Inhibition of Jagged-mediated notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy

Development

Volumn 131, Issue 22, 2004, Pages 5753-5766

  Lorent, Kristin ^a   Yeo, Sang Yeob ^b   Oda, Takaya ^c,e   Chandrasekharappa, Settara ^c   Chitnis, Ajay ^b   Matthews, Randolph P ^d   Pack, Michael ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Alagille syndrome; Bile duct; Biliary development; Jagged; Notch; Zebrafish

Indexed keywords

JAGGED PROTEIN; MEMBRANE PROTEIN; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ALAGILLE SYNDROME; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; CRANIOFACIAL MALFORMATION; DEVELOPMENTAL DISORDER; EMBRYO; GENE EXPRESSION; GENE MUTATION; HEART DEVELOPMENT; HEART DISEASE; HEPATOBILIARY DISEASE; HEPATOBILIARY SYSTEM; KIDNEY DEVELOPMENT; KIDNEY DISEASE; LIVER DEVELOPMENT; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ZEBRA FISH;

ALAGILLE SYNDROME; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BILE DUCTS; BILIARY TRACT; CALCIUM-BINDING PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LIVER; MAMMALS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 10344236467     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01411     Document Type: Article

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