-
1
-
-
1042301303
-
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
-
Ali A, Zhang J, Bao SD, Liu I, Otterness D, Dean NM, Abraham RT, Wang XF. (2004). Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev 18:249-254.
-
(2004)
Genes Dev
, vol.18
, pp. 249-254
-
-
Ali, A.1
Zhang, J.2
Bao, S.D.3
Liu, I.4
Otterness, D.5
Dean, N.M.6
Abraham, R.T.7
Wang, X.F.8
-
2
-
-
2942581416
-
Protein tyrosine phosphatases in the human genome
-
DOI 10.1016/j.cell.2004.05.018, PII S0092867404005343
-
Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. (2004). Protein tyrosine phosphatases in the human genome. Cell 117:699-711. (Pubitemid 38748887)
-
(2004)
Cell
, vol.117
, Issue.6
, pp. 699-711
-
-
Alonso, A.1
Sasin, J.2
Bottini, N.3
Friedberg, I.4
Friedberg, I.5
Osterman, A.6
Godzik, A.7
Hunter, T.8
Dixon, J.9
Mustelin, T.10
-
3
-
-
27744597059
-
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein
-
DOI 10.1074/jbc.M503673200
-
Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, Southerland W, Gordeuk VR, Bollen M, Nekhai S. (2005). Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem 280:36364-36371. (Pubitemid 41633910)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.43
, pp. 36364-36371
-
-
Ammosova, T.1
Jerebtsova, M.2
Beullens, M.3
Lesage, B.4
Jackson, A.5
Kashanchi, F.6
Southerland, W.7
Gordeuk, V.R.8
Bollen, M.9
Nekhai, S.10
-
4
-
-
0032961714
-
Dynamics of microcystins in the mussel Mytilus galloprovincialis
-
Amorim A, Vasconcelos V. (1999). Dynamics of microcystins in the mussel Mytilus galloprovincialis. Toxicon 37:1041-1052.
-
(1999)
Toxicon
, vol.37
, pp. 1041-1052
-
-
Amorim, A.1
Vasconcelos, V.2
-
5
-
-
0028560013
-
Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins
-
An J, Carmichael WW (1994). Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins. Toxicon 32, 1495-1507.
-
(1994)
Toxicon
, vol.32
, pp. 1495-1507
-
-
An, J.1
Carmichael, W.W.2
-
6
-
-
0033062523
-
RdgC/PP5-related phosphatases: Novel components in signal transduction
-
Andreeva AV, Kutuzov MA. (1999). RdgC/PP5-related phosphatases: Novel components in signal transduction. Cell Signal 11:555-562.
-
(1999)
Cell Signal
, vol.11
, pp. 555-562
-
-
Andreeva, A.V.1
Kutuzov, M.A.2
-
7
-
-
0035103719
-
PPP family of protein Ser/Tr phosphatases: Two distinct branches?
-
Andreeva AV, Kutuzov MA. (2001). PPP family of protein Ser/Tr phosphatases: Two distinct branches? Mol Biol Evol 18: 448-452.
-
(2001)
Mol Biol Evol
, vol.18
, pp. 448-452
-
-
Andreeva, A.V.1
Kutuzov, M.A.2
-
8
-
-
0031460227
-
An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae
-
Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J. (1997). An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94:14300-14305.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14300-14305
-
-
Archambault, J.1
Chambers, R.S.2
Kobor, M.S.3
Ho, Y.4
Cartier, M.5
Bolotin, D.6
Andrews, B.7
Kane, C.M.8
Greenblatt, J.9
-
9
-
-
0030475875
-
Te novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fssion yeast ppe1, which are involved in cell cycle regulation
-
Bastians H, Ponstingl H. (1996). Te novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fssion yeast ppe1, which are involved in cell cycle regulation. J Cell Sci 109:2865-2874.
-
(1996)
J Cell Sci
, vol.109
, pp. 2865-2874
-
-
Bastians, H.1
Ponstingl, H.2
-
10
-
-
68549115381
-
Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
-
Bertini I, Calderone V, Fragai M, Luchinat C, Talluri E. (2009). Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin. J Med Chem 52:4838-4843.
-
(2009)
J Med Chem
, vol.52
, pp. 4838-4843
-
-
Bertini, I.1
Calderone, V.2
Fragai, M.3
Luchinat, C.4
Talluri, E.5
-
11
-
-
0023691731
-
Inhibitory efect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specifcity and kinetics
-
Bialojan C, Takai A. (1988). Inhibitory efect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specifcity and kinetics. Biochem J 256:283-290.
-
(1988)
Biochem J
, vol.256
, pp. 283-290
-
-
Bialojan, C.1
Takai, A.2
-
12
-
-
3042663533
-
Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues
-
Bialy L, Waldmann H. (2004). Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Chem Eur J 10:2759-2780.
-
(2004)
Chem Eur J
, vol.10
, pp. 2759-2780
-
-
Bialy, L.1
Waldmann, H.2
-
13
-
-
0344496513
-
Te tetratricopeptide repeat: A structural motif mediating protein-protein interactions
-
Blatch GL, Lassle M. (1999). Te tetratricopeptide repeat: A structural motif mediating protein-protein interactions. Bioessays 21:932-939.
-
(1999)
Bioessays
, vol.21
, pp. 932-939
-
-
Blatch, G.L.1
Lassle, M.2
-
14
-
-
0034800738
-
Total synthesis of fostriecin (CI-920)
-
Boger DL, Ichikawa S, Zhong W. (2001). Total synthesis of fostriecin (CI-920). J Am Chem Soc 123:4161-4167.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 4161-4167
-
-
Boger, D.L.1
Ichikawa, S.2
Zhong, W.3
-
15
-
-
0023798520
-
Inhibition of type II topoisomerase by fostriecin
-
Boritzki TJ, Wolfard TS, Besserer JA, Jackson RC, Fry DW. (1988). Inhibition of type II topoisomerase by fostriecin. Biochem Pharmacol 37:4063-4068.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 4063-4068
-
-
Boritzki, T.J.1
Wolfard, T.S.2
Besserer, J.A.3
Jackson, R.C.4
Fry, D.W.5
-
16
-
-
0346728803
-
Functional diversity of protein phosphatase-1, a cellular economizer and reset button
-
Ceulemans H, Bollen M. (2004). Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev 84:1-39.
-
(2004)
Physiol Rev
, vol.84
, pp. 1-39
-
-
Ceulemans, H.1
Bollen, M.2
-
17
-
-
0032577919
-
Alpha 4 associates with protein phosphatases 2A, 4, and 6
-
Chen J, Peterson RT, Schreiber SL. (1998). Alpha 4 associates with protein phosphatases 2A, 4, and 6. Biochem Biophys Res Commun 247:827-832.
-
(1998)
Biochem Biophys Res Commun
, vol.247
, pp. 827-832
-
-
Chen, J.1
Peterson, R.T.2
Schreiber, S.L.3
-
18
-
-
0029751136
-
Te tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant
-
Chen MS, Silverstein AM, Pratt WB, Chinkers M. (1996). Te tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J Biol Chem 271:32315-32320.
-
(1996)
J Biol Chem
, vol.271
, pp. 32315-32320
-
-
Chen, M.S.1
Silverstein, A.M.2
Pratt, W.B.3
Chinkers, M.4
-
19
-
-
0031015069
-
Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain
-
Chen MX, Cohen PTW. (1997). Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain. FEBS Lett 400:136-140.
-
(1997)
FEBS Lett
, vol.400
, pp. 136-140
-
-
Chen, M.X.1
Cohen, P.T.W.2
-
20
-
-
0028133445
-
A novel human protein serine/threonine phosphatase, which possesses 4 tetratricopeptide repeat motifs and localizes to the nucleus
-
Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PTW. (1994). A novel human protein serine/threonine phosphatase, which possesses 4 tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J 13:4278-4290.
-
(1994)
EMBO J
, vol.13
, pp. 4278-4290
-
-
Chen, M.X.1
McPartlin, A.E.2
Brown, L.3
Chen, Y.H.4
Barker, H.M.5
Cohen, P.T.W.6
-
21
-
-
0024558577
-
A new antibiotic, tautomycetin
-
Chen X-C, Kihara T, Ying X, Uramoto M, Osada H, Kusakabe H, Wang B-N, Kobayashi Y, Ko K, Yamaguchi I, Shen Y-C, Isono K. (1989). A new antibiotic, tautomycetin. J Antibiot 42:141-144.
-
(1989)
J Antibiot
, vol.42
, pp. 141-144
-
-
Chen, X.-C.1
Kihara, T.2
Ying, X.3
Uramoto, M.4
Osada, H.5
Kusakabe, H.6
Wang, B.-N.7
Kobayashi, Y.8
Ko, K.9
Yamaguchi, I.10
Shen, Y.-C.11
Isono, K.12
-
22
-
-
0025375299
-
The structure of tautomycetin, a dialkylmaleic anhydride antibiotic
-
Chen X-C, Ubukata M, Isono K. (1990). Te structure of tautomycetin, a dialkylmaleic anhydride antibiotic. J Antibiot 43:890-896. (Pubitemid 20239830)
-
(1990)
Journal of Antibiotics
, vol.43
, Issue.7
, pp. 890-896
-
-
Cheng, X.-C.1
Ubukata, M.2
Isono, K.3
-
23
-
-
0028117770
-
Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial-natriuretic-peptide receptor
-
Chinkers M. (1994). Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial-natriuretic-peptide receptor. Proc Natl Acad Sci USA 91:11075-11079.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 11075-11079
-
-
Chinkers, M.1
-
24
-
-
0035234311
-
Protein phosphatase 5 in signal transduction
-
Chinkers M. (2001). Protein phosphatase 5 in signal transduction. Trends Endocrinol Metab 12:28-32.
-
(2001)
Trends Endocrinol Metab
, vol.12
, pp. 28-32
-
-
Chinkers, M.1
-
25
-
-
0034383949
-
Te regulation of protein function by multisite phosphorylation-A 25 year update
-
Cohen P. (2000). Te regulation of protein function by multisite phosphorylation-A 25 year update. Trends Biochem Sci 25:596-601.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 596-601
-
-
Cohen, P.1
-
26
-
-
0025181418
-
Okadaic acid-A new probe for the study of cellular regulation
-
Cohen P, Holmes CFB, Tsukitani Y. (1990). Okadaic acid-A new probe for the study of cellular regulation. Trends Biochem Sci 15:98-102.
-
(1990)
Trends Biochem Sci
, vol.15
, pp. 98-102
-
-
Cohen, P.1
Holmes, C.F.B.2
Tsukitani, Y.3
-
27
-
-
0030790128
-
Novel protein serine/threonine phosphatases: Variety is the spice of life
-
Cohen PTW. (1997). Novel protein serine/threonine phosphatases: Variety is the spice of life. Trends Biochem Sci 22:245-251.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 245-251
-
-
Cohen, P.T.W.1
-
28
-
-
20444422553
-
Protein phosphatase 4-From obscurity to vital functions
-
Cohen PTW, Philp A, Vazquez-Martin C. (2005). Protein phosphatase 4-From obscurity to vital functions. FEBS Lett 579:3278-3286.
-
(2005)
FEBS Lett
, vol.579
, pp. 3278-3286
-
-
Cohen, P.T.W.1
Philp, A.2
Vazquez-Martin, C.3
-
29
-
-
0033529415
-
Importance of the β12-β13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors
-
Connor JH, Kleeman T, Barik S, Honkanen RE, Shenolikar S. (1999). Importance of the β12-β13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. J Biol Chem 274:22366-22372.
-
(1999)
J Biol Chem
, vol.274
, pp. 22366-22372
-
-
Connor, J.H.1
Kleeman, T.2
Barik, S.3
Honkanen, R.E.4
Shenolikar, S.5
-
30
-
-
0030344872
-
Molecular mechanisms underlying the interaction of motuporin and microycystins with type-1 and type-2A protein phosphatases
-
Craig M, Luu HA, McCready TL, Williams D, Andersen RJ, Holmes CFB. (1996). Molecular mechanisms underlying the interaction of motuporin and microycystins with type-1 and type-2A protein phosphatases. Biochem Cell Biol 74:569-578.
-
(1996)
Biochem Cell Biol
, vol.74
, pp. 569-578
-
-
Craig, M.1
Luu, H.A.2
McCready, T.L.3
Williams, D.4
Andersen, R.J.5
Holmes, C.F.B.6
-
31
-
-
0027751617
-
Identifcation and characterization of hydrophobic microcystins in Canadian freshwater cyanobacteria
-
Craig M, McCready TL, Luu HA, Smillie MA, Dubord P, Holmes CFB. (1993). Identifcation and characterization of hydrophobic microcystins in Canadian freshwater cyanobacteria. Toxicon 31:1541-1549.
-
(1993)
Toxicon
, vol.31
, pp. 1541-1549
-
-
Craig, M.1
McCready, T.L.2
Luu, H.A.3
Smillie, M.A.4
Dubord, P.5
Holmes, C.F.B.6
-
32
-
-
0032473425
-
Te structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
-
Das AK, Cohen PTW, Barford D. (1998). Te structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions. EMBO J 17:1192-1199.
-
(1998)
EMBO J
, vol.17
, pp. 1192-1199
-
-
Das, A.K.1
Cohen, P.T.W.2
Barford, D.3
-
33
-
-
0030465532
-
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 angstrom resolution
-
Das AK, Helps NR, Cohen PTW, Barford D. (1996). Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 angstrom resolution. EMBO J. 15:6798-6809.
-
(1996)
EMBO J.
, vol.15
, pp. 6798-6809
-
-
Das, A.K.1
Helps, N.R.2
Cohen, P.T.W.3
Barford, D.4
-
34
-
-
0032124844
-
Te toxicology of microcystins
-
Dawson RM. (1998). Te toxicology of microcystins. Toxicon 36:953-962.
-
(1998)
Toxicon
, vol.36
, pp. 953-962
-
-
Dawson, R.M.1
-
36
-
-
0032176512
-
Protein tyrosine phosphatases: Mechanisms of catalysis and regulation
-
Denu JM, Dixon JE. (1998). Protein tyrosine phosphatases: Mechanisms of catalysis and regulation. Curr Opin Chem Biol 2:633-641.
-
(1998)
Curr Opin Chem Biol
, vol.2
, pp. 633-641
-
-
Denu, J.M.1
Dixon, J.E.2
-
37
-
-
0030977268
-
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1
-
Eglof MP, Johnson DF, Moorhead G, Cohen PTW, Cohen P, Barford D. (1997). Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J. 16:1876-1887.
-
(1997)
EMBO J.
, vol.16
, pp. 1876-1887
-
-
Eglof, M.P.1
Johnson, D.F.2
Moorhead, G.3
Cohen, P.T.W.4
Cohen, P.5
Barford, D.6
-
40
-
-
0035354316
-
Te predicted β12-β13 loop is important for inhibition of PP2Acα by the antitumor drug fostriecin
-
Evans DRH, Simon JA. (2001). Te predicted β12-β13 loop is important for inhibition of PP2Acα by the antitumor drug fostriecin. FEBS Lett 498:110-115.
-
(2001)
FEBS Lett
, vol.498
, pp. 110-115
-
-
Drh, E.1
Simon, J.A.2
-
41
-
-
34047116506
-
Arabidopsis PPP family of serine/threonine phosphatases
-
Farkas I, Dombradi V, Miskei M, Szabados L, Koncz C. (2007). Arabidopsis PPP family of serine/threonine phosphatases. Trends Plant Sci 12:169-176.
-
(2007)
Trends Plant Sci
, vol.12
, pp. 169-176
-
-
Farkas, I.1
Dombradi, V.2
Miskei, M.3
Szabados, L.4
Koncz, C.5
-
42
-
-
0030924806
-
Diferential inhibition and posttranslational modifcation of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
-
Favre B, Turowski P, Hemmings BA. (1997). Diferential inhibition and posttranslational modifcation of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J Biol Chem 272:13856-13863.
-
(1997)
J Biol Chem
, vol.272
, pp. 13856-13863
-
-
Favre, B.1
Turowski, P.2
Hemmings, B.A.3
-
43
-
-
0026503434
-
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
-
Fruman DA, Klee CB, Bierer BE, Burakof SJ. (1992). Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 89:3686-3690.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3686-3690
-
-
Fruman, D.A.1
Klee, C.B.2
Bierer, B.E.3
Burakof, S.J.4
-
44
-
-
0021174011
-
Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system
-
Fry DW, Besserer JA, Boritzki TJ. (1984). Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system. Cancer Res 44:3366-3370.
-
(1984)
Cancer Res
, vol.44
, pp. 3366-3370
-
-
Fry, D.W.1
Besserer, J.A.2
Boritzki, T.J.3
-
45
-
-
0035848412
-
Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A
-
Frydrychowski VA, Urbanek RA, Dounay AB, Forsyth CJ. (2001). Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A. Bioorg Med Chem Lett 11:647-649.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 647-649
-
-
Frydrychowski, V.A.1
Urbanek, R.A.2
Dounay, A.B.3
Forsyth, C.J.4
-
46
-
-
0027272945
-
Tumor promotion by inhibitors of protein phosphatases 1 and 2A: Te okadaic acid class of compounds
-
Fujiki H, Suganuma M. (1993). Tumor promotion by inhibitors of protein phosphatases 1 and 2A: Te okadaic acid class of compounds. Adv Cancer Res 61:143-194.
-
(1993)
Adv Cancer Res
, vol.61
, pp. 143-194
-
-
Fujiki, H.1
Suganuma, M.2
-
47
-
-
0029868933
-
Inhibition of protein serine threonine phosphatases by fumonisin B-1, a mycotoxin
-
Fukuda H, Shima H, Vesonder RF, Tokuda H, Nishino H, Katoh S, Tamura S, Sugimura T, Nagao M. (1996). Inhibition of protein serine threonine phosphatases by fumonisin B-1, a mycotoxin. Biochem Biophys Res Commun 220:160-165.
-
(1996)
Biochem Biophys Res Commun
, vol.220
, pp. 160-165
-
-
Fukuda, H.1
Shima, H.2
Vesonder, R.F.3
Tokuda, H.4
Nishino, H.5
Katoh, S.6
Tamura, S.7
Sugimura, T.8
Nagao, M.9
-
48
-
-
0024393917
-
Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F
-
Fushimi S, Furihata K, Seto H. (1989). Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F. J Antibiot 42:1026-1036. (Pubitemid 19193422)
-
(1989)
Journal of Antibiotics
, vol.42
, Issue.7
, pp. 1026-1036
-
-
Fushimi, S.1
Furihata, K.2
Seto, H.3
-
49
-
-
21644448038
-
A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes
-
Gigena MS, Ito A, Nojima H, Rogers TB. (2005). A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes. Am J Physiol Heart Circ Physiol 289(1 58-1).
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.289
, Issue.1
, pp. 58-1
-
-
Gigena, M.S.1
Ito, A.2
Nojima, H.3
Rogers, T.B.4
-
50
-
-
0029094754
-
Tree-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
-
Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC, Kuriyan J. (1995). Tree-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature 376: 745-753.
-
(1995)
Nature
, vol.376
, pp. 745-753
-
-
Goldberg, J.1
Huang, H.B.2
Kwon, Y.G.3
Greengard, P.4
Nairn, A.C.5
Kuriyan, J.6
-
51
-
-
0029133116
-
X-ray structure of calcineurin inhibited by the immunophilin- immunosuppressant FKBP12-FK506 complex
-
Grifth JP, Kim JL, Kim EE, Sintchak MD, Tomson JA, Fitzgibbon MJ, Fleming MA, Caron PR, Hsiao K, Navia MA. (1995). X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell 82:507-522.
-
(1995)
Cell
, vol.82
, pp. 507-522
-
-
Grifth, J.P.1
Kim, J.L.2
Kim, E.E.3
Sintchak, M.D.4
Tomson, J.A.5
Fitzgibbon, M.J.6
Fleming, M.A.7
Caron, P.R.8
Hsiao, K.9
Navia, M.A.10
-
52
-
-
0030806027
-
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A
-
Gupta V, Ogawa AK, Du X, Houk KN, Armstrong RW. (1997). A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A. J Med Chem 40: 3199-3206.
-
(1997)
J Med Chem
, vol.40
, pp. 3199-3206
-
-
Gupta, V.1
Ogawa, A.K.2
Du, X.3
Houk, K.N.4
Armstrong, R.W.5
-
53
-
-
0025188593
-
Structural determination of geometrical isomers of microcystins LR and RR from cyanobacteria by two-dimensional NMR spectroscopic techniques
-
Harada KI, Ogawa K, Matsuura K, Murata H, Suzuki M, Watanabe MF, Itezono Y, Nakayama N. (1990). Structural determination of geometrical isomers of microcystins LR and RR from cyanobacteria by two-dimensional NMR spectroscopic techniques. Chem Res Toxicol 3:473-481.
-
(1990)
Chem Res Toxicol
, vol.3
, pp. 473-481
-
-
Harada, K.I.1
Ogawa, K.2
Matsuura, K.3
Murata, H.4
Suzuki, M.5
Watanabe, M.F.6
Itezono, Y.7
Nakayama, N.8
-
54
-
-
27644546445
-
Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclin
-
Hastie CJ, Borthwick EB, Morrison LF, Codd GA, Cohen PTW. (2005). Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclin. Biochim Biophys Acta Gen Subj 1726:187-193.
-
(2005)
Biochim Biophys Acta Gen Subj
, vol.1726
, pp. 187-193
-
-
Hastie, C.J.1
Borthwick, E.B.2
Morrison, L.F.3
Codd, G.A.4
Cohen, P.T.W.5
-
55
-
-
0034192404
-
A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres
-
Hastie CJ, Carnegie GK, Morrice N, Cohen PTW. (2000). A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. Biochem J 347:845-855.
-
(2000)
Biochem J
, vol.347
, pp. 845-855
-
-
Hastie, C.J.1
Carnegie, G.K.2
Morrice, N.3
Cohen, P.T.W.4
-
56
-
-
0032563347
-
Purifcation of protein phosphatase 4 catalytic subunit: Inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters
-
Hastie CJ, Cohen PTW. (1998). Purifcation of protein phosphatase 4 catalytic subunit: Inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett 431: 357-361.
-
(1998)
FEBS Lett
, vol.431
, pp. 357-361
-
-
Hastie, C.J.1
Cohen, P.T.W.2
-
57
-
-
0031799965
-
Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos
-
Helps NR, Brewis ND, Lineruth K, Davis T, Kaiser K, Cohen PTW. (1998). Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J Cell Sci 111:1331-1340.
-
(1998)
J Cell Sci
, vol.111
, pp. 1331-1340
-
-
Helps, N.R.1
Brewis, N.D.2
Lineruth, K.3
Davis, T.4
Kaiser, K.5
Cohen, P.T.W.6
-
58
-
-
64749085585
-
Docking motif-guided mapping of the interactome of protein phosphatase-1
-
Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M. (2009). Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol 16:365-371.
-
(2009)
Chem Biol
, vol.16
, pp. 365-371
-
-
Hendrickx, A.1
Beullens, M.2
Ceulemans, H.3
Den Abt, T.4
Van Eynde, A.5
Nicolaescu, E.6
Lesage, B.7
Bollen, M.8
-
59
-
-
57549101901
-
Norcantharidin analogues: Syn thesis, anticancer activity and protein phosphatase 1 and 2A inhibition
-
Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakof JA, McCluskey A. (2008). Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition. ChemMedChem 3:1878-1892.
-
(2008)
Chem Med Chem
, vol.3
, pp. 1878-1892
-
-
Hill, T.A.1
Stewart, S.G.2
Gordon, C.P.3
Ackland, S.P.4
Gilbert, J.5
Sauer, B.6
Sakof, J.A.7
McCluskey, A.8
-
60
-
-
0025002918
-
Inhibition of protein phosphatases-1 and -2A with acanthifolicin: Comparison with diarrhetic shellfsh toxins and identifcation of a region on okadaic acid important for phosphatase inhibition
-
Holmes CFB, Luu HA, Carrier F, Schmitz FJ. (1990). Inhibition of protein phosphatases-1 and -2A with acanthifolicin: Comparison with diarrhetic shellfsh toxins and identifcation of a region on okadaic acid important for phosphatase inhibition. FEBS Lett 270: 216-218.
-
(1990)
FEBS Lett
, vol.270
, pp. 216-218
-
-
Holmes, C.F.B.1
Luu, H.A.2
Carrier, F.3
Schmitz, F.J.4
-
61
-
-
0027217027
-
Cantharidin, another natural toxin that inhibits the activity of serine threonine protein phosphatases type-1 and type-2a
-
Honkanen RE. (1993). Cantharidin, another natural toxin that inhibits the activity of serine threonine protein phosphatases type-1 and type-2a. FEBS Lett 330:283-286.
-
(1993)
FEBS Lett
, vol.330
, pp. 283-286
-
-
Honkanen, R.E.1
-
62
-
-
0026015352
-
Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases
-
Honkanen RE, Dukelow M, Zwiller J, Moore RE, Khatra BS, Boynton AL. (1991). Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases. Mol Pharmacol 40: 577-583.
-
(1991)
Mol Pharmacol
, vol.40
, pp. 577-583
-
-
Honkanen, R.E.1
Dukelow, M.2
Zwiller, J.3
Moore, R.E.4
Khatra, B.S.5
Boynton, A.L.6
-
63
-
-
0036032778
-
Regulators of serine/threonine protein phosphatases at the dawn of a clinical era
-
Honkanen RE, Golden T. (2002). Regulators of serine/threonine protein phosphatases at the dawn of a clinical era. Curr Med Chem 9:2055-2075.
-
(2002)
Curr Med Chem
, vol.9
, pp. 2055-2075
-
-
Honkanen, R.E.1
Golden, T.2
-
64
-
-
0037126026
-
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
-
Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H. (2002). Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proc Natl Acad Sci USA 99:12037-12042.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12037-12042
-
-
Huai, Q.1
Kim, H.Y.2
Liu, Y.3
Zhao, Y.4
Mondragon, A.5
Liu, J.O.6
Ke, H.7
-
65
-
-
0030963598
-
Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding
-
Huang HB, Horiuchi A, Goldberg J, Greengard P, Nairn AC. (1997). Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding. Proc Natl Acad Sci USA 94:3530-3535.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3530-3535
-
-
Huang, H.B.1
Horiuchi, A.2
Goldberg, J.3
Greengard, P.4
Nairn, A.C.5
-
66
-
-
4344610451
-
Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
-
Huang SL, Shu LL, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ. (2004). Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. J Biol Chem 279:36490-36496.
-
(2004)
J Biol Chem
, vol.279
, pp. 36490-36496
-
-
Huang, S.L.1
Shu, L.L.2
Easton, J.3
Harwood, F.C.4
Germain, G.S.5
Ichijo, H.6
Houghton, P.J.7
-
67
-
-
0031915128
-
Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)
-
Huang XZ, Honkanen RE. (1998). Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC). J Biol Chem 273: 1462-1468.
-
(1998)
J Biol Chem
, vol.273
, pp. 1462-1468
-
-
Huang, X.Z.1
Honkanen, R.E.2
-
68
-
-
72749095543
-
A structural basis for the reduced toxicity of dinophysistoxin-2
-
Huhn J, Jefrey PD, Larsen K, Rundberget T, Rise F, Cox NR, Arcus V, Shi Y, Miles CO. (2009). A structural basis for the reduced toxicity of dinophysistoxin-2. Chem Res Toxicol 22:1782-1786.
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 1782-1786
-
-
Huhn, J.1
Jefrey, P.D.2
Larsen, K.3
Rundberget, T.4
Rise, F.5
Cox, N.R.6
Arcus, V.7
Shi, Y.8
Miles, C.O.9
-
69
-
-
0028838971
-
Protein-kinases and phosphatases-Te yin and yang of protein- phosphorylation and signaling
-
Hunter T. (1995). Protein-kinases and phosphatases-Te yin and yang of protein-phosphorylation and signaling. Cell 80: 225-236.
-
(1995)
Cell
, vol.80
, pp. 225-236
-
-
Hunter, T.1
-
70
-
-
0024517280
-
Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity
-
Ishihara H, Martin BL, Brautigan DL, Karaki H, Ozaki H, Kato Y, Fusetani N, Watabe S, Hashimoto K, Uemura D, Hartshorne DJ. (1989). Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity. Biochem Biophys Res Commun 159:871-877.
-
(1989)
Biochem Biophys Res Commun
, vol.159
, pp. 871-877
-
-
Ishihara, H.1
Martin, B.L.2
Brautigan, D.L.3
Karaki, H.4
Ozaki, H.5
Kato, Y.6
Fusetani, N.7
Watabe, S.8
Hashimoto, K.9
Uemura, D.10
Hartshorne, D.J.11
-
71
-
-
0035252894
-
Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
Janssens V, Goris J. (2001). Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353:417-439.
-
(2001)
Biochem J
, vol.353
, pp. 417-439
-
-
Janssens, V.1
Goris, J.2
-
72
-
-
0037108767
-
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
-
Jin L, Harrison SC. (2002). Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci USA 99:13522-13526.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13522-13526
-
-
Jin, L.1
Harrison, S.C.2
-
73
-
-
18144451569
-
Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil
-
Jochimsen EM, Carmichael WW, An JS, Cardo DM, Cookson ST, Holmes CEM, Antunes MBD, de Melo DA, Lyra TM, Barreto VST, Azevedo S, Jarvis WR. (1998). Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N Engl J Med 338:873-878.
-
(1998)
N Engl J Med
, vol.338
, pp. 873-878
-
-
Jochimsen, E.M.1
Carmichael, W.W.2
An, J.S.3
Cardo, D.M.4
Cookson, S.T.5
Holmes, C.E.M.6
Antunes, M.B.D.7
De Melo, D.A.8
Lyra, T.M.9
Barreto, V.S.T.10
Azevedo, S.11
Jarvis, W.R.12
-
74
-
-
34248338345
-
Treatment of molluscum contagiosum and herpes simplex virus cutaneous infections
-
Jones S, Kress D. (2007). Treatment of molluscum contagiosum and herpes simplex virus cutaneous infections. Cutis 79:11-17.
-
(2007)
Cutis
, vol.79
, pp. 11-17
-
-
Jones, S.1
Kress, D.2
-
75
-
-
64349110787
-
Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity
-
Ju J, Li W, Yuan Q, Peters NR, Hofmann FM, Rajski SR, Osada H, Shen B. (2009). Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. Org Lett 11:1639-1642.
-
(2009)
Org Lett
, vol.11
, pp. 1639-1642
-
-
Ju, J.1
Li, W.2
Yuan, Q.3
Peters, N.R.4
Hofmann, F.M.5
Rajski, S.R.6
Osada, H.7
Shen, B.8
-
76
-
-
38849143925
-
Confrmation of the stereostructure of (+)-cytostatin by fuorous mixture synthesis of four candidate stereoisomers
-
Jung WH, Guyenne S, Riesco-Fagundo C, Mancuso J, Nakamura S, Curran DP. (2008). Confrmation of the stereostructure of (+)-cytostatin by fuorous mixture synthesis of four candidate stereoisomers. Angew Chem 47:1130-1133.
-
(2008)
Angew Chem
, vol.47
, pp. 1130-1133
-
-
Jung, W.H.1
Guyenne, S.2
Riesco-Fagundo, C.3
Mancuso, J.4
Nakamura, S.5
Curran, D.P.6
-
77
-
-
4143117908
-
Structure and mechanism of RNA polymerase IICTD phosphatases
-
Kamenski T, Heilmeier S, Meinhart A, Cramer P. (2004). Structure and mechanism of RNA polymerase IICTD phosphatases. Mol Cell 15:399-407.
-
(2004)
Mol Cell
, vol.15
, pp. 399-407
-
-
Kamenski, T.1
Heilmeier, S.2
Meinhart, A.3
Cramer, P.4
-
78
-
-
0035807022
-
Identifcation of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation
-
Kang H, Sayner SL, Gross KL, Russell LC, Chinkers M. (2001). Identifcation of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation. Biochemistry 40: 10485-10490.
-
(2001)
Biochemistry
, vol.40
, pp. 10485-10490
-
-
Kang, H.1
Sayner, S.L.2
Gross, K.L.3
Russell, L.C.4
Chinkers, M.5
-
79
-
-
0023795469
-
Isolation and structure elucidation of calyculins B, C, and D, novel antitumor metabolites, from the marine sponge Discodermia calyx
-
Kato Y, Fusetani N, Matsunaga S, Hashimoto K, Koseki K. (1988). Isolation and structure elucidation of calyculins B, C, and D, novel antitumor metabolites, from the marine sponge Discodermia calyx. J Org Chem 53:3930-3932.
-
(1988)
J Org Chem
, vol.53
, pp. 3930-3932
-
-
Kato, Y.1
Fusetani, N.2
Matsunaga, S.3
Hashimoto, K.4
Koseki, K.5
-
80
-
-
0032991501
-
Diferential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin
-
Kawada M, Amemiya M, Ishizuka M, Takeuchi T. (1999). Diferential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Jpn J Cancer Res 90:219-225.
-
(1999)
Jpn J Cancer Res
, vol.90
, pp. 219-225
-
-
Kawada, M.1
Amemiya, M.2
Ishizuka, M.3
Takeuchi, T.4
-
81
-
-
57749209868
-
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: A novel scafold for structure-based drug design of serine/threonine phosphatase inhibitors
-
Kelker MS, Page R, Peti W. (2009). Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: A novel scafold for structure-based drug design of serine/threonine phosphatase inhibitors. J Mol Biol 385:11-21.
-
(2009)
J Mol Biol
, vol.385
, pp. 11-21
-
-
Kelker, M.S.1
Page, R.2
Peti, W.3
-
82
-
-
0037335790
-
Archaeal protein kinases and protein phosphatases: Insights from genomics and biochemistry
-
Kennelly PJ. (2003). Archaeal protein kinases and protein phosphatases: Insights from genomics and biochemistry. Biochem J 370:373-389.
-
(2003)
Biochem J
, vol.370
, pp. 373-389
-
-
Kennelly, P.J.1
-
83
-
-
0028848524
-
Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex
-
Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, Gastinel LN, Habuka N, Chen X, Maldonado F, Barker JE, Bacquet R, Villafranca JE. (1995). Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature 378:641-644.
-
(1995)
Nature
, vol.378
, pp. 641-644
-
-
Kissinger, C.R.1
Parge, H.E.2
Knighton, D.R.3
Lewis, C.T.4
Pelletier, L.A.5
Tempczyk, A.6
Kalish, V.J.7
Tucker, K.D.8
Showalter, R.E.9
Moomaw, E.W.10
Gastinel, L.N.11
Habuka, N.12
Chen, X.13
Maldonado, F.14
Barker, J.E.15
Bacquet, R.16
Villafranca, J.E.17
-
84
-
-
0036111253
-
Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1
-
Kita A, Matsunaga S, Takai A, Kataiwa H, Wakimoto T, Fusetani N, Isobe M, Miki K. (2002). Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1. Structure 10:715-724.
-
(2002)
Structure
, vol.10
, pp. 715-724
-
-
Kita, A.1
Matsunaga, S.2
Takai, A.3
Kataiwa, H.4
Wakimoto, T.5
Fusetani, N.6
Isobe, M.7
Miki, K.8
-
85
-
-
0030714161
-
Carboxymethylation of nuclear protein serine/threonine phosphatase X
-
Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE. (1997). Carboxymethylation of nuclear protein serine/threonine phosphatase X. Biochem J 327:481-486.
-
(1997)
Biochem J
, vol.327
, pp. 481-486
-
-
Kloeker, S.1
Bryant, J.C.2
Strack, S.3
Colbran, R.J.4
Wadzinski, B.E.5
-
86
-
-
0033605130
-
Purifcation and identifcation of a novel subunit of protein serine/threonine phosphatase 4
-
Kloeker S, Wadzinski BE. (1999). Purifcation and identifcation of a novel subunit of protein serine/threonine phosphatase 4. J Biol Chem 274:5339-5347.
-
(1999)
J Biol Chem
, vol.274
, pp. 5339-5347
-
-
Kloeker, S.1
Wadzinski, B.E.2
-
87
-
-
26444470525
-
Post-translational generation of constitutively active cores from larger phosphatases in the malaria parasite, Plasmodium falciparum: Implications for proteomics
-
Kumar R, Musiyenko A, Oldenburg A, Adams B, Barik S. (2004). Post-translational generation of constitutively active cores from larger phosphatases in the malaria parasite, Plasmodium falciparum: Implications for proteomics. BMC Mol Biol 5:6.
-
(2004)
BMC Mol Biol
, vol.5
, pp. 6
-
-
Kumar, R.1
Musiyenko, A.2
Oldenburg, A.3
Adams, B.4
Barik, S.5
-
89
-
-
33845928989
-
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition
-
Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. (2006). Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition. J Am Chem Soc 128:16720-16732.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 16720-16732
-
-
Lawhorn, B.G.1
Boga, S.B.2
Wolkenberg, S.E.3
Colby, D.A.4
Gauss, C.M.5
Swingle, M.R.6
Amable, L.7
Honkanen, R.E.8
Boger, D.L.9
-
91
-
-
0036161826
-
Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A
-
Li X, Virshup DM. (2002). Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem 269:546-552.
-
(2002)
Eur J Biochem
, vol.269
, pp. 546-552
-
-
Li, X.1
Virshup, D.M.2
-
92
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. (2005). Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22:1942-1950.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
93
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifes new regulators of apoptosis and chemoresistance
-
MacKeigan JP, Murphy LO, Blenis J. (2005). Sensitized RNAi screen of human kinases and phosphatases identifes new regulators of apoptosis and chemoresistance. Nat Cell Biol 7:591-600.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
94
-
-
0025333146
-
Cyanobacterial microcystin-LR is a potent and specifc inhibitor of protein phosphatase-1 and phosphatase-2a from both mammals and higher-plants
-
Mackintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA. (1990). Cyanobacterial microcystin-LR is a potent and specifc inhibitor of protein phosphatase-1 and phosphatase-2a from both mammals and higher-plants. FEBS Lett 264:187-192.
-
(1990)
FEBS Lett
, vol.264
, pp. 187-192
-
-
MacKintosh, C.1
Beattie, K.A.2
Klumpp, S.3
Cohen, P.4
Codd, G.A.5
-
95
-
-
0025635610
-
Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specifc inhibitor of protein phosphatases 1 and 2A
-
MacKintosh C, Klumpp S. (1990). Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specifc inhibitor of protein phosphatases 1 and 2A. FEBS Lett 277:137-140.
-
(1990)
FEBS Lett
, vol.277
, pp. 137-140
-
-
MacKintosh, C.1
Klumpp, S.2
-
96
-
-
0028089860
-
Inhibitors of protein-kinases and phosphatases
-
Mackintosh C, Mackintosh RW. (1994). Inhibitors of protein-kinases and phosphatases. Trends Biochem Sci 19:444-448.
-
(1994)
Trends Biochem Sci
, vol.19
, pp. 444-448
-
-
MacKintosh, C.1
MacKintosh, R.W.2
-
97
-
-
0029088182
-
Te cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1
-
MacKintosh RW, Dalby KN, Campbell DG, Cohen PTW, Cohen P, MacKintosh C. (1995). Te cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett 371:236-240.
-
(1995)
FEBS Lett
, vol.371
, pp. 236-240
-
-
MacKintosh, R.W.1
Dalby, K.N.2
Campbell, D.G.3
Cohen, P.T.W.4
Cohen, P.5
MacKintosh, C.6
-
99
-
-
0029014647
-
Inhibitory efect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells
-
Masuda T, Watanabe S, Amemiya M, Ishizuka M, Takeuchi T. (1995). Inhibitory efect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells. J Antibiot 48:528-529.
-
(1995)
J Antibiot
, vol.48
, pp. 528-529
-
-
Masuda, T.1
Watanabe, S.2
Amemiya, M.3
Ishizuka, M.4
Takeuchi, T.5
-
100
-
-
0026080853
-
Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2A, from the marine sponge Discodermia calyx
-
Matsunaga S, Fujiki H, Sakata D, Fusetani N. (1991). Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2A, from the marine sponge Discodermia calyx. Tetrahedron 47:2999-3006.
-
(1991)
Tetrahedron
, vol.47
, pp. 2999-3006
-
-
Matsunaga, S.1
Fujiki, H.2
Sakata, D.3
Fusetani, N.4
-
101
-
-
0027946005
-
Tyrsiferyl 23-acetate is a novel specifc inhibitor of protein phosphatase PP2A
-
Matsuzawa SI. (1994). Tyrsiferyl 23-acetate is a novel specifc inhibitor of protein phosphatase PP2A. FEBS Lett 356:272-274.
-
(1994)
FEBS Lett
, vol.356
, pp. 272-274
-
-
Matsuzawa, S.I.1
-
103
-
-
0035941284
-
Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1
-
Maynes JT, Bateman KS, Cherney MM, Das AK, Luu HA, Holmes CFB, James MNG. (2001). Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1. J Biol Chem 276: 44078-44082.
-
(2001)
J Biol Chem
, vol.276
, pp. 44078-44082
-
-
Maynes, J.T.1
Bateman, K.S.2
Cherney, M.M.3
Das, A.K.4
Luu, H.A.5
Holmes, C.F.B.6
James, M.N.G.7
-
104
-
-
30344447686
-
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: Elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins
-
Maynes JT, Luu HA, Cherney MM, Andersen RJ, Williams D, Holmes CFB, James MNG. (2006). Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: Elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. J Mol Biol 356:111-120.
-
(2006)
J Mol Biol
, vol.356
, pp. 111-120
-
-
Maynes, J.T.1
Luu, H.A.2
Cherney, M.M.3
Andersen, R.J.4
Williams, D.5
Holmes, C.F.B.6
James, M.N.G.7
-
105
-
-
5644290640
-
Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding
-
Maynes JT, Perreault KR, Cherny MM, Luu HA, James MNG, Holmes CFB. (2004). Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding. J Biol Chem 279:43198-43206.
-
(2004)
J Biol Chem
, vol.279
, pp. 43198-43206
-
-
Maynes, J.T.1
Perreault, K.R.2
Cherny, M.M.3
Luu, H.A.4
James, M.N.G.5
Holmes, C.F.B.6
-
106
-
-
0037075845
-
Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies
-
McCluskey A, Sim ATR, Sakof JA. (2002). Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. J Med Chem 45:1151-1175.
-
(2002)
J Med Chem
, vol.45
, pp. 1151-1175
-
-
McCluskey, A.1
Atr, S.2
Sakof, J.A.3
-
107
-
-
22344456265
-
A structural perspective of CTD function
-
Meinhart A, Kamenski T, Hoeppner S, Baumli S, Cramer P. (2005). A structural perspective of CTD function. Genes Dev 19:1401-1415.
-
(2005)
Genes Dev
, vol.19
, pp. 1401-1415
-
-
Meinhart, A.1
Kamenski, T.2
Hoeppner, S.3
Baumli, S.4
Cramer, P.5
-
108
-
-
0035929178
-
Tautomycetin is a novel and specifc inhibitor of serine/threonine protein phosphatase type 1, PP1
-
Mitsuhashi S, Matsuura N, Ubukata M, Oikawa H, Shima H, Kikuchi K. (2001). Tautomycetin is a novel and specifc inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem Biophys Res Commun 287:328-331.
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 328-331
-
-
Mitsuhashi, S.1
Matsuura, N.2
Ubukata, M.3
Oikawa, H.4
Shima, H.5
Kikuchi, K.6
-
109
-
-
0034787110
-
Cantharidin revisited: A blistering defense of an ancient medicine
-
Moed L, Shwayder TA, Chang MW. (2001). Cantharidin revisited: A blistering defense of an ancient medicine. Arch Dermatol 137:1357-1360.
-
(2001)
Arch Dermatol
, vol.137
, pp. 1357-1360
-
-
Moed, L.1
Shwayder, T.A.2
Chang, M.W.3
-
111
-
-
0035503696
-
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
-
Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H. (2001). Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J 20:6028-6036.
-
(2001)
EMBO J
, vol.20
, pp. 6028-6036
-
-
Morita, K.1
Saitoh, M.2
Tobiume, K.3
Matsuura, H.4
Enomoto, S.5
Nishitoh, H.6
Ichijo, H.7
-
112
-
-
0042914346
-
Functional expression cloning reveals proapoptotic role for protein phosphatase 4
-
Mourtada-Maarabouni M, Kirkham L, Jenkins B, Rayner J, Gonda TJ, Starr R, Trayner I, Farzaneh F, Williams GT. (2003). Functional expression cloning reveals proapoptotic role for protein phosphatase 4. Cell Death Difer 10:1016-1024.
-
(2003)
Cell Death Difer
, vol.10
, pp. 1016-1024
-
-
Mourtada-Maarabouni, M.1
Kirkham, L.2
Jenkins, B.3
Rayner, J.4
Gonda, T.J.5
Starr, R.6
Trayner, I.7
Farzaneh, F.8
Williams, G.T.9
-
113
-
-
85008014440
-
Identifcation of okadaic acid as a toxic component of a marine dinofagellate Prorocentrum lima
-
Murakami Y, Oshima Y, Yasumoto T. (1982). Identifcation of okadaic acid as a toxic component of a marine dinofagellate Prorocentrum lima. Bull Japan Soc Sci Fish 48:69-72.
-
(1982)
Bull Japan Soc Sci Fish
, vol.48
, pp. 69-72
-
-
Murakami, Y.1
Oshima, Y.2
Yasumoto, T.3
-
114
-
-
0025284251
-
Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane
-
Nam KY, Hiro M, Kimura S, Fujiki H, Imanishi Y. (1990). Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane. Carcinogenesis 11:1171-1174.
-
(1990)
Carcinogenesis
, vol.11
, pp. 1171-1174
-
-
Nam, K.Y.1
Hiro, M.2
Kimura, S.3
Fujiki, H.4
Imanishi, Y.5
-
115
-
-
0000154978
-
Identifcation of 12 hepatotoxins from a homer lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: Nine new microcystins
-
Namikoshi M, Rinehart KL, Sakai R, Stotts RR, Dahlem AM, Beasley VR, Carmichael WW, Evans WR. (1992). Identifcation of 12 hepatotoxins from a homer lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: Nine new microcystins. J Org Chem 57:866-872.
-
(1992)
J Org Chem
, vol.57
, pp. 866-872
-
-
Namikoshi, M.1
Rinehart, K.L.2
Sakai, R.3
Stotts, R.R.4
Dahlem, A.M.5
Beasley, V.R.6
Carmichael, W.W.7
Evans, W.R.8
-
116
-
-
33750456519
-
Global, in vivo, and site-specifc phosphorylation dynamics in signaling networks
-
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M. (2006). Global, in vivo, and site-specifc phosphorylation dynamics in signaling networks. Cell 127:635-648.
-
(2006)
Cell
, vol.127
, pp. 635-648
-
-
Olsen, J.V.1
Blagoev, B.2
Gnad, F.3
MacEk, B.4
Kumar, C.5
Mortensen, P.6
Mann, M.7
-
117
-
-
1842527952
-
Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identifcation of a new B56Agamma subunit (B56Agamma4) specifcally expressed in testis
-
Ortega-La Zaro JC, Del Mazo J. (2003). Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identifcation of a new B56Agamma subunit (B56Agamma4) specifcally expressed in testis. Cytogenet Genome Res 103:345-351.
-
(2003)
Cytogenet Genome Res
, vol.103
, pp. 345-351
-
-
Ortega-La Zaro, J.C.1
Del Mazo, J.2
-
118
-
-
0002357912
-
Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil
-
Pouria S, De Andrade A, Barbosa J, Cavalcanti RL, Barreto VTS, Ward CJ, Preiser W, Poon GK, Neild GH, Codd GA. (1998). Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 352:21-26.
-
(1998)
Lancet
, vol.352
, pp. 21-26
-
-
Pouria, S.1
De Andrade, A.2
Barbosa, J.3
Cavalcanti, R.L.4
Barreto, V.T.S.5
Ward, C.J.6
Preiser, W.7
Poon, G.K.8
Neild, G.H.9
Codd, G.A.10
-
119
-
-
33750076984
-
Te alpha 4 regulatory subunit exerts opposing allosteric efects on protein phosphatases PP6 and PP2A
-
Prickett TD, Brautigan DL. (2006). Te alpha 4 regulatory subunit exerts opposing allosteric efects on protein phosphatases PP6 and PP2A. J Biol Chem 281:30503-30511.
-
(2006)
J Biol Chem
, vol.281
, pp. 30503-30511
-
-
Prickett, T.D.1
Brautigan, D.L.2
-
120
-
-
0027252977
-
Te conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects
-
Quinn RJ, Taylor C, Suganuma M, Fujiki H. (1993). Te conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects. Bioorg Med Chem Lett 3:1029-1034.
-
(1993)
Bioorg Med Chem Lett
, vol.3
, pp. 1029-1034
-
-
Quinn, R.J.1
Taylor, C.2
Suganuma, M.3
Fujiki, H.4
-
121
-
-
0037197702
-
Identifcation of potential physiological activators of protein phosphatase 5
-
Ramsey AJ, Chinkers M. (2002). Identifcation of potential physiological activators of protein phosphatase 5. Biochemistry 41:5625-5632.
-
(2002)
Biochemistry
, vol.41
, pp. 5625-5632
-
-
Ramsey, A.J.1
Chinkers, M.2
-
122
-
-
0347635514
-
Phylogenetic evidence for the early evolution of microcystin synthesis
-
Rantala A, Fewer DP, Hisbergues M, Rouhiainen L, Vaitomaa J, Borner T, Sivonen K. (2004). Phylogenetic evidence for the early evolution of microcystin synthesis. Proc Natl Acad Sci USA 101:568-573.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 568-573
-
-
Rantala, A.1
Fewer, D.P.2
Hisbergues, M.3
Rouhiainen, L.4
Vaitomaa, J.5
Borner, T.6
Sivonen, K.7
-
123
-
-
0000483177
-
Structure and biosynthesis of toxins from blue-green algae (cyanobacteria)
-
Rinehart KL, Namikoshi M, Choi BW. (1994). Structure and biosynthesis of toxins from blue-green algae (cyanobacteria). J Appl Phycol 6:159-176.
-
(1994)
J Appl Phycol
, vol.6
, pp. 159-176
-
-
Rinehart, K.L.1
Namikoshi, M.2
Choi, B.W.3
-
124
-
-
0028806986
-
Microcystin uptake and inhibition of protein phosphatases: Efects of chemoprotectants and self-inhibition in relation to known hepatic transporters
-
Runnegar M, Berndt N, Kaplowitz N. (1995). Microcystin uptake and inhibition of protein phosphatases: Efects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol 134:264-272.
-
(1995)
Toxicol Appl Pharmacol
, vol.134
, pp. 264-272
-
-
Runnegar, M.1
Berndt, N.2
Kaplowitz, N.3
-
125
-
-
0028863478
-
In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A
-
Runnegar M, Berndt N, Kong SM, Lee EYC, Zhang L. (1995). In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A. Biochem Biophys Res Commun 216:162-169.
-
(1995)
Biochem Biophys Res Commun
, vol.216
, pp. 162-169
-
-
Runnegar, M.1
Berndt, N.2
Kong, S.M.3
Lee, E.Y.C.4
Zhang, L.5
-
126
-
-
0023375195
-
Te neighbor-joining method: A new method for reconstructing phylogenetic trees
-
Saitou N, Nei M. (1987). Te neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol Biol Evol 4: 406-425.
-
(1987)
Mol Biol Evol
, vol.4
, pp. 406-425
-
-
Saitou, N.1
Nei, M.2
-
127
-
-
33748442867
-
Cytotoxicity of cantharidin analogues targeting protein phosphatase 2A
-
Shan HB, Cai YC, Liu Y, Zeng WN, Chen HX, Fan BT, Liu XH, Xu ZL, Wang B, Xian LJ. (2006). Cytotoxicity of cantharidin analogues targeting protein phosphatase 2A. Anti-Cancer Drugs 17:905-911.
-
(2006)
Anti-Cancer Drugs
, vol.17
, pp. 905-911
-
-
Shan, H.B.1
Cai, Y.C.2
Liu, Y.3
Zeng, W.N.4
Chen, H.X.5
Fan, B.T.6
Liu, X.H.7
Xu, Z.L.8
Wang, B.9
Xian, L.J.10
-
128
-
-
0036679005
-
Immunosuppressive efects of tautomycetin in vivo and in vitro via T cell-specifc apoptosis induction
-
Shim J-H, Lee H-K, Chang, E-J, Chae W-J, Han, J-H, Han D-J, Morio T, Yang J-J, Bothwell A, Lee S-K. (2002). Immunosuppressive efects of tautomycetin in vivo and in vitro via T cell-specifc apoptosis induction. Proc Natl Acad Sci USA 99:10617-10622.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10617-10622
-
-
Shim, J.-H.1
Lee, H.-K.2
Chang, E.-J.3
Chae, W.-J.4
Han, J.-H.5
Han, D.-J.6
Morio, T.7
Yang, J.-J.8
Bothwell, A.9
Lee, S.-K.10
-
129
-
-
0028169615
-
Characterization of the PP2Aα gene mutation in okadaic acid-resistant variants of CHO-K1 cells
-
Shima H, Tohda H, Aonuma S, Nakayasu M, Depaoli-Roach AA, Sugimura T, Nagao M. (1994). Characterization of the PP2Aα gene mutation in okadaic acid-resistant variants of CHO-K1 cells. Proc Natl Acad Sci USA 91:9267-9271.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9267-9271
-
-
Shima, H.1
Tohda, H.2
Aonuma, S.3
Nakayasu, M.4
Depaoli-Roach, A.A.5
Sugimura, T.6
Nagao, M.7
-
130
-
-
0033551778
-
Te tetratricopeptide repeat domain and a C-terminal region control the activity of Ser/Tr protein phosphatase 5
-
Sinclair C, Borchers C, Parker C, Tomer K, Charbonneau H, Rossie S. (1999). Te tetratricopeptide repeat domain and a C-terminal region control the activity of Ser/Tr protein phosphatase 5. J Biol Chem 274:23666-23672.
-
(1999)
J Biol Chem
, vol.274
, pp. 23666-23672
-
-
Sinclair, C.1
Borchers, C.2
Parker, C.3
Tomer, K.4
Charbonneau, H.5
Rossie, S.6
-
131
-
-
0030451563
-
Yeast protein serine/threonine phosphatases: Multiple roles and diverse regulation
-
Stark MJR. (1996). Yeast protein serine/threonine phosphatases: Multiple roles and diverse regulation. Yeast 12:1647-1675.
-
(1996)
Yeast
, vol.12
, pp. 1647-1675
-
-
Stark, M.J.R.1
-
132
-
-
33747334635
-
Protein phosphatase 6 subunit with conserved sit4-associated protein domain targets i kappa B epsilon
-
Stefansson B, Brautigan DL. (2006). Protein phosphatase 6 subunit with conserved sit4-associated protein domain targets I kappa B epsilon. J Biol Chem 281:22624-22634.
-
(2006)
J Biol Chem
, vol.281
, pp. 22624-22634
-
-
Stefansson, B.1
Brautigan, D.L.2
-
133
-
-
38849182807
-
Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains
-
Stefansson B, Ohama T, Daugherty AE, Brautigan DL. (2008). Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry 47:1442-1451.
-
(2008)
Biochemistry
, vol.47
, pp. 1442-1451
-
-
Stefansson, B.1
Ohama, T.2
Daugherty, A.E.3
Brautigan, D.L.4
-
134
-
-
33845881426
-
Evolution of the metazoan protein phosphatase 2C superfamily
-
Stern A, Privman E, Rasis M, Lavi S, Pupko T. (2007). Evolution of the metazoan protein phosphatase 2C superfamily. J Mol Evol 64:61-70.
-
(2007)
J Mol Evol
, vol.64
, pp. 61-70
-
-
Stern, A.1
Privman, E.2
Rasis, M.3
Lavi, S.4
Pupko, T.5
-
135
-
-
11144358198
-
A gene atlas of the mouse and human protein-encoding transcriptomes
-
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. (2004). A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA 101:6062-6067.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6062-6067
-
-
Su, A.I.1
Wiltshire, T.2
Batalov, S.3
Lapp, H.4
Ching, K.A.5
Block, D.6
Zhang, J.7
Soden, R.8
Hayakawa, M.9
Kreiman, G.10
Cooke, M.P.11
Walker, J.R.12
Hogenesch, J.B.13
-
136
-
-
0030035016
-
Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor
-
Sugiyama Y, Ohtani II, Isobe M, Takai A, Ubukata M, Isono K. (1996). Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor. Bioorg Med Chem Lett 6:3-8.
-
(1996)
Bioorg Med Chem Lett
, vol.6
, pp. 3-8
-
-
Sugiyama, Y.1
Ohtani, I.I.2
Isobe, M.3
Takai, A.4
Ubukata, M.5
Isono, K.6
-
137
-
-
0021960098
-
Teurilene and thyrsiferyl 23-acetate, meso and remarkably cytotoxic compounds from the marine red alga Laurencia obtusa (Hudson) Lamouroux
-
Suzuki T, Suzuki M, Furusaki A. (1985). Teurilene and thyrsiferyl 23-acetate, meso and remarkably cytotoxic compounds from the marine red alga Laurencia obtusa (Hudson) Lamouroux. Tetrahedron Lett 26:1329-1332.
-
(1985)
Tetrahedron Lett
, vol.26
, pp. 1329-1332
-
-
Suzuki, T.1
Suzuki, M.2
Furusaki, A.3
-
138
-
-
34447275978
-
Small molecule inhibitors of ser/thr protein phosphatases: Specifcity, use and common forms of abuse
-
Swingle M, Ni L, Honkanen RE. (2007). Small molecule inhibitors of ser/thr protein phosphatases: Specifcity, use and common forms of abuse. Methods Mol Biol 365:23-38.
-
(2007)
Methods Mol Biol
, vol.365
, pp. 23-38
-
-
Swingle, M.1
Ni, L.2
Honkanen, R.E.3
-
139
-
-
70349312573
-
Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and (β12-β13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors
-
Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE. (2009). Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and (β12-β13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. J Pharmacol Exp Ter 331: 45-53.
-
(2009)
J Pharmacol Exp ter
, vol.331
, pp. 45-53
-
-
Swingle, M.R.1
Amable, L.2
Lawhorn, B.G.3
Buck, S.B.4
Burke, C.P.5
Ratti, P.6
Fischer, K.L.7
Boger, D.L.8
Honkanen, R.E.9
-
140
-
-
4043101125
-
Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5
-
Swingle MR, Honkanen RE, Ciszak EM. (2004). Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5. J Biol Chem 279:33992-33999.
-
(2004)
J Biol Chem
, vol.279
, pp. 33992-33999
-
-
Swingle, M.R.1
Honkanen, R.E.2
Ciszak, E.M.3
-
141
-
-
0019443232
-
Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria
-
Tachibana K, Scheuer PJ, Tsukitani Y, Kikuchi H, Van Engen D, Clardy J, Gopichand Y, Schmitz FJ. (1981). Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria. J Am Chem Soc 103:2469-2471.
-
(1981)
J Am Chem Soc
, vol.103
, pp. 2469-2471
-
-
Tachibana, K.1
Scheuer, P.J.2
Tsukitani, Y.3
Kikuchi, H.4
Van Engen, D.5
Clardy, J.6
Gopichand, Y.7
Schmitz, F.J.8
-
142
-
-
34547781750
-
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0
-
Tamura K, Dudley J, Nei M, Kumar S. (2007). MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24:1596-1599.
-
(2007)
Mol Biol Evol
, vol.24
, pp. 1596-1599
-
-
Tamura, K.1
Dudley, J.2
Nei, M.3
Kumar, S.4
-
144
-
-
3042547846
-
Structural basis of protein phosphatase 1 regulation
-
Terrak M, Kerf F, Langsetmo K, Tao T, Dominguez R. (2004). Structural basis of protein phosphatase 1 regulation. Nature 429:780-784.
-
(2004)
Nature
, vol.429
, pp. 780-784
-
-
Terrak, M.1
Kerf, F.2
Langsetmo, K.3
Tao, T.4
Dominguez, R.5
-
145
-
-
17644377575
-
Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells
-
Teruya T, Simizu S, Kanoh N, Osada H. (2005). Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells. FEBS Lett 579:2463-2468.
-
(2005)
FEBS Lett
, vol.579
, pp. 2463-2468
-
-
Teruya, T.1
Simizu, S.2
Kanoh, N.3
Osada, H.4
-
146
-
-
0034331359
-
Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits
-
Tolstykh T, Lee J, Vafai S, Stock JB. (2000). Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J 19:5682-5691.
-
(2000)
EMBO J
, vol.19
, pp. 5682-5691
-
-
Tolstykh, T.1
Lee, J.2
Vafai, S.3
Stock, J.B.4
-
147
-
-
33750299450
-
Protein tyrosine phosphatases: From genes, to function, to disease
-
Tonks NK. (2006). Protein tyrosine phosphatases: From genes, to function, to disease. Nat Rev Mol Cell Biol 7:833-846.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 833-846
-
-
Tonks, N.K.1
-
148
-
-
0025340581
-
Te structure of tautomycin, a regulator of eukaryotic cell growth
-
Ubukata M, Cheng XC, Isono K. (1990). Te structure of tautomycin, a regulator of eukaryotic cell growth. J Chem Soc Chem Commun xx:244-246.
-
(1990)
J Chem Soc Chem Commun
, vol.20
, pp. 244-246
-
-
Ubukata, M.1
Cheng, X.C.2
Isono, K.3
-
149
-
-
0030006616
-
Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay
-
Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe MF, Park HD, Chen GC, Chen G, Yu SZ. (1996). Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 17:1317-1321.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1317-1321
-
-
Ueno, Y.1
Nagata, S.2
Tsutsumi, T.3
Hasegawa, A.4
Watanabe, M.F.5
Park, H.D.6
Chen, G.C.7
Chen, G.8
Yu, S.Z.9
-
150
-
-
0038660681
-
Identifcation of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression
-
Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE. (2003). Identifcation of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression. J Biol Chem 278:9747-9753.
-
(2003)
J Biol Chem
, vol.278
, pp. 9747-9753
-
-
Urban, G.1
Golden, T.2
Aragon, I.V.3
Cowsert, L.4
Cooper, S.R.5
Dean, N.M.6
Honkanen, R.E.7
-
151
-
-
0032981362
-
Protein phosphatase 2A inhibitors, phoslactomycins. efects on the cytoskeleton in NIH/3T3 cells
-
Usui T, Marriott G, Inagaki M, Swarup G, Osada H. (1999). Protein phosphatase 2A inhibitors, phoslactomycins. efects on the cytoskeleton in NIH/3T3 cells. J Biochem 125:960-965.
-
(1999)
J Biochem
, vol.125
, pp. 960-965
-
-
Usui, T.1
Marriott, G.2
Inagaki, M.3
Swarup, G.4
Osada, H.5
-
152
-
-
33846459471
-
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells
-
Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, Beullens M, Kaufman RJ, Bollen M, Schuit FC. (2007). Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells. Endocrinology 148:609-617.
-
(2007)
Endocrinology
, vol.148
, pp. 609-617
-
-
Vander Mierde, D.1
Scheuner, D.2
Quintens, R.3
Patel, R.4
Song, B.5
Tsukamoto, K.6
Beullens, M.7
Kaufman, R.J.8
Bollen, M.9
Schuit, F.C.10
-
153
-
-
0034908990
-
Impact of a toxic and a non-toxic strain of Microcystis aeruginosa on the crayfsh Procambarus clarkii
-
Vasconcelos V, Oliveira S, Teles FO. (2001). Impact of a toxic and a non-toxic strain of Microcystis aeruginosa on the crayfsh Procambarus clarkii. Toxicon 39:1461-1470.
-
(2001)
Toxicon
, vol.39
, pp. 1461-1470
-
-
Vasconcelos, V.1
Oliveira, S.2
Teles, F.O.3
-
154
-
-
0029035276
-
Uptake and depuration of the heptapeptide toxin microcystin-LR in Mytilus galloprovincialis
-
Vasconcelos VM. (1995). Uptake and depuration of the heptapeptide toxin microcystin-LR in Mytilus galloprovincialis. Aquat Toxicol 32:227-237.
-
(1995)
Aquat Toxicol
, vol.32
, pp. 227-237
-
-
Vasconcelos, V.M.1
-
155
-
-
0036009335
-
Insight into binding of calyculin A to protein phosphatase 1: Isolation of hemicalyculin A and chemical transformation of calyculin A
-
Wakimoto T, Matsunaga S, Takai A, Fusetani N. (2002). Insight into binding of calyculin A to protein phosphatase 1: Isolation of hemicalyculin A and chemical transformation of calyculin A. Chem Biol 9:309-319.
-
(2002)
Chem Biol
, vol.9
, pp. 309-319
-
-
Wakimoto, T.1
Matsunaga, S.2
Takai, A.3
Fusetani, N.4
-
156
-
-
0030720062
-
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A
-
Walsh AH, Cheng A, Honkanen RE. (1997). Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett 416:230-234.
-
(1997)
FEBS Lett
, vol.416
, pp. 230-234
-
-
Walsh, A.H.1
Cheng, A.2
Honkanen, R.E.3
-
157
-
-
0024428817
-
Medical uses of mylabris in ancient China and recent studies
-
Wang GS. (1989). Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol 26:147-162.
-
(1989)
J Ethnopharmacol
, vol.26
, pp. 147-162
-
-
Wang, G.S.1
-
158
-
-
0842320995
-
DNA-PKcs function regulated specifcally by protein phosphatase 5
-
Wechsler T, Chen BPC, Harper R, Morotomi-Yano K, Huang BCB, Meek K, Cleaver JE, Chen DJ, Wabl M. (2004). DNA-PKcs function regulated specifcally by protein phosphatase 5. Proc Natl Acad Sci USA 101:1247-1252.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1247-1252
-
-
Wechsler, T.1
Chen, B.P.C.2
Harper, R.3
Morotomi-Yano, K.4
Huang, B.C.B.5
Meek, K.6
Cleaver, J.E.7
Chen, D.J.8
Wabl, M.9
-
159
-
-
33750006297
-
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
-
Xing Y, Xu YH, Chen Y, Jefrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi YG. (2006). Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell 127:341-353.
-
(2006)
Cell
, vol.127
, pp. 341-353
-
-
Xing, Y.1
Xu, Y.H.2
Chen, Y.3
Jefrey, P.D.4
Chao, Y.5
Lin, Z.6
Li, Z.7
Strack, S.8
Stock, J.B.9
Shi, Y.G.10
-
160
-
-
0034015738
-
Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins
-
Xu L, Lam PKS, Chen J, Zhang Y, Harada K. (2000). Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon idellus) and mouse protein phosphatases by microcystins. Environ Toxicol 15:71-75.
-
(2000)
Environ Toxicol
, vol.15
, pp. 71-75
-
-
Xu, L.1
Pks, L.2
Chen, J.3
Zhang, Y.4
Harada, K.5
-
161
-
-
33845404441
-
Structure of the protein phosphatase 2A holoenzyme
-
Xu YH, Xing YN, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jefrey PD, Shi YG. (2006). Structure of the protein phosphatase 2A holoenzyme. Cell 127:1239-1251.
-
(2006)
Cell
, vol.127
, pp. 1239-1251
-
-
Xu, Y.H.1
Xing, Y.N.2
Chen, Y.3
Chao, Y.4
Lin, Z.5
Fan, E.6
Yu, J.W.7
Strack, S.8
Jefrey, P.D.9
Shi, Y.G.10
-
162
-
-
0037031156
-
G alpha and G alpha(13) interact with Ser/Tr protein phosphatase type 5 and stimulate its phosphatase activity
-
Yamaguchi Y, Katoh H, Mori K, Negishi M. (2002). G alpha and G alpha(13) interact with Ser/Tr protein phosphatase type 5 and stimulate its phosphatase activity. Curr Biol 12: 1353-1358.
-
(2002)
Curr Biol
, vol.12
, pp. 1353-1358
-
-
Yamaguchi, Y.1
Katoh, H.2
Mori, K.3
Negishi, M.4
-
163
-
-
13244253758
-
Molecular basis for TPR domain-mediated regulation of protein phosphatase
-
Yang J, Roe SM, Clif MJ, Williams MA, Ladbury JE, Cohen PTW, Barford D. (2005). Molecular basis for TPR domain-mediated regulation of protein phosphatase. EMBO J 24:1-10.
-
(2005)
EMBO J
, vol.24
, pp. 1-10
-
-
Yang, J.1
Roe, S.M.2
Clif, M.J.3
Williams, M.A.4
Ladbury, J.E.5
Cohen, P.T.W.6
Barford, D.7
-
164
-
-
0348013155
-
PP2A: B56E is required for Wnt/beta-catenin signaling during embryonic development
-
Yang J, Wu J, Tan C, Klein PS. (2003). PP2A: B56E is required for Wnt/beta-catenin signaling during embryonic development. Development 130:5569-5578.
-
(2003)
Development
, vol.130
, pp. 5569-5578
-
-
Yang, J.1
Wu, J.2
Tan, C.3
Klein, P.S.4
-
165
-
-
0028818446
-
Primary prevention of hepatocellular carcinoma
-
Yu SZ. (1995). Primary prevention of hepatocellular carcinoma. J Gastroenterol Hepatol 10:674-682.
-
(1995)
J Gastroenterol Hepatol
, vol.10
, pp. 674-682
-
-
Yu, S.Z.1
-
166
-
-
12744273395
-
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
-
Zeke T, Morrice N, Vazquez-Martin C, Cohen PTW. (2005). Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. Biochem J 385:45-56.
-
(2005)
Biochem J
, vol.385
, pp. 45-56
-
-
Zeke, T.1
Morrice, N.2
Vazquez-Martin, C.3
Cohen, P.T.W.4
-
167
-
-
0030065764
-
Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins
-
Zhang L, Zhang Z, Long F, Lee EYC. (1996). Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins. Biochemistry 35:1606-1611.
-
(1996)
Biochemistry
, vol.35
, pp. 1606-1611
-
-
Zhang, L.1
Zhang, Z.2
Long, F.3
Eyc, L.4
-
168
-
-
0028298882
-
A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity
-
Zhang Z, Zhao S, Long F, Zhang L, Bai G, Shima H, Nagao M, Lee EYC. (1994). A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity. J Biol Chem 269:16997-17000.
-
(1994)
J Biol Chem
, vol.269
, pp. 16997-17000
-
-
Zhang, Z.1
Zhao, S.2
Long, F.3
Zhang, L.4
Bai, G.5
Shima, H.6
Nagao, M.7
Eyc, L.8
-
169
-
-
0031266991
-
Human blue-light photoreceptor hCRY2 specifcally interacts with protein
-
Zhao SY, Sancar A. (1997). Human blue-light photoreceptor hCRY2 specifcally interacts with protein serine/threonine phosphatase 5 and modulates its activity. Photochem Photobiol 66: 727-731.
-
(1997)
Photochem Photobiol
, vol.66
, pp. 727-731
-
-
Zhao, S.Y.1
Sancar, A.2
-
170
-
-
8744271485
-
Ser/Tr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade
-
Zhou GF, Golden T, Aragon IV, Honkanen RE. (2004). Ser/Tr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. J Biol Chem 279:46595-46605.
-
(2004)
J Biol Chem
, vol.279
, pp. 46595-46605
-
-
Zhou, G.F.1
Golden, T.2
Aragon, I.V.3
Honkanen, R.E.4
-
171
-
-
0032524677
-
Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest
-
Zuo Z, Dean NM, Honkanen RE. (1998). Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest. J Biol Chem 273:12250-12258.
-
(1998)
J Biol Chem
, vol.273
, pp. 12250-12258
-
-
Zuo, Z.1
Dean, N.M.2
Honkanen, R.E.3
-
172
-
-
0040370216
-
Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest
-
DOI 10.1021/bi990842e
-
Zuo Z, Urban G, Scammell JG, Dean NM, McLean TK, Aragon I, Honkanen RE. (1999). Ser/Tr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest. Biochemistry 38:8849-8857. (Pubitemid 29334645)
-
(1999)
Biochemistry
, vol.38
, Issue.28
, pp. 8849-8857
-
-
Zuo, Z.1
Urban, G.2
Scammell, J.G.3
Dean, N.M.4
McLean, T.K.5
Aragon, I.6
Honkanen, R.E.7
-
173
-
-
11244346943
-
Hepatotoxic cyanobacteria: A review of the biological importance of microcystins in freshwater environments
-
Zurawell RW, Chen HR, Burke JM, Prepas EE. (2005). Hepatotoxic cyanobacteria: A review of the biological importance of microcystins in freshwater environments. J Toxicol Environ Health B Crit Rev 8:1-37.
-
(2005)
J Toxicol Environ Health B Crit Rev
, vol.8
, pp. 1-37
-
-
Zurawell, R.W.1
Chen, H.R.2
Burke, J.M.3
Prepas, E.E.4
|