Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition

Journal of the American Chemical Society

Volumn 128, Issue 51, 2006, Pages 16720-16732

  Lawhorn, Brian G ^a   Boga, Sobhana B ^a   Wolkenberg, Scott E ^a   Colby, David A ^a   Gauss, Carla Maria ^a   Swingle, Mark R ^b   Amable, Lauren ^b   Honkanen, Richard E ^b   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSTATIN; DIASTEREOMERS; NUCLEOPHILIC ADDITION; STEREOSELECTIVITY;

CHELATION; ENZYME INHIBITION; EPOXY RESINS; ISOMERS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL); TUMORS;

AROMATIC COMPOUNDS;

11 DESHYDROXYCYTOSTATIN; ANTINEOPLASTIC AGENT; DEPHOSPHOCYTOSTATIN; FOSTRIECIN; HEXESTROL DIPHOSPHATE; NATURAL PRODUCT; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2A INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; SULFOCYTOSTATIN; SULTRIECIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHELATION; COVALENT BOND; DIASTEREOISOMER; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INHIBITION KINETICS; STEREOCHEMISTRY;

ALKENES; ANIMALS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; LEUKEMIA L1210; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORIC ACID ESTERS; PYRONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845928989     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja066477d     Document Type: Article

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