메뉴 건너뛰기




Volumn 74, Issue 4, 1996, Pages 569-578

Molecular mechanisms underlying the interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases

Author keywords

Microcystins; Motuporin; Nodularin; Protein phosphatases; Protein phosphorylation

Indexed keywords

CYANOGINOSIN; CYANOGINOSIN LR; CYANOGINOSIN-LA; CYCLOPEPTIDE; ENZYME INHIBITOR; MICROCYSTIN LL; MOTUPORIN; NODULARIN R; PHOSPHOPROTEIN PHOSPHATASE;

EID: 0030344872     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o96-061     Document Type: Article
Times cited : (138)

References (35)
  • 1
    • 0027233603 scopus 로고
    • Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme
    • Alessi, D.R., Street, A.J., Cohen, P., and Cohen, P.T.W. 1993. Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme. Eur. J. Biochem. 213: 1055-1066.
    • (1993) Eur. J. Biochem. , vol.213 , pp. 1055-1066
    • Alessi, D.R.1    Street, A.J.2    Cohen, P.3    Cohen, P.T.W.4
  • 4
    • 0027332393 scopus 로고
    • Identification of type-1 protein phosphatase in the okadaic acid-producing marine dinoflagellate Prorocentrum lima
    • Boland, M.P., Taylor, F.J.R., and Holmes, C.F.B. 1993. Identification of type-1 protein phosphatase in the okadaic acid-producing marine dinoflagellate Prorocentrum lima. FEBS Lett. 334: 13-17.
    • (1993) FEBS Lett. , vol.334 , pp. 13-17
    • Boland, M.P.1    Taylor, F.J.R.2    Holmes, C.F.B.3
  • 5
    • 0026651340 scopus 로고
    • Cyanobacteria secondary metabolites - The cyanotoxins
    • Carmichael, W.W. 1992. Cyanobacteria secondary metabolites - the cyanotoxins. J. Appl. Bacteriol. 72: 445-459.
    • (1992) J. Appl. Bacteriol. , vol.72 , pp. 445-459
    • Carmichael, W.W.1
  • 6
    • 0028127691 scopus 로고
    • The toxins of Cyanobacteria
    • January
    • Carmichael, W.W. 1994. The toxins of Cyanobacteria. Sci. Am. January: 78-86.
    • (1994) Sci. Am. , pp. 78-86
    • Carmichael, W.W.1
  • 8
    • 0024792262 scopus 로고
    • Protein phosphatases come of age
    • Cohen, P., and Cohen, P.T.W. 1989. Protein phosphatases come of age. J. Biol. Chem. 264: 21 435-21 438.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21435-21438
    • Cohen, P.1    Cohen, P.T.W.2
  • 9
    • 0027751617 scopus 로고
    • Identification and characterization of hydrophobic microcystins in Canadian freshwater cyanobacteria
    • Craig, M., McCready, T.L., Luu, H.A., Smillie, M.A., Dubord, P., and Holmes, C.F.B. 1993. Identification and characterization of hydrophobic microcystins in Canadian freshwater cyanobacteria. Toxicon, 31: 1541-1558.
    • (1993) Toxicon , vol.31 , pp. 1541-1558
    • Craig, M.1    McCready, T.L.2    Luu, H.A.3    Smillie, M.A.4    Dubord, P.5    Holmes, C.F.B.6
  • 10
    • 0026528205 scopus 로고
    • Motuporin, a potent new protein phosphatase inhibitor from the Papua New Guinea sponge Theonella swinboei
    • Desilva, E.D., Williams, D.E., Andersen, R.J., Klix, H., Holmes, C.F.B., and Allen, T.M. 1992. Motuporin, a potent new protein phosphatase inhibitor from the Papua New Guinea sponge Theonella swinboei. Tetrahedron Lett. 33, 1561-1564.
    • (1992) Tetrahedron Lett. , vol.33 , pp. 1561-1564
    • Desilva, E.D.1    Williams, D.E.2    Andersen, R.J.3    Klix, H.4    Holmes, C.F.B.5    Allen, T.M.6
  • 12
    • 0027272945 scopus 로고
    • Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
    • Fujiki, H., and Suganuma, M. 1993. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. Adv. Cancer Res. 61: 143-154.
    • (1993) Adv. Cancer Res. , vol.61 , pp. 143-154
    • Fujiki, H.1    Suganuma, M.2
  • 13
    • 0029094754 scopus 로고
    • Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
    • Goldberg, J., Huang, H.B., Kwon, Y.G., Greengard, P., Nairn, A.C., and Kuriyan, J. 1995. Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature (London), 376: 745-753.
    • (1995) Nature (London) , vol.376 , pp. 745-753
    • Goldberg, J.1    Huang, H.B.2    Kwon, Y.G.3    Greengard, P.4    Nairn, A.C.5    Kuriyan, J.6
  • 14
    • 0026093355 scopus 로고
    • Liquid chromatography-linked protein phosphatase bioassay: A highly sensitive marine bioscreen for okadaic acid and related diarrhetic shellfish toxins
    • Holmes, C.F.B. 1991. Liquid chromatography-linked protein phosphatase bioassay: a highly sensitive marine bioscreen for okadaic acid and related diarrhetic shellfish toxins. Toxicon, 29: 469-477.
    • (1991) Toxicon , vol.29 , pp. 469-477
    • Holmes, C.F.B.1
  • 15
    • 0027138757 scopus 로고
    • Inhibitors of protein phosphatase-1 and -2A: Two of the major serine/threonine protein phosphatases involved in cellular regulation
    • Holmes, C.F.B., and Boland, M.P. 1993. Inhibitors of protein phosphatase-1 and -2A: two of the major serine/threonine protein phosphatases involved in cellular regulation. Curr. Opin. Struct. Biol. 3: 934-943.
    • (1993) Curr. Opin. Struct. Biol. , vol.3 , pp. 934-943
    • Holmes, C.F.B.1    Boland, M.P.2
  • 16
  • 18
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London), 227: 680-685.
    • (1970) Nature (London) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 19
    • 0025333146 scopus 로고
    • Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants
    • Mackintosh, C., Beattie, K.A., Klumpp, S., Cohen, P., and Codd, G.A. 1990. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264: 187-192.
    • (1990) FEBS Lett. , vol.264 , pp. 187-192
    • Mackintosh, C.1    Beattie, K.A.2    Klumpp, S.3    Cohen, P.4    Codd, G.A.5
  • 20
    • 0029088182 scopus 로고
    • The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1
    • Mackintosh, R.W., Dalby, K.N., Campbell, D.G., Cohen, P.T.W., Cohen, P., and Mackintosh, C. 1995. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett. 371: 236-240.
    • (1995) FEBS Lett. , vol.371 , pp. 236-240
    • Mackintosh, R.W.1    Dalby, K.N.2    Campbell, D.G.3    Cohen, P.T.W.4    Cohen, P.5    Mackintosh, C.6
  • 21
    • 0028132006 scopus 로고
    • Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography
    • Moorhead, G., Mackintosh, R.W., Morrice, N., Gallagher, T., and MacKintosh, C. 1994. Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography. FEBS Lett. 356: 46-50.
    • (1994) FEBS Lett. , vol.356 , pp. 46-50
    • Moorhead, G.1    Mackintosh, R.W.2    Morrice, N.3    Gallagher, T.4    MacKintosh, C.5
  • 24
    • 0027057360 scopus 로고
    • Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumour promoter, in primary cultured rat hepatocytes
    • Ohta, T., Nishiwaki, R., Yatsunami, J., Komori, A., Suganuma, M., and Fujiki, H. 1992. Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumour promoter, in primary cultured rat hepatocytes. Carcinogenesis, 13: 2443-2447.
    • (1992) Carcinogenesis , vol.13 , pp. 2443-2447
    • Ohta, T.1    Nishiwaki, R.2    Yatsunami, J.3    Komori, A.4    Suganuma, M.5    Fujiki, H.6
  • 27
    • 0000483177 scopus 로고
    • Structure and biosynthesis of toxins from blue-green algae (cyanobacteria)
    • Rinehart, K.L., Namikoshi, M., and Choi, B.W. 1994. Structure and biosynthesis of toxins from blue-green algae (cyanobacteria). J. Appl. Phycol. 6: 159-176.
    • (1994) J. Appl. Phycol. , vol.6 , pp. 159-176
    • Rinehart, K.L.1    Namikoshi, M.2    Choi, B.W.3
  • 28
    • 0026217677 scopus 로고
    • Association of microcystin-LR and its biotransformation product with a hepatic-cytosolic protein
    • Robinson, N.A., Matson, C.F., and Pace, J.G. 1991. Association of microcystin-LR and its biotransformation product with a hepatic-cytosolic protein. J. Biochem. Toxicol. 6: 171-180.
    • (1991) J. Biochem. Toxicol. , vol.6 , pp. 171-180
    • Robinson, N.A.1    Matson, C.F.2    Pace, J.G.3
  • 30
    • 0028950664 scopus 로고
    • Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: Method of analysis of interactions of tight-binding ligands with target protein
    • Takai, A., Sasaki, K., Nagai, H., Mieskes, G., Isobe, M., Isono, K., and Yasumoto, T. 1995. Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein. Biochem. J. 306: 657-665.
    • (1995) Biochem. J. , vol.306 , pp. 657-665
    • Takai, A.1    Sasaki, K.2    Nagai, H.3    Mieskes, G.4    Isobe, M.5    Isono, K.6    Yasumoto, T.7
  • 31
    • 0028319067 scopus 로고
    • Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates
    • Toivola, D.M., Eriksson, I.E., and Brautigan, D.L. 1994. Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates. FEBS Lett. 344: 175-180.
    • (1994) FEBS Lett. , vol.344 , pp. 175-180
    • Toivola, D.M.1    Eriksson, I.E.2    Brautigan, D.L.3
  • 33
    • 0030065764 scopus 로고    scopus 로고
    • Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins
    • Zhang, L., Zhang, Z., Long, F., and Lee, E.Y.C. 1996. Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins. Biochemistry, 35: 1606-1611.
    • (1996) Biochemistry , vol.35 , pp. 1606-1611
    • Zhang, L.1    Zhang, Z.2    Long, F.3    Lee, E.Y.C.4
  • 34
    • 0026567879 scopus 로고
    • Expression of the catalytic subunit of phosphorylase phosphatase (protein phosphatase-1) in Escherichia coli
    • Zhang, Z., Bai, G., Deans-Zirattu, S., Browner, M.F., and Lee, E.Y.C. 1992. Expression of the catalytic subunit of phosphorylase phosphatase (protein phosphatase-1) in Escherichia coli. J. Biol. Chem. 267: 1484-1490.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1484-1490
    • Zhang, Z.1    Bai, G.2    Deans-Zirattu, S.3    Browner, M.F.4    Lee, E.Y.C.5
  • 35


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.