Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A

European Journal of Biochemistry

Volumn 269, Issue 2, 2002, Pages 546-552

  Li, Xinghai ^a   Virshup, David M ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Phosphoprotein phosphatase; Phosphorylation; PP2A; Subunit interactions

Indexed keywords

AMINO ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN SUBUNIT;

ALPHA CHAIN; AMINO ACID SEQUENCE; ARTICLE; BETA CHAIN; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; GLUTATHIONE TRANSFERASE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEIN PHOSPHATASE; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0036161826     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02680.x     Document Type: Article

References (28)

1. Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
2. Protein phosphatase 2A: A panoply of enzymes
3. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
4. Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus
5. Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A
6. The 55 kDa regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase
7. Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs
8. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation
9. Alterations of the PPP2R1B gene in human lung and colon cancer
10. Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene
11. Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aα and Aβ subunit genes
12. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
13. Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens
14. Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus
15. Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits
16. Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
17. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Bα regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen
18. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit
19. Identification of a new family of protein phosphatase 2A regulatory subunits
20. The B56 family of protein phosphatase 2A regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm
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22. Saccharomyces cerevisiae homologs of mammalian B and Bα subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions
23. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
24. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation
25. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
26. Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A
27. Molecular model of the A subunit of protein phosphatase 2A: Interaction with other subunits and tumor antigens
28. Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene