Crystal Structure of the Tumor-promoter Okadaic Acid Bound to Protein Phosphatase-1

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 44078-44082

  Maynes, Jason T ^a   Bateman, Katherine S ^a,c   Cherney, Maia M ^a   Das, Amit K ^b   Luu, Hue Anh ^a   Holmes, Charles F B ^a   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b INDIAN INSTITUTE OF TECHNOLOGY   (India)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; HYDROGEN BONDS; HYDROPHOBICITY; METABOLISM; MICROORGANISMS; ORGANIC ACIDS; PROTEINS; TUMORS;

CYCLIC STRUCTURE; MUSCLE CONTRACTION;

BIOCHEMISTRY;

CALCINEURIN; CYANOGINOSIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; TUMOR PROMOTER; CARCINOGEN; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; CELL CYCLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; DIARRHEA; DRUG PROTEIN BINDING; DRUG SELECTIVITY; FOOD POISONING; GLYCOGEN METABOLISM; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SHELLFISH; SMOOTH MUSCLE CONTRACTION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; X RAY CRYSTALLOGRAPHY;

CARCINOGENS; CRYSTALLOGRAPHY, X-RAY; MOLECULAR STRUCTURE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE;

EID: 0035941284     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107656200     Document Type: Article

References (36)

1. Dawson, J. F., and Holmes, C. F. B. (1999) Front. Biosci. 4, 646-658
2. Sheppeck, J. E., Gauss, C., and Chamberlain, R. A. (1997) Bioorg. Med. Chem. 5, 1739-1750
3. Suganuma, M., Fujiki, H., Suguri, H., Yoshizawa, S., Hirota, M., Nakayasu, M., Ojika, M., Wakamatsu, K., Yamado, K., and Sugimura, T. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 1768-1771
4. Cohen, P., Tsukitani, Y., Holmes, C. F. B. (1990) Trends Biochem. Sci. 15, 98-102
5. Takai, A., Bialojan, C., Troschka, M., and Ruegg, J. C. (1987) FEBS Lett. 217, 81-84
6. Tachibana, K., Scheuer, P. J., Tsukitani, Y., Kikuchi, H., Van Enden, D., Clardy, J., Gopichand, Y., and Schmitz, F. J. (1981) J. Am. Chem. Soc. 103, 2469-2471
7. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzmol. 277, 505-524
8. Goldberg, J., Huang, H., Kwon, Y., Greengard, P., Nairn, A. C., and Kuriyan, J. (1995) Nature 376, 745-753
9. Craig, M., Luu, H. A., McCready, T. L., Williams, D., Andersen, R. J., and Holmes, C. F. B. (1996) Biochem. Cell Biol. 74, 569-578
10. Dawson, J. F. (1998) Regulation of Protein Phosphatase-1 by Reversible Phosphorylation and Marine Toxins, Ph.D. thesis, University of Alberta, Edmonton, Alberta, Canada
11. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
12. Navaza, J., and Saludjian, P. (1997) Methods Enzymol. 276, 581-594
13. Brunger, A. T., Adams, P. D., Clore, G. M., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D 54, 905-921
14. McRee, D. E. (1993) Practical Protein Crystallography, pp. 303-310, Academic Press, San Diego, CA
15. Hooft, R. W. W, Vriend, G., Sander, C., and Abola, E. E. (1996) Nature 381, 272
16. Laskowski, R. A., MacArthur, M. W., Moss, D. S., Thornton, J. M. J. (1993) J. Appl. Crystallogr. 26, 283-291
17. Egloff, M., Cohen, P. T. W., Reinemer, P., and Barford, D. (1995) J. Mol. Biol. 254, 942-959
18. Griffith, J. P., Kim, J. L., Kim, E. E., Sintchak, M. D., Thomson, J. A., Fitzgibbon, M. J., Fleming, M. A., Caron, P. R., Hsiao, K., Navia, M. A. (1995) Cell 82, 507-522
19. Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., Moomaw, E. W. (1995) Nature 378, 641-644
20. Nishiwaki, S., Fujiki, H., Suganuma, M., Furuya-Suguri, H., Matsushima, R., Iida, Y., Ojika, M., Yamada, K., Uemura, D., and Yasumoto, T. (1990) Carcinogenesis 11, 1837-1841
21. Lindvall, M. K., Pihko, P. M., and Koskinen, A. M. P. (1997) J. Biol. Chem. 272, 23312-23316
22. Zhang, L., Zhang, Z., Long, F., and Lee, E. Y. C. (1996) Biochemistry 35, 1606-1611
23. Evans, D. R. H., and Simon, J. A. (2001) FEBS Lett. 498, 110-115
24. Takai, A., Murata, M., Torigoe, K., Isobe, M., Mieskes, G., and Yasumoto, T. (1992) Biochem. J. 284, 539-544
25. Huang, H., Horiuchi, A., Goldberg, J., Greengard, P., and Nairn, A. C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3530-3535
26. Connor, J. H., Kleeman, T., Barik, S., Honkanen, R. E., and Shenolikar, S. (1999) J. Biol. Chem. 274, 22366-22372
27. Lee, E. Y., Zhang, L., Zhao, S., Wei, Q., Zhang, J., Qi, Z. Q., and Belmonte, E. R. (1999) Front. Biosci. 15, D270-D285
28. Holmes, C. F. B., and Boland, M. P. (1993) Curr. Opin. Struc. Biol. 3, 934-943
29. Gauss, C., Sheppeck, J. E., Nairn, A. C., and Chamberlin, R. (1997) Bioorg. Med. Chem. 5, 1751-1773
30. Gupta, V., Ogawa, A. K., Du, X., Houk, K. N., and Armstrong, R. W. (1997) J. Med. Chem. 40, 3199-3206
31. Bagu, J. R., Sykes, B. D., Craig, M. M., and Holmes, C. F. B. (1997) J. Biol. Chem. 272, 5087-5097
32. Quinn, R., Taylor, C., Suganuma, M., and Fujiki, H. (1993) Bioorg. Med. Chem. Lett. 3, 1029-1034
33. Bialojan, C., and Takai, A. (1988) Biochem. J. 256, 283-290
34. Kraulis, P. J. (1991) J. Appl. Cryst. 24, 946-950
35. Esnouf, R. M. (1997) J. Mol. Graph. Model. 15, 132
36. Nicholls, A., Sharp, K., and Honig, B. (1991) Proteins Struct. Funct. Genet. 11, 281