998 28 5 1260-1268 (Pubitemid 28493836)
    • (1998) Hepatology , vol.28 , Issue.5 , pp. 1260-1268
    • Liu, Z.1    Sakamoto, T.2    Ezure, T.3    Yokomuro, S.4    Murase, N.5    Michalopoulos, G.6    Demetris, A.J.7
  • 6
    • 33645741989 scopus 로고    scopus 로고
    • Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways
    • Yokoyama T, Komori A, Nakamura M et al. Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways. Liver Int 2006 26 4 467-476
    • (2006) Liver Int , vol.26 , Issue.4 , pp. 467-476
    • Yokoyama, T.1    Komori, A.2    Nakamura, M.3
  • 8
    • 16444387687 scopus 로고    scopus 로고
    • Histopathology of chronic cholestasis and adult ductopenic syndrome
    • Desmet V J. Histopathology of chronic cholestasis and adult ductopenic syndrome. Clin Liver Dis 1998 2 2 249-264, viii
    • (1998) Clin Liver Dis , vol.2 , Issue.2 , pp. 249-264
    • Desmet, V.J.1
  • 9
    • 33646472475 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism
    • Gaudio E, Barbaro B, Alvaro D et al. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 2006 130 4 1270-1282
    • (2006) Gastroenterology , vol.130 , Issue.4 , pp. 1270-1282
    • Gaudio, E.1    Barbaro, B.2    Alvaro, D.3
  • 11
    • 0031722948 scopus 로고    scopus 로고
    • Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes
    • Caligiuri A, Glaser S, Rodgers R E. et al. Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. Am J Physiol 1998 275 4 Pt 1 G835-G846
    • (1998) Am J Physiol , vol.275 , Issue.4 PART 1
    • Caligiuri, A.1    Glaser, S.2    Rodgers, R.E.3
  • 13
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis
    • DOI 10.1073/pnas.96.22.12719
    • George J, Roulot D, Koteliansky V E., Bissell D M. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci U S A 1999 96 22 12719-12724 (Pubitemid 29513569)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.22 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 15
    • 0031883604 scopus 로고    scopus 로고
    • Increased expression of interleukin-6 and tumor necrosis factor-α in pathologic biliary epithelial cells: In situ and culture study
    • Yasoshima M, Kono N, Sugawara H, Katayanagi K, Harada K, Nakanuma Y. Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: in situ and culture study. Lab Invest 1998 78 1 89-100 (Pubitemid 28074312)
    • (1998) Laboratory Investigation , vol.78 , Issue.1 , pp. 89-100
    • Yasoshima, M.1    Kono, N.2    Sugawara, H.3    Katayanagi, K.4    Harada, K.5    Nakanuma, Y.6
  • 17
    • 70350041702 scopus 로고    scopus 로고
    • Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia
    • Barnes B H., Tucker R M., Wehrmann F, Mack D G., Ueno Y, Mack C L. Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia. Liver Int 2009 29 8 1253-1261
    • (2009) Liver Int , vol.29 , Issue.8 , pp. 1253-1261
    • Barnes, B.H.1    Tucker, R.M.2    Wehrmann, F.3    MacK, D.G.4    Ueno, Y.5    MacK, C.L.6
  • 19
    • 0034086273 scopus 로고    scopus 로고
    • Bile duct ligation in rats induces biliary expression of cytokine- induced neutrophil chemoattractant
    • Saito J M., Maher J J. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology 2000 118 6 1157-1168 (Pubitemid 30346993)
    • (2000) Gastroenterology , vol.118 , Issue.6 , pp. 1157-1168
    • Saito, J.M.1    Maher, J.J.2
  • 21
    • 39149111929 scopus 로고    scopus 로고
    • Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    • Popov Y, Patsenker E, Stickel F et al. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 2008 48 3 453-464
    • (2008) J Hepatol , vol.48 , Issue.3 , pp. 453-464
    • Popov, Y.1    Patsenker, E.2    Stickel, F.3
  • 22
    • 48549103201 scopus 로고    scopus 로고
    • Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
    • Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman S L., Schuppan D. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology 2008 135 2 660-670
    • (2008) Gastroenterology , vol.135 , Issue.2 , pp. 660-670
    • Patsenker, E.1    Popov, Y.2    Stickel, F.3    Jonczyk, A.4    Goodman, S.L.5    Schuppan, D.6
  • 23
    • 68949172199 scopus 로고    scopus 로고
    • The amazing universe of hepatic microstructure
    • Desmet V J. The amazing universe of hepatic microstructure. Hepatology 2009 50 2 333-344
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 333-344
    • Desmet, V.J.1
  • 25
    • 32444445952 scopus 로고    scopus 로고
    • Transcriptional profiling implicates TGFβ/BMP and Notch signaling pathways in ductular differentiation of fetal murine hepatoblasts
    • DOI 10.1016/j.mod.2005.10.003, PII S092547730500167X
    • Ader T, Norel R, Levoci L, Rogler L E. Transcriptional profiling implicates TGFbeta/BMP and Notch signaling pathways in ductular differentiation of fetal murine hepatoblasts. Mech Dev 2006 123 2 177-194 (Pubitemid 43227944)
    • (2006) Mechanisms of Development , vol.123 , Issue.2 , pp. 177-194
    • Ader, T.1    Norel, R.2    Levoci, L.3    Rogler, L.E.4
  • 26
    • 34248674146 scopus 로고    scopus 로고
    • WNT/β-catenin signaling in liver health and disease
    • DOI 10.1002/hep.21651
    • Thompson M D., Monga S P. WNT/beta-catenin signaling in liver health and disease. Hepatology 2007 45 5 1298-1305 (Pubitemid 46775794)
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.S.2
  • 27
    • 0036330165 scopus 로고    scopus 로고
    • Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures
    • DOI 10.1053/jhep.2002.34858
    • Michalopoulos G K., Bowen W C., Mul K, Lopez-Talavera J C., Mars W. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 2002 36 2 278-283 (Pubitemid 34810346)
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 278-283
    • Michalopoulos, G.K.1    Bowen, W.C.2    Mule, K.3    Lopez-Talavera, J.C.4    Mars, W.5
  • 28
    • 38649103789 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling mediates oval cell response in rodents
    • DOI 10.1002/hep.21973
    • Apte U, Thompson M D., Cui S, Liu B, Cieply B, Monga S P. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology 2008 47 1 288-295 (Pubitemid 351171066)
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 288-295
    • Apte, U.1    Thompson, M.D.2    Cui, S.3    Liu, B.4    Cieply, B.5    Monga, S.P.S.6
  • 29
    • 33645467222 scopus 로고    scopus 로고
    • Progenitor cells in liver regeneration: Molecular responses controlling their activation and expansion
    • DOI 10.1111/j.1600-0463.2005.apm-386.x
    • Santoni-Rugiu E, Jelnes P, Thorgeirsson S S., Bisgaard H C. Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion. APMIS 2005 113 11-12 876-902 (Pubitemid 43934227)
    • (2005) APMIS , vol.113 , Issue.11-12 , pp. 876-902
    • Santoni-Rugiu, E.1    Jelnes, P.2    Thorgeirsson, S.S.3    Bisgaard, H.C.4
  • 31
    • 77951652812 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 regulate bile duct development in mice
    • Strazzabosco M. Foxa1 and Foxa2 regulate bile duct development in mice. J Hepatol 2010 52 5 765-767
    • (2010) J Hepatol , vol.52 , Issue.5 , pp. 765-767
    • Strazzabosco, M.1
  • 32
    • 48549088729 scopus 로고    scopus 로고
    • Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function
    • Semela D, Das A, Langer D, Kang N, Leof E, Shah V. Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function. Gastroenterology 2008 135 2 671-679
    • (2008) Gastroenterology , vol.135 , Issue.2 , pp. 671-679
    • Semela, D.1    Das, A.2    Langer, D.3    Kang, N.4    Leof, E.5    Shah, V.6
  • 36
    • 51549114943 scopus 로고    scopus 로고
    • Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice
    • Abrahm S, Szab A, Kaszaki J et al. Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice. Shock 2008 30 1 69-74
    • (2008) Shock , vol.30 , Issue.1 , pp. 69-74
    • Abrahm, S.1    Szab, A.2    Kaszaki, J.3
  • 39
    • 77249139206 scopus 로고    scopus 로고
    • Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
    • Popov Y, Sverdlov D Y., Bhaskar K R. et al. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol 2010 298 3 G323-G334
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , Issue.3
    • Popov, Y.1    Sverdlov, D.Y.2    Bhaskar, K.R.3
  • 43
    • 75449089682 scopus 로고    scopus 로고
    • CX3CL1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosis
    • Shimoda S, Harada K, Niiro H et al. CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis. Hepatology 2010 51 2 567-575
    • (2010) Hepatology , vol.51 , Issue.2 , pp. 567-575
    • Shimoda, S.1    Harada, K.2    Niiro, H.3
  • 44
    • 37049003544 scopus 로고    scopus 로고
    • Kupffer cell heterogeneity: Functional properties of bone marrow-derived and sessile hepatic macrophages
    • DOI 10.1182/blood-2007-02-073841
    • Klein I, Cornejo J C., Polakos N K. et al. Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood 2007 110 12 4077-4085 (Pubitemid 350248465)
    • (2007) Blood , vol.110 , Issue.12 , pp. 4077-4085
    • Klein, I.1    Cornejo, J.C.2    Polakos, N.K.3    John, B.4    Wuensch, S.A.5    Topham, D.J.6    Pierce, R.H.7    Crispe, I.N.8
  • 45
    • 11144281835 scopus 로고    scopus 로고
    • Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats
    • DOI 10.1053/j.gastro.2004.10.005, PII S0016508504019225
    • Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H. Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology 2005 128 1 138-146 (Pubitemid 40039965)
    • (2005) Gastroenterology , vol.128 , Issue.1 , pp. 138-146
    • Imamura, M.1    Ogawa, T.2    Sasaguri, Y.3    Chayama, K.4    Ueno, H.5
  • 47
    • 67651174837 scopus 로고    scopus 로고
    • Hepatic recruitment of the inflammatory Gr1 + monocyte subset upon liver injury promotes hepatic fibrosis
    • Karlmark K R., Weiskirchen R, Zimmermann H W. et al. Hepatic recruitment of the inflammatory Gr1 + monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 2009 50 1 261-274
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 261-274
    • Karlmark, K.R.1    Weiskirchen, R.2    Zimmermann, H.W.3
  • 48
    • 77955096540 scopus 로고    scopus 로고
    • Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    • Zimmermann H W., Seidler S, Nattermann J et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS ONE 2010 5 6 e11049
    • (2010) PLoS ONE , vol.5 , Issue.6
    • Zimmermann, H.W.1    Seidler, S.2    Nattermann, J.3
  • 50
    • 0003340122 scopus 로고
    • Hepatic mesenchymal cell reaction in liver disease
    • Schaffner F, Barka T, Popper H. Hepatic mesenchymal cell reaction in liver disease. Exp Mol Pathol 1963 31 419-441
    • (1963) Exp Mol Pathol , vol.31 , pp. 419-441
    • Schaffner, F.1    Barka, T.2    Popper, H.3
  • 51
    • 77950611682 scopus 로고    scopus 로고
    • Portal fibroblasts: Underappreciated mediators of biliary fibrosis
    • Dranoff J A., Wells R G. Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology 2010 51 4 1438-1444
    • (2010) Hepatology , vol.51 , Issue.4 , pp. 1438-1444
    • Dranoff, J.A.1    Wells, R.G.2
  • 52
    • 0026320289 scopus 로고
    • Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease
    • Milani S, Herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991 139 6 1221-1229
    • (1991) Am J Pathol , vol.139 , Issue.6 , pp. 1221-1229
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Stein, H.4    Surrenti, C.5
  • 53
    • 33645818769 scopus 로고    scopus 로고
    • Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts
    • Kruglov E A., Nathanson R A., Nguyen T, Dranoff J A. Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. Am J Physiol Gastrointest Liver Physiol 2006 290 4 G765-G771
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , Issue.4
    • Kruglov, E.A.1    Nathanson, R.A.2    Nguyen, T.3    Dranoff, J.A.4
  • 54
    • 20744441669 scopus 로고    scopus 로고
    • Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2
    • DOI 10.1074/jbc.M412371200
    • Jhandier M N., Kruglov E A., Lavoie E G., Svigny J, Dranoff J A. Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. J Biol Chem 2005 280 24 22986-22992 (Pubitemid 40853208)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.24 , pp. 22986-22992
    • Jhandieri, M.N.1    Kruglovi, E.A.2    Lavoie, E.G.3    Sevigny, J.4    Dranoff, J.A.5
  • 55
    • 0037329896 scopus 로고    scopus 로고
    • The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis
    • Kinnman N, Francoz C, Barbu V et al. The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis. Lab Invest 2003 83 2 163-173 (Pubitemid 36255362)
    • (2003) Laboratory Investigation , vol.83 , Issue.2 , pp. 163-173
    • Kinnman, N.1    Francoz, C.2    Barbu, V.3    Wendum, D.4    Rey, C.5    Hultcrantz, R.6    Poupon, R.7    Housset, C.8
  • 57
    • 77950612565 scopus 로고    scopus 로고
    • The epithelial-to-mesenchymal transition in liver fibrosis: Here today, gone tomorrow?
    • Wells R G. The epithelial-to-mesenchymal transition in liver fibrosis: here today, gone tomorrow? Hepatology 2010 51 3 737-740
    • (2010) Hepatology , vol.51 , Issue.3 , pp. 737-740
    • Wells, R.G.1
  • 58
    • 0036166579 scopus 로고    scopus 로고
    • Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers
    • DOI 10.1016/S0168-8278(01)00260-4, PII S0168827801002604
    • Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 2002 36 2 200-209 (Pubitemid 34146426)
    • (2002) Journal of Hepatology , vol.36 , Issue.2 , pp. 200-209
    • Cassiman, D.1    Libbrecht, L.2    Desmet, V.3    Denef, C.4    Roskams, T.5
  • 59
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of Hepatic Fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • Friedman S L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008 134 6 1655-1669 (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 62
    • 0033980284 scopus 로고    scopus 로고
    • Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells
    • Ankoma-Sey V, Wang Y, Dai Z. Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells. Hepatology 2000 31 1 141-148 (Pubitemid 30033700)
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 141-148
    • Ankoma-Sey, V.1    Wang, Y.2    Dai, Z.3
  • 64
    • 70349270647 scopus 로고    scopus 로고
    • Hepatic myofibroblasts: A heterogeneous population of multifunctional cells in liver fibrogenesis
    • Novo E, di Bonzo L V., Cannito S, Colombatto S, Parola M. Hepatic myofibroblasts: a heterogeneous population of multifunctional cells in liver fibrogenesis. Int J Biochem Cell Biol 2009 41 11 2089-2093
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.11 , pp. 2089-2093
    • Novo, E.1    Di Bonzo, L.V.2    Cannito, S.3    Colombatto, S.4    Parola, M.5
  • 65
    • 0034810089 scopus 로고    scopus 로고
    • Cytokine receptors and signaling in hepatic stellate cells
    • DOI 10.1055/s-2001-17554
    • Pinzani M, Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 2001 21 3 397-416 (Pubitemid 32923768)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.3 , pp. 397-416
    • Pinzani, M.1    Marra, F.2
  • 66
    • 28844502262 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ suppresses proximal α1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells
    • DOI 10.1074/jbc.M510094200
    • Yavrom S, Chen L, Xiong S, Wang J, Rippe R A., Tsukamoto H. Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J Biol Chem 2005 280 49 40650-40659 (Pubitemid 41780556)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.49 , pp. 40650-40659
    • Yavrom, S.1    Chen, L.2    Xiong, S.3    Wang, J.4    Rippe, R.A.5    Tsukamoto, H.6
  • 67
    • 68949122522 scopus 로고    scopus 로고
    • Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1alpha-mediated stellate cell activation
    • Hong F, Tuyama A, Lee T F. et al. Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. Hepatology 2009 49 6 2055-2067
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 2055-2067
    • Hong, F.1    Tuyama, A.2    Lee, T.F.3
  • 68
    • 0031883714 scopus 로고    scopus 로고
    • Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes
    • Chesney J, Metz C, Stavitsky A B., Bacher M, Bucala R. Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J Immunol 1998 160 1 419-425 (Pubitemid 28116757)
    • (1998) Journal of Immunology , vol.160 , Issue.1 , pp. 419-425
    • Chesney, J.1    Metz, C.2    Stavitsky, A.B.3    Bacher, M.4    Bucala, R.5
  • 70
    • 64749117099 scopus 로고    scopus 로고
    • The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders
    • Keeley E C., Mehrad B, Strieter R M. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders. Thromb Haemost 2009 101 4 613-618
    • (2009) Thromb Haemost , vol.101 , Issue.4 , pp. 613-618
    • Keeley, E.C.1    Mehrad, B.2    Strieter, R.M.3
  • 75
    • 48949117344 scopus 로고    scopus 로고
    • Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
    • Andersson-Sjland A, de Alba C G., Nihlberg K et al. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 2008 40 10 2129-2140
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.10 , pp. 2129-2140
    • Andersson-Sjland, A.1    De Alba, C.G.2    Nihlberg, K.3
  • 77
    • 35948978184 scopus 로고    scopus 로고
    • Hepatic fibrogenesis
    • DOI 10.1055/s-2007-991517
    • Guo J, Friedman S L. Hepatic fibrogenesis. Semin Liver Dis 2007 27 4 413-426 (Pubitemid 350071841)
    • (2007) Seminars in Liver Disease , vol.27 , Issue.4 , pp. 413-426
    • Guo, J.1    Friedman, S.L.2
  • 78
    • 51149113802 scopus 로고    scopus 로고
    • Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia
    • Jafri M, Donnelly B, Allen S et al. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol 2008 295 1 G16-G26
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.1
    • Jafri, M.1    Donnelly, B.2    Allen, S.3
  • 80
    • 75949103899 scopus 로고    scopus 로고
    • Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
    • Margadant C, Sonnenberg A. Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 2010 11 2 97-105
    • (2010) EMBO Rep , vol.11 , Issue.2 , pp. 97-105
    • Margadant, C.1    Sonnenberg, A.2
  • 82
    • 33645533798 scopus 로고    scopus 로고
    • Galectin-3 regulates myofibroblast activation and hepatic fibrosis
    • Henderson N C., Mackinnon A C., Farnworth S L. et al. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A 2006 103 13 5060-5065
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.13 , pp. 5060-5065
    • Henderson, N.C.1    MacKinnon, A.C.2    Farnworth, S.L.3
  • 83
    • 0022972814 scopus 로고
    • Tenascin: An extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis
    • Chiquet-Ehrismann R, Mackie E J., Pearson C A., Sakakura T. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell 1986 47 1 131-139 (Pubitemid 17181535)
    • (1986) Cell , vol.47 , Issue.1 , pp. 131-139
    • Chiquet-Ehrismann, R.1    Mackie, E.J.2    Pearson, C.A.3    Sakakura, T.4
  • 85
    • 0025126836 scopus 로고
    • Expression of the novel extracellular matrix component tenascin in normal and diseased human liver. An immunohistochemical study
    • DOI 10.1016/0168-8278(90)90270-2
    • Van Eyken P, Sciot R, Desmet V J. Expression of the novel extracellular matrix component tenascin in normal and diseased human liver. An immunohistochemical study. J Hepatol 1990 11 1 43-52 (Pubitemid 20250826)
    • (1990) Journal of Hepatology , vol.11 , Issue.1 , pp. 43-52
    • Van Eyken, P.1    Sciot, R.2    Desmet, V.J.3
  • 86
    • 0026587932 scopus 로고
    • Localization and cellular source of the extracellular matrix protein tenascin in normal and fibrotic rat liver
    • Van Eyken P, Geerts A, De Bleser P et al. Localization and cellular source of the extracellular matrix protein tenascin in normal and fibrotic rat liver. Hepatology 1992 15 5 909-916
    • (1992) Hepatology , vol.15 , Issue.5 , pp. 909-916
    • Van Eyken, P.1    Geerts, A.2    De Bleser, P.3
  • 87
    • 0027739652 scopus 로고
    • Transient expression of tenascin in experimentally induced cholestatic fibrosis in rat liver: An immunohistochemical study
    • Miyazaki H, Van Eyken P, Roskams T, De Vos R, Desmet V J. Transient expression of tenascin in experimentally induced cholestatic fibrosis in rat liver: an immunohistochemical study. J Hepatol 1993 19 3 353-366 (Pubitemid 24029911)
    • (1993) Journal of Hepatology , vol.19 , Issue.3 , pp. 353-366
    • Miyazaki, H.1    Van Eyken, P.2    Roskams, T.3    De Vos, R.4    Desmet, V.J.5
  • 88
    • 0142135370 scopus 로고    scopus 로고
    • Tenascin Expression at the Invasive Front Is Associated with Poor Prognosis in Intrahepatic Cholangiocarcinoma
    • DOI 10.1097/01.MP.0000086860.65672.73
    • Aishima S, Taguchi K, Terashi T, Matsuura S, Shimada M, Tsuneyoshi M. Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma. Mod Pathol 2003 16 10 1019-1027 (Pubitemid 37280818)
    • (2003) Modern Pathology , vol.16 , Issue.10 , pp. 1019-1027
    • Aishima, S.-I.1    Taguchi, K.-I.2    Terashi, T.3    Matsuura, S.4    Shimada, M.5    Tsuneyoshi, M.6
  • 89
    • 0029816535 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycan expression in chronic cholestatic human liver diseases
    • DOI 10.1053/jhep.1996.v24.pm0008781318
    • Roskams T, Rosenbaum J, De Vos R, David G, Desmet V. Heparan sulfate proteoglycan expression in chronic cholestatic human liver diseases. Hepatology 1996 24 3 524-532 (Pubitemid 26295991)
    • (1996) Hepatology , vol.24 , Issue.3 , pp. 524-532
    • Roskams, T.1    Rosenbaum, J.2    De Vos, R.3    David, G.4    Desmet, V.5
  • 90
    • 68449084138 scopus 로고    scopus 로고
    • Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation
    • Liu B, Paranjpe S, Bowen W C. et al. Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. Am J Pathol 2009 175 2 717-724
    • (2009) Am J Pathol , vol.175 , Issue.2 , pp. 717-724
    • Liu, B.1    Paranjpe, S.2    Bowen, W.C.3
  • 91
    • 77249164222 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis
    • Karlsen T H., Franke A, Melum E et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010 138 3 1102-1111
    • (2010) Gastroenterology , vol.138 , Issue.3 , pp. 1102-1111
    • Karlsen, T.H.1    Franke, A.2    Melum, E.3
  • 92
    • 0033955026 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis
    • DOI 10.1002/(SICI)1096-9896(200001)190:1<93::AID-PATH507>3.0.CO;2-A
    • Yasoshima M, Tsuneyama K, Harada K, Sasaki M, Gershwin M E., Nakanuma Y. Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis. J Pathol 2000 190 1 93-99 (Pubitemid 30053359)
    • (2000) Journal of Pathology , vol.190 , Issue.1 , pp. 93-99
    • Yasoshima, M.1    Tsuneyama, K.2    Harada, K.3    Sasaki, M.4    Gershwin, M.E.5    Nakanuma, Y.6
  • 93
    • 60549090416 scopus 로고    scopus 로고
    • Matrix proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's disease
    • Yasoshima M, Sato Y, Furubo S et al. Matrix proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's disease. J Pathol 2009 217 3 442-451
    • (2009) J Pathol , vol.217 , Issue.3 , pp. 442-451
    • Yasoshima, M.1    Sato, Y.2    Furubo, S.3
  • 94
    • 0026469730 scopus 로고
    • Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor
    • Joplin R, Hishida T, Tsubouchi H et al. Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor. J Clin Invest 1992 90 4 1284-1289
    • (1992) J Clin Invest , vol.90 , Issue.4 , pp. 1284-1289
    • Joplin, R.1    Hishida, T.2    Tsubouchi, H.3
  • 96
    • 0029146465 scopus 로고
    • Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats
    • Matsuda Y, Matsumoto K, Ichida T, Nakamura T. Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. J Biochem 1995 118 3 643-649
    • (1995) J Biochem , vol.118 , Issue.3 , pp. 643-649
    • Matsuda, Y.1    Matsumoto, K.2    Ichida, T.3    Nakamura, T.4
  • 97
    • 0029817895 scopus 로고    scopus 로고
    • Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats
    • DOI 10.1053/jhep.1996.v24.pm0008781336
    • Yasuda H, Imai E, Shiota A, Fujise N, Morinaga T, Higashio K. Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats. Hepatology 1996 24 3 636-642 (Pubitemid 26296009)
    • (1996) Hepatology , vol.24 , Issue.3 , pp. 636-642
    • Yasuda, H.1    Imai, E.2    Shiota, A.3    Fujise, N.4    Morinaga, T.5    Higashio, K.6
  • 99
    • 33646501750 scopus 로고    scopus 로고
    • Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation
    • Xia J L., Dai C, Michalopoulos G K., Liu Y. Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. Am J Pathol 2006 168 5 1500-1512
    • (2006) Am J Pathol , vol.168 , Issue.5 , pp. 1500-1512
    • Xia, J.L.1    Dai, C.2    Michalopoulos, G.K.3    Liu, Y.4
  • 100
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • Pinzani M, Gesualdo L, Sabbah G M., Abboud H E. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989 84 6 1786-1793 (Pubitemid 20016182)
    • (1989) Journal of Clinical Investigation , vol.84 , Issue.6 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 101
    • 0024852111 scopus 로고
    • Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors
    • Friedman S L., Arthur M J. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 1989 84 6 1780-1785 (Pubitemid 20016181)
    • (1989) Journal of Clinical Investigation , vol.84 , Issue.6 , pp. 1780-1785
    • Friedman, S.L.1    Arthur, M.J.P.2
  • 102
    • 0035209823 scopus 로고    scopus 로고
    • Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury
    • Kinnman N, Goria O, Wendum D et al. Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury. Lab Invest 2001 81 12 1709-1716 (Pubitemid 33144433)
    • (2001) Laboratory Investigation , vol.81 , Issue.12 , pp. 1709-1716
    • Kinnman, N.1    Goria, O.2    Wendum, D.3    Gendron, M.-C.4    Rey, C.5    Poupon, R.6    Housset, C.7
  • 104
    • 36549082913 scopus 로고    scopus 로고
    • ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells
    • DOI 10.1016/j.jhep.2007.08.010, PII S0168827807005296
    • Rovida E, Navari N, Caligiuri A, Dello Sbarba P, Marra F. ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells. J Hepatol 2008 48 1 107-115 (Pubitemid 350191987)
    • (2008) Journal of Hepatology , vol.48 , Issue.1 , pp. 107-115
    • Rovida, E.1    Navari, N.2    Caligiuri, A.3    Dello Sbarba, P.4    Marra, F.5
  • 105
    • 34250346521 scopus 로고    scopus 로고
    • Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis
    • DOI 10.1002/hep.21606
    • Melton A C., Yee H F. Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis. Hepatology 2007 45 6 1446-1453 (Pubitemid 46918328)
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1446-1453
    • Melton, A.C.1    Yee Jr., H.F.2
  • 107
    • 0037837754 scopus 로고    scopus 로고
    • Smads 2 and 3 are differentially activated by transforming growth factor-β (TGF-β) in quiescent and activated hepatic stellate cells: Constitutive nuclear localization of Smads in activated cells is TGF-β-independent
    • DOI 10.1074/jbc.M207728200
    • Liu C, Gaa M D., Swenson E S., Vellucci V F., Reiss M, Wells R G. Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 2003 278 13 11721-11728 (Pubitemid 36792736)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.13 , pp. 11721-11728
    • Liu, C.1    Gaca, M.D.A.2    Swenson, E.S.3    Vellucci, V.F.4    Reiss, M.5    Wells, R.G.6
  • 108
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • DOI 10.1101/gad.1350705
    • Massagu J, Seoane J, Wotton D. Smad transcription factors. Genes Dev 2005 19 23 2783-2810 (Pubitemid 41739965)
    • (2005) Genes and Development , vol.19 , Issue.23 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 109
    • 33846951514 scopus 로고    scopus 로고
    • Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis
    • Inagaki Y, Okazaki I. Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut 2007 56 2 284-292
    • (2007) Gut , vol.56 , Issue.2 , pp. 284-292
    • Inagaki, Y.1    Okazaki, I.2
  • 110
    • 33646569993 scopus 로고    scopus 로고
    • Biology of vascular endothelial growth factors
    • DOI 10.1016/j.febslet.2006.03.087, PII S0014579306004157
    • Roy H, Bhardwaj S, Yl-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett 2006 580 12 2879-2887 (Pubitemid 43729175)
    • (2006) FEBS Letters , vol.580 , Issue.12 , pp. 2879-2887
    • Roy, H.1    Bhardwaj, S.2    Yla-Herttuala, S.3
  • 114
    • 72249123155 scopus 로고    scopus 로고
    • ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice
    • Spirli C, Okolicsanyi S, Fiorotto R et al. ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology 2010 138 1 360-371, e7
    • (2010) Gastroenterology , vol.138 , Issue.1 , pp. 360-371
    • Spirli, C.1    Okolicsanyi, S.2    Fiorotto, R.3
  • 115
    • 77951429069 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice
    • Spirli C, Okolicsanyi S, Fiorotto R et al. Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology 2010 51 5 1778-1788
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1778-1788
    • Spirli, C.1    Okolicsanyi, S.2    Fiorotto, R.3
  • 116
    • 0036707893 scopus 로고    scopus 로고
    • Genetics and pathogenesis of polycystic kidney disease
    • DOI 10.1097/01.ASN.0000028643.17901.42
    • Igarashi P, Somlo S. Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 2002 13 9 2384-2398 (Pubitemid 34925250)
    • (2002) Journal of the American Society of Nephrology , vol.13 , Issue.9 , pp. 2384-2398
    • Igarashi, P.1    Somlo, S.2
  • 117
    • 2942534582 scopus 로고    scopus 로고
    • Polycystic kidney disease: New understanding in the pathogenesis
    • DOI 10.1016/j.biocel.2004.03.012, PII S1357272504001396
    • Wilson P D. Polycystic kidney disease: new understanding in the pathogenesis. Int J Biochem Cell Biol 2004 36 10 1868-1873 (Pubitemid 38760015)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.10 , pp. 1868-1873
    • Wilson, P.D.1
  • 120
    • 0031026475 scopus 로고    scopus 로고
    • + progenitors to peripheral blood
    • DOI 10.1084/jem.185.1.111
    • Aiuti A, Webb I J., Bleul C, Springer T, Gutierrez-Ramos J C. The chemokine SDF-1 is a chemoattractant for human CD34 + hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34 + progenitors to peripheral blood. J Exp Med 1997 185 1 111-120 (Pubitemid 27039446)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.1 , pp. 111-120
    • Aiuti, A.1    Webb, I.J.2    Bleul, C.3    Springer, T.4    Gutierrez-Ramos, J.C.5
  • 121
    • 0032473398 scopus 로고    scopus 로고
    • B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement
    • DOI 10.1084/jem.187.5.753
    • Bleul C C., Schultze J L., Springer T A. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement. J Exp Med 1998 187 5 753-762 (Pubitemid 28115191)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.5 , pp. 753-762
    • Bleul, C.C.1    Schultze, J.L.2    Springer, T.A.3
  • 125
    • 33745104992 scopus 로고    scopus 로고
    • Local balance of transforming growth factor-β1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma
    • DOI 10.1111/j.1440-1827.2006.01982.x
    • Ohira S, Itatsu K, Sasaki M et al. Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma. Pathol Int 2006 56 7 381-389 (Pubitemid 43886802)
    • (2006) Pathology International , vol.56 , Issue.7 , pp. 381-389
    • Ohira, S.1    Itatsu, K.2    Sasaki, M.3    Harada, K.4    Sato, Y.5    Zen, Y.6    Ishikawa, A.7    Oda, K.8    Nagasaka, T.9    Nimura, Y.10    Nakanuma, Y.11
  • 126
    • 33645458005 scopus 로고    scopus 로고
    • Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma
    • Ohira S, Sasaki M, Harada K et al. Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. Am J Pathol 2006 168 4 1155-1168
    • (2006) Am J Pathol , vol.168 , Issue.4 , pp. 1155-1168
    • Ohira, S.1    Sasaki, M.2    Harada, K.3
  • 127
    • 0026055366 scopus 로고
    • Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
    • Bradham D M., Igarashi A, Potter R L., Grotendorst G R. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991 114 6 1285-1294 (Pubitemid 21909886)
    • (1991) Journal of Cell Biology , vol.114 , Issue.6 , pp. 1285-1294
    • Bradham, D.M.1    Igarashi, A.2    Potter, R.L.3    Grotendorst, G.R.4
  • 128
  • 129
    • 0026164948 scopus 로고
    • Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein
    • Ryseck R P., Macdonald-Bravo H, Matti M G., Bravo R. Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ 1991 2 5 225-233
    • (1991) Cell Growth Differ , vol.2 , Issue.5 , pp. 225-233
    • Ryseck, R.P.1    MacDonald-Bravo, H.2    Matti, M.G.3    Bravo, R.4
  • 130
    • 0027229995 scopus 로고
    • Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
    • Igarashi A, Okochi H, Bradham D M., Grotendorst G R. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 1993 4 6 637-645 (Pubitemid 23183611)
    • (1993) Molecular Biology of the Cell , vol.4 , Issue.6 , pp. 637-645
    • Igarashi, A.1    Okochi, H.2    Bradham, D.M.3    Grotendorst, G.R.4
  • 131
    • 0036281460 scopus 로고    scopus 로고
    • Effects and regulation of connective tissue growth factor on hepatic stellate cells
    • Paradis V, Dargere D, Bonvoust F, Vidaud M, Segarini P, Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 2002 82 6 767-774
    • (2002) Lab Invest , vol.82 , Issue.6 , pp. 767-774
    • Paradis, V.1    Dargere, D.2    Bonvoust, F.3    Vidaud, M.4    Segarini, P.5    Bedossa, P.6
  • 132
    • 1242292348 scopus 로고    scopus 로고
    • Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells
    • DOI 10.1016/j.jhep.2003.11.012
    • Gao R, Ball D K., Perbal B, Brigstock D R. Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells. J Hepatol 2004 40 3 431-438 (Pubitemid 38230844)
    • (2004) Journal of Hepatology , vol.40 , Issue.3 , pp. 431-438
    • Gao, R.1    Ball, D.K.2    Perbal, B.3    Brigstock, D.R.4
  • 137
    • 41549118422 scopus 로고    scopus 로고
    • The Adventures of Sonic Hedgehog in Development and Repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • DOI 10.1152/ajpgi.00543.2007
    • Omenetti A, Diehl A M. The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 2008 294 3 G595-G598 (Pubitemid 351468754)
    • (2008) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.294 , Issue.3
    • Omenetti, A.1    Diehl, A.M.2
  • 138
    • 55849135600 scopus 로고    scopus 로고
    • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
    • Omenetti A, Porrello A, Jung Y et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 2008 118 10 3331-3342
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3331-3342
    • Omenetti, A.1    Porrello, A.2    Jung, Y.3
  • 139
    • 34248669615 scopus 로고    scopus 로고
    • Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis
    • DOI 10.1002/hep.21660
    • Jung Y, McCall S J., Li Y X., Diehl A M. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology 2007 45 5 1091-1096 (Pubitemid 46775770)
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1091-1096
    • Jung, Y.1    McCall, S.J.2    Li, Y.-X.3    Diehl, A.M.4
  • 140
    • 50249151525 scopus 로고    scopus 로고
    • The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
    • Omenetti A, Popov Y, Jung Y et al. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut 2008 57 9 1275-1282
    • (2008) Gut , vol.57 , Issue.9 , pp. 1275-1282
    • Omenetti, A.1    Popov, Y.2    Jung, Y.3
  • 141
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • DOI 10.1146/annurev.cellbio.20.010403.113126
    • Logan C Y., Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004 20 781-810 (Pubitemid 39488658)
    • (2004) Annual Review of Cell and Developmental Biology , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 142
    • 70549107058 scopus 로고    scopus 로고
    • Foxl1 promotes liver repair following cholestatic injury in mice
    • Sackett S D., Gao Y, Shin S et al. Foxl1 promotes liver repair following cholestatic injury in mice. Lab Invest 2009 89 12 1387-1396
    • (2009) Lab Invest , vol.89 , Issue.12 , pp. 1387-1396
    • Sackett, S.D.1    Gao, Y.2    Shin, S.3
  • 143
    • 0037220834 scopus 로고    scopus 로고
    • β-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification
    • DOI 10.1053/gast.2003.50000
    • Monga S P., Monga H K., Tan X, Mul K, Pediaditakis P, Michalopoulos G K. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology 2003 124 1 202-216 (Pubitemid 36055352)
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 202-216
    • Monga, S.P.S.1    Monga, H.K.2    Tan, X.3    Mule, K.4    Pediaditakis, P.5    Michalopoulos, G.K.6
  • 146
    • 33746511526 scopus 로고    scopus 로고
    • Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
    • DOI 10.1016/j.jhep.2006.03.016, PII S0168827806002261
    • Jiang F, Parsons C J., Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 2006 45 3 401-409 (Pubitemid 44142112)
    • (2006) Journal of Hepatology , vol.45 , Issue.3 , pp. 401-409
    • Jiang, F.1    Parsons, C.J.2    Stefanovic, B.3
  • 148
    • 38349091357 scopus 로고    scopus 로고
    • Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
    • Cheng J H., She H, Han Y P. et al. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2008 294 1 G39-G49
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , Issue.1
    • Cheng, J.H.1    She, H.2    Han, Y.P.3
  • 150
    • 77955418239 scopus 로고    scopus 로고
    • Cystic kidney disease: The role of Wnt signaling
    • Lancaster M A., Gleeson J G. Cystic kidney disease: the role of Wnt signaling. Trends Mol Med 2010 16 8 349-360
    • (2010) Trends Mol Med , vol.16 , Issue.8 , pp. 349-360
    • Lancaster, M.A.1    Gleeson, J.G.2
  • 151
    • 1642382833 scopus 로고    scopus 로고
    • Notch signaling: Control of cell communication and cell fate
    • DOI 10.1242/dev.01074
    • Lai E C. Notch signaling: control of cell communication and cell fate. Development 2004 131 5 965-973 (Pubitemid 38380451)
    • (2004) Development , vol.131 , Issue.5 , pp. 965-973
    • Lai, E.C.1
  • 152
    • 27144433568 scopus 로고    scopus 로고
    • Notch in the pathway: The roles of Notch signaling in neural crest development
    • DOI 10.1016/j.semcdb.2005.06.009, PII S108495210500073X, Molecular Determination of the Neural Crest
    • Cornell R A., Eisen J S. Notch in the pathway: the roles of Notch signaling in neural crest development. Semin Cell Dev Biol 2005 16 6 663-672 (Pubitemid 41506974)
    • (2005) Seminars in Cell and Developmental Biology , vol.16 , Issue.6 , pp. 663-672
    • Cornell, R.A.1    Eisen, J.S.2
  • 153
    • 38349121930 scopus 로고    scopus 로고
    • Signaling pathways governing stem-cell fate
    • Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood 2008 111 2 492-503
    • (2008) Blood , vol.111 , Issue.2 , pp. 492-503
    • Blank, U.1    Karlsson, G.2    Karlsson, S.3
  • 154
    • 33750566665 scopus 로고    scopus 로고
    • Notch signaling in stem cell systems
    • DOI 10.1634/stemcells.2005-0661
    • Chiba S. Notch signaling in stem cell system. Stem Cells 2006 24 2437-2447 (Pubitemid 44674304)
    • (2006) Stem Cells , vol.24 , Issue.11 , pp. 2437-2447
    • Chiba, S.1
  • 155
    • 0037390535 scopus 로고    scopus 로고
    • Notch signaling and inherited disease syndromes
    • Gridley T. Notch signaling and inherited disease syndromes. Hum Mol Genet 2003 12 Spec No 1 R9-R13 (Pubitemid 36442950)
    • (2003) Human Molecular Genetics , vol.12 , Issue.REV. ISS. 1
    • Gridley, T.1
  • 156
    • 1242265691 scopus 로고    scopus 로고
    • Regulation of Notch Signaling Activity
    • DOI 10.1016/S0960-9822(04)00038-7
    • Schweisguth F. Regulation of notch signaling activity. Curr Biol 2004 14 3 R129-R138 (Pubitemid 38215343)
    • (2004) Current Biology , vol.14 , Issue.3
    • Schweisguth, F.1
  • 157
    • 68549115658 scopus 로고    scopus 로고
    • Notch signaling controls liver development by regulating biliary differentiation
    • Zong Y, Panikkar A, Xu J et al. Notch signaling controls liver development by regulating biliary differentiation. Development 2009 136 10 1727-1739
    • (2009) Development , vol.136 , Issue.10 , pp. 1727-1739
    • Zong, Y.1    Panikkar, A.2    Xu, J.3
  • 158
    • 49649095393 scopus 로고    scopus 로고
    • Notch signaling in bile duct development: New insights raise new questions
    • Lemaigre F P. Notch signaling in bile duct development: new insights raise new questions. Hepatology 2008 48 2 358-360
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 358-360
    • Lemaigre, F.P.1
  • 159
    • 4344567112 scopus 로고    scopus 로고
    • Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors
    • DOI 10.1242/jcs.01169
    • Tanimizu N, Miyajima A. Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci 2004 117 Pt 15 3165-3174 (Pubitemid 39139903)
    • (2004) Journal of Cell Science , vol.117 , Issue.15 , pp. 3165-3174
    • Tanimizu, N.1    Miyajima, A.2
  • 161
    • 0038875342 scopus 로고    scopus 로고
    • Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
    • Li L, Krantz I D., Deng Y et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet 1997 16 3 243-251
    • (1997) Nat Genet , vol.16 , Issue.3 , pp. 243-251
    • Li, L.1    Krantz, I.D.2    Deng, Y.3
  • 162
    • 0030914459 scopus 로고    scopus 로고
    • Mutations in the human Jagged1 gene are responsible for Alagille syndrome
    • Oda T, Elkahloun A G., Pike B L. et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet 1997 16 3 235-242
    • (1997) Nat Genet , vol.16 , Issue.3 , pp. 235-242
    • Oda, T.1    Elkahloun, A.G.2    Pike, B.L.3
  • 163
    • 0033839965 scopus 로고    scopus 로고
    • JAGGED1 gene expression during human embryogenesis elucidates the wide phenotypic spectrum of Alagille syndrome
    • Crosnier C, Atti-Bitach T, Encha-Razavi F et al. JAGGED1 gene expression during human embryogenesis elucidates the wide phenotypic spectrum of Alagille syndrome. Hepatology 2000 32 3 574-581
    • (2000) Hepatology , vol.32 , Issue.3 , pp. 574-581
    • Crosnier, C.1    Atti-Bitach, T.2    Encha-Razavi, F.3
  • 164
    • 0035203709 scopus 로고    scopus 로고
    • Alagille syndrome and the jagged1 gene
    • DOI 10.1055/s-2001-19036
    • Piccoli D A., Spinner N B. Alagille syndrome and the Jagged1 gene. Semin Liver Dis 2001 21 4 525-534 (Pubitemid 33131044)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.4 , pp. 525-534
    • Piccoli, D.A.1    Spinner, N.B.2
  • 165
    • 0031609085 scopus 로고    scopus 로고
    • Ludwig symposium on biliary disorderspart I. Pathogenesis of ductal plate abnormalities
    • Desmet V J. Ludwig symposium on biliary disorderspart I. Pathogenesis of ductal plate abnormalities. Mayo Clin Proc 1998 73 1 80-89
    • (1998) Mayo Clin Proc , vol.73 , Issue.1 , pp. 80-89
    • Desmet, V.J.1
  • 166
    • 33645297918 scopus 로고    scopus 로고
    • Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression
    • Katuri V, Tang Y, Li C et al. Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene 2006 25 13 1871-1886
    • (2006) Oncogene , vol.25 , Issue.13 , pp. 1871-1886
    • Katuri, V.1    Tang, Y.2    Li, C.3
  • 167
    • 58449088387 scopus 로고    scopus 로고
    • Gastrointestinal stem cells in development and cancer
    • Brabletz S, Schmalhofer O, Brabletz T. Gastrointestinal stem cells in development and cancer. J Pathol 2009 217 2 307-317
    • (2009) J Pathol , vol.217 , Issue.2 , pp. 307-317
    • Brabletz, S.1    Schmalhofer, O.2    Brabletz, T.3
  • 168
    • 33645080922 scopus 로고    scopus 로고
    • Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
    • Fujikura J, Hosoda K, Iwakura H et al. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab 2006 3 1 59-65
    • (2006) Cell Metab , vol.3 , Issue.1 , pp. 59-65
    • Fujikura, J.1    Hosoda, K.2    Iwakura, H.3
  • 169
    • 36248953716 scopus 로고    scopus 로고
    • Mammary stem cells and breast cancer - Role of notch signalling
    • DOI 10.1007/s12015-007-0023-5, PII SCR32169
    • Farnie G, Clarke R B. Mammary stem cells and breast cancerrole of Notch signalling. Stem Cell Rev 2007 3 2 169-175 (Pubitemid 350129719)
    • (2007) Stem Cell Reviews , vol.3 , Issue.2 , pp. 169-175
    • Farnie, G.1    Clarke, R.B.2
  • 170
    • 38349121930 scopus 로고    scopus 로고
    • Signaling pathways governing stem-cell fate
    • Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood 2008 111 2 492-503
    • (2008) Blood , vol.111 , Issue.2 , pp. 492-503
    • Blank, U.1    Karlsson, G.2    Karlsson, S.3
  • 171
    • 33644635913 scopus 로고    scopus 로고
    • Notch signaling is required to maintain all neural stem cell populationsirrespective of spatial or temporal niche
    • Alexson T O., Hitoshi S, Coles B L., Bernstein A, van der Kooy D. Notch signaling is required to maintain all neural stem cell populationsirrespective of spatial or temporal niche. Dev Neurosci 2006 28 1-2 34-48
    • (2006) Dev Neurosci , vol.28 , Issue.1-2 , pp. 34-48
    • Alexson, T.O.1    Hitoshi, S.2    Coles, B.L.3    Bernstein, A.4    Van Der Kooy, D.5
  • 172
    • 75749091836 scopus 로고    scopus 로고
    • Notch and the skeleton
    • Zanotti S, Canalis E. Notch and the skeleton. Mol Cell Biol 2010 30 4 886-896
    • (2010) Mol Cell Biol , vol.30 , Issue.4 , pp. 886-896
    • Zanotti, S.1    Canalis, E.2
  • 173
    • 78049254816 scopus 로고    scopus 로고
    • Notch signalling is required for the survival of epithelial stem cells in the continuously growing mouse incisor
    • Felszeghy S, Suomalainen M, Thesleff I. Notch signalling is required for the survival of epithelial stem cells in the continuously growing mouse incisor. Differentiation 2010 80 241-248
    • (2010) Differentiation , vol.80 , pp. 241-248
    • Felszeghy, S.1    Suomalainen, M.2    Thesleff, I.3
  • 174
    • 53249155910 scopus 로고    scopus 로고
    • Mimicking stem cell niches to increase stem cell expansion
    • Dellatore S M., Garcia A S., Miller W M. Mimicking stem cell niches to increase stem cell expansion. Curr Opin Biotechnol 2008 19 5 534-540
    • (2008) Curr Opin Biotechnol , vol.19 , Issue.5 , pp. 534-540
    • Dellatore, S.M.1    Garcia, A.S.2    Miller, W.M.3
  • 175
    • 0036094234 scopus 로고    scopus 로고
    • Altered Notch ligand expression in human liver disease: Further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects
    • Nijjar S S., Wallace L, Crosby H A., Hubscher S G., Strain A J. Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am J Pathol 2002 160 5 1695-1703 (Pubitemid 34525649)
    • (2002) American Journal of Pathology , vol.160 , Issue.5 , pp. 1695-1703
    • Nijjar, S.S.1    Wallace, L.2    Crosby, H.A.3    Hubscher, S.G.4    Strain, A.J.5
  • 176
    • 77149158796 scopus 로고    scopus 로고
    • Characterisation of the liver progenitor cell niche in liver diseases: Potential involvement of Wnt and Notch signalling
    • Spee B, Carpino G, Schotanus B A. et al. Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut 2010 59 2 247-257
    • (2010) Gut , vol.59 , Issue.2 , pp. 247-257
    • Spee, B.1    Carpino, G.2    Schotanus, B.A.3
  • 178
    • 79951879221 scopus 로고    scopus 로고
    • Progenitor cell activation and liver repair is altered in Notch2- and RBP-Jk-defective mice exposed to cholestatic injuries
    • Fiorotto R, Spirli C, Scirpo R et al. Progenitor cell activation and liver repair is altered in Notch2- and RBP-Jk-defective mice exposed to cholestatic injuries. J Hepatol 2010 52 S45
    • (2010) J Hepatol , vol.52
    • Fiorotto, R.1    Spirli, C.2    Scirpo, R.3
  • 179
    • 70349515743 scopus 로고    scopus 로고
    • The niche of stellate cells within rat liver
    • Sawitza I, Kordes C, Reister S, Hussinger D. The niche of stellate cells within rat liver. Hepatology 2009 50 5 1617-1624
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1617-1624
    • Sawitza, I.1    Kordes, C.2    Reister, S.3    Hussinger, D.4
  • 181
    • 20544437490 scopus 로고    scopus 로고
    • Role of reactive oxygen species in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    • DOI 10.1681/ASN.2004050425
    • Rhyu D Y., Yang Y, Ha H et al. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005 16 3 667-675 (Pubitemid 41725103)
    • (2005) Journal of the American Society of Nephrology , vol.16 , Issue.3 , pp. 667-675
    • Rhyu, D.Y.1    Yang, Y.2    Ha, H.3    Lee, G.T.4    Song, J.S.5    Uh, S.-T.6    Lee, H.B.7
  • 182
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson E G. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009 119 6 1429-1437
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 183
    • 38349043703 scopus 로고    scopus 로고
    • Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat
    • Sato Y, Harada K, Ozaki S et al. Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat. Am J Pathol 2007 171 6 1859-1871
    • (2007) Am J Pathol , vol.171 , Issue.6 , pp. 1859-1871
    • Sato, Y.1    Harada, K.2    Ozaki, S.3
  • 184
    • 64549142000 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia
    • Harada K, Sato Y, Ikeda H et al. Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J Pathol 2009 217 5 654-664
    • (2009) J Pathol , vol.217 , Issue.5 , pp. 654-664
    • Harada, K.1    Sato, Y.2    Ikeda, H.3
  • 185
    • 77954586069 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by transforming growth factor-beta1/snail activation aggravates invasive growth of cholangiocarcinoma
    • Sato Y, Harada K, Itatsu K et al. Epithelial-mesenchymal transition induced by transforming growth factor-beta1/snail activation aggravates invasive growth of cholangiocarcinoma. Am J Pathol 2010 177 1 141-152
    • (2010) Am J Pathol , vol.177 , Issue.1 , pp. 141-152
    • Sato, Y.1    Harada, K.2    Itatsu, K.3
  • 186
    • 0029091682 scopus 로고
    • Identification and characterization of a fibroblast marker: FSP1
    • Strutz F, Okada H, Lo C W. et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 1995 130 2 393-405
    • (1995) J Cell Biol , vol.130 , Issue.2 , pp. 393-405
    • Strutz, F.1    Okada, H.2    Lo, C.W.3
  • 187
    • 21544440606 scopus 로고    scopus 로고
    • Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys
    • DOI 10.1007/s00418-005-0788-z
    • Le Hir M, Hegyi I, Cueni-Loffing D, Loffing J, Kaissling B. Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem Cell Biol 2005 123 4-5 335-346 (Pubitemid 40922217)
    • (2005) Histochemistry and Cell Biology , vol.123 , Issue.4-5 , pp. 335-346
    • Le Hir, M.1    Hegyi, I.2    Cueni-Loffing, D.3    Loffing, J.4    Kaissling, B.5
  • 188
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • Taura K, Miura K, Iwaisako K et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 2010 51 3 1027-1036
    • (2010) Hepatology , vol.51 , Issue.3 , pp. 1027-1036
    • Taura, K.1    Miura, K.2    Iwaisako, K.3
  • 189
    • 10344236467 scopus 로고    scopus 로고
    • Inhibition of Jagged-mediated notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy
    • DOI 10.1242/dev.01411
    • Lorent K, Yeo S Y., Oda T et al. Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development 2004 131 22 5753-5766 (Pubitemid 39625217)
    • (2004) Development , vol.131 , Issue.22 , pp. 5753-5766
    • Lorent, K.1    Yeo, S.-Y.2    Oda, T.3    Chandrasekharappa, S.4    Chitnis, A.5    Matthews, R.P.6    Pack, M.7
  • 190
    • 66149104013 scopus 로고    scopus 로고
    • Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    • Antoniou A, Raynaud P, Cordi S et al. Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology 2009 136 7 2325-2333
    • (2009) Gastroenterology , vol.136 , Issue.7 , pp. 2325-2333
    • Antoniou, A.1    Raynaud, P.2    Cordi, S.3
  • 191
    • 19544379346 scopus 로고    scopus 로고
    • Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: Further evidence supporting a lack of postnatal bile duct branching and elongation
    • DOI 10.1097/01.pas.0000161325.36348.25
    • Libbrecht L, Spinner N B., Moore E C., Cassiman D, Van Damme-Lombaerts R, Roskams T. Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: further evidence supporting a lack of postnatal bile duct branching and elongation. Am J Surg Pathol 2005 29 6 820-826 (Pubitemid 40734433)
    • (2005) American Journal of Surgical Pathology , vol.29 , Issue.6 , pp. 820-826
    • Libbrecht, L.1    Spinner, N.B.2    Moore, E.C.3    Cassiman, D.4    Van Damme-Lombaerts, R.5    Roskams, T.6
  • 193
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment
    • DOI 10.1002/hep.22310
    • Blechacz B, Gores G J. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008 48 1 308-321 (Pubitemid 351975555)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 308-321
    • Blechacz, B.1    Gores, G.J.2
  • 194
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - Bipolar effects of the tumour stroma in cancer
    • DOI 10.1038/nrc1477
    • Mueller M M., Fusenig N E. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004 4 11 839-849 (Pubitemid 39472951)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 195
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg R A. The basics of epithelial-mesenchymal transition. J Clin Invest 2009 119 6 1420-1428
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 196
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch R L., Gould S E., Scales S J. et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008 455 7211 406-410
    • (2008) Nature , vol.455 , Issue.7211 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 197
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez N, Truitt M, Olson P, Arron S T., Hanahan D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010 17 2 135-147
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 198
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006 6 5 392-401
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 199
    • 70349595100 scopus 로고    scopus 로고
    • Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis
    • Santamaria-Martnez A, Barquinero J, Barbosa-Desongles A et al. Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis. Exp Cell Res 2009 315 17 3004-3013
    • (2009) Exp Cell Res , vol.315 , Issue.17 , pp. 3004-3013
    • Santamaria-Martnez, A.1    Barquinero, J.2    Barbosa-Desongles, A.3
  • 200
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • DOI 10.1038/nrm1835, PII NRM1835
    • Thiery J P., Sleeman J P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006 7 2 131-142 (Pubitemid 43278296)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 201
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 2009 119 6 1417-1419
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1417-1419
    • Kalluri, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.