A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 1 58-1, 2005, Pages

  Gigena, Marisa S ^a   Ito, Akihiko ^b   Nojima, Hiroshi ^c   Rogers, Terry B ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HEMAGGLUTININ; MONOCLONAL ANTIBODY; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHORUS 32; POLYCLONAL ANTIBODY;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME SUBUNIT; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSGENE; VIRUS RECOMBINANT;

AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; GENE TRANSFER TECHNIQUES; HUMANS; ISOENZYMES; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; PHOSPHOPROTEIN PHOSPHATASE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 21644448038     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01291.2004     Document Type: Article

References (40)

1. Bollen M and Beullens M. Signaling by protein phosphatases in the nucleus. Trends Cell Biol 12: 138-145, 2002.
2. 2+ oscillations. Science 279: 227-230, 1998.
3. Ding JH, Xu X, Yang D, Chu PH, Dalton ND, Ye Z, Yeakley JM, Cheng H, Xiao RP, Ross J, Chen J, and Fu XD. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J 23: 885-896, 2004.
4. DuBell WH, Gigena MS, Guatimosim S, Long XL, Lederer WJ, and Rogers TB. Effects of the PP1/PP2A inhibitor calyculin A on the EC-coupling cascade in murine ventricular myocytes. Am J Physiol Heart Circ Physiol 282: H38-H48, 2002.
5. DuBell WH, Lederer WJ, and Rogers TB. Dynamic modulation of cardiac excitation-contraction coupling by protein phosphatases. J Physiol 493: 793-800, 1996.
6. DuBell WH, Lewartowski B, Spurgeon HA, Silverman HS, and Lakatta EG. Repletion of sarcoplasmic reticulum Ca after ryanodine in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 265: H604-H615, 1993.
7. + currents in rat ventricular myocytes. J Physiol 501: 509-516, 1997.
8. Eilbracht JE and Schmidt-Zachmann MS. Identification of a sequence element directing a protein to nuclear speckles. Proc Natl Acad Sci USA 98: 3849-3854, 2001.
9. Evans DR and Hemmings BA. Mutation of the C-terminal leucine residue of PP2Ac inhibits PR55/B subunit binding and confers supersensitivity to microtubule destabilization in Saccharomyces cerevisiae. Mol Gen Genet 264: 425-432, 2000.
10. Gigena MS and Rogers TB. Localization of PP2A targeting subunits, B56α and B56γ1, to cardiac sarcomere regions. Biophys J 82: 595a, 2002.
11. Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, Polyakova V, Bauer EP, Klovekorn WP, and Schaper J. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107: 984-991, 2003.
12. Ito A, Kataoka TR, Watanabe M, Mazur W, Sabe H, Kitamura Y, and Nojima H. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J 19: 562-571, 2000.
13. Ito A, Koma YI, Sohda M, Watabe K, Nagano T, Misumi Y, Nojima H, and Kitamura Y. Localization of the PP2A B56γ regulatory subunit at the Golgi complex. Am J Pathol 162: 479-489, 2003.
14. Kamibayashi C, Estes R, Lickteig RL, Yang SI, Craft C, and Mumby MC. Comparison of heterotrimeric protein phosphatase 2A containing different B subunits. J Biol Chem 269: 20139-20148, 1994.
15. Kohomoto O, Levi AJ, and Bridge JH. Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circ Res 74: 550-554, 1994.
16. Kohout TA, O'Brian JR, Gaa ST, Lederer WJ, and Rogers TB. A novel adenovirus component system that transfects cultured cardiac cells with high efficiency. Circ Res 78: 971-977, 1996.
17. Lamond AI and Earnshaw WC. Structure and function in the nucleus. Science 280: 547-553, 1998.
18. Lamond AI and Spector DL. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 4: 605-612, 2003.
19. 1 receptors in cardiomyocytes: role for p38 MAPK. Am J Physiol Heart Circ Physiol 285: H97-H103, 2003.
20. Liu Q and Hofmann PA, Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol 286: H2204-H2212, 2004.
21. McCright B, Brothman AR, and Virshup DM. Assignment of human protein phosphatase 2A regulatory subunit genes b56α, b56β, b56γ, b56δ, and b56ε (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p112 → p12. Genomics 36: 168-170, 1996.
22. McCright B, Rivers AM, Audlin S, and Virshup DM. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation- induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem 271: 22081-22089, 1996.
23. McCright B and Virshup DM. Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem 270: 26123-26128, 1995.
24. Millward TA, Zolnierowicz S, and Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 24: 186-191, 1999.
25. Mintz PJ, Patterson SD, Neuwald AF, Spahr CS, and Spector DL. Purification and biochemical characterization of interchromation granule clusters. EMBO J 18: 4308-4320, 2002.
26. Misteli T. Protein dynamics: implications for nuclear architecture and gene expression. Science 291: 843-847, 2001.
27. Misteli T, Caceres JF, and Spector DL. The dynamics of pre-mRNA splicing factor in living cells. Nature 387: 523-527, 1997.
28. Misteli T and Spector DL. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. Mol Biol Cell 7: 1559-1572, 1996.
29. Misteli T and Spector DL. The cellular organization of gene expression. Curr Opin Cell Biol 10: 323-331, 2001.
30. Mumby MC and Walter G. Protein serine/threonine phosphatases: structure, regulation and functions in cell growth. Physiol Rev 73: 673-699, 1995.
31. Price NE and Mumby MC. Effects of regulatory subunits on the kinetics of protein phosphatase 2A. Biochemistry 39: 11312-11318, 2000.
32. Sacco-Bubulya P and Spector DL. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J Cell Biol 156: 425-436, 2002.
33. Shenolikar S. Protein serine/threonine phosphatases-new avenues for cell regulation. Annu Rev Cell Biol 10: 55-86, 1994.
34. Sontag E. Protein phosphatase 2A: the Trojan horse of cellular signaling. Cell Signal 13: 7-16, 2001.
35. Tehrani MA, Mumby MC, and Kamibayashi C. Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J Biol Chem 271: 5164-5170, 1996.
36. Thompson JD, Higgins DG, and Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680, 1994.
37. Turowski P, Fernandez A, Favre B, Lamb NJ, and Hemmings BA. Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression. J Cell Biol 129: 397-410, 1995.
38. Virshup DM. Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol 12: 180-185, 2000.
39. Wang Y, Krushel LA, and Edelman GM. Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. Proc Natl Acad Sci USA 93: 3932-3936, 1996.
40. Zeng C, Kim E, Warren SL, and Berget SM. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO J 16: 1401-1412, 1997.