Cholangiocytes as immune modulators in rotavirus-induced murine biliaryatresia

Liver International

Volumn 29, Issue 8, 2009, Pages 1253-1261

  Barnes, Barrett H ^a   Tucker, Rebecca M ^b   Wehrmann, Fabian ^a   Mack, Doug G ^b   Ueno, Yoshiyuki ^c   Mack, Cara L ^a,b  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen presentation; Autoimmunity; Chemokines; Cholangitis; Cytokines

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RANTES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BILE DUCT ATRESIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HELPER CELL; IMMUNOMODULATION; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MOUSE; NEWBORN; NONHUMAN; ROTAVIRUS; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRUS INFECTION; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CELL SEPARATION; DISEASE MODEL; FLOW CYTOMETRY; HEPATIC DUCT; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE; VIROLOGY; VIRUS REPLICATION;

ANIMALS; ANIMALS, NEWBORN; ANTIGEN-PRESENTING CELLS; BILE DUCTS, EXTRAHEPATIC; BILIARY ATRESIA; CELL LINE; CELL SEPARATION; CHEMOKINES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS; MICE; MICE, INBRED BALB C; ROTAVIRUS; ROTAVIRUS INFECTIONS; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 70350041702     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01921.x     Document Type: Article

References (27)

1. Chardot C, Carton M, Spire-Bendelac N, et al. Epidemiology of biliary atresia in France: a national study 1986-96. J Hepatol 1999; 31: 1006-13.
2. Chen SM, Chang MHthe Taiwan Infant Stool Color Card Study Group, et al. Screening for biliary atresia by infant stool color card in Taiwan. Pediatrics 2006; 117: 1147-54.
3. Karrer FM, Price MR, Bensard DD, et al. Long-term results with the Kasai operation for biliary atresia. Arch Surg 1996; 131: 493-6.
4. Karrer FM, Bensard D.D. Neonatal cholestasis. Semin Pediatr Surg 2000; 9: 166-9.
5. Mack CL, Sokol R.J. Unraveling the pathogenesis and etiology of biliary atresia. Pediatr Res 2005; 57: 87R-94R.
6. Riepenhoff-Talty M, Gouvea V, Evans MJ, et al. Detection of group C rotavirus in infants with extrahepatic biliary atresia. J Infect Dis 1996; 174: 8-15.
7. Petersen C, Biermanns D, Kuske M, et al. New aspects in a murine model fro extrahepatic biliary atresia. J Pediatr Surg 1997; 32: 1190-5.
8. Riepenhoff-Talty M, Schaekel K, Clark HF, et al. Group A rotaviruses produce extrahepatic biliary obstruction inorally inoculated newborn mice. Pediatr Res 1993; 33: 394-9.
9. Davenport M, Gonde C, Redkar R, et al. Immunohistochemistry of the liver and biliary tree in extrahepatic biliary atresia. J Pediatr Surg 2001; 36: 1017-25.
10. Kotb MA, El Henawy A, Talaat S, et al. Immune-mediated liver injury: prognostic value of CD41, CD81, and CD681in infants with extrahepatic biliary atresia. J Pediatr Surg 2005; 40: 1252-7.
11. Mack CL, Tucker RM, Sokol RJ, et al. Biliary atresia is associated with CD41 Th1 cell-mediated portal tract inflammation. Pediatr Res 2004; 56: 79-87.
12. Mack CL, Tucker RM, Sokol RJ, Kotzin B.L. Armed CD41 Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia. Clin Immunol 2005; 115: 200-9.
13. Shivakumar P, Campbell K, Sabla G, et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-g in experimental biliary atresia. J Clin Invest 2004; 114: 322-9.
14. Cruickshank S, Southgate J, Selby P, Trejdosiewicz L. Expression and cytokine regulation of immune recognition elements by normal human biliary epithelial and established cell lines in vitro. J Hepatol 1998; 29: 550-8.
15. Fava G, Glaser S, Francis H, Alpini G. The immunophysiology of biliary epithelium. Semin Liver Dis 2005; 25: 251-64.
16. Himeno H, Saibara T, Onishi S, Yamamoto Y, Enzan H. Administration of interleukin-2 induces major histocompatibility complex class II expression on the biliary epithelial cells, possibly through endogenous interferon-g production. Hepatology 1992; 16: 409-17.
17. Hreha G, Jefferson DM, Chang-Hong Y, et al. Immortalized intrahepatic mouse biliary epithelial cells: immunologic characterization and immunogenicity. Hepatology 1999; 30: 358-71.
18. Leon M, Bassendine M, Wilson J, et al. Immunogenicity of biliary epithelium: investigation of antigen presentation to CD41 T cells. Hepatology 1996; 24: 561-7.
19. Paradis K, Le O, Russo P, et al. Characterization and response to interleukin 1 and tumor necrosis factor of immortalized murine biliary epithelial cells. Gastroenterology 1995; 109: 1308-15.
20. Reynoso-Paz S, Coppel R, Mackay I, et al. The immunobiology of bile and biliary epithelium. Hepatology 1999; 30: 351-7.
21. Hirota K, Hashimoto M, Yoshitomi H, et al. T cell selfreactivity forms a cytokine milieu for spontaneous development of IL-171 Th cells that cause autoimmune arthritis. J Exp Med 2007; 204: 41-7.
22. Schreiber RA, Kleinman R.E. Genetics, immunology and biliary atresia: an opening or a diversion? J Pediatr Gastroenterol Nutr 1993; 16: 111-3.
23. Mack CL, Sokol R.J. Unraveling the pathogenesis and etiology of biliary atresia. Pediatr Res 2005; 57: 87R-94R.
24. Van den Oord JJ, Sciot R, Desmet V.J. Expression of MHC products by normal and abnormal bile duct epithelium. J Hepatol 1986; 3: 310-7.
25. Wu CT, Davis P, Luketic V, Gershwin M.E. A review of the physiological and immunological functions of biliary epithelial cells: targets for primary biliary cirrhosis, primary sclerosing cholangitis and druginduced ductopenias. Clin Dev Immunol 2004; 11: 205-13.
26. Kamihira T, Shimoda S, Nakamura M, et al. Biliary epithelial cell regulate autoreactive T cell: implications for biliary specific diseases. Hepatology 2005; 41: 151-9.
27. Lazaridis KN, Strazzabosco M, LaRusso N.F. The cholangiopathies: disorders of biliary epithelia. Gastroenterology 2004; 127: 1565-77.