ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice

Gastroenterology

Volumn 138, Issue 1, 2010, Pages

  Spirli, Carlo ^a,b   Okolicsanyi, Stefano ^a,b   Fiorotto, Romina ^a,b   Fabris, Luca ^b   Cadamuro, Massimiliano ^b   Lecchi, Silvia ^a,b   Tian, Xin ^a   Somlo, Stefan ^a   Strazzabosco, Mario ^a,b,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OSPEDALI RIUNITI   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYCYSTIN 1; POLYCYSTIN 2; SEMAXANIB; SMALL INTERFERING RNA; TAMOXIFEN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BODY WEIGHT; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; KNOCKOUT MOUSE; LIVER CELL; LIVER CELL CULTURE; LIVER CYST; LIVER WEIGHT; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 72249123155     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.09.005     Document Type: Article

References (44)

1. Bae K.T., Zhu F., Chapman A.B., et al. Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. Clin J Am Soc Nephrol 1 (2006) 64-69
2. Everson G.T., Taylor M.R., and Doctor R.B. Polycystic disease of the liver. Hepatology 40 (2004) 774-782
3. Qian Q., Du H., King B.F., et al. Sirolimus reduces polycystic liver volume in ADPKD patients. J Am Soc Nephrol 19 (2008) 631-638
4. Masyuk T.V., Masyuk A.I., Torres V.E., et al. Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3′,5′-cyclic monophosphate. Gastroenterology 132 (2007) 1104-1116
5. Torres V.E., and Harris P.C. Mechanisms of disease: autosomal dominant and recessive polycystic kidney diseases. Nat Clin Pract Nephrol 2 (2006) 40-55
6. Qian F., and Noben-Trauth K. Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2). Pflugers Arch 451 (2005) 277-285
7. Aguiari G., Campanella M., Manzati E., et al. Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells. Biochem Biophys Res Commun 301 (2003) 657-664
8. Anyatonwu G.I., Estrada M., Tian X., et al. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A 104 (2007) 6454-6459
9. Li Y., Wright J.M., Qian F., et al. Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. J Biol Chem 280 (2005) 41298-41306
10. Strazzabosco M., Fabris L., and Spirli C. Pathophysiology of cholangiopathies. J Clin Gastroenterol 39 (2005) S90-S102
11. Nichols M.T., Gidey E., Matzakos T., et al. Secretion of cytokines and growth factors into autosomal dominant polycystic kidney disease liver cyst fluid. Hepatology 40 (2004) 836-846
12. Fabris L., Cadamuro M., Fiorotto R., et al. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Hepatology 43 (2006) 1001-1012
13. Shibuya M. Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol 39 (2006) 469-478
14. Fabris L., Cadamuro M., Libbrecht L., et al. Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development. Hepatology 47 (2008) 719-728
15. Amura C., Brodsky K.S., Groff R., et al. VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. Am J Physiol Cell Physiol 293 (2007) C419-C428
16. Shibazaki S., Yu Z., Nishio S., et al. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17 (2008) 1505-1516
17. Guo C., Yang W., and Lobe C.G. A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis 32 (2002) 8-18
18. Torres V.E., Wang X., Qian Q., et al. Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med 10 (2004) 363-364
19. Jebreel A., England J., Bedford K., et al. Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases. Int J Exp Pathol 88 (2007) 271-277
20. Spirli C., Fiorotto R., Song L., et al. Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism. Gastroenterology 129 (2005) 220-233
21. Masyuk A.I., Masyuk T.V., Splinter P.L., et al. Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131 (2006) 911-920
22. Ye C., Sweeny D., Sukbuntherng J., et al. Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416. Toxicol In Vitro 20 (2006) 154-162
23. Sukbuntherng J., Cropp G., Hannah A., et al. Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416. J Pharm Pharmacol 53 (2001) 1629-1636
24. Alvaro D., Onori P., Alpini G., et al. Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease. Am J Pathol 172 (2008) 321-332
25. Barr M.M. Caenorhabditis elegans as a model to study renal development and disease: sexy cilia. J Am Soc Nephrol 16 (2005) 305-312
26. Pennekamp P., Karcher C., Fischer A., et al. The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol 12 (2002) 938-943
27. Ellis L.M., and Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8 (2008) 579-591
28. Lee C.B., and Socinski M.A. Vascular endothelial growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: a review of recent clinical trials. Rev Recent Clin Trials 2 (2007) 117-120
29. Veeravagu A., Hsu A.R., Cai W., et al. Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy. Recent Patents Anticancer Drug Discov 2 (2007) 59-71
30. Itokawa T., Nokihara H., Nishioka Y., et al. Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling. Mol Cancer Ther 1 (2002) 295-302
31. Mendel D.B., Schreck R.E., West D.C., et al. The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function. Clin Cancer Res 6 (2000) 4848-4858
32. Gaudio E., Barbaro B., Alvaro D., et al. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 130 (2006) 1270-1282
33. Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9 (2003) 677-684
34. Ke Q., and Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70 (2006) 1469-1480
35. Belibi F.A., Reif G., Wallace D.P., et al. Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells. Kidney Int 66 (2004) 964-973
36. Banales J.M., Masyuk T.V., Gradilone S.A., et al. The cAMP effectors Epac and protein kinase A (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD). Hepatology 49 (2009) 160-174
37. Anyatonwu G.I., and Ehrlich B.E. Calcium signaling and polycystin-2. Biochem Biophys Res Commun 322 (2004) 1364-1373
38. Geng L., Boehmerle W., Maeda Y., et al. Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Proc Natl Acad Sci U S A 105 (2008) 15920-15925
39. Lefkimmiatis K., Srikanthan M., Maiellaro I., et al. Store-operated cyclic AMP signalling mediated by STIM1. Nat Cell Biol 11 (2009) 433-442
40. Lazaridis K.N., Strazzabosco M., and Larusso N.F. The cholangiopathies: disorders of biliary epithelia. Gastroenterology 127 (2004) 1565-1577
41. Strazzabosco M., and Fabris L. Functional anatomy of normal bile ducts. Anat Rec (Hoboken) 291 (2008) 653-660
42. LeSage G., Glaser S., and Alpini G. Regulation of cholangiocyte proliferation. Liver 21 (2001) 73-80
43. Alvaro D., Mancino M.G., Glaser S., et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 132 (2007) 415-431
44. Grimm D.H., Karihaloo A., Cai Y., et al. Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells. J Biol Chem 281 (2006) 137-144