Local balance of transforming growth factor-β1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma

Pathology International

Volumn 56, Issue 7, 2006, Pages 381-389

  Ohira, Shusaku ^a,c   Itatsu, Keita ^a,c   Sasaki, Motoko ^a   Harada, Kenichi ^a   Sato, Yasunori ^a   Zen, Yoh ^b   Ishikawa, Akira ^c   Oda, Koji ^c   Nagasaka, Tetsuro ^c   Nimura, Yuji ^c   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b FUKUI KEN SAISEIKAI HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cholangiocarcinoma; Fibroblasts; Invasion; SDF 1; TGF 1; Tumor stroma

Indexed keywords

NEUTRALIZING ANTIBODY; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER INVASION; CARCINOMA CELL; CELL INTERACTION; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN SECRETION; STROMA CELL; SUPERNATANT;

AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL LINE, TUMOR; CHEMOKINES, CXC; CHOLANGIOCARCINOMA; FEMALE; FIBROBLASTS; GENE EXPRESSION; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33745104992     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2006.01982.x     Document Type: Article

References (29)

1. Chung LW. The role of stromal-epithelial interaction in normal and malignant growth. Cancer Surv 1995 23 : 33 42.
2. Liotta LA Kohn EC. The microenvironment of the tumour-host interface. Nature 2001 411 : 375 9.
3. Pupa SM Menard S Forti S Tagliabue E. New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 2002 190 : 259 67.
4. Hayashi N Cunha GR. Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma. Cancer Res 1991 51 : 4924 30.
5. Bhowmick NA Chytil A Plieth D et al. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 2004 303 : 848 51.
6. Nakamura T Matsumoto K Kiritoshi A Tano Y Nakamura T. Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: In vitro analysis of tumor-stromal interactions. Cancer Res 1997 57 : 3305 13.
7. Sabit H Tsuneyama K Shimonishi T et al. Enhanced expression of basement-membrane-type heparan sulfate proteoglycan in tumor fibro-myxoid stroma of intrahepatic cholangiocarcinoma. Pathol Int 2001 51 : 248 56.
8. Ozaki S Sato Y Yasoshima M Harada K Nakanuma Y. Diffuse expression of heparan sulfate proteoglycan and connective tissue growth factor in fibrous septa with many mast cells relate to un-resolving hepatic fibrosis of congenital hepatic fibrosis. Liver Int 2005 25 : 817 28.
9. Turkeri LN Erton ML Cevik I Akdas A. Impact of the expression of epidermal growth factor, transforming growth factor alpha, and epidermal growth factor receptor on the prognosis of superficial bladder cancer. Urology 1998 51 : 645 9.
10. Kajita T Ohta Y Kimura K et al. The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer. Br J Cancer 2001 85 : 255 60.
11. Koshiba T Hosotani R Miyamoto Y et al. Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression. Clin Cancer Res 2000 6 : 3530 35.
12. Ohira S Sasaki M Harada K et al. Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor α and stromal derived facor-1 released in stroma. Am J Pathol 2006 168 : 1155 68.
13. Jankowski K Kucia M Wysoczynski M et al. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res 2003 63 : 7926 35.
14. Sehgal A Ricks S Boynton AL Warrick J Murphy GP. Molecular characterization of CXCR-4: A potential brain tumor-associated gene. J Surg Oncol 1998 69 : 239 48.
15. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998 67 : 753 91.
16. Muraoka-Cook RS Dumont N Arteaga CL. Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression. Clin Cancer Res 2005 11 : 937s 43s.
17. Benckert C Jonas S Cramer T et al. Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells. Cancer Res 2003 63 : 1083 92.
18. Zen Y Harada K Sasaki M et al. Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1. Lab Invest 2005 85 : 572 81.
19. Wright N de Lera TL Garcia-Moruja C et al. Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: Functional consequences in cell migration and adhesion. Blood 2003 102 : 1978 84.
20. Salvucci O Yao L Villalba S Sajewicz A Pittaluga S Tosato G. Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood 2002 99 : 2703 11.
21. Okuda K Nakanuma Y Miyazaki M. Cholangiocarcinoma: Recent progress. Part 2: Molecular pathology and treatment. J Gastroenterol Hepatol 2002 17 : 1056 63.
22. Okuda K Nakanuma Y Miyazaki M. Cholangiocarcinoma: Recent progress. Part 1: Epidemiology and etiology. J Gastroenterol Hepatol 2002 17 : 1049 55.
23. Sugawara H Yasoshima M Katayanagi K et al. Relationship between interleukin-6 and proliferation and differentiation in cholangiocarcinoma. Histopathology 1998 33 : 145 53.
24. Saito K Minato H Kono N Nakanuma Y Ishida F Kosugi M. Establishment of the human cholangiocellular carcinoma cell line (CCKS1). Acta Hepatol Jpn 1993 34 : 122 9.
25. Perissinotto E Cavalloni G Leone F et al. Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. Clin Cancer Res 2005 11 : 490 97.
26. Scotton CJ Wilson JL Scott K et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002 62 : 5930 38.
27. Zhou Y Larsen PH Hao C Yong VW. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 2002 277 : 49 81 7.
28. Muller A Homey B Soto H et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001 410 : 50 56.
29. Scala S Ottaiano A Ascierto PA et al. Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res 2005 11 : 1835 41.