Human Blue-light Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity

Photochemistry and Photobiology

Volumn 66, Issue 5, 1997, Pages 727-731

  Zhao, Shaying ^a   Sancar, Aziz ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS THALIANA; CHLAMYDOMONAS REINHARDTII; SINAPIS ALBA;

CRYPTOCHROME; CRYPTOCHROME PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; EYE PROTEIN; FLAVOPROTEIN; G PROTEIN COUPLED RECEPTOR; NUCLEAR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PP5 PROTEIN SERINE THREONINE PHOSPHATASE; PP5 PROTEIN-SERINE-THREONINE PHOSPHATASE; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; PHOTORECEPTOR; PROTEIN BINDING; RADIATION EXPOSURE; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA PROTEINS; EYE PROTEINS; FLAVOPROTEINS; HUMANS; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PHOTORECEPTORS; PHOTORECEPTORS, INVERTEBRATE; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0031266991     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb03214.x     Document Type: Article

References (29)

1. Todo, T., H. Ryo, K. Yamamoto, H. Toh, T. Inui, H. Ayaki, T. Nomura and M. Ikenaga (1996) Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog and the DNA photolyase blue-light photoreceptor family. Science 272, 109-112.
2. Ahmad, M. and A. R. Cashmore (1993) HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor. Nature 366, 162-166.
3. Malhotra, K., S. T. Kim, A. Batschauer, L. Dawut and A. Sancar (1995) Putative blue-light photoreceptors from Arabidopsis thaliana and Sinapis alba with a high degree of sequence homology to DNA photolyase contain the two photolyase cofactors but lack DNA repair activity. Biochemistry 34, 6892-6899.
4. Small, G. D., B. Min and P. Lefebvre (1995) Characterization of a Chlamydomonas reinhardtii gene encoding a protein of the DNA photolyase/blue light photoreceptor family. Plant Mol. Biol. 28, 443-454.
5. Hsu, D. S., X. Zhao, S. Zhao, A. Kazantsev, R. P. Wang, T. Todo, Y. F. Wei and A. Sancar (1996) Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. Biochemistry 35, 13871-13877.
6. Pang, Q. and J. B. Hays (1991) UV-B inducible and temperature-sensitive photoreactivation of cyclobutane pyrimidine dimers in Arabidopsis thaliana. Plant Physiol. 95, 536-543.
7. Jiang, C. Z., J. Yee, D. L. Mitchell and A. B. Britt (1997) Photorepair mutants of Arabidopsis. Proc. Natl. Acad. Sci. USA 94, 7441-7445.
8. Hoffman, P. D., A. Batschauer and J. B. Hays (1996) PHH1, a novel gene from Arabidopsis thaliana that encodes a protein similar to plant blue-light photoreceptors and microbial photolyases. Mol. Gen. Genet. 253, 259-265.
9. Lin, C., M. Ahmad, J. Chan and A. R. Cashmore (1996) CRY2: a second member of the Arabidopsis cryptochrome gene family. Plant Physiol. 110, 1047.
10. van der Spek, P. J., K. Kobayashi, D. Bootsma, M. Takao, A. P. M. Eker and A. Yasui (1996) Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. Genomics 37, 177-182.
11. Mathews, C. K. and K. E. Van Holde (1996) Biochemistry, 2nd ed., pp. 688-689. Benjamin/Cummings, Menlo Park, CA.
12. Takahashi, J. T., P. J. DeCoursey, L. Bauman and M. Menaker (1984) Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms. Nature 308, 186-188.
13. Fields, S. and O. K. Song (1989) A novel genetic system to detect protein-protein interactions. Nature 340, 245-246.
14. Chen, M. X., A. E. McPartlin, L. Brown, Y. H. Chen, H. M. Barker and P. T. W. Cohen (1994) A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J. 13, 4278-4290.
15. Murthy, A. E., A. Bernards, D. Church, J. Washmuth and J. F. Gusella (1996) Identification and characterization of two novel tetratricopeptide repeat-containing genes. DNA Cell Biol. 15, 727-735.
16. Zhao, X., J. Liu, D. S. Hsu, S. Zhao, J. S. Taylor and A. Sancar (1997) Reaction mechanism of (6-4) photolyase. J. Biol. Chem. 273. (In press)
17. Bogerd, H. P., R. A. Fridell, S. Madore and B. Cullen (1995) Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82, 485-494.
18. Yong, W. H., K. Ueki, D. Chou, S. A. Reeves, A. von Deimling, J. F. Gusella, H. W. Mohrenweiser, A. J. Buckler and D. N. Louis (1995) Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region of chromosome 19q13.3. Genomics 29, 533-536.
19. Selby, C. P. and A. Sancar (1995) Structure and function of transcription-repair coupling factor I. Structural domains and binding properties. J. Biol. Chem. 270, 4882-4884.
20. Skinner, J., C. Sinclair, C. Romeo, D. Armstrong, H. Charbonneau and S. Rossie (1997) Purification of a fatty acid-stmulated protein Ser/Thr phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5. J. Biol. Chem. 272, 22464-22471.
21. Lin, C., D. E. Robertson, M. Ahmad, A. A. Raibekas, M. M. Jorns, P. L. Dutton and A. R. Cashmore (1995) Association of flavin adenine dinucleotide with the Arabidopsis blue-light receptor CRY1. Science 269, 948-970.
22. Lin, C., M. Ahmad, D. Gordon and A. R. Cashmore (1995) Expression of an Arabidopsis cryptochrome gene in transgenic tobacco results in hypersensitivity to blue, UV-A, and green light. Proc. Natl. Acad. Sci. USA 92, 8423-8427.
23. Ahmad, M. and A. R. Cashmore (1996) Seeing blue: the discovery of cryptochrome. Plant Mol. Biol. 30, 851-861.
24. Cohen, P. T. W. (1997) Novel protein serine/threonine phosphatases: variety is the spice of life. Trends Biochem. Sci. 22, 245-251.
25. Chinkers, M. (1994) Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc. Natl. Acad. Sci. USA 91, 11075-11079.
26. Chen, M. S., A. M. Silverstein, W. B. Pratt and M. Chinkers (1996) The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J. Biol. Chem. 271, 32315-32320.
27. Chen, M. X., Y. H. Chen and P. T. W. Cohen (1992) Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatase. FEBS Lett. 306, 54-58.
28. Steele, F. R., T. Washburn, R. Rieger and J. E. O'Tousa (1992) Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase. Cell 69, 669-676.
29. Vinos, J., K. Jalink, R. W. Hardy, S. G. Britt and C. S. Zuker (1997) A G protein-coupled receptor phosphatase required for rhodopsin function. Science 277, 687-690.